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Items: 41

1.

Plazomicin Retains Antibiotic Activity against Most Aminoglycoside Modifying Enzymes.

Cox G, Ejim L, Stogios PJ, Koteva K, Bordeleau E, Evdokimova E, Sieron AO, Savchenko A, Serio AW, Krause KM, Wright GD.

ACS Infect Dis. 2018 Jun 8;4(6):980-987. doi: 10.1021/acsinfecdis.8b00001. Epub 2018 Apr 19.

2.

Rox, a Rifamycin Resistance Enzyme with an Unprecedented Mechanism of Action.

Koteva K, Cox G, Kelso JK, Surette MD, Zubyk HL, Ejim L, Stogios P, Savchenko A, Sørensen D, Wright GD.

Cell Chem Biol. 2018 Apr 19;25(4):403-412.e5. doi: 10.1016/j.chembiol.2018.01.009. Epub 2018 Feb 1.

3.

The evolution of substrate discrimination in macrolide antibiotic resistance enzymes.

Pawlowski AC, Stogios PJ, Koteva K, Skarina T, Evdokimova E, Savchenko A, Wright GD.

Nat Commun. 2018 Jan 9;9(1):112. doi: 10.1038/s41467-017-02680-0.

4.

The complex resistomes of Paenibacillaceae reflect diverse antibiotic chemical ecologies.

Pawlowski AC, Westman EL, Koteva K, Waglechner N, Wright GD.

ISME J. 2018 Mar;12(3):885-897. doi: 10.1038/s41396-017-0017-5. Epub 2017 Dec 19.

5.

A Common Platform for Antibiotic Dereplication and Adjuvant Discovery.

Cox G, Sieron A, King AM, De Pascale G, Pawlowski AC, Koteva K, Wright GD.

Cell Chem Biol. 2017 Jan 19;24(1):98-109. doi: 10.1016/j.chembiol.2016.11.011. Epub 2016 Dec 22.

6.

A diverse intrinsic antibiotic resistome from a cave bacterium.

Pawlowski AC, Wang W, Koteva K, Barton HA, McArthur AG, Wright GD.

Nat Commun. 2016 Dec 8;7:13803. doi: 10.1038/ncomms13803.

7.

Total Synthesis of Aspergillomarasmine A and Related Compounds: A Sulfamidate Approach Enables Exploration of Structure-Activity Relationships.

Albu SA, Koteva K, King AM, Al-Karmi S, Wright GD, Capretta A.

Angew Chem Int Ed Engl. 2016 Oct 10;55(42):13259-13262. doi: 10.1002/anie.201606657.

PMID:
27633338
8.

Liquid Chromatography-Tandem Mass Spectrometry to Define Sortase Cleavage Products.

Duong A, Koteva K, Sexton DL, Elliot MA.

Methods Mol Biol. 2016;1440:99-108. doi: 10.1007/978-1-4939-3676-2_8.

PMID:
27311667
9.

Rifampin phosphotransferase is an unusual antibiotic resistance kinase.

Stogios PJ, Cox G, Spanogiannopoulos P, Pillon MC, Waglechner N, Skarina T, Koteva K, Guarné A, Savchenko A, Wright GD.

Nat Commun. 2016 Apr 22;7:11343. doi: 10.1038/ncomms11343.

10.

Total Synthesis and Activity of the Metallo-β-lactamase Inhibitor Aspergillomarasmine A.

Koteva K, King AM, Capretta A, Wright GD.

Angew Chem Int Ed Engl. 2016 Feb 5;55(6):2210-2. doi: 10.1002/anie.201510057. Epub 2015 Dec 28.

PMID:
26709849
11.

Structural and functional plasticity of antibiotic resistance nucleotidylyltransferases revealed by molecular characterization of lincosamide nucleotidylyltransferases lnu(A) and lnu(D).

Stogios PJ, Evdokimova E, Morar M, Koteva K, Wright GD, Courvalin P, Savchenko A.

J Mol Biol. 2015 Jun 19;427(12):2229-43. doi: 10.1016/j.jmb.2015.04.008. Epub 2015 Apr 18.

12.

Harnessing the synthetic capabilities of glycopeptide antibiotic tailoring enzymes: characterization of the UK-68,597 biosynthetic cluster.

Yim G, Kalan L, Koteva K, Thaker MN, Waglechner N, Tang I, Wright GD.

Chembiochem. 2014 Nov 24;15(17):2613-23. doi: 10.1002/cbic.201402179. Epub 2014 Sep 26.

PMID:
25255985
13.

A macrophage-stimulating compound from a screen of microbial natural products.

Perry JA, Koteva K, Verschoor CP, Wang W, Bowdish DM, Wright GD.

J Antibiot (Tokyo). 2015 Jan;68(1):40-6. doi: 10.1038/ja.2014.83. Epub 2014 Jul 2.

PMID:
24984798
14.

A rifamycin inactivating phosphotransferase family shared by environmental and pathogenic bacteria.

Spanogiannopoulos P, Waglechner N, Koteva K, Wright GD.

Proc Natl Acad Sci U S A. 2014 May 13;111(19):7102-7. doi: 10.1073/pnas.1402358111. Epub 2014 Apr 28.

15.

An unusual class of anthracyclines potentiate Gram-positive antibiotics in intrinsically resistant Gram-negative bacteria.

Cox G, Koteva K, Wright GD.

J Antimicrob Chemother. 2014 Jul;69(7):1844-55. doi: 10.1093/jac/dku057. Epub 2014 Mar 13.

16.

Designing analogs of ticlopidine, a wall teichoic acid inhibitor, to avoid formation of its oxidative metabolites.

Farha MA, Koteva K, Gale RT, Sewell EW, Wright GD, Brown ED.

Bioorg Med Chem Lett. 2014 Feb 1;24(3):905-10. doi: 10.1016/j.bmcl.2013.12.069. Epub 2013 Dec 23.

PMID:
24393581
17.

Glycopeptide antibiotic biosynthesis.

Yim G, Thaker MN, Koteva K, Wright G.

J Antibiot (Tokyo). 2014 Jan;67(1):31-41. doi: 10.1038/ja.2013.117. Epub 2013 Nov 13. Review.

PMID:
24220108
18.

Self resistance to the atypical cationic antimicrobial peptide edeine of Brevibacillus brevis Vm4 by the N-acetyltransferase EdeQ.

Westman EL, Yan M, Waglechner N, Koteva K, Wright GD.

Chem Biol. 2013 Aug 22;20(8):983-90. doi: 10.1016/j.chembiol.2013.06.010. Epub 2013 Jul 25.

19.

The comprehensive antibiotic resistance database.

McArthur AG, Waglechner N, Nizam F, Yan A, Azad MA, Baylay AJ, Bhullar K, Canova MJ, De Pascale G, Ejim L, Kalan L, King AM, Koteva K, Morar M, Mulvey MR, O'Brien JS, Pawlowski AC, Piddock LJ, Spanogiannopoulos P, Sutherland AD, Tang I, Taylor PL, Thaker M, Wang W, Yan M, Yu T, Wright GD.

Antimicrob Agents Chemother. 2013 Jul;57(7):3348-57. doi: 10.1128/AAC.00419-13. Epub 2013 May 6.

20.

Glycopeptide sulfation evades resistance.

Kalan L, Perry J, Koteva K, Thaker M, Wright G.

J Bacteriol. 2013 Jan;195(1):167-71. doi: 10.1128/JB.01617-12. Epub 2012 Oct 26.

21.

Bacterial inactivation of the anticancer drug doxorubicin.

Westman EL, Canova MJ, Radhi IJ, Koteva K, Kireeva I, Waglechner N, Wright GD.

Chem Biol. 2012 Oct 26;19(10):1255-64. doi: 10.1016/j.chembiol.2012.08.011.

22.

Characterization of a rifampin-inactivating glycosyltransferase from a screen of environmental actinomycetes.

Spanogiannopoulos P, Thaker M, Koteva K, Waglechner N, Wright GD.

Antimicrob Agents Chemother. 2012 Oct;56(10):5061-9. doi: 10.1128/AAC.01166-12. Epub 2012 Jul 16.

23.

Antibiotic resistance is prevalent in an isolated cave microbiome.

Bhullar K, Waglechner N, Pawlowski A, Koteva K, Banks ED, Johnston MD, Barton HA, Wright GD.

PLoS One. 2012;7(4):e34953. doi: 10.1371/journal.pone.0034953. Epub 2012 Apr 11.

24.

Mechanism and diversity of the erythromycin esterase family of enzymes.

Morar M, Pengelly K, Koteva K, Wright GD.

Biochemistry. 2012 Feb 28;51(8):1740-51. doi: 10.1021/bi201790u. Epub 2012 Feb 10.

PMID:
22303981
25.

Small-molecule modulators of Listeria monocytogenes biofilm development.

Nguyen UT, Wenderska IB, Chong MA, Koteva K, Wright GD, Burrows LL.

Appl Environ Microbiol. 2012 Mar;78(5):1454-65. doi: 10.1128/AEM.07227-11. Epub 2011 Dec 22.

26.

Inactivation of the lipopeptide antibiotic daptomycin by hydrolytic mechanisms.

D'Costa VM, Mukhtar TA, Patel T, Koteva K, Waglechner N, Hughes DW, Wright GD, De Pascale G.

Antimicrob Agents Chemother. 2012 Feb;56(2):757-64. doi: 10.1128/AAC.05441-11. Epub 2011 Nov 14.

27.

Receptor domains of two-component signal transduction systems.

Perry J, Koteva K, Wright G.

Mol Biosyst. 2011 May;7(5):1388-98. doi: 10.1039/c0mb00329h. Epub 2011 Feb 24. Review.

PMID:
21347487
28.

A vancomycin photoprobe identifies the histidine kinase VanSsc as a vancomycin receptor.

Koteva K, Hong HJ, Wang XD, Nazi I, Hughes D, Naldrett MJ, Buttner MJ, Wright GD.

Nat Chem Biol. 2010 May;6(5):327-9. doi: 10.1038/nchembio.350. Epub 2010 Apr 11.

PMID:
20383152
29.

Induction of antimicrobial activities in heterologous streptomycetes using alleles of the Streptomyces coelicolor gene absA1.

McKenzie NL, Thaker M, Koteva K, Hughes DW, Wright GD, Nodwell JR.

J Antibiot (Tokyo). 2010 Apr;63(4):177-82. doi: 10.1038/ja.2010.13. Epub 2010 Mar 12.

PMID:
20224601
30.

The wall teichoic acid polymerase TagF efficiently synthesizes poly(glycerol phosphate) on the TagB product lipid III.

Pereira MP, Schertzer JW, D'Elia MA, Koteva KP, Hughes DW, Wright GD, Brown ED.

Chembiochem. 2008 Jun 16;9(9):1385-90. doi: 10.1002/cbic.200800026. No abstract available.

PMID:
18465758
31.

Rifamycin antibiotic resistance by ADP-ribosylation: Structure and diversity of Arr.

Baysarowich J, Koteva K, Hughes DW, Ejim L, Griffiths E, Zhang K, Junop M, Wright GD.

Proc Natl Acad Sci U S A. 2008 Mar 25;105(12):4886-91. doi: 10.1073/pnas.0711939105. Epub 2008 Mar 18.

32.

Inhibitors of bacterial cystathionine beta-lyase: leads for new antimicrobial agents and probes of enzyme structure and function.

Ejim LJ, Blanchard JE, Koteva KP, Sumerfield R, Elowe NH, Chechetto JD, Brown ED, Junop MS, Wright GD.

J Med Chem. 2007 Feb 22;50(4):755-64.

PMID:
17300162
33.

An in vitro screen of bacterial lipopolysaccharide biosynthetic enzymes identifies an inhibitor of ADP-heptose biosynthesis.

De Leon GP, Elowe NH, Koteva KP, Valvano MA, Wright GD.

Chem Biol. 2006 Apr;13(4):437-41.

34.

Biosynthesis of sulfated glycopeptide antibiotics by using the sulfotransferase StaL.

Lamb SS, Patel T, Koteva KP, Wright GD.

Chem Biol. 2006 Feb;13(2):171-81.

35.

Chimeric streptogramin-tyrocidine antibiotics that overcome streptogramin resistance.

Mukhtar TA, Koteva KP, Wright GD.

Chem Biol. 2005 Feb;12(2):229-35.

36.

TetX is a flavin-dependent monooxygenase conferring resistance to tetracycline antibiotics.

Yang W, Moore IF, Koteva KP, Bareich DC, Hughes DW, Wright GD.

J Biol Chem. 2004 Dec 10;279(50):52346-52. Epub 2004 Sep 27.

37.

Small molecule functional discrimination of the kinases required for the microbial synthesis of threonine and isoleucine.

Bareich D, Koteva K, Nazi I, Wright GD.

Bioorg Med Chem. 2004 Feb 15;12(4):807-15.

PMID:
14759741
38.

One-pot chemoenzymatic preparation of coenzyme A analogues.

Nazi I, Koteva KP, Wright GD.

Anal Biochem. 2004 Jan 1;324(1):100-5.

PMID:
14654051
39.

Enzyme-assisted suicide: molecular basis for the antifungal activity of 5-hydroxy-4-oxonorvaline by potent inhibition of homoserine dehydrogenase.

Jacques SL, Mirza IA, Ejim L, Koteva K, Hughes DW, Green K, Kinach R, Honek JF, Lai HK, Berghuis AM, Wright GD.

Chem Biol. 2003 Oct;10(10):989-95.

PMID:
14583265
40.

Broad-spectrum peptide inhibitors of aminoglycoside antibiotic resistance enzymes.

Boehr DD, Draker KA, Koteva K, Bains M, Hancock RE, Wright GD.

Chem Biol. 2003 Feb;10(2):189-96.

PMID:
12618191
41.

Vgb from Staphylococcus aureus inactivates streptogramin B antibiotics by an elimination mechanism not hydrolysis.

Mukhtar TA, Koteva KP, Hughes DW, Wright GD.

Biochemistry. 2001 Jul 31;40(30):8877-86.

PMID:
11467949

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