Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 52

1.

Alternative Translation Initiation Generates a Functionally Distinct Isoform of the Stress-Activated Protein Kinase MK2.

Trulley P, Snieckute G, Bekker-Jensen D, Menon MB, Freund R, Kotlyarov A, Olsen JV, Diaz-Muñoz MD, Turner M, Bekker-Jensen S, Gaestel M, Tiedje C.

Cell Rep. 2019 Jun 4;27(10):2859-2870.e6. doi: 10.1016/j.celrep.2019.05.024.

2.

Germ Line Deletion Reveals a Nonessential Role of Atypical Mitogen-Activated Protein Kinase 6/Extracellular Signal-Regulated Kinase 3.

Ronkina N, Schuster-Gossler K, Hansmann F, Kunze-Schumacher H, Sandrock I, Yakovleva T, Lafera J, Baumgärtner W, Krueger A, Prinz I, Gossler A, Kotlyarov A, Gaestel M.

Mol Cell Biol. 2019 Mar 1;39(6). pii: e00516-18. doi: 10.1128/MCB.00516-18. Print 2019 Mar 15.

3.

p38MAPK/MK2-dependent phosphorylation controls cytotoxic RIPK1 signalling in inflammation and infection.

Menon MB, Gropengießer J, Fischer J, Novikova L, Deuretzbacher A, Lafera J, Schimmeck H, Czymmeck N, Ronkina N, Kotlyarov A, Aepfelbacher M, Gaestel M, Ruckdeschel K.

Nat Cell Biol. 2017 Oct;19(10):1248-1259. doi: 10.1038/ncb3614. Epub 2017 Sep 18.

PMID:
28920954
4.

Stress-dependent phosphorylation of myocardin-related transcription factor A (MRTF-A) by the p38(MAPK)/MK2 axis.

Ronkina N, Lafera J, Kotlyarov A, Gaestel M.

Sci Rep. 2016 Aug 5;6:31219. doi: 10.1038/srep31219.

5.

GTPase domain driven dimerization of SEPT7 is dispensable for the critical role of septins in fibroblast cytokinesis.

Abbey M, Hakim C, Anand R, Lafera J, Schambach A, Kispert A, Taft MH, Kaever V, Kotlyarov A, Gaestel M, Menon MB.

Sci Rep. 2016 Jan 28;6:20007. doi: 10.1038/srep20007.

6.

Comparative Analysis of Two Gene-Targeting Approaches Challenges the Tumor-Suppressive Role of the Protein Kinase MK5/PRAK.

Ronkina N, Johansen C, Bohlmann L, Lafera J, Menon MB, Tiedje C, Laaß K, Turk BE, Iversen L, Kotlyarov A, Gaestel M.

PLoS One. 2015 Aug 21;10(8):e0136138. doi: 10.1371/journal.pone.0136138. eCollection 2015.

7.

The MAPK-Activated Kinase MK2 Attenuates Dendritic Cell-Mediated Th1 Differentiation and Autoimmune Encephalomyelitis.

Soukup K, Halfmann A, Le Bras M, Sahin E, Vittori S, Poyer F, Schuh C, Luger R, Niederreiter B, Haider T, Stoiber D, Blüml S, Schabbauer G, Kotlyarov A, Gaestel M, Felzmann T, Dohnal AM.

J Immunol. 2015 Jul 15;195(2):541-52. doi: 10.4049/jimmunol.1401663. Epub 2015 Jun 15.

8.

The problem of pyridinyl imidazole class inhibitors of MAPK14/p38α and MAPK11/p38β in autophagy research.

Menon MB, Dhamija S, Kotlyarov A, Gaestel M.

Autophagy. 2015;11(8):1425-7. doi: 10.1080/15548627.2015.1059562.

9.

p38MAPK/MK2-mediated phosphorylation of RBM7 regulates the human nuclear exosome targeting complex.

Tiedje C, Lubas M, Tehrani M, Menon MB, Ronkina N, Rousseau S, Cohen P, Kotlyarov A, Gaestel M.

RNA. 2015 Feb;21(2):262-78. doi: 10.1261/rna.048090.114. Epub 2014 Dec 18.

10.

Genetic deletion of SEPT7 reveals a cell type-specific role of septins in microtubule destabilization for the completion of cytokinesis.

Menon MB, Sawada A, Chaturvedi A, Mishra P, Schuster-Gossler K, Galla M, Schambach A, Gossler A, Förster R, Heuser M, Kotlyarov A, Kinoshita M, Gaestel M.

PLoS Genet. 2014 Aug 14;10(8):e1004558. doi: 10.1371/journal.pgen.1004558. eCollection 2014 Aug.

11.

Endoplasmic reticulum-associated ubiquitin-conjugating enzyme Ube2j1 is a novel substrate of MK2 (MAPKAP kinase-2) involved in MK2-mediated TNFα production.

Menon MB, Tiedje C, Lafera J, Ronkina N, Konen T, Kotlyarov A, Gaestel M.

Biochem J. 2013 Dec 1;456(2):163-72. doi: 10.1042/BJ20130755. Erratum in: Biochem J. 2014 Jan 1;457(1):229.

PMID:
24020373
12.

The p38/MK2-driven exchange between tristetraprolin and HuR regulates AU-rich element-dependent translation.

Tiedje C, Ronkina N, Tehrani M, Dhamija S, Laass K, Holtmann H, Kotlyarov A, Gaestel M.

PLoS Genet. 2012 Sep;8(9):e1002977. doi: 10.1371/journal.pgen.1002977. Epub 2012 Sep 27.

13.

The extracellular signal-regulated kinase 3 (mitogen-activated protein kinase 6 [MAPK6])-MAPK-activated protein kinase 5 signaling complex regulates septin function and dendrite morphology.

Brand F, Schumacher S, Kant S, Menon MB, Simon R, Turgeon B, Britsch S, Meloche S, Gaestel M, Kotlyarov A.

Mol Cell Biol. 2012 Jul;32(13):2467-78. doi: 10.1128/MCB.06633-11. Epub 2012 Apr 16.

14.

Small-molecule protein and lipid kinase inhibitors in inflammation and specific models for their evaluation.

Gaestel M, Kotlyarov A.

Methods Mol Biol. 2012;795:35-44. doi: 10.1007/978-1-61779-337-0_2.

PMID:
21960213
15.

SB202190-induced cell type-specific vacuole formation and defective autophagy do not depend on p38 MAP kinase inhibition.

Menon MB, Kotlyarov A, Gaestel M.

PLoS One. 2011;6(8):e23054. doi: 10.1371/journal.pone.0023054. Epub 2011 Aug 10.

16.

Distinct functions of the mitogen-activated protein kinase-activated protein (MAPKAP) kinases MK2 and MK3: MK2 mediates lipopolysaccharide-induced signal transducers and activators of transcription 3 (STAT3) activation by preventing negative regulatory effects of MK3.

Ehlting C, Ronkina N, Böhmer O, Albrecht U, Bode KA, Lang KS, Kotlyarov A, Radzioch D, Gaestel M, Häussinger D, Bode JG.

J Biol Chem. 2011 Jul 8;286(27):24113-24. doi: 10.1074/jbc.M111.235275. Epub 2011 May 17.

17.

Molecular mechanisms of phosphorylation-regulated TTP (tristetraprolin) action and screening for further TTP-interacting proteins.

Tiedje C, Kotlyarov A, Gaestel M.

Biochem Soc Trans. 2010 Dec;38(6):1632-7. doi: 10.1042/BST0381632.

PMID:
21118139
18.

Stress induced gene expression: a direct role for MAPKAP kinases in transcriptional activation of immediate early genes.

Ronkina N, Menon MB, Schwermann J, Arthur JS, Legault H, Telliez JB, Kayyali US, Nebreda AR, Kotlyarov A, Gaestel M.

Nucleic Acids Res. 2011 Apr;39(7):2503-18. doi: 10.1093/nar/gkq1178. Epub 2010 Nov 24.

19.

p38 MAP kinase and MAPKAP kinases MK2/3 cooperatively phosphorylate epithelial keratins.

Menon MB, Schwermann J, Singh AK, Franz-Wachtel M, Pabst O, Seidler U, Omary MB, Kotlyarov A, Gaestel M.

J Biol Chem. 2010 Oct 22;285(43):33242-51. doi: 10.1074/jbc.M110.132357. Epub 2010 Aug 19.

20.

MAPKAP kinases MK2 and MK3 in inflammation: complex regulation of TNF biosynthesis via expression and phosphorylation of tristetraprolin.

Ronkina N, Menon MB, Schwermann J, Tiedje C, Hitti E, Kotlyarov A, Gaestel M.

Biochem Pharmacol. 2010 Dec 15;80(12):1915-20. doi: 10.1016/j.bcp.2010.06.021. Epub 2010 Jun 23. Review.

PMID:
20599781
21.

Fluorescence-based quantitative scratch wound healing assay demonstrating the role of MAPKAPK-2/3 in fibroblast migration.

Menon MB, Ronkina N, Schwermann J, Kotlyarov A, Gaestel M.

Cell Motil Cytoskeleton. 2009 Dec;66(12):1041-7. doi: 10.1002/cm.20418.

PMID:
19743408
22.

Targeting innate immunity protein kinase signalling in inflammation.

Gaestel M, Kotlyarov A, Kracht M.

Nat Rev Drug Discov. 2009 Jun;8(6):480-99. doi: 10.1038/nrd2829. Review.

PMID:
19483709
23.

MAPKAP kinase MK2 maintains self-renewal capacity of haematopoietic stem cells.

Schwermann J, Rathinam C, Schubert M, Schumacher S, Noyan F, Koseki H, Kotlyarov A, Klein C, Gaestel M.

EMBO J. 2009 May 20;28(10):1392-406. doi: 10.1038/emboj.2009.100. Epub 2009 Apr 16.

24.

MAP-kinase-activated protein kinase 2 expression and activity is induced after neuronal depolarization.

Thomas T, Hitti E, Kotlyarov A, Potschka H, Gaestel M.

Eur J Neurosci. 2008 Aug;28(4):642-54. doi: 10.1111/j.1460-9568.2008.06382.x.

PMID:
18702688
25.

MK2 and MK3--a pair of isoenzymes?

Ronkina N, Kotlyarov A, Gaestel M.

Front Biosci. 2008 May 1;13:5511-21. Review.

PMID:
18508601
26.

MAPKAP kinase 2-deficiency prevents neurons from cell death by reducing neuroinflammation--relevance in a mouse model of Parkinson's disease.

Thomas T, Timmer M, Cesnulevicius K, Hitti E, Kotlyarov A, Gaestel M.

J Neurochem. 2008 Jun;105(5):2039-52. doi: 10.1111/j.1471-4159.2008.05310.x. Epub 2008 Feb 22.

27.

The mitogen-activated protein kinase (MAPK)-activated protein kinases MK2 and MK3 cooperate in stimulation of tumor necrosis factor biosynthesis and stabilization of p38 MAPK.

Ronkina N, Kotlyarov A, Dittrich-Breiholz O, Kracht M, Hitti E, Milarski K, Askew R, Marusic S, Lin LL, Gaestel M, Telliez JB.

Mol Cell Biol. 2007 Jan;27(1):170-81. Epub 2006 Oct 9.

28.

Characterization of the atypical MAPK ERK4 and its activation of the MAPK-activated protein kinase MK5.

Kant S, Schumacher S, Singh MK, Kispert A, Kotlyarov A, Gaestel M.

J Biol Chem. 2006 Nov 17;281(46):35511-9. Epub 2006 Sep 13.

30.

Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetraprolin expression, stability, and binding to adenine/uridine-rich element.

Hitti E, Iakovleva T, Brook M, Deppenmeier S, Gruber AD, Radzioch D, Clark AR, Blackshear PJ, Kotlyarov A, Gaestel M.

Mol Cell Biol. 2006 Mar;26(6):2399-407.

31.

Gene deletion of MK2 inhibits TNF-alpha and IL-6 and protects against cerulein-induced pancreatitis.

Tietz AB, Malo A, Diebold J, Kotlyarov A, Herbst A, Kolligs FT, Brandt-Nedelev B, Halangk W, Gaestel M, Göke B, Schäfer C.

Am J Physiol Gastrointest Liver Physiol. 2006 Jun;290(6):G1298-306. Epub 2006 Jan 19.

32.

HDM2 phosphorylation by MAPKAP kinase 2.

Weber HO, Ludwig RL, Morrison D, Kotlyarov A, Gaestel M, Vousden KH.

Oncogene. 2005 Mar 17;24(12):1965-72.

PMID:
15688025
33.

Scaffolding by ERK3 regulates MK5 in development.

Schumacher S, Laass K, Kant S, Shi Y, Visel A, Gruber AD, Kotlyarov A, Gaestel M.

EMBO J. 2004 Dec 8;23(24):4770-9. Epub 2004 Nov 11.

34.

A requirement of MAPKAPK2 in the uropod localization of PTEN during FMLP-induced neutrophil chemotaxis.

Wu Y, Hannigan MO, Kotlyarov A, Gaestel M, Wu D, Huang CK.

Biochem Biophys Res Commun. 2004 Apr 9;316(3):666-72.

PMID:
15033451
35.

Elimination of protein kinase MK5/PRAK activity by targeted homologous recombination.

Shi Y, Kotlyarov A, Laabeta K, Gruber AD, Butt E, Marcus K, Meyer HE, Friedrich A, Volk HD, Gaestel M.

Mol Cell Biol. 2003 Nov;23(21):7732-41.

36.

Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease.

Kontoyiannis D, Boulougouris G, Manoloukos M, Armaka M, Apostolaki M, Pizarro T, Kotlyarov A, Forster I, Flavell R, Gaestel M, Tsichlis P, Cominelli F, Kollias G.

J Exp Med. 2002 Dec 16;196(12):1563-74.

37.
38.

Distinct cellular functions of MK2.

Kotlyarov A, Yannoni Y, Fritz S, Laass K, Telliez JB, Pitman D, Lin LL, Gaestel M.

Mol Cell Biol. 2002 Jul;22(13):4827-35.

39.

Mitogen-activated protein kinase-activated protein kinase 2-deficient mice show increased susceptibility to Listeria monocytogenes infection.

Lehner MD, Schwoebel F, Kotlyarov A, Leist M, Gaestel M, Hartung T.

J Immunol. 2002 May 1;168(9):4667-73.

40.

MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels.

Neininger A, Kontoyiannis D, Kotlyarov A, Winzen R, Eckert R, Volk HD, Holtmann H, Kollias G, Gaestel M.

J Biol Chem. 2002 Feb 1;277(5):3065-8. Epub 2001 Dec 6.

42.

Interleukin-10 targets p38 MAPK to modulate ARE-dependent TNF mRNA translation and limit intestinal pathology.

Kontoyiannis D, Kotlyarov A, Carballo E, Alexopoulou L, Blackshear PJ, Gaestel M, Davis R, Flavell R, Kollias G.

EMBO J. 2001 Jul 16;20(14):3760-70.

43.
44.

Mouse Hsp25, a small shock protein. The role of its C-terminal extension in oligomerization and chaperone action.

Lindner RA, Carver JA, Ehrnsperger M, Buchner J, Esposito G, Behlke J, Lutsch G, Kotlyarov A, Gaestel M.

Eur J Biochem. 2000 Apr;267(7):1923-32.

45.

MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis.

Kotlyarov A, Neininger A, Schubert C, Eckert R, Birchmeier C, Volk HD, Gaestel M.

Nat Cell Biol. 1999 Jun;1(2):94-7.

PMID:
10559880
47.

Regulation of Hsp27 oligomerization, chaperone function, and protective activity against oxidative stress/tumor necrosis factor alpha by phosphorylation.

Rogalla T, Ehrnsperger M, Preville X, Kotlyarov A, Lutsch G, Ducasse C, Paul C, Wieske M, Arrigo AP, Buchner J, Gaestel M.

J Biol Chem. 1999 Jul 2;274(27):18947-56.

48.

MAPKAP kinase 2 phosphorylates serum response factor in vitro and in vivo.

Heidenreich O, Neininger A, Schratt G, Zinck R, Cahill MA, Engel K, Kotlyarov A, Kraft R, Kostka S, Gaestel M, Nordheim A.

J Biol Chem. 1999 May 14;274(20):14434-43.

49.

Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation.

Engel K, Kotlyarov A, Gaestel M.

EMBO J. 1998 Jun 15;17(12):3363-71.

50.

Constitutive activation of mitogen-activated protein kinase-activated protein kinase 2 by mutation of phosphorylation sites and an A-helix motif.

Engel K, Schultz H, Martin F, Kotlyarov A, Plath K, Hahn M, Heinemann U, Gaestel M.

J Biol Chem. 1995 Nov 10;270(45):27213-21.

Supplemental Content

Loading ...
Support Center