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Items: 33

1.

A Flexible and Scalable High-Throughput Platform for Recombinant Membrane Protein Production.

Xu H, Clairfeuille T, Jao CC, Ho H, Sweeney Z, Payandeh J, Koth CM.

Methods Mol Biol. 2019;2025:389-402. doi: 10.1007/978-1-4939-9624-7_18.

PMID:
31267463
2.

Massive antibody discovery used to probe structure-function relationships of the essential outer membrane protein LptD.

Storek KM, Chan J, Vij R, Chiang N, Lin Z, Bevers J 3rd, Koth CM, Vernes JM, Meng YG, Yin J, Wallweber H, Dalmas O, Shriver S, Tam C, Schneider K, Seshasayee D, Nakamura G, Smith PA, Payandeh J, Koerber JT, Comps-Agrar L, Rutherford ST.

Elife. 2019 Jun 25;8. pii: e46258. doi: 10.7554/eLife.46258.

3.

Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin.

Xu H, Li T, Rohou A, Arthur CP, Tzakoniati F, Wong E, Estevez A, Kugel C, Franke Y, Chen J, Ciferri C, Hackos DH, Koth CM, Payandeh J.

Cell. 2019 Feb 21;176(5):1238-1239. doi: 10.1016/j.cell.2019.01.047. No abstract available.

PMID:
30794776
4.

Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin.

Xu H, Li T, Rohou A, Arthur CP, Tzakoniati F, Wong E, Estevez A, Kugel C, Franke Y, Chen J, Ciferri C, Hackos DH, Koth CM, Payandeh J.

Cell. 2019 Feb 7;176(4):702-715.e14. doi: 10.1016/j.cell.2018.12.018. Epub 2019 Jan 17. Erratum in: Cell. 2019 Feb 21;176(5):1238-1239.

PMID:
30661758
5.

Disrupting Gram-Negative Bacterial Outer Membrane Biosynthesis through Inhibition of the Lipopolysaccharide Transporter MsbA.

Alexander MK, Miu A, Oh A, Reichelt M, Ho H, Chalouni C, Labadie S, Wang L, Liang J, Nickerson NN, Hu H, Yu L, Du M, Yan D, Park S, Kim J, Xu M, Sellers BD, Purkey HE, Skelton NJ, Koehler MFT, Payandeh J, Verma V, Xu Y, Koth CM, Nishiyama M.

Antimicrob Agents Chemother. 2018 Oct 24;62(11). pii: e01142-18. doi: 10.1128/AAC.01142-18. Print 2018 Nov.

6.

A targeted boost-and-sort immunization strategy using Escherichia coli BamA identifies rare growth inhibitory antibodies.

Vij R, Lin Z, Chiang N, Vernes JM, Storek KM, Park S, Chan J, Meng YG, Comps-Agrar L, Luan P, Lee S, Schneider K, Bevers J 3rd, Zilberleyb I, Tam C, Koth CM, Xu M, Gill A, Auerbach MR, Smith PA, Rutherford ST, Nakamura G, Seshasayee D, Payandeh J, Koerber JT.

Sci Rep. 2018 May 8;8(1):7136. doi: 10.1038/s41598-018-25609-z.

7.

Structural basis for dual-mode inhibition of the ABC transporter MsbA.

Ho H, Miu A, Alexander MK, Garcia NK, Oh A, Zilberleyb I, Reichelt M, Austin CD, Tam C, Shriver S, Hu H, Labadie SS, Liang J, Wang L, Wang J, Lu Y, Purkey HE, Quinn J, Franke Y, Clark K, Beresini MH, Tan MW, Sellers BD, Maurer T, Koehler MFT, Wecksler AT, Kiefer JR, Verma V, Xu Y, Nishiyama M, Payandeh J, Koth CM.

Nature. 2018 May;557(7704):196-201. doi: 10.1038/s41586-018-0083-5. Epub 2018 May 2.

PMID:
29720648
8.

A Novel Inhibitor of the LolCDE ABC Transporter Essential for Lipoprotein Trafficking in Gram-Negative Bacteria.

Nickerson NN, Jao CC, Xu Y, Quinn J, Skippington E, Alexander MK, Miu A, Skelton N, Hankins JV, Lopez MS, Koth CM, Rutherford S, Nishiyama M.

Antimicrob Agents Chemother. 2018 Mar 27;62(4). pii: e02151-17. doi: 10.1128/AAC.02151-17. Print 2018 Apr.

9.

Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions.

Chiang EY, Li T, Jeet S, Peng I, Zhang J, Lee WP, DeVoss J, Caplazi P, Chen J, Warming S, Hackos DH, Mukund S, Koth CM, Grogan JL.

Nat Commun. 2017 Mar 1;8:14644. doi: 10.1038/ncomms14644.

10.

Voltage-gated sodium channels viewed through a structural biology lens.

Clairfeuille T, Xu H, Koth CM, Payandeh J.

Curr Opin Struct Biol. 2017 Aug;45:74-84. doi: 10.1016/j.sbi.2016.11.022. Epub 2016 Dec 15. Review.

PMID:
27988421
11.

Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist.

Ahuja S, Mukund S, Deng L, Khakh K, Chang E, Ho H, Shriver S, Young C, Lin S, Johnson JP Jr, Wu P, Li J, Coons M, Tam C, Brillantes B, Sampang H, Mortara K, Bowman KK, Clark KR, Estevez A, Xie Z, Verschoof H, Grimwood M, Dehnhardt C, Andrez JC, Focken T, Sutherlin DP, Safina BS, Starovasnik MA, Ortwine DF, Franke Y, Cohen CJ, Hackos DH, Koth CM, Payandeh J.

Science. 2015 Dec 18;350(6267):aac5464. doi: 10.1126/science.aac5464.

PMID:
26680203
12.

Structural analysis of bacterial ABC transporter inhibition by an antibody fragment.

Ahuja S, Rougé L, Swem DL, Sudhamsu J, Wu P, Russell SJ, Alexander MK, Tam C, Nishiyama M, Starovasnik MA, Koth CM.

Structure. 2015 Apr 7;23(4):713-23. doi: 10.1016/j.str.2015.01.020. Epub 2015 Mar 5.

13.

Inhibitory mechanism of an allosteric antibody targeting the glucagon receptor.

Mukund S, Shang Y, Clarke HJ, Madjidi A, Corn JE, Kates L, Kolumam G, Chiang V, Luis E, Murray J, Zhang Y, Hötzel I, Koth CM, Allan BB.

J Biol Chem. 2013 Dec 13;288(50):36168-78. doi: 10.1074/jbc.M113.496984. Epub 2013 Nov 4.

14.

Histone deacetylase (HDAC) inhibitor kinetic rate constants correlate with cellular histone acetylation but not transcription and cell viability.

Lauffer BE, Mintzer R, Fong R, Mukund S, Tam C, Zilberleyb I, Flicke B, Ritscher A, Fedorowicz G, Vallero R, Ortwine DF, Gunzner J, Modrusan Z, Neumann L, Koth CM, Lupardus PJ, Kaminker JS, Heise CE, Steiner P.

J Biol Chem. 2013 Sep 13;288(37):26926-43. doi: 10.1074/jbc.M113.490706. Epub 2013 Jul 29.

15.

Molecular basis for negative regulation of the glucagon receptor.

Koth CM, Murray JM, Mukund S, Madjidi A, Minn A, Clarke HJ, Wong T, Chiang V, Luis E, Estevez A, Rondon J, Zhang Y, Hötzel I, Allan BB.

Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14393-8. doi: 10.1073/pnas.1206734109. Epub 2012 Aug 20.

16.

Crystal structure of the ectodomain complex of the CGRP receptor, a class-B GPCR, reveals the site of drug antagonism.

ter Haar E, Koth CM, Abdul-Manan N, Swenson L, Coll JT, Lippke JA, Lepre CA, Garcia-Guzman M, Moore JM.

Structure. 2010 Sep 8;18(9):1083-93. doi: 10.1016/j.str.2010.05.014.

17.

Refolding and characterization of a soluble ectodomain complex of the calcitonin gene-related peptide receptor.

Koth CM, Abdul-Manan N, Lepre CA, Connolly PJ, Yoo S, Mohanty AK, Lippke JA, Zwahlen J, Coll JT, Doran JD, Garcia-Guzman M, Moore JM.

Biochemistry. 2010 Mar 9;49(9):1862-72. doi: 10.1021/bi901848m.

PMID:
20099900
18.

Strategies for the cloning and expression of membrane proteins.

Koth CM, Payandeh J.

Adv Protein Chem Struct Biol. 2009;76:43-86. doi: 10.1016/S1876-1623(08)76002-4. Epub 2009 Nov 27. Review.

PMID:
20663478
19.

Structural proteomics of membrane proteins: a survey of published techniques and design of a rational high throughput strategy.

Willis MS, Koth CM.

Methods Mol Biol. 2008;426:277-95. doi: 10.1007/978-1-60327-058-8_18.

PMID:
18542871
20.

A robust purification strategy to accelerate membrane proteomics.

Dobrovetsky E, Menendez J, Edwards AM, Koth CM.

Methods. 2007 Apr;41(4):381-7. Review.

PMID:
17367710
21.

Crystal structure of the CorA Mg2+ transporter.

Lunin VV, Dobrovetsky E, Khutoreskaya G, Zhang R, Joachimiak A, Doyle DA, Bochkarev A, Maguire ME, Edwards AM, Koth CM.

Nature. 2006 Apr 6;440(7085):833-7.

22.

High-throughput production of prokaryotic membrane proteins.

Dobrovetsky E, Lu ML, Andorn-Broza R, Khutoreskaya G, Bray JE, Savchenko A, Arrowsmith CH, Edwards AM, Koth CM.

J Struct Funct Genomics. 2005;6(1):33-50.

PMID:
15909233
23.

Mechanism of intramembrane proteolysis investigated with purified rhomboid proteases.

Lemberg MK, Menendez J, Misik A, Garcia M, Koth CM, Freeman M.

EMBO J. 2005 Feb 9;24(3):464-72. Epub 2004 Dec 23.

24.

Use of limited proteolysis to identify protein domains suitable for structural analysis.

Koth CM, Orlicky SM, Larson SM, Edwards AM.

Methods Enzymol. 2003;368:77-84. No abstract available.

PMID:
14674269
25.

From clone to crystal: maximizing the amount of protein samples for structure determination.

Koth CM, Edwards AM.

Adv Protein Chem. 2003;65:343-52. Review. No abstract available.

PMID:
12964375
26.

Activation of Notch signaling pathway precedes heart regeneration in zebrafish.

Raya A, Koth CM, Büscher D, Kawakami Y, Itoh T, Raya RM, Sternik G, Tsai HJ, Rodríguez-Esteban C, Izpisúa-Belmonte JC.

Proc Natl Acad Sci U S A. 2003 Sep 30;100 Suppl 1:11889-95. Epub 2003 Aug 8.

27.

MKP3 mediates the cellular response to FGF8 signalling in the vertebrate limb.

Kawakami Y, Rodríguez-León J, Koth CM, Büscher D, Itoh T, Raya A, Ng JK, Esteban CR, Takahashi S, Henrique D, Schwarz MF, Asahara H, Izpisúa Belmonte JC.

Nat Cell Biol. 2003 Jun;5(6):513-9.

PMID:
12766772
28.

Notch activity induces Nodal expression and mediates the establishment of left-right asymmetry in vertebrate embryos.

Raya A, Kawakami Y, Rodriguez-Esteban C, Buscher D, Koth CM, Itoh T, Morita M, Raya RM, Dubova I, Bessa JG, de la Pompa JL, Izpisua Belmonte JC.

Genes Dev. 2003 May 15;17(10):1213-8. Epub 2003 May 2.

29.

The limb identity gene Tbx5 promotes limb initiation by interacting with Wnt2b and Fgf10.

Ng JK, Kawakami Y, Büscher D, Raya A, Itoh T, Koth CM, Rodríguez Esteban C, Rodríguez-León J, Garrity DM, Fishman MC, Izpisúa Belmonte JC.

Development. 2002 Nov;129(22):5161-70.

30.

Solution structure and dynamics of yeast elongin C in complex with a von Hippel-Lindau peptide.

Botuyan MV, Mer G, Yi GS, Koth CM, Case DA, Edwards AM, Chazin WJ, Arrowsmith CH.

J Mol Biol. 2001 Sep 7;312(1):177-86.

PMID:
11545595
31.

Elongin from Saccharomyces cerevisiae.

Koth CM, Botuyan MV, Moreland RJ, Jansma DB, Conaway JW, Conaway RC, Chazin WJ, Friesen JD, Arrowsmith CH, Edwards AM.

J Biol Chem. 2000 Apr 14;275(15):11174-80.

32.

Structure of a conserved domain common to the transcription factors TFIIS, elongin A, and CRSP70.

Booth V, Koth CM, Edwards AM, Arrowsmith CH.

J Biol Chem. 2000 Oct 6;275(40):31266-8.

33.

Binding of elongin A or a von Hippel-Lindau peptide stabilizes the structure of yeast elongin C.

Botuyan MV, Koth CM, Mer G, Chakrabartty A, Conaway JW, Conaway RC, Edwards AM, Arrowsmith CH, Chazin WJ.

Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9033-8.

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