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Items: 1 to 50 of 73

1.

Manufacturing Clinical Grade Recombinant Adeno-Associated Virus Using Invertebrate Cell Lines.

Kotin RM, Snyder RO.

Hum Gene Ther. 2017 Apr;28(4):350-360. doi: 10.1089/hum.2017.042.

PMID:
28351174
2.

Germline viral "fossils" guide in silico reconstruction of a mid-Cenozoic era marsupial adeno-associated virus.

Smith RH, Hallwirth CV, Westerman M, Hetherington NA, Tseng YS, Cecchini S, Virag T, Ziegler ML, Rogozin IB, Koonin EV, Agbandje-McKenna M, Kotin RM, Alexander IE.

Sci Rep. 2016 Jul 5;6:28965. doi: 10.1038/srep28965.

3.

In Vivo Selection Yields AAV-B1 Capsid for Central Nervous System and Muscle Gene Therapy.

Choudhury SR, Fitzpatrick Z, Harris AF, Maitland SA, Ferreira JS, Zhang Y, Ma S, Sharma RB, Gray-Edwards HL, Johnson JA, Johnson AK, Alonso LC, Punzo C, Wagner KR, Maguire CA, Kotin RM, Martin DR, Sena-Esteves M.

Mol Ther. 2016 Aug;24(7):1247-57. doi: 10.1038/mt.2016.84. Epub 2016 Apr 27.

4.

Forelimb treatment in a large cohort of dystrophic dogs supports delivery of a recombinant AAV for exon skipping in Duchenne patients.

Le Guiner C, Montus M, Servais L, Cherel Y, Francois V, Thibaud JL, Wary C, Matot B, Larcher T, Guigand L, Dutilleul M, Domenger C, Allais M, Beuvin M, Moraux A, Le Duff J, Devaux M, Jaulin N, Guilbaud M, Latournerie V, Veron P, Boutin S, Leborgne C, Desgue D, Deschamps JY, Moullec S, Fromes Y, Vulin A, Smith RH, Laroudie N, Barnay-Toutain F, Rivière C, Bucher S, Le TH, Delaunay N, Gasmi M, Kotin RM, Bonne G, Adjali O, Masurier C, Hogrel JY, Carlier P, Moullier P, Voit T.

Mol Ther. 2014 Nov;22(11):1923-35. doi: 10.1038/mt.2014.151. Epub 2014 Aug 4.

5.

Production and characterization of novel recombinant adeno-associated virus replicative-form genomes: a eukaryotic source of DNA for gene transfer.

Li L, Dimitriadis EK, Yang Y, Li J, Yuan Z, Qiao C, Beley C, Smith RH, Garcia L, Kotin RM.

PLoS One. 2013 Aug 1;8(8):e69879. doi: 10.1371/journal.pone.0069879. Print 2013.

6.

Baculovirus: an insect-derived vector for diverse gene transfer applications.

Airenne KJ, Hu YC, Kost TA, Smith RH, Kotin RM, Ono C, Matsuura Y, Wang S, Ylä-Herttuala S.

Mol Ther. 2013 Apr;21(4):739-49. doi: 10.1038/mt.2012.286. Epub 2013 Feb 26. Review.

7.

MRI roadmap-guided transendocardial delivery of exon-skipping recombinant adeno-associated virus restores dystrophin expression in a canine model of Duchenne muscular dystrophy.

Barbash IM, Cecchini S, Faranesh AZ, Virag T, Li L, Yang Y, Hoyt RF, Kornegay JN, Bogan JR, Garcia L, Lederman RJ, Kotin RM.

Gene Ther. 2013 Mar;20(3):274-82. doi: 10.1038/gt.2012.38. Epub 2012 May 3.

8.

Long-term restoration of cardiac dystrophin expression in golden retriever muscular dystrophy following rAAV6-mediated exon skipping.

Bish LT, Sleeper MM, Forbes SC, Wang B, Reynolds C, Singletary GE, Trafny D, Morine KJ, Sanmiguel J, Cecchini S, Virag T, Vulin A, Beley C, Bogan J, Wilson JM, Vandenborne K, Kornegay JN, Walter GA, Kotin RM, Garcia L, Sweeney HL.

Mol Ther. 2012 Mar;20(3):580-9. doi: 10.1038/mt.2011.264. Epub 2011 Dec 6.

9.

Versatile and efficient genome editing in human cells by combining zinc-finger nucleases with adeno-associated viral vectors.

Händel EM, Gellhaus K, Khan K, Bednarski C, Cornu TI, Müller-Lerch F, Kotin RM, Heilbronn R, Cathomen T.

Hum Gene Ther. 2012 Mar;23(3):321-9. doi: 10.1089/hum.2011.140. Epub 2011 Dec 14.

10.

Large-scale recombinant adeno-associated virus production.

Kotin RM.

Hum Mol Genet. 2011 Apr 15;20(R1):R2-6. doi: 10.1093/hmg/ddr141. Epub 2011 Apr 29. Review.

11.

Reproducible high yields of recombinant adeno-associated virus produced using invertebrate cells in 0.02- to 200-liter cultures.

Cecchini S, Virag T, Kotin RM.

Hum Gene Ther. 2011 Aug;22(8):1021-30. doi: 10.1089/hum.2010.250. Epub 2011 May 16.

12.
13.

A simplified baculovirus-AAV expression vector system coupled with one-step affinity purification yields high-titer rAAV stocks from insect cells.

Smith RH, Levy JR, Kotin RM.

Mol Ther. 2009 Nov;17(11):1888-96. doi: 10.1038/mt.2009.128. Epub 2009 Jun 16.

14.

Evidence of prior exposure to human bocavirus as determined by a retrospective serological study of 404 serum samples from adults in the United States.

Cecchini S, Negrete A, Virag T, Graham BS, Cohen JI, Kotin RM.

Clin Vaccine Immunol. 2009 May;16(5):597-604. doi: 10.1128/CVI.00470-08. Epub 2009 Feb 25.

15.

Large-scale production of recombinant adeno-associated viral vectors.

Negrete A, Kotin RM.

Methods Mol Biol. 2008;433:79-96. doi: 10.1007/978-1-59745-237-3_5.

PMID:
18679618
16.

Strategies for manufacturing recombinant adeno-associated virus vectors for gene therapy applications exploiting baculovirus technology.

Negrete A, Kotin RM.

Brief Funct Genomic Proteomic. 2008 Jul;7(4):303-11. doi: 10.1093/bfgp/eln034. Epub 2008 Jul 16. Review.

17.

Chromatography-based purification of adeno-associated virus.

Smith RH, Yang L, Kotin RM.

Methods Mol Biol. 2008;434:37-54. doi: 10.1007/978-1-60327-248-3_4.

PMID:
18470638
18.

Toward exascale production of recombinant adeno-associated virus for gene transfer applications.

Cecchini S, Negrete A, Kotin RM.

Gene Ther. 2008 Jun;15(11):823-30. doi: 10.1038/gt.2008.61. Epub 2008 Apr 10. Review.

PMID:
18401433
19.

Glucose- and metabolically regulated hepatic insulin gene therapy for diabetes.

Hsu PY, Kotin RM, Yang YW.

Pharm Res. 2008 Jun;25(6):1460-8. doi: 10.1007/s11095-008-9539-x.

PMID:
18293064
20.

Economized large-scale production of high yield of rAAV for gene therapy applications exploiting baculovirus expression system.

Negrete A, Yang LC, Mendez AF, Levy JR, Kotin RM.

J Gene Med. 2007 Nov;9(11):938-48.

PMID:
17764098
21.

Process optimization of large-scale production of recombinant adeno-associated vectors using dielectric spectroscopy.

Negrete A, Esteban G, Kotin RM.

Appl Microbiol Biotechnol. 2007 Sep;76(4):761-72. Epub 2007 Aug 7.

PMID:
17680241
22.

Production of recombinant adeno-associated vectors using two bioreactor configurations at different scales.

Negrete A, Kotin RM.

J Virol Methods. 2007 Nov;145(2):155-61. Epub 2007 Jul 2.

23.

Recombinant adeno-associated virus vector for gene transfer to the transplanted rat heart.

Schirmer JM, Miyagi N, Rao VP, Ricci D, Federspiel MJ, Kotin RM, Russell SJ, McGregor CG.

Transpl Int. 2007 Jun;20(6):550-7. Epub 2007 Apr 2.

24.

Development of recombinant adeno-associated virus vectors carrying small interfering RNA (shHec1)-mediated depletion of kinetochore Hec1 protein in tumor cells.

Li L, Yang L, Scudiero DA, Miller SA, Yu ZX, Stukenberg PT, Shoemaker RH, Kotin RM.

Gene Ther. 2007 May;14(10):814-27. Epub 2007 Mar 1.

PMID:
17330085
25.

Adeno-associated virus (AAV) serotypes 2, 4 and 5 display similar transduction profiles and penetrate solid tumor tissue in models of human glioma.

Thorsen F, Afione S, Huszthy PC, Tysnes BB, Svendsen A, Bjerkvig R, Kotin RM, Lønning PE, Hoover F.

J Gene Med. 2006 Sep;8(9):1131-40.

PMID:
16810631
26.

Scalable generation of high-titer recombinant adeno-associated virus type 5 in insect cells.

Urabe M, Nakakura T, Xin KQ, Obara Y, Mizukami H, Kume A, Kotin RM, Ozawa K.

J Virol. 2006 Feb;80(4):1874-85.

27.

Profiles of PrKX expression in developmental mouse embryo and human tissues.

Li W, Yu ZX, Kotin RM.

J Histochem Cytochem. 2005 Aug;53(8):1003-9. Epub 2005 May 6.

PMID:
15879576
28.
29.

RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model.

Harper SQ, Staber PD, He X, Eliason SL, Martins IH, Mao Q, Yang L, Kotin RM, Paulson HL, Davidson BL.

Proc Natl Acad Sci U S A. 2005 Apr 19;102(16):5820-5. Epub 2005 Apr 5.

31.

RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia.

Xia H, Mao Q, Eliason SL, Harper SQ, Martins IH, Orr HT, Paulson HL, Yang L, Kotin RM, Davidson BL.

Nat Med. 2004 Aug;10(8):816-20. Epub 2004 Jul 4.

PMID:
15235598
32.
33.

Adeno-associated virus type 5: transduction efficiency and cell-type specificity in the primate retina.

Lotery AJ, Yang GS, Mullins RF, Russell SR, Schmidt M, Stone EM, Lindbloom JD, Chiorini JA, Kotin RM, Davidson BL.

Hum Gene Ther. 2003 Nov 20;14(17):1663-71.

PMID:
14633408
34.

Serum-free production and column purification of adeno-associated virus type 5.

Smith RH, Ding C, Kotin RM.

J Virol Methods. 2003 Dec;114(2):115-24.

PMID:
14625046
35.

Insect cells as a factory to produce adeno-associated virus type 2 vectors.

Urabe M, Ding C, Kotin RM.

Hum Gene Ther. 2002 Nov 1;13(16):1935-43.

PMID:
12427305
36.
37.

Transposase-mediated construction of an integrated adeno-associated virus type 5 helper plasmid.

Smith RH, Afione SA, Kotin RM.

Biotechniques. 2002 Jul;33(1):204-6, 208, 210-1.

38.

Immunological aspects of recombinant adeno-associated virus delivery to the mammalian brain.

Mastakov MY, Baer K, Symes CW, Leichtlein CB, Kotin RM, During MJ.

J Virol. 2002 Aug;76(16):8446-54.

40.

Recombinant adeno-associated virus serotype 2 vectors mediate stable interleukin 10 secretion from salivary glands into the bloodstream.

Yamano S, Huang LY, Ding C, Chiorini JA, Goldsmith CM, Wellner RB, Golding B, Kotin RM, Scott DE, Baum BJ.

Hum Gene Ther. 2002 Jan 20;13(2):287-98.

PMID:
11812284
41.

Biochemical characterization of Junonia coenia densovirus nonstructural protein NS-1.

Ding C, Urabe M, Bergoin M, Kotin RM.

J Virol. 2002 Jan;76(1):338-45.

42.
43.
44.

Adeno-associated virus type 5 (AAV5) but not AAV2 binds to the apical surfaces of airway epithelia and facilitates gene transfer.

Zabner J, Seiler M, Walters R, Kotin RM, Fulgeras W, Davidson BL, Chiorini JA.

J Virol. 2000 Apr;74(8):3852-8.

46.

Recombinant adeno-associated virus type 2, 4, and 5 vectors: transduction of variant cell types and regions in the mammalian central nervous system.

Davidson BL, Stein CS, Heth JA, Martins I, Kotin RM, Derksen TA, Zabner J, Ghodsi A, Chiorini JA.

Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3428-32.

48.

PrKX is a novel catalytic subunit of the cAMP-dependent protein kinase regulated by the regulatory subunit type I.

Zimmermann B, Chiorini JA, Ma Y, Kotin RM, Herberg FW.

J Biol Chem. 1999 Feb 26;274(9):5370-8.

49.

Cloning and characterization of adeno-associated virus type 5.

Chiorini JA, Kim F, Yang L, Kotin RM.

J Virol. 1999 Feb;73(2):1309-19.

50.

Adenoassociated virus-mediated transfer of a functional water channel into salivary epithelial cells in vitro and in vivo.

Braddon VR, Chiorini JA, Wang S, Kotin RM, Baum BJ.

Hum Gene Ther. 1998 Dec 10;9(18):2777-85.

PMID:
9874275

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