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Items: 1 to 50 of 90

1.

The Impact of Perioperative Cannabis Use: A Narrative Scoping Review.

Ladha KS, Manoo V, Virji AF, Hanlon JG, Mclaren-Blades A, Goel A, Wijeysundera DN, Kotra LP, Ibarra C, Englesakis M, Clarke H.

Cannabis Cannabinoid Res. 2019 Dec 6;4(4):219-230. doi: 10.1089/can.2019.0054. eCollection 2019. Review.

PMID:
31872058
2.

Cannabis Use Disorder and Perioperative Outcomes in Major Elective Surgeries: A Retrospective Cohort Analysis.

Goel A, McGuinness B, Jivraj NK, Wijeysundera DN, Mittleman MA, Bateman BT, Clarke H, Kotra LP, Ladha KS.

Anesthesiology. 2020 Apr;132(4):625-635. doi: 10.1097/ALN.0000000000003067.

PMID:
31789638
3.

Extractions of Medical Cannabis Cultivars and the Role of Decarboxylation in Optimal Receptor Responses.

Lewis-Bakker MM, Yang Y, Vyawahare R, Kotra LP.

Cannabis Cannabinoid Res. 2019 Sep 23;4(3):183-194. doi: 10.1089/can.2018.0067. eCollection 2019.

4.

Chemical Profiling of Medical Cannabis Extracts.

Lewis MM, Yang Y, Wasilewski E, Clarke HA, Kotra LP.

ACS Omega. 2017 Sep 30;2(9):6091-6103. doi: 10.1021/acsomega.7b00996. Epub 2017 Sep 22.

5.

Drug Repurposing in the Development of Anticancer Agents.

Olgen S, Kotra LP.

Curr Med Chem. 2019;26(28):5410-5427. doi: 10.2174/0929867325666180713155702. Review.

PMID:
30009698
6.

Biochemically altered myelin triggers autoimmune demyelination.

Caprariello AV, Rogers JA, Morgan ML, Hoghooghi V, Plemel JR, Koebel A, Tsutsui S, Dunn JF, Kotra LP, Ousman SS, Wee Yong V, Stys PK.

Proc Natl Acad Sci U S A. 2018 May 22;115(21):5528-5533. doi: 10.1073/pnas.1721115115. Epub 2018 May 4.

7.

Surfactant protein D regulates caspase-8-mediated cascade of the intrinsic pathway of apoptosis while promoting bleb formation.

Djiadeu P, Farmakovski N, Azzouz D, Kotra LP, Sweezey N, Palaniyar N.

Mol Immunol. 2017 Dec;92:190-198. doi: 10.1016/j.molimm.2017.10.016. Epub 2017 Nov 4.

PMID:
29107869
8.

Cannabis sativa (Hemp) Seeds, Δ9-Tetrahydrocannabinol, and Potential Overdose.

Yang Y, Lewis MM, Bello AM, Wasilewski E, Clarke HA, Kotra LP.

Cannabis Cannabinoid Res. 2017 Oct 1;2(1):274-281. doi: 10.1089/can.2017.0040. eCollection 2017.

9.

Noncovalent Protein Arginine Deiminase (PAD) Inhibitors Are Efficacious in Animal Models of Multiple Sclerosis.

Tejeda EJC, Bello AM, Wasilewski E, Koebel A, Dunn S, Kotra LP.

J Med Chem. 2017 Nov 9;60(21):8876-8887. doi: 10.1021/acs.jmedchem.7b01102. Epub 2017 Oct 30.

PMID:
29045782
10.

A novel class of Plasmodial ClpP protease inhibitors as potential antimalarial agents.

Mundra S, Thakur V, Bello AM, Rathore S, Asad M, Wei L, Yang J, Chakka SK, Mahesh R, Malhotra P, Mohmmed A, Kotra LP.

Bioorg Med Chem. 2017 Oct 15;25(20):5662-5677. doi: 10.1016/j.bmc.2017.08.049. Epub 2017 Sep 5.

PMID:
28917450
11.

A Conserved Residue, Tyrosine (Y) 84, in H5N1 Influenza A Virus NS1 Regulates IFN Signaling Responses to Enhance Viral Infection.

Wang BX, Wei L, Kotra LP, Brown EG, Fish EN.

Viruses. 2017 May 12;9(5). pii: E107. doi: 10.3390/v9050107.

12.

Ultraviolet irradiation increases green fluorescence of dihydrorhodamine (DHR) 123: false-positive results for reactive oxygen species generation.

Djiadeu P, Azzouz D, Khan MA, Kotra LP, Sweezey N, Palaniyar N.

Pharmacol Res Perspect. 2017 Mar 10;5(2):e00303. doi: 10.1002/prp2.303. eCollection 2017 Apr.

13.

Inhibitors of protein arginine deiminases and their efficacy in animal models of multiple sclerosis.

Sarswat A, Wasilewski E, Chakka SK, Bello AM, Caprariello AV, Muthuramu CM, Stys PK, Dunn SE, Kotra LP.

Bioorg Med Chem. 2017 May 1;25(9):2643-2656. doi: 10.1016/j.bmc.2017.03.006. Epub 2017 Mar 6.

PMID:
28341402
14.

Surfactant protein D delays Fas- and TRAIL-mediated extrinsic pathway of apoptosis in T cells.

Djiadeu P, Kotra LP, Sweezey N, Palaniyar N.

Apoptosis. 2017 May;22(5):730-740. doi: 10.1007/s10495-017-1348-4.

PMID:
28168327
15.

Small molecule phagocytosis inhibitors for immune cytopenias.

Neschadim A, Kotra LP, Branch DR.

Autoimmun Rev. 2016 Aug;15(8):843-7. doi: 10.1016/j.autrev.2016.06.004. Epub 2016 Jun 11. Review.

PMID:
27296447
16.

Small Molecule Agonists for the Type I Interferon Receptor: An In Silico Approach.

Wei L, Bello AM, Majchrzak-Kita B, Salum N, Lewis MM, Kotra LP, Fish EN.

J Interferon Cytokine Res. 2016 Mar;36(3):180-91. doi: 10.1089/jir.2015.0123. Epub 2015 Dec 24.

PMID:
26700737
17.

Peptidyl Arginine Deiminases and Neurodegenerative Diseases.

Tu R, Grover HM, Kotra LP.

Curr Med Chem. 2016;23(2):104-14. Review.

PMID:
26577926
18.

Orotidine Monophosphate Decarboxylase--A Fascinating Workhorse Enzyme with Therapeutic Potential.

Fujihashi M, Mnpotra JS, Mishra RK, Pai EF, Kotra LP.

J Genet Genomics. 2015 May 20;42(5):221-34. doi: 10.1016/j.jgg.2015.04.005. Epub 2015 May 16. Review.

PMID:
26059770
19.

Identification of novel class of falcipain-2 inhibitors as potential antimalarial agents.

Chakka SK, Kalamuddin M, Sundararaman S, Wei L, Mundra S, Mahesh R, Malhotra P, Mohmmed A, Kotra LP.

Bioorg Med Chem. 2015 May 1;23(9):2221-40. doi: 10.1016/j.bmc.2015.02.062. Epub 2015 Mar 18.

PMID:
25840796
20.

Structure-activity relationships of pyrazole derivatives as potential therapeutics for immune thrombocytopenias.

Purohit MK, Chakka SK, Scovell I, Neschadim A, Bello AM, Salum N, Katsman Y, Bareau MC, Branch DR, Kotra LP.

Bioorg Med Chem. 2014 May 1;22(9):2739-52. doi: 10.1016/j.bmc.2014.03.016. Epub 2014 Mar 19.

PMID:
24685704
21.

Design of inhibitors of ODCase.

Mundra S, Kotra LP.

Future Med Chem. 2014 Feb;6(2):165-77. doi: 10.4155/fmc.13.198. Review.

PMID:
24467242
22.

Small molecule mimetics of an interferon-α receptor interacting domain.

Bello AM, Wei L, Majchrzak-Kita B, Salum N, Purohit MK, Fish EN, Kotra LP.

Bioorg Med Chem. 2014 Feb 1;22(3):978-85. doi: 10.1016/j.bmc.2013.12.049. Epub 2014 Jan 2.

PMID:
24433965
23.

Substrate distortion contributes to the catalysis of orotidine 5'-monophosphate decarboxylase.

Fujihashi M, Ishida T, Kuroda S, Kotra LP, Pai EF, Miki K.

J Am Chem Soc. 2013 Nov 20;135(46):17432-43. doi: 10.1021/ja408197k. Epub 2013 Nov 11.

24.

Guaifenesin derivatives promote neurite outgrowth and protect diabetic mice from neuropathy.

Hadimani MB, Purohit MK, Vanampally C, Van der Ploeg R, Arballo V, Morrow D, Frizzi KE, Calcutt NA, Fernyhough P, Kotra LP.

J Med Chem. 2013 Jun 27;56(12):5071-8. doi: 10.1021/jm400401y. Epub 2013 Jun 13.

PMID:
23758573
25.

Disulfide linked pyrazole derivatives inhibit phagocytosis of opsonized blood cells.

Purohit MK, Scovell I, Neschadim A, Katsman Y, Branch DR, Kotra LP.

Bioorg Med Chem Lett. 2013 Apr 15;23(8):2324-7. doi: 10.1016/j.bmcl.2013.02.064. Epub 2013 Feb 26.

PMID:
23489619
26.

Novel inhibitors of protein arginine deiminase with potential activity in multiple sclerosis animal model.

Wei L, Wasilewski E, Chakka SK, Bello AM, Moscarello MA, Kotra LP.

J Med Chem. 2013 Feb 28;56(4):1715-22. doi: 10.1021/jm301755q. Epub 2013 Feb 19.

PMID:
23421315
27.

Antimalarial activities of 6-iodouridine and its prodrugs and potential for combination therapy.

Crandall IE, Wasilewski E, Bello AM, Mohmmed A, Malhotra P, Pai EF, Kain KC, Kotra LP.

J Med Chem. 2013 Mar 28;56(6):2348-58. doi: 10.1021/jm301678j. Epub 2013 Mar 6.

PMID:
23410043
28.

Interrogation of the Active Sites of Protein Arginine Deiminases (PAD1, -2, and -4) Using Designer Probes.

Bello AM, Wasilewski E, Wei L, Moscarello MA, Kotra LP.

ACS Med Chem Lett. 2013 Jan 15;4(2):249-53. doi: 10.1021/ml300377d. eCollection 2013 Feb 14.

29.

Novel cytidine-based orotidine-5'-monophosphate decarboxylase inhibitors with an unusual twist.

Purohit MK, Poduch E, Wei LW, Crandall IE, To T, Kain KC, Pai EF, Kotra LP.

J Med Chem. 2012 Nov 26;55(22):9988-97. doi: 10.1021/jm301176r. Epub 2012 Oct 18.

PMID:
22991951
30.

Substituted phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonamides as antimitotics. Antiproliferative, antiangiogenic and antitumoral activity, and quantitative structure-activity relationships.

Fortin S, Wei L, Moreau E, Lacroix J, Côté MF, Petitclerc E, Kotra LP, Gaudreault RC.

Eur J Med Chem. 2011 Nov;46(11):5327-42. doi: 10.1016/j.ejmech.2011.08.034. Epub 2011 Aug 30.

PMID:
21920638
31.

Hydrolytic mechanism of OXA-58 enzyme, a carbapenem-hydrolyzing class D β-lactamase from Acinetobacter baumannii.

Verma V, Testero SA, Amini K, Wei W, Liu J, Balachandran N, Monoharan T, Stynes S, Kotra LP, Golemi-Kotra D.

J Biol Chem. 2011 Oct 28;286(43):37292-303. doi: 10.1074/jbc.M111.280115. Epub 2011 Aug 31.

32.

Design, synthesis, biological evaluation, and structure-activity relationships of substituted phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates as new tubulin inhibitors mimicking combretastatin A-4.

Fortin S, Wei L, Moreau E, Lacroix J, Côté MF, Petitclerc E, Kotra LP, C-Gaudreault R.

J Med Chem. 2011 Jul 14;54(13):4559-80. doi: 10.1021/jm200488a. Epub 2011 Jun 13.

33.

Novel interactions of fluorinated nucleotide derivatives targeting orotidine 5'-monophosphate decarboxylase.

Lewis M, Meza-Avina ME, Wei L, Crandall IE, Bello AM, Poduch E, Liu Y, Paige CJ, Kain KC, Pai EF, Kotra LP.

J Med Chem. 2011 Apr 28;54(8):2891-901. doi: 10.1021/jm101642g. Epub 2011 Mar 21.

34.

Immunological targets in inflammation from the small molecule perspective.

Bello AM, Purohit MK, Cui TJ, Stead SB, Kotra LP.

Antiinflamm Antiallergy Agents Med Chem. 2011;10(2):121-31.

PMID:
25182059
35.

Structural determinants for the inhibitory ligands of orotidine-5'-monophosphate decarboxylase.

Meza-Avina ME, Wei L, Liu Y, Poduch E, Bello AM, Mishra RK, Pai EF, Kotra LP.

Bioorg Med Chem. 2010 Jun 1;18(11):4032-41. doi: 10.1016/j.bmc.2010.04.017. Epub 2010 Apr 9.

36.

Mechanism of action of N-phenyl-N'-(2-chloroethyl)ureas in the colchicine-binding site at the interface between alpha- and beta-tubulin.

Fortin S, Wei L, Moreau E, Labrie P, Petitclerc E, Kotra LP, C-Gaudreault R.

Bioorg Med Chem. 2009 May 15;17(10):3690-7. doi: 10.1016/j.bmc.2009.03.056. Epub 2009 Apr 1.

PMID:
19398206
37.

Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents.

Bello AM, Konforte D, Poduch E, Furlonger C, Wei L, Liu Y, Lewis M, Pai EF, Paige CJ, Kotra LP.

J Med Chem. 2009 Mar 26;52(6):1648-58. doi: 10.1021/jm801224t.

PMID:
19260677
38.

Structural characterization of the molecular events during a slow substrate-product transition in orotidine 5'-monophosphate decarboxylase.

Fujihashi M, Wei L, Kotra LP, Pai EF.

J Mol Biol. 2009 Apr 17;387(5):1199-210. doi: 10.1016/j.jmb.2009.02.037. Epub 2009 Feb 21.

39.

Inhibition of orotidine-5'-monophosphate decarboxylase--discoveries and lessons.

Kotra LP, Pai EF.

Nucleic Acids Symp Ser (Oxf). 2008;(52):85-6. doi: 10.1093/nass/nrn043.

PMID:
18776265
40.

De novo design of nonpeptidic compounds targeting the interactions between interferon-alpha and its cognate cell surface receptor.

Bello AM, Bende T, Wei L, Wang X, Majchrzak-Kita B, Fish EN, Kotra LP.

J Med Chem. 2008 May 8;51(9):2734-43. doi: 10.1021/jm701182y. Epub 2008 Apr 5.

PMID:
18393399
41.

Inhibition of orotidine 5'-monophosphate decarboxylase and its therapeutic potential.

Meza-Avina ME, Wei L, Buhendwa MG, Poduch E, Bello AM, Pai EF, Kotra LP.

Mini Rev Med Chem. 2008 Mar;8(3):239-47. Review.

PMID:
18336344
42.

Protein kinase C isozymes and their selectivity towards ruboxistaurin.

Tang S, Xiao V, Wei L, Whiteside CI, Kotra LP.

Proteins. 2008 Jul;72(1):447-60. doi: 10.1002/prot.21942.

PMID:
18214957
43.

Structure-activity relationships of C6-uridine derivatives targeting plasmodia orotidine monophosphate decarboxylase.

Bello AM, Poduch E, Liu Y, Wei L, Crandall I, Wang X, Dyanand C, Kain KC, Pai EF, Kotra LP.

J Med Chem. 2008 Feb 14;51(3):439-48. doi: 10.1021/jm7010673. Epub 2008 Jan 12.

PMID:
18189347
44.

Structural diversity and plasticity associated with nucleotides targeting orotidine monophosphate decarboxylase.

Poduch E, Wei L, Pai EF, Kotra LP.

J Med Chem. 2008 Feb 14;51(3):432-8. doi: 10.1021/jm700968x. Epub 2008 Jan 9.

PMID:
18181562
45.
46.

A structural basis for interferon-alpha-receptor interactions.

Kumaran J, Wei L, Kotra LP, Fish EN.

FASEB J. 2007 Oct;21(12):3288-96. Epub 2007 May 21.

PMID:
17517919
47.

A potent, covalent inhibitor of orotidine 5'-monophosphate decarboxylase with antimalarial activity.

Bello AM, Poduch E, Fujihashi M, Amani M, Li Y, Crandall I, Hui R, Lee PI, Kain KC, Pai EF, Kotra LP.

J Med Chem. 2007 Mar 8;50(5):915-21. Epub 2007 Feb 10. Erratum in: J Med Chem. 2007 May 17;50(10):2541.

PMID:
17290979
48.
49.

Cyanocobalamin (vitamin B12) conjugates with enhanced solubility.

Wang X, Wei L, Kotra LP.

Bioorg Med Chem. 2007 Feb 15;15(4):1780-7. Epub 2006 Nov 29.

PMID:
17161950
50.

Design of inhibitors of orotidine monophosphate decarboxylase using bioisosteric replacement and determination of inhibition kinetics.

Poduch E, Bello AM, Tang S, Fujihashi M, Pai EF, Kotra LP.

J Med Chem. 2006 Aug 10;49(16):4937-45.

PMID:
16884305

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