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Message in a vesicle - trans-kingdom intercommunication at the vector-host interface.

Chávez ASO, O'Neal AJ, Santambrogio L, Kotsyfakis M, Pedra JHF.

J Cell Sci. 2019 Mar 18;132(6). pii: jcs224212. doi: 10.1242/jcs.224212. Review.


The structure and function of Iristatin, a novel immunosuppressive tick salivary cystatin.

Kotál J, Stergiou N, Buša M, Chlastáková A, Beránková Z, Řezáčová P, Langhansová H, Schwarz A, Calvo E, Kopecký J, Mareš M, Schmitt E, Chmelař J, Kotsyfakis M.

Cell Mol Life Sci. 2019 May;76(10):2003-2013. doi: 10.1007/s00018-019-03034-3. Epub 2019 Feb 12.


Exosome-Mediated Pathogen Transmission by Arthropod Vectors.

Hackenberg M, Kotsyfakis M.

Trends Parasitol. 2018 Jul;34(7):549-552. doi: 10.1016/ Epub 2018 Apr 24.


Ixonnexin from Tick Saliva Promotes Fibrinolysis by Interacting with Plasminogen and Tissue-Type Plasminogen Activator, and Prevents Arterial Thrombosis.

Assumpção TC, Mizurini DM, Ma D, Monteiro RQ, Ahlstedt S, Reyes M, Kotsyfakis M, Mather TN, Andersen JF, Lukszo J, Ribeiro JMC, Francischetti IMB.

Sci Rep. 2018 Mar 19;8(1):4806. doi: 10.1038/s41598-018-22780-1.


Protease Inhibitors in Tick Saliva: The Role of Serpins and Cystatins in Tick-host-Pathogen Interaction.

Chmelař J, Kotál J, Langhansová H, Kotsyfakis M.

Front Cell Infect Microbiol. 2017 May 29;7:216. doi: 10.3389/fcimb.2017.00216. eCollection 2017. Review.


In silico target network analysis of de novo-discovered, tick saliva-specific microRNAs reveals important combinatorial effects in their interference with vertebrate host physiology.

Hackenberg M, Langenberger D, Schwarz A, Erhart J, Kotsyfakis M.

RNA. 2017 Aug;23(8):1259-1269. doi: 10.1261/rna.061168.117. Epub 2017 May 4.


Antiplasmodial Activity Is an Ancient and Conserved Feature of Tick Defensins.

Cabezas-Cruz A, Tonk M, Bouchut A, Pierrot C, Pierce RJ, Kotsyfakis M, Rahnamaeian M, Vilcinskas A, Khalife J, Valdés JJ.

Front Microbiol. 2016 Oct 24;7:1682. eCollection 2016.


For Whom the Bell Tolls (and Nods): Spit-acular Saliva.

Shaw DK, Kotsyfakis M, Pedra JH.

Curr Trop Med Rep. 2016 Jun;3(2):40-50. Epub 2016 Apr 5.


The Prostaglandin E2-EP3 Receptor Axis Regulates Anaplasma phagocytophilum-Mediated NLRC4 Inflammasome Activation.

Wang X, Shaw DK, Hammond HL, Sutterwala FS, Rayamajhi M, Shirey KA, Perkins DJ, Bonventre JV, Velayutham TS, Evans SM, Rodino KG, VieBrock L, Scanlon KM, Carbonetti NH, Carlyon JA, Miao EA, McBride JW, Kotsyfakis M, Pedra JH.

PLoS Pathog. 2016 Aug 2;12(8):e1005803. doi: 10.1371/journal.ppat.1005803. eCollection 2016 Aug.


The Tick Protein Sialostatin L2 Binds to Annexin A2 and Inhibits NLRC4-Mediated Inflammasome Activation.

Wang X, Shaw DK, Sakhon OS, Snyder GA, Sundberg EJ, Santambrogio L, Sutterwala FS, Dumler JS, Shirey KA, Perkins DJ, Richard K, Chagas AC, Calvo E, Kopecký J, Kotsyfakis M, Pedra JHF.

Infect Immun. 2016 May 24;84(6):1796-1805. doi: 10.1128/IAI.01526-15. Print 2016 Jun.


All For One and One For All on the Tick-Host Battlefield.

Chmelař J, Kotál J, Kopecký J, Pedra JHF, Kotsyfakis M.

Trends Parasitol. 2016 May;32(5):368-377. doi: 10.1016/ Epub 2016 Jan 30. Review.


SALO, a novel classical pathway complement inhibitor from saliva of the sand fly Lutzomyia longipalpis.

Ferreira VP, Fazito Vale V, Pangburn MK, Abdeladhim M, Mendes-Sousa AF, Coutinho-Abreu IV, Rasouli M, Brandt EA, Meneses C, Lima KF, Nascimento Araújo R, Pereira MH, Kotsyfakis M, Oliveira F, Kamhawi S, Ribeiro JM, Gontijo NF, Collin N, Valenzuela JG.

Sci Rep. 2016 Jan 13;6:19300. doi: 10.1038/srep19300.


In Vitro Mode of Action and Anti-thrombotic Activity of Boophilin, a Multifunctional Kunitz Protease Inhibitor from the Midgut of a Tick Vector of Babesiosis, Rhipicephalus microplus.

Assumpção TC, Ma D, Mizurini DM, Kini RM, Ribeiro JM, Kotsyfakis M, Monteiro RQ, Francischetti IM.

PLoS Negl Trop Dis. 2016 Jan 8;10(1):e0004298. doi: 10.1371/journal.pntd.0004298. eCollection 2016 Jan.


Sialomes and Mialomes: A Systems-Biology View of Tick Tissues and Tick-Host Interactions.

Chmelař J, Kotál J, Karim S, Kopacek P, Francischetti IMB, Pedra JHF, Kotsyfakis M.

Trends Parasitol. 2016 Mar;32(3):242-254. doi: 10.1016/ Epub 2015 Oct 28. Review.


Ixodes ricinus defensins attack distantly-related pathogens.

Tonk M, Cabezas-Cruz A, Valdés JJ, Rego RO, Grubhoffer L, Estrada-Peña A, Vilcinskas A, Kotsyfakis M, Rahnamaeian M.

Dev Comp Immunol. 2015 Dec;53(2):358-65. doi: 10.1016/j.dci.2015.08.001. Epub 2015 Aug 5.


Identification and Mechanistic Analysis of a Novel Tick-Derived Inhibitor of Thrombin.

Jablonka W, Kotsyfakis M, Mizurini DM, Monteiro RQ, Lukszo J, Drake SK, Ribeiro JM, Andersen JF.

PLoS One. 2015 Aug 5;10(8):e0133991. doi: 10.1371/journal.pone.0133991. eCollection 2015.


Modulation of host immunity by tick saliva.

Kotál J, Langhansová H, Lieskovská J, Andersen JF, Francischetti IM, Chavakis T, Kopecký J, Pedra JH, Kotsyfakis M, Chmelař J.

J Proteomics. 2015 Oct 14;128:58-68. doi: 10.1016/j.jprot.2015.07.005. Epub 2015 Jul 17. Review.


Correction: Deep Sequencing Analysis of the Ixodes ricinus Haemocytome.

Kotsyfakis M, Kopáček P, Franta Z, Pedra JH, Ribeiro JM.

PLoS Negl Trop Dis. 2015 Jul 17;9(7):e0003909. doi: 10.1371/journal.pntd.0003909. eCollection 2015 Jul. No abstract available.


Tick Salivary Sialostatin L Represses the Initiation of Immune Responses by Targeting IRF4-Dependent Transcription in Murine Mast Cells.

Klein M, Brühl TJ, Staudt V, Reuter S, Grebe N, Gerlitzki B, Hoffmann M, Bohn T, Ulges A, Stergiou N, de Graaf J, Löwer M, Taube C, Becker M, Hain T, Dietzen S, Stassen M, Huber M, Lohoff M, Campos Chagas A, Andersen J, Kotál J, Langhansová H, Kopecký J, Schild H, Kotsyfakis M, Schmitt E, Bopp T.

J Immunol. 2015 Jul 15;195(2):621-31. doi: 10.4049/jimmunol.1401823. Epub 2015 Jun 15.


Tick sialostatins L and L2 differentially influence dendritic cell responses to Borrelia spirochetes.

Lieskovská J, Páleníková J, Langhansová H, Campos Chagas A, Calvo E, Kotsyfakis M, Kopecký J.

Parasit Vectors. 2015 May 15;8:275. doi: 10.1186/s13071-015-0887-1.


Deep Sequencing Analysis of the Ixodes ricinus Haemocytome.

Kotsyfakis M, Kopáček P, Franta Z, Pedra JH, Ribeiro JM.

PLoS Negl Trop Dis. 2015 May 13;9(5):e0003754. doi: 10.1371/journal.pntd.0003754. eCollection 2015 May. Erratum in: PLoS Negl Trop Dis. 2015 Jul;9(7):e0003909.


Tissue- and time-dependent transcription in Ixodes ricinus salivary glands and midguts when blood feeding on the vertebrate host.

Kotsyfakis M, Schwarz A, Erhart J, Ribeiro JM.

Sci Rep. 2015 Mar 13;5:9103. doi: 10.1038/srep09103.


Ixodes ricinus salivary serpin IRS-2 affects Th17 differentiation via inhibition of the interleukin-6/STAT-3 signaling pathway.

Páleníková J, Lieskovská J, Langhansová H, Kotsyfakis M, Chmelař J, Kopecký J.

Infect Immun. 2015 May;83(5):1949-56. doi: 10.1128/IAI.03065-14. Epub 2015 Feb 23.


Tick salivary cystatin sialostatin L2 suppresses IFN responses in mouse dendritic cells.

Lieskovská J, Páleníková J, Širmarová J, Elsterová J, Kotsyfakis M, Campos Chagas A, Calvo E, Růžek D, Kopecký J.

Parasite Immunol. 2015 Feb;37(2):70-8. doi: 10.1111/pim.12162.


Plasmodium falciparum infection induces expression of a mosquito salivary protein (Agaphelin) that targets neutrophil function and inhibits thrombosis without impairing hemostasis.

Waisberg M, Molina-Cruz A, Mizurini DM, Gera N, Sousa BC, Ma D, Leal AC, Gomes T, Kotsyfakis M, Ribeiro JM, Lukszo J, Reiter K, Porcella SF, Oliveira CJ, Monteiro RQ, Barillas-Mury C, Pierce SK, Francischetti IM.

PLoS Pathog. 2014 Sep 11;10(9):e1004338. doi: 10.1371/journal.ppat.1004338. eCollection 2014 Sep.


A systems level analysis reveals transcriptomic and proteomic complexity in Ixodes ricinus midgut and salivary glands during early attachment and feeding.

Schwarz A, Tenzer S, Hackenberg M, Erhart J, Gerhold-Ay A, Mazur J, Kuharev J, Ribeiro JM, Kotsyfakis M.

Mol Cell Proteomics. 2014 Oct;13(10):2725-35. doi: 10.1074/mcp.M114.039289. Epub 2014 Jul 21.


The tick salivary protein sialostatin L2 inhibits caspase-1-mediated inflammation during Anaplasma phagocytophilum infection.

Chen G, Wang X, Severo MS, Sakhon OS, Sohail M, Brown LJ, Sircar M, Snyder GA, Sundberg EJ, Ulland TK, Olivier AK, Andersen JF, Zhou Y, Shi GP, Sutterwala FS, Kotsyfakis M, Pedra JH.

Infect Immun. 2014 Jun;82(6):2553-64. doi: 10.1128/IAI.01679-14. Epub 2014 Mar 31.


Effects of Aedes aegypti salivary components on dendritic cell and lymphocyte biology.

Bizzarro B, Barros MS, Maciel C, Gueroni DI, Lino CN, Campopiano J, Kotsyfakis M, Amarante-Mendes GP, Calvo E, Capurro ML, Sá-Nunes A.

Parasit Vectors. 2013 Nov 15;6:329. doi: 10.1186/1756-3305-6-329.


Desmolaris, a novel factor XIa anticoagulant from the salivary gland of the vampire bat (Desmodus rotundus) inhibits inflammation and thrombosis in vivo.

Ma D, Mizurini DM, Assumpção TC, Li Y, Qi Y, Kotsyfakis M, Ribeiro JM, Monteiro RQ, Francischetti IM.

Blood. 2013 Dec 12;122(25):4094-106. doi: 10.1182/blood-2013-08-517474. Epub 2013 Oct 24.


A Nod to disease vectors: mitigation of pathogen sensing by arthropod saliva.

Sakhon OS, Severo MS, Kotsyfakis M, Pedra JH.

Front Microbiol. 2013 Oct 21;4:308. doi: 10.3389/fmicb.2013.00308. eCollection 2013. Review.


De novo Ixodes ricinus salivary gland transcriptome analysis using two next-generation sequencing methodologies.

Schwarz A, von Reumont BM, Erhart J, Chagas AC, Ribeiro JM, Kotsyfakis M.

FASEB J. 2013 Dec;27(12):4745-56. doi: 10.1096/fj.13-232140. Epub 2013 Aug 20.


Tryptogalinin is a tick Kunitz serine protease inhibitor with a unique intrinsic disorder.

Valdés JJ, Schwarz A, Cabeza de Vaca I, Calvo E, Pedra JH, Guallar V, Kotsyfakis M.

PLoS One. 2013 May 3;8(5):e62562. doi: 10.1371/journal.pone.0062562. Print 2013.


Primary cervical and uterine corpus lymphoma; a case report and literature review.

Anagnostopoulos A, Mouzakiti N, Ruthven S, Herod J, Kotsyfakis M.

Int J Clin Exp Med. 2013 Apr 12;6(4):298-306. Print 2013.


Ixodes scapularis saliva mitigates inflammatory cytokine secretion during Anaplasma phagocytophilum stimulation of immune cells.

Chen G, Severo MS, Sohail M, Sakhon OS, Wikel SK, Kotsyfakis M, Pedra JH.

Parasit Vectors. 2012 Oct 10;5:229. doi: 10.1186/1756-3305-5-229.


Lufaxin, a novel factor Xa inhibitor from the salivary gland of the sand fly Lutzomyia longipalpis blocks protease-activated receptor 2 activation and inhibits inflammation and thrombosis in vivo.

Collin N, Assumpção TC, Mizurini DM, Gilmore DC, Dutra-Oliveira A, Kotsyfakis M, Sá-Nunes A, Teixeira C, Ribeiro JM, Monteiro RQ, Valenzuela JG, Francischetti IM.

Arterioscler Thromb Vasc Biol. 2012 Sep;32(9):2185-98. doi: 10.1161/ATVBAHA.112.253906. Epub 2012 Jul 12.


Anaplasma phagocytophilum dihydrolipoamide dehydrogenase 1 affects host-derived immunopathology during microbial colonization.

Chen G, Severo MS, Sakhon OS, Choy A, Herron MJ, Felsheim RF, Wiryawan H, Liao J, Johns JL, Munderloh UG, Sutterwala FS, Kotsyfakis M, Pedra JH.

Infect Immun. 2012 Sep;80(9):3194-205. doi: 10.1128/IAI.00532-12. Epub 2012 Jul 2.


Anaplasma phagocytophilum: deceptively simple or simply deceptive?

Severo MS, Stephens KD, Kotsyfakis M, Pedra JH.

Future Microbiol. 2012 Jun;7(6):719-31. doi: 10.2217/fmb.12.45. Review.


The role of cystatins in tick physiology and blood feeding.

Schwarz A, Valdés JJ, Kotsyfakis M.

Ticks Tick Borne Dis. 2012 Jun;3(3):117-27. doi: 10.1016/j.ttbdis.2012.03.004. Epub 2012 Apr 20. Review.


The Anopheles gambiae cE5, a tight- and fast-binding thrombin inhibitor with post-transcriptionally regulated salivary-restricted expression.

Ronca R, Kotsyfakis M, Lombardo F, Rizzo C, Currà C, Ponzi M, Fiorentino G, Ribeiro JM, Arcà B.

Insect Biochem Mol Biol. 2012 Sep;42(9):610-20. doi: 10.1016/j.ibmb.2012.04.008. Epub 2012 May 14.


Tick salivary secretion as a source of antihemostatics.

Chmelar J, Calvo E, Pedra JH, Francischetti IM, Kotsyfakis M.

J Proteomics. 2012 Jul 16;75(13):3842-54. doi: 10.1016/j.jprot.2012.04.026. Epub 2012 Apr 27. Review.


An epithelial serine protease, AgESP, is required for Plasmodium invasion in the mosquito Anopheles gambiae.

Rodrigues J, Oliveira GA, Kotsyfakis M, Dixit R, Molina-Cruz A, Jochim R, Barillas-Mury C.

PLoS One. 2012;7(4):e35210. doi: 10.1371/journal.pone.0035210. Epub 2012 Apr 11.


Simukunin from the salivary glands of the black fly Simulium vittatum inhibits enzymes that regulate clotting and inflammatory responses.

Tsujimoto H, Kotsyfakis M, Francischetti IM, Eum JH, Strand MR, Champagne DE.

PLoS One. 2012;7(2):e29964. doi: 10.1371/journal.pone.0029964. Epub 2012 Feb 23.


The tick salivary protein sialostatin L inhibits the Th9-derived production of the asthma-promoting cytokine IL-9 and is effective in the prevention of experimental asthma.

Horka H, Staudt V, Klein M, Taube C, Reuter S, Dehzad N, Andersen JF, Kopecky J, Schild H, Kotsyfakis M, Hoffmann M, Gerlitzki B, Stassen M, Bopp T, Schmitt E.

J Immunol. 2012 Mar 15;188(6):2669-76. doi: 10.4049/jimmunol.1100529. Epub 2012 Feb 10.


Defibrotide interferes with several steps of the coagulation-inflammation cycle and exhibits therapeutic potential to treat severe malaria.

Francischetti IM, Oliveira CJ, Ostera GR, Yager SB, Debierre-Grockiego F, Carregaro V, Jaramillo-Gutierrez G, Hume JC, Jiang L, Moretz SE, Lin CK, Ribeiro JM, Long CA, Vickers BK, Schwarz RT, Seydel KB, Iacobelli M, Ackerman HC, Srinivasan P, Gomes RB, Wang X, Monteiro RQ, Kotsyfakis M, Sá-Nunes A, Waisberg M.

Arterioscler Thromb Vasc Biol. 2012 Mar;32(3):786-98. doi: 10.1161/ATVBAHA.111.240291. Epub 2011 Nov 23.


Alboserpin, a factor Xa inhibitor from the mosquito vector of yellow fever, binds heparin and membrane phospholipids and exhibits antithrombotic activity.

Calvo E, Mizurini DM, Sá-Nunes A, Ribeiro JM, Andersen JF, Mans BJ, Monteiro RQ, Kotsyfakis M, Francischetti IM.

J Biol Chem. 2011 Aug 12;286(32):27998-8010. doi: 10.1074/jbc.M111.247924. Epub 2011 Jun 14.


Cysteine proteases from bloodfeeding arthropod ectoparasites.

Sojka D, Francischetti IM, Calvo E, Kotsyfakis M.

Adv Exp Med Biol. 2011;712:177-91. doi: 10.1007/978-1-4419-8414-2_11. Review.


A tick salivary protein targets cathepsin G and chymase and inhibits host inflammation and platelet aggregation.

Chmelar J, Oliveira CJ, Rezacova P, Francischetti IM, Kovarova Z, Pejler G, Kopacek P, Ribeiro JM, Mares M, Kopecky J, Kotsyfakis M.

Blood. 2011 Jan 13;117(2):736-44. doi: 10.1182/blood-2010-06-293241. Epub 2010 Oct 12.


The crystal structures of two salivary cystatins from the tick Ixodes scapularis and the effect of these inhibitors on the establishment of Borrelia burgdorferi infection in a murine model.

Kotsyfakis M, Horka H, Salat J, Andersen JF.

Mol Microbiol. 2010 Jul;77(2):456-70. doi: 10.1111/j.1365-2958.2010.07220.x. Epub 2010 Jun 1.


Crystal structure and functional characterization of an immunomodulatory salivary cystatin from the soft tick Ornithodoros moubata.

Salát J, Paesen GC, Rezácová P, Kotsyfakis M, Kovárová Z, Sanda M, Majtán J, Grunclová L, Horká H, Andersen JF, Brynda J, Horn M, Nunn MA, Kopácek P, Kopecký J, Mares M.

Biochem J. 2010 Jul 1;429(1):103-12. doi: 10.1042/BJ20100280.


The salivary gland transcriptome of the eastern tree hole mosquito, Ochlerotatus triseriatus.

Calvo E, Sanchez-Vargas I, Kotsyfakis M, Favreau AJ, Barbian KD, Pham VM, Olson KE, Ribeiro JM.

J Med Entomol. 2010 May;47(3):376-86.

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