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Items: 1 to 50 of 88

1.

The Role of E3, E4 Ubiquitin Ligase (UBE4B) in Human Pathologies.

Antoniou N, Lagopati N, Balourdas DI, Nikolaou M, Papalampros A, Vasileiou PVS, Myrianthopoulos V, Kotsinas A, Shiloh Y, Liontos M, Gorgoulis VG.

Cancers (Basel). 2019 Dec 24;12(1). pii: E62. doi: 10.3390/cancers12010062. Review.

2.

A Deep Learning Framework for Predicting Response to Therapy in Cancer.

Sakellaropoulos T, Vougas K, Narang S, Koinis F, Kotsinas A, Polyzos A, Moss TJ, Piha-Paul S, Zhou H, Kardala E, Damianidou E, Alexopoulos LG, Aifantis I, Townsend PA, Panayiotidis MI, Sfikakis P, Bartek J, Fitzgerald RC, Thanos D, Mills Shaw KR, Petty R, Tsirigos A, Gorgoulis VG.

Cell Rep. 2019 Dec 10;29(11):3367-3373.e4. doi: 10.1016/j.celrep.2019.11.017.

3.

Antitumor Reactive T-Cell Responses Are Enhanced In Vivo by DAMP Prothymosin Alpha and Its C-Terminal Decapeptide.

Birmpilis AI, Karachaliou CE, Samara P, Ioannou K, Selemenakis P, Kostopoulos IV, Kavrochorianou N, Kalbacher H, Livaniou E, Haralambous S, Kotsinas A, Farzaneh F, Trougakos IP, Voelter W, Dimopoulos MA, Bamias A, Tsitsilonis O.

Cancers (Basel). 2019 Nov 9;11(11). pii: E1764. doi: 10.3390/cancers11111764.

4.

Machine learning and data mining frameworks for predicting drug response in cancer: An overview and a novel in silico screening process based on association rule mining.

Vougas K, Sakellaropoulos T, Kotsinas A, Foukas GP, Ntargaras A, Koinis F, Polyzos A, Myrianthopoulos V, Zhou H, Narang S, Georgoulias V, Alexopoulos L, Aifantis I, Townsend PA, Sfikakis P, Fitzgerald R, Thanos D, Bartek J, Petty R, Tsirigos A, Gorgoulis VG.

Pharmacol Ther. 2019 Nov;203:107395. doi: 10.1016/j.pharmthera.2019.107395. Epub 2019 Jul 30. Review.

PMID:
31374225
5.

Correction to: A Novel Quantitative Method for the Detection of Lipofuscin, the Main By-Product of Cellular Senescence, in Fluids.

Rizou SV, Evangelou K, Myrianthopoulos V, Mourouzis I, Havaki S, Athanasiou A, Vasileiou PVS, Margetis A, Kotsinas A, Kastrinakis NG, Sfikakis P, Townsend P, Mikros E, Pantos C, Gorgoulis VG.

Methods Mol Biol. 2019;1896:C1-C2. doi: 10.1007/978-1-4939-8931-7_19.

PMID:
30725385
6.

Cura"x"ing Cancer and Beyond.

Gorgoulis VG, Kotsinas A.

Bioessays. 2019 Jan;41(1):e1800223. doi: 10.1002/bies.201800223. Epub 2018 Dec 3. No abstract available.

PMID:
30507004
7.

A Novel Quantitative Method for the Detection of Lipofuscin, the Main By-Product of Cellular Senescence, in Fluids.

Rizou SV, Evangelou K, Myrianthopoulos V, Mourouzis I, Havaki S, Athanasiou A, Vasileiou PVS, Margetis A, Kotsinas A, Kastrinakis NG, Sfikakis P, Townsend P, Mikros E, Pantos C, Gorgoulis VG.

Methods Mol Biol. 2019;1896:119-138. doi: 10.1007/978-1-4939-8931-7_12. Erratum in: Methods Mol Biol. 2019;1896:C1-C2.

PMID:
30474845
8.

Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability.

Galanos P, Pappas G, Polyzos A, Kotsinas A, Svolaki I, Giakoumakis NN, Glytsou C, Pateras IS, Swain U, Souliotis VL, Georgakilas AG, Geacintov N, Scorrano L, Lukas C, Lukas J, Livneh Z, Lygerou Z, Chowdhury D, Sørensen CS, Bartek J, Gorgoulis VG.

Genome Biol. 2018 Mar 16;19(1):37. doi: 10.1186/s13059-018-1401-9.

9.

Editorial: DNA Damage and Inflammation under Stress.

Georgakilas AG, Kotsinas A.

Front Genet. 2017 Oct 17;8:152. doi: 10.3389/fgene.2017.00152. eCollection 2017. No abstract available.

10.

Monitoring Autophagy Immunohistochemically and Ultrastructurally during Human Head and Neck Carcinogenesis. Relationship with the DNA Damage Response Pathway.

Havaki S, Vlachou V, Zampetidis CP, Selemenakis P, Kotsinas A, Mavrogonatou E, Rizou SV, Kyrodimos E, Evangelou K, Kletsas D, Giatromanolaki A, Gorgoulis VG.

Int J Mol Sci. 2017 Sep 7;18(9). pii: E1920. doi: 10.3390/ijms18091920.

11.

Genetic Variability as a Regulator of TLR4 and NOD Signaling in Response to Bacterial Driven DNA Damage Response (DDR) and Inflammation: Focus on the Gastrointestinal (GI) Tract.

Spanou E, Kalisperati P, Pateras IS, Papalampros A, Barbouti A, Tzioufas AG, Kotsinas A, Sougioultzis S.

Front Genet. 2017 May 29;8:65. doi: 10.3389/fgene.2017.00065. eCollection 2017. Review.

12.

MiR-signing gastrointestinal (con-)tract cancer.

Gorgoulis VG, Pateras IS, Kotsinas A.

Oncotarget. 2017 May 2;8(18):29536-29537. doi: 10.18632/oncotarget.15701. No abstract available.

13.

Robust, universal biomarker assay to detect senescent cells in biological specimens.

Evangelou K, Lougiakis N, Rizou SV, Kotsinas A, Kletsas D, Muñoz-Espín D, Kastrinakis NG, Pouli N, Marakos P, Townsend P, Serrano M, Bartek J, Gorgoulis VG.

Aging Cell. 2017 Feb;16(1):192-197. doi: 10.1111/acel.12545. Epub 2016 Nov 17.

14.

MicroRNAs Determining Inflammation as Novel Biomarkers and Potential Therapeutic Targets.

Kotsinas A, Sigala F, Garbis SD, Galyfos G, Filis K, Vougas K, Papalampros A, Johnson EE, Chronopoulos E, Georgakilas AG, Gorgoulis VG.

Curr Med Chem. 2015;22(22):2666-79. Review.

PMID:
26180004
15.

Recombining overlapping BACs into single large BACs.

Kotzamanis G, Kotsinas A.

Methods Mol Biol. 2015;1227:123-39. doi: 10.1007/978-1-4939-1652-8_6.

PMID:
25239744
16.

Are common fragile sites merely structural domains or highly organized "functional" units susceptible to oncogenic stress?

Georgakilas AG, Tsantoulis P, Kotsinas A, Michalopoulos I, Townsend P, Gorgoulis VG.

Cell Mol Life Sci. 2014 Dec;71(23):4519-44. doi: 10.1007/s00018-014-1717-x. Epub 2014 Sep 20. Review.

17.

E2F transcription factors and digestive system malignancies: how much do we know?

Evangelou K, Havaki S, Kotsinas A.

World J Gastroenterol. 2014 Aug 7;20(29):10212-6. doi: 10.3748/wjg.v20.i29.10212.

18.

ARF: a versatile DNA damage response ally at the crossroads of development and tumorigenesis.

Kotsinas A, Papanagnou P, Evangelou K, Trigas GC, Kostourou V, Townsend P, Gorgoulis VG.

Front Genet. 2014 Jul 22;5:236. doi: 10.3389/fgene.2014.00236. eCollection 2014.

19.

MKK7 and ARF: new players in the DNA damage response scenery.

Kotsinas A, Papanagnou P, Galanos P, Schramek D, Townsend P, Penninger JM, Bartek J, Gorgoulis VG.

Cell Cycle. 2014;13(8):1227-36. doi: 10.4161/cc.28654. Epub 2014 Mar 26.

20.

The role of oxidative DNA damage in radiation induced bystander effect.

Havaki S, Kotsinas A, Chronopoulos E, Kletsas D, Georgakilas A, Gorgoulis VG.

Cancer Lett. 2015 Jan 1;356(1):43-51. doi: 10.1016/j.canlet.2014.01.023. Epub 2014 Feb 11. Review.

PMID:
24530228
21.

The DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesis.

Evangelou K, Bartkova J, Kotsinas A, Pateras IS, Liontos M, Velimezi G, Kosar M, Liloglou T, Trougakos IP, Dyrskjot L, Andersen CL, Papaioannou M, Drosos Y, Papafotiou G, Hodny Z, Sosa-Pineda B, Wu XR, Klinakis A, Ørntoft T, Lukas J, Bartek J, Gorgoulis VG.

Cell Death Differ. 2013 Nov;20(11):1485-97. doi: 10.1038/cdd.2013.76. Epub 2013 Jul 12.

22.

Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer.

Velimezi G, Liontos M, Vougas K, Roumeliotis T, Bartkova J, Sideridou M, Dereli-Oz A, Kocylowski M, Pateras IS, Evangelou K, Kotsinas A, Orsolic I, Bursac S, Cokaric-Brdovcak M, Zoumpourlis V, Kletsas D, Papafotiou G, Klinakis A, Volarevic S, Gu W, Bartek J, Halazonetis TD, Gorgoulis VG.

Nat Cell Biol. 2013 Aug;15(8):967-77. doi: 10.1038/ncb2795. Epub 2013 Jul 14. Erratum in: Nat Cell Biol. 2013 Oct;15(10):1260.

PMID:
23851489
23.

The relationship between E2F family members and tumor growth in colorectal adenocarcinomas: A comparative immunohistochemical study of 100 cases.

Xanthoulis A, Kotsinas A, Tiniakos D, Fiska A, Tentes AA, Kyroudi A, Kittas C, Gorgoulis V.

Appl Immunohistochem Mol Morphol. 2014 Jul;22(6):471-7. doi: 10.1097/PAI.0b013e3182598198.

PMID:
22688350
24.

Oral lichen planus as a preneoplastic inflammatory model.

Georgakopoulou EA, Achtari MD, Achtaris M, Foukas PG, Kotsinas A.

J Biomed Biotechnol. 2012;2012:759626. doi: 10.1155/2012/759626. Epub 2012 May 17. Review.

25.

The single nucleotide polymorphism g.1548A >G (K469E) of the ICAM-1 gene is associated with worse prognosis in non-small cell lung cancer.

Thanopoulou E, Kotzamanis G, Pateras IS, Ziras N, Papalambros A, Mariolis-Sapsakos T, Sigala F, Johnson E, Kotsinas A, Scorilas A, Gorgoulis VG.

Tumour Biol. 2012 Oct;33(5):1429-36. doi: 10.1007/s13277-012-0393-4. Epub 2012 May 6.

PMID:
22562265
26.

Oxidative stress-mediated biomolecular damage and inflammation in tumorigenesis.

Sesti F, Tsitsilonis OE, Kotsinas A, Trougakos IP.

In Vivo. 2012 May-Jun;26(3):395-402. Review.

PMID:
22523291
27.

Detection of herplex simplex virus-1 and -2 in cardiac myxomas.

Pateras IS, Evangelou K, Tsimaratou K, Liontos M, Sakellariou S, Barlogiannis T, Karakitsos P, Papalois A, Kotsinas A, Gorgoulis VG.

J Biomed Biotechnol. 2012;2012:823949. doi: 10.1155/2012/823949. Epub 2012 Feb 28.

28.

Implementation of formalin-fixed, paraffin-embedded cell line pellets as high-quality process controls in quality assessment programs for KRAS mutation analysis.

Dijkstra JR, Opdam FJ, Boonyaratanakornkit J, Schönbrunner ER, Shahbazian M, Edsjö A, Hoefler G, Jung A, Kotsinas A, Gorgoulis VG, López-Ríos F, de Stricker K, Rouleau E, Biesmans B, van Krieken JH.

J Mol Diagn. 2012 May-Jun;14(3):187-91. doi: 10.1016/j.jmoldx.2012.01.002. Epub 2012 Mar 10.

29.

Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins.

Sideridou M, Zakopoulou R, Evangelou K, Liontos M, Kotsinas A, Rampakakis E, Gagos S, Kahata K, Grabusic K, Gkouskou K, Trougakos IP, Kolettas E, Georgakilas AG, Volarevic S, Eliopoulos AG, Zannis-Hadjopoulos M, Moustakas A, Gorgoulis VG.

J Cell Biol. 2011 Dec 26;195(7):1123-40. doi: 10.1083/jcb.201108121.

30.

PIG3: a novel link between oxidative stress and DNA damage response in cancer.

Kotsinas A, Aggarwal V, Tan EJ, Levy B, Gorgoulis VG.

Cancer Lett. 2012 Dec 31;327(1-2):97-102. doi: 10.1016/j.canlet.2011.12.009. Epub 2011 Dec 14. Review.

PMID:
22178897
31.

Bacterial delivery of large intact genomic-DNA-containing BACs into mammalian cells.

Cheung W, Kotzamanis G, Abdulrazzak H, Goussard S, Kaname T, Kotsinas A, Gorgoulis VG, Grillot-Courvalin C, Huxley C.

Bioeng Bugs. 2012 Mar-Apr;3(2):86-92. doi: 10.4161/bbug.18621. Epub 2012 Mar 1.

32.

GIST mimicking an hyperplastic polyp of descending colon.

Troupis TG, Chatzikokolis S, Michalinos A, Sarakinos A, Kotsopoulos P, Patsea H, Kotsinas A, Evangelou K, Gorgoulis VG.

Ann Ital Chir. 2011 Mar-Apr;82(2):141-6.

PMID:
21682105
33.

Upregulation and nuclear localization of TNF-like cytokine 1A (TL1A) and its receptors DR3 and DcR3 in psoriatic skin lesions.

Bamias G, Evangelou K, Vergou T, Tsimaratou K, Kaltsa G, Antoniou C, Kotsinas A, Kim S, Gorgoulis V, Stratigos AJ, Sfikakis PP.

Exp Dermatol. 2011 Sep;20(9):725-31. doi: 10.1111/j.1600-0625.2011.01304.x. Epub 2011 Jun 14.

PMID:
21672030
34.

External quality assessment for KRAS testing is needed: setup of a European program and report of the first joined regional quality assessment rounds.

Bellon E, Ligtenberg MJ, Tejpar S, Cox K, de Hertogh G, de Stricker K, Edsjö A, Gorgoulis V, Höfler G, Jung A, Kotsinas A, Laurent-Puig P, López-Ríos F, Hansen TP, Rouleau E, Vandenberghe P, van Krieken JJ, Dequeker E.

Oncologist. 2011;16(4):467-78. doi: 10.1634/theoncologist.2010-0429. Epub 2011 Mar 26.

35.

The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression.

Schramek D, Kotsinas A, Meixner A, Wada T, Elling U, Pospisilik JA, Neely GG, Zwick RH, Sigl V, Forni G, Serrano M, Gorgoulis VG, Penninger JM.

Nat Genet. 2011 Mar;43(3):212-9. doi: 10.1038/ng.767. Epub 2011 Feb 13.

PMID:
21317887
36.

Why is p53-inducible gene 3 rarely affected in cancer?

Kotsinas A, Pateras IS, Galanos PS, Karamouzis MV, Sfikakis PP, Gorgoulis VG.

Oncogene. 2010 Sep 16;29(37):5220. doi: 10.1038/onc.2010.263. Epub 2010 Jul 5. No abstract available.

PMID:
20603616
37.

Oxidized LDL in human carotid plaques is related to symptomatic carotid disease and lesion instability.

Sigala F, Kotsinas A, Savari P, Filis K, Markantonis S, Iliodromitis EK, Gorgoulis VG, Andreadou I.

J Vasc Surg. 2010 Sep;52(3):704-13. doi: 10.1016/j.jvs.2010.03.047. Epub 2010 Jun 22.

38.

p57KIP2: "Kip"ing the cell under control.

Pateras IS, Apostolopoulou K, Niforou K, Kotsinas A, Gorgoulis VG.

Mol Cancer Res. 2009 Dec;7(12):1902-19. doi: 10.1158/1541-7786.MCR-09-0317. Epub 2009 Nov 24. Review.

39.

Modulation of the E2F1-driven cancer cell fate by the DNA damage response machinery and potential novel E2F1 targets in osteosarcomas.

Liontos M, Niforou K, Velimezi G, Vougas K, Evangelou K, Apostolopoulou K, Vrtel R, Damalas A, Kontovazenitis P, Kotsinas A, Zoumpourlis V, Tsangaris GT, Kittas C, Ginsberg D, Halazonetis TD, Bartek J, Gorgoulis VG.

Am J Pathol. 2009 Jul;175(1):376-91. doi: 10.2353/ajpath.2009.081160. Epub 2009 Jun 18.

40.

Is exclusive Skp2 targeting always beneficial in cancer therapy?

Koutsami M, Velimezi G, Kotsinas A, Evangelou K, Papavassiliou AG, Kittas C, Gorgoulis VG.

Blood. 2008 Dec 1;112(12):4777-9. doi: 10.1182/blood-2008-06-161802. No abstract available.

PMID:
19029458
41.

Hypomethylation of retrotransposable elements correlates with genomic instability in non-small cell lung cancer.

Daskalos A, Nikolaidis G, Xinarianos G, Savvari P, Cassidy A, Zakopoulou R, Kotsinas A, Gorgoulis V, Field JK, Liloglou T.

Int J Cancer. 2009 Jan 1;124(1):81-7. doi: 10.1002/ijc.23849.

42.

CFTR expression from a BAC carrying the complete human gene and associated regulatory elements.

Kotzamanis G, Abdulrazzak H, Gifford-Garner J, Haussecker PL, Cheung W, Grillot-Courvalin C, Harris A, Kittas C, Kotsinas A, Gorgoulis VG, Huxley C.

J Cell Mol Med. 2009 Sep;13(9A):2938-48. doi: 10.1111/j.1582-4934.2008.00433.x. Epub 2008 Jul 24.

43.

Oncogene-induced replication stress preferentially targets common fragile sites in preneoplastic lesions. A genome-wide study.

Tsantoulis PK, Kotsinas A, Sfikakis PP, Evangelou K, Sideridou M, Levy B, Mo L, Kittas C, Wu XR, Papavassiliou AG, Gorgoulis VG.

Oncogene. 2008 May 22;27(23):3256-64. Epub 2007 Dec 17.

PMID:
18084328
44.

The 3' UTR IGF2R-A2/B2 variant is associated with increased tumor growth and advanced stages in non-small cell lung cancer.

Kotsinas A, Evangelou K, Sideridou M, Kotzamanis G, Constantinides C, Zavras AI, Douglass CW, Papavassiliou AG, Gorgoulis VG.

Cancer Lett. 2008 Feb 8;259(2):177-85. Epub 2007 Nov 26.

PMID:
18037232
45.

Deregulated overexpression of hCdt1 and hCdc6 promotes malignant behavior.

Liontos M, Koutsami M, Sideridou M, Evangelou K, Kletsas D, Levy B, Kotsinas A, Nahum O, Zoumpourlis V, Kouloukoussa M, Lygerou Z, Taraviras S, Kittas C, Bartkova J, Papavassiliou AG, Bartek J, Halazonetis TD, Gorgoulis VG.

Cancer Res. 2007 Nov 15;67(22):10899-909.

46.

E2F-1 overexpression correlates with decreased proliferation and better prognosis in adenocarcinomas of Barrett oesophagus.

Evangelou K, Kotsinas A, Mariolis-Sapsakos T, Giannopoulos A, Tsantoulis PK, Constantinides C, Troupis TG, Salmas M, Kyroudis A, Kittas C, Gorgoulis VG.

J Clin Pathol. 2008 May;61(5):601-5. Epub 2007 Oct 1.

PMID:
17908803
47.

Gene amplification is a relatively frequent event leading to ZBTB7A (Pokemon) overexpression in non-small cell lung cancer.

Apostolopoulou K, Pateras IS, Evangelou K, Tsantoulis PK, Liontos M, Kittas C, Tiniakos DG, Kotsinas A, Cordon-Cardo C, Gorgoulis VG.

J Pathol. 2007 Nov;213(3):294-302.

PMID:
17907153
48.

Downregulation of the KIP family members p27(KIP1) and p57(KIP2) by SKP2 and the role of methylation in p57(KIP2) inactivation in nonsmall cell lung cancer.

Pateras IS, Apostolopoulou K, Koutsami M, Evangelou K, Tsantoulis P, Liloglou T, Nikolaidis G, Sigala F, Kittas C, Field JK, Kotsinas A, Gorgoulis VG.

Int J Cancer. 2006 Dec 1;119(11):2546-56.

49.

Heregulin, cysteine rich-61 and matrix metalloproteinase 9 expression in human carotid atherosclerotic plaques: relationship with clinical data.

Sigala F, Georgopoulos S, Papalambros E, Chasiotis D, Vourliotakis G, Niforou A, Kotsinas A, Kavantzas N, Patsouris E, Gorgoulis VG, Bastounis E.

Eur J Vasc Endovasc Surg. 2006 Sep;32(3):238-45. Epub 2006 Jun 13.

50.

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions.

Gorgoulis VG, Vassiliou LV, Karakaidos P, Zacharatos P, Kotsinas A, Liloglou T, Venere M, Ditullio RA Jr, Kastrinakis NG, Levy B, Kletsas D, Yoneta A, Herlyn M, Kittas C, Halazonetis TD.

Nature. 2005 Apr 14;434(7035):907-13.

PMID:
15829965

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