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Items: 1 to 50 of 200

1.

Synthesis and biological evaluation of PSMA-targeting paclitaxel conjugates.

Machulkin AE, Skvortsov DA, Ivanenkov YA, Ber AP, Kavalchuk MV, Aladinskaya AV, Uspenskaya AA, Shafikov RR, Plotnikova EA, Yakubovskaya RI, Nimenko EA, Zyk NU, Beloglazkina EK, Zyk NV, Koteliansky VE, Majouga AG.

Bioorg Med Chem Lett. 2019 Aug 15;29(16):2229-2235. doi: 10.1016/j.bmcl.2019.06.035. Epub 2019 Jun 20.

PMID:
31248772
2.

Liquid-crystal organization of liver tissue.

Morales-Navarrete H, Nonaka H, Scholich A, Segovia-Miranda F, de Back W, Meyer K, Bogorad RL, Koteliansky V, Brusch L, Kalaidzidis Y, Jülicher F, Friedrich BM, Zerial M.

Elife. 2019 Jun 17;8. pii: e44860. doi: 10.7554/eLife.44860.

3.

Corrigendum to 'Synthesis and biological evaluation of Doxorubicin-containing conjugate targeting PSMA' [Bioor. Med. Chem. Lett. 29/10 (2019) 1246-1255].

Ivanenkov YA, Machulkin AE, Garanina AS, Skvortsov DA, Uspenskaya AA, Deyneka EV, Trofimenko AV, Beloglazkina EK, Zyk NV, Koteliansky VE, Bezrukov DS, Aladinskaya AV, Vorobyeva NS, Puchinina MM, Ryabykh GK, Sofronova AA, Malyshev AS, Majouga AG.

Bioorg Med Chem Lett. 2019 Jul 1;29(13):1688. doi: 10.1016/j.bmcl.2019.04.038. Epub 2019 May 2. No abstract available.

PMID:
31056242
4.

Synthesis and biological evaluation of Doxorubicin-containing conjugate targeting PSMA.

Ivanenkov YA, Machulkin AE, Garanina AS, Skvortsov DA, Uspenskaya AA, Deyneka EV, Trofimenko AV, Beloglazkina EK, Zyk NV, Koteliansky VE, Bezrukov DS, Aladinskaya AV, Vorobyeva NS, Puchinina MM, Riabykh GK, Sofronova AA, Malyshev AS, Majouga AG.

Bioorg Med Chem Lett. 2019 May 15;29(10):1246-1255. doi: 10.1016/j.bmcl.2019.01.040. Epub 2019 Feb 1. Erratum in: Bioorg Med Chem Lett. 2019 Jul 1;29(13):1688.

PMID:
30904185
5.

Corrigendum: Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration.

Raven A, Lu WY, Man TY, Ferreira-Gonzalez S, O'Duibhir E, Dwyer BJ, Thomson JP, Meehan RR, Bogorad R, Koteliansky V, Kotelevtsev Y, Ffrench-Constant C, Boulter L, Forbes SJ.

Nature. 2018 Mar 14;555(7696):402. doi: 10.1038/nature25996.

PMID:
29542689
6.

Partial DNA-guided Cas9 enables genome editing with reduced off-target activity.

Yin H, Song CQ, Suresh S, Kwan SY, Wu Q, Walsh S, Ding J, Bogorad RL, Zhu LJ, Wolfe SA, Koteliansky V, Xue W, Langer R, Anderson DG.

Nat Chem Biol. 2018 Mar;14(3):311-316. doi: 10.1038/nchembio.2559. Epub 2018 Jan 29.

7.

Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing.

Yin H, Song CQ, Suresh S, Wu Q, Walsh S, Rhym LH, Mintzer E, Bolukbasi MF, Zhu LJ, Kauffman K, Mou H, Oberholzer A, Ding J, Kwan SY, Bogorad RL, Zatsepin T, Koteliansky V, Wolfe SA, Xue W, Langer R, Anderson DG.

Nat Biotechnol. 2017 Dec;35(12):1179-1187. doi: 10.1038/nbt.4005. Epub 2017 Nov 13.

8.

Large-Scale Quantitative Proteomics Identifies the Ubiquitin Ligase Nedd4-1 as an Essential Regulator of Liver Regeneration.

Bachofner M, Speicher T, Bogorad RL, Muzumdar S, Derrer CP, Hürlimann F, Böhm F, Nanni P, Kockmann T, Kachaylo E, Meyer M, Padrissa-Altés S, Graf R, Anderson DG, Koteliansky V, Auf dem Keller U, Werner S.

Dev Cell. 2017 Sep 25;42(6):616-625.e8. doi: 10.1016/j.devcel.2017.07.025. Epub 2017 Sep 7.

9.

Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration.

Raven A, Lu WY, Man TY, Ferreira-Gonzalez S, O'Duibhir E, Dwyer BJ, Thomson JP, Meehan RR, Bogorad R, Koteliansky V, Kotelevtsev Y, Ffrench-Constant C, Boulter L, Forbes SJ.

Nature. 2017 Jul 20;547(7663):350-354. doi: 10.1038/nature23015. Epub 2017 Jul 12. Erratum in: Nature. 2018 Mar 14;555(7696):402.

10.

Identification of Novel Fibrosis Modifiers by In Vivo siRNA Silencing.

Vollmann EH, Cao L, Amatucci A, Reynolds T, Hamann S, Dalkilic-Liddle I, Cameron TO, Hossbach M, Kauffman KJ, Mir FF, Anderson DG, Novobrantseva T, Koteliansky V, Kisseleva T, Brenner D, Duffield J, Burkly LC.

Mol Ther Nucleic Acids. 2017 Jun 16;7:314-323. doi: 10.1016/j.omtn.2017.04.014. Epub 2017 Apr 20.

11.

Lipid nanoparticles for targeted siRNA delivery - going from bench to bedside.

Zatsepin TS, Kotelevtsev YV, Koteliansky V.

Int J Nanomedicine. 2016 Jul 5;11:3077-86. doi: 10.2147/IJN.S106625. eCollection 2016. Review.

12.

mRNA-Based Therapeutics - Advances and Perspectives.

Sergeeva OV, Koteliansky VE, Zatsepin TS.

Biochemistry (Mosc). 2016 Jul;81(7):709-22. doi: 10.1134/S0006297916070075. Review.

13.

Identification of Novel Small-Molecule ASGP-R Ligands.

Majouga AG, Ivanenkov YA, Veselov MS, Lopuhov AV, Maklakova SV, Beloglazkina EK, Binevski PV, Klyachko NL, Sandulenko YB, Galkina NY, Koteliansky VE.

Curr Drug Deliv. 2016;13(8):1303-1312.

PMID:
27440073
14.

lncRNA in the liver: Prospects for fundamental research and therapy by RNA interference.

Smekalova EM, Kotelevtsev YV, Leboeuf D, Shcherbinina EY, Fefilova AS, Zatsepin TS, Koteliansky V.

Biochimie. 2016 Dec;131:159-172. doi: 10.1016/j.biochi.2016.06.007. Epub 2016 Jun 16. Review.

PMID:
27318030
15.

Small-molecule PSMA ligands. Current state, SAR and perspectives.

Machulkin AE, Ivanenkov YA, Aladinskaya AV, Veselov MS, Aladinskiy VA, Beloglazkina EK, Koteliansky VE, Shakhbazyan AG, Sandulenko YB, Majouga AG.

J Drug Target. 2016 Sep;24(8):679-93. doi: 10.3109/1061186X.2016.1154564. Epub 2016 Mar 10. Review.

PMID:
26887438
16.

Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo.

Yin H, Song CQ, Dorkin JR, Zhu LJ, Li Y, Wu Q, Park A, Yang J, Suresh S, Bizhanova A, Gupta A, Bolukbasi MF, Walsh S, Bogorad RL, Gao G, Weng Z, Dong Y, Koteliansky V, Wolfe SA, Langer R, Xue W, Anderson DG.

Nat Biotechnol. 2016 Mar;34(3):328-33. doi: 10.1038/nbt.3471. Epub 2016 Feb 1.

17.

Synthesis, isomerization and biological activity of novel 2-selenohydantoin derivatives.

Ivanenkov YA, Veselov MS, Rezekin IG, Skvortsov DA, Sandulenko YB, Polyakova MV, Bezrukov DS, Vasilevsky SV, Kukushkin ME, Moiseeva AA, Finko AV, Koteliansky VE, Klyachko NL, Filatova LA, Beloglazkina EK, Zyk NV, Majouga AG.

Bioorg Med Chem. 2016 Feb 15;24(4):802-11. doi: 10.1016/j.bmc.2015.12.050. Epub 2016 Jan 2.

PMID:
26780833
18.

N6-Methylated Adenosine in RNA: From Bacteria to Humans.

Sergiev PV, Golovina AY, Osterman IA, Nesterchuk MV, Sergeeva OV, Chugunova AA, Evfratov SA, Andreianova ES, Pletnev PI, Laptev IG, Petriukov KS, Navalayeu TI, Koteliansky VE, Bogdanov AA, Dontsova OA.

J Mol Biol. 2016 May 22;428(10 Pt B):2134-45. doi: 10.1016/j.jmb.2015.12.013. Epub 2015 Dec 19. Review.

PMID:
26707202
19.

RNAi-nanoparticulate manipulation of gene expression as a new functional genomics tool in the liver.

Yin H, Bogorad RL, Barnes C, Walsh S, Zhuang I, Nonaka H, Ruda V, Kuchimanchi S, Nechev L, Akinc A, Xue W, Zerial M, Langer R, Anderson DG, Koteliansky V.

J Hepatol. 2016 Apr;64(4):899-907. doi: 10.1016/j.jhep.2015.11.028. Epub 2015 Nov 30.

20.

A Comprehensive Insight into the Chemical Space and ADME Features of Small Molecule NS5A Inhibitors.

Ivanenkov YA, Veselov MS, Shakhbazyan AG, Aladinskiy VA, Aladinskaya AV, Yartseva SM, Majouga AG, Vantskul AS, Leonov SV, Ivachtchenko AV, Koteliansky VE.

Curr Top Med Chem. 2016;16(12):1372-82. Review.

PMID:
26585933
21.

In Silico Approaches to the Design of NS5A Inhibitors.

Ivanenkov YA, Veselov MS, Aladinskiy VA, Shakhbazyan AG, Yartseva SM, Majouga AG, Aladinskaya AV, Vantskul AS, Leonov SV, Ivachtchenko AV, Koteliansky VE.

Curr Top Med Chem. 2016;16(12):1383-91. Review.

PMID:
26585932
22.

Identification of siRNA delivery enhancers by a chemical library screen.

Gilleron J, Paramasivam P, Zeigerer A, Querbes W, Marsico G, Andree C, Seifert S, Amaya P, Stöter M, Koteliansky V, Waldmann H, Fitzgerald K, Kalaidzidis Y, Akinc A, Maier MA, Manoharan M, Bickle M, Zerial M.

Nucleic Acids Res. 2015 Sep 18;43(16):7984-8001. doi: 10.1093/nar/gkv762. Epub 2015 Jul 28.

23.

Regulation of liver metabolism by the endosomal GTPase Rab5.

Zeigerer A, Bogorad RL, Sharma K, Gilleron J, Seifert S, Sales S, Berndt N, Bulik S, Marsico G, D'Souza RCJ, Lakshmanaperumal N, Meganathan K, Natarajan K, Sachinidis A, Dahl A, Holzhütter HG, Shevchenko A, Mann M, Koteliansky V, Zerial M.

Cell Rep. 2015 May 12;11(6):884-892. doi: 10.1016/j.celrep.2015.04.018. Epub 2015 Apr 30.

24.

Control of hepatocyte proliferation and survival by Fgf receptors is essential for liver regeneration in mice.

Padrissa-Altés S, Bachofner M, Bogorad RL, Pohlmeier L, Rossolini T, Böhm F, Liebisch G, Hellerbrand C, Koteliansky V, Speicher T, Werner S.

Gut. 2015 Sep;64(9):1444-53.

PMID:
25416068
25.

Loss of α-catenin elicits a cholestatic response and impairs liver regeneration.

Herr KJ, Tsang YH, Ong JW, Li Q, Yap LL, Yu W, Yin H, Bogorad RL, Dahlman JE, Chan YG, Bay BH, Singaraja R, Anderson DG, Koteliansky V, Viasnoff V, Thiery JP.

Sci Rep. 2014 Oct 30;4:6835. doi: 10.1038/srep06835.

26.

The roles of individual mammalian argonautes in RNA interference in vivo.

Ruda VM, Chandwani R, Sehgal A, Bogorad RL, Akinc A, Charisse K, Tarakhovsky A, Novobrantseva TI, Koteliansky V.

PLoS One. 2014 Jul 3;9(7):e101749. doi: 10.1371/journal.pone.0101749. eCollection 2014.

27.

Silencing of CCR2 in myocarditis.

Leuschner F, Courties G, Dutta P, Mortensen LJ, Gorbatov R, Sena B, Novobrantseva TI, Borodovsky A, Fitzgerald K, Koteliansky V, Iwamoto Y, Bohlender M, Meyer S, Lasitschka F, Meder B, Katus HA, Lin C, Libby P, Swirski FK, Anderson DG, Weissleder R, Nahrendorf M.

Eur Heart J. 2015 Jun 14;36(23):1478-88. doi: 10.1093/eurheartj/ehu225. Epub 2014 Jun 20.

28.

Nanoparticle-formulated siRNA targeting integrins inhibits hepatocellular carcinoma progression in mice.

Bogorad RL, Yin H, Zeigerer A, Nonaka H, Ruda VM, Zerial M, Anderson DG, Koteliansky V.

Nat Commun. 2014 May 21;5:3869. doi: 10.1038/ncomms4869.

29.

Knockdown and knockout of β1-integrin in hepatocytes impairs liver regeneration through inhibition of growth factor signalling.

Speicher T, Siegenthaler B, Bogorad RL, Ruppert R, Petzold T, Padrissa-Altes S, Bachofner M, Anderson DG, Koteliansky V, Fässler R, Werner S.

Nat Commun. 2014 May 21;5:3862. doi: 10.1038/ncomms4862.

PMID:
24844558
30.

Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype.

Yin H, Xue W, Chen S, Bogorad RL, Benedetti E, Grompe M, Koteliansky V, Sharp PA, Jacks T, Anderson DG.

Nat Biotechnol. 2014 Jun;32(6):551-3. doi: 10.1038/nbt.2884. Epub 2014 Mar 30. Erratum in: Nat Biotechnol. 2014 Sep;32(9):952.

31.

Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates.

Dong Y, Love KT, Dorkin JR, Sirirungruang S, Zhang Y, Chen D, Bogorad RL, Yin H, Chen Y, Vegas AJ, Alabi CA, Sahay G, Olejnik KT, Wang W, Schroeder A, Lytton-Jean AK, Siegwart DJ, Akinc A, Barnes C, Barros SA, Carioto M, Fitzgerald K, Hettinger J, Kumar V, Novobrantseva TI, Qin J, Querbes W, Koteliansky V, Langer R, Anderson DG.

Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):3955-60. doi: 10.1073/pnas.1322937111. Epub 2014 Feb 10. Erratum in: Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5753.

32.

Image-based analysis of lipid nanoparticle-mediated siRNA delivery, intracellular trafficking and endosomal escape.

Gilleron J, Querbes W, Zeigerer A, Borodovsky A, Marsico G, Schubert U, Manygoats K, Seifert S, Andree C, Stöter M, Epstein-Barash H, Zhang L, Koteliansky V, Fitzgerald K, Fava E, Bickle M, Kalaidzidis Y, Akinc A, Maier M, Zerial M.

Nat Biotechnol. 2013 Jul;31(7):638-46. doi: 10.1038/nbt.2612. Epub 2013 Jun 23.

PMID:
23792630
33.

MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca²⁺ uniporter.

Csordás G, Golenár T, Seifert EL, Kamer KJ, Sancak Y, Perocchi F, Moffat C, Weaver D, de la Fuente Perez S, Bogorad R, Koteliansky V, Adijanto J, Mootha VK, Hajnóczky G.

Cell Metab. 2013 Jun 4;17(6):976-87. doi: 10.1016/j.cmet.2013.04.020.

34.

MICU2, a paralog of MICU1, resides within the mitochondrial uniporter complex to regulate calcium handling.

Plovanich M, Bogorad RL, Sancak Y, Kamer KJ, Strittmatter L, Li AA, Girgis HS, Kuchimanchi S, De Groot J, Speciner L, Taneja N, Oshea J, Koteliansky V, Mootha VK.

PLoS One. 2013;8(2):e55785. doi: 10.1371/journal.pone.0055785. Epub 2013 Feb 7.

35.

Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells.

Novobrantseva TI, Borodovsky A, Wong J, Klebanov B, Zafari M, Yucius K, Querbes W, Ge P, Ruda VM, Milstein S, Speciner L, Duncan R, Barros S, Basha G, Cullis P, Akinc A, Donahoe JS, Narayanannair Jayaprakash K, Jayaraman M, Bogorad RL, Love K, Whitehead K, Levins C, Manoharan M, Swirski FK, Weissleder R, Langer R, Anderson DG, de Fougerolles A, Nahrendorf M, Koteliansky V.

Mol Ther Nucleic Acids. 2012 Jan 24;1:e4. doi: 10.1038/mtna.2011.3.

36.

Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice.

So JS, Hur KY, Tarrio M, Ruda V, Frank-Kamenetsky M, Fitzgerald K, Koteliansky V, Lichtman AH, Iwawaki T, Glimcher LH, Lee AH.

Cell Metab. 2012 Oct 3;16(4):487-99. doi: 10.1016/j.cmet.2012.09.004.

37.

Rab5 is necessary for the biogenesis of the endolysosomal system in vivo.

Zeigerer A, Gilleron J, Bogorad RL, Marsico G, Nonaka H, Seifert S, Epstein-Barash H, Kuchimanchi S, Peng CG, Ruda VM, Del Conte-Zerial P, Hengstler JG, Kalaidzidis Y, Koteliansky V, Zerial M.

Nature. 2012 May 23;485(7399):465-70. doi: 10.1038/nature11133.

PMID:
22622570
38.

Treatment of erythropoietin deficiency in mice with systemically administered siRNA.

Querbes W, Bogorad RL, Moslehi J, Wong J, Chan AY, Bulgakova E, Kuchimanchi S, Akinc A, Fitzgerald K, Koteliansky V, Kaelin WG Jr.

Blood. 2012 Aug 30;120(9):1916-22. doi: 10.1182/blood-2012-04-423715. Epub 2012 May 18.

39.

The Scap/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglyceridemia in animals.

Moon YA, Liang G, Xie X, Frank-Kamenetsky M, Fitzgerald K, Koteliansky V, Brown MS, Goldstein JL, Horton JD.

Cell Metab. 2012 Feb 8;15(2):240-6. doi: 10.1016/j.cmet.2011.12.017.

40.

Origins of tumor-associated macrophages and neutrophils.

Cortez-Retamozo V, Etzrodt M, Newton A, Rauch PJ, Chudnovskiy A, Berger C, Ryan RJ, Iwamoto Y, Marinelli B, Gorbatov R, Forghani R, Novobrantseva TI, Koteliansky V, Figueiredo JL, Chen JW, Anderson DG, Nahrendorf M, Swirski FK, Weissleder R, Pittet MJ.

Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2491-6. doi: 10.1073/pnas.1113744109. Epub 2012 Jan 30.

41.

IRE1α activation protects mice against acetaminophen-induced hepatotoxicity.

Hur KY, So JS, Ruda V, Frank-Kamenetsky M, Fitzgerald K, Koteliansky V, Iwawaki T, Glimcher LH, Lee AH.

J Exp Med. 2012 Feb 13;209(2):307-18. doi: 10.1084/jem.20111298. Epub 2012 Jan 30.

42.

Therapeutic siRNA silencing in inflammatory monocytes in mice.

Leuschner F, Dutta P, Gorbatov R, Novobrantseva TI, Donahoe JS, Courties G, Lee KM, Kim JI, Markmann JF, Marinelli B, Panizzi P, Lee WW, Iwamoto Y, Milstein S, Epstein-Barash H, Cantley W, Wong J, Cortez-Retamozo V, Newton A, Love K, Libby P, Pittet MJ, Swirski FK, Koteliansky V, Langer R, Weissleder R, Anderson DG, Nahrendorf M.

Nat Biotechnol. 2011 Oct 9;29(11):1005-10. doi: 10.1038/nbt.1989.

43.

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter.

Baughman JM, Perocchi F, Girgis HS, Plovanich M, Belcher-Timme CA, Sancak Y, Bao XR, Strittmatter L, Goldberger O, Bogorad RL, Koteliansky V, Mootha VK.

Nature. 2011 Jun 19;476(7360):341-5. doi: 10.1038/nature10234.

44.

From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus.

Musunuru K, Strong A, Frank-Kamenetsky M, Lee NE, Ahfeldt T, Sachs KV, Li X, Li H, Kuperwasser N, Ruda VM, Pirruccello JP, Muchmore B, Prokunina-Olsson L, Hall JL, Schadt EE, Morales CR, Lund-Katz S, Phillips MC, Wong J, Cantley W, Racie T, Ejebe KG, Orho-Melander M, Melander O, Koteliansky V, Fitzgerald K, Krauss RM, Cowan CA, Kathiresan S, Rader DJ.

Nature. 2010 Aug 5;466(7307):714-9. doi: 10.1038/nature09266.

45.

Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms.

Akinc A, Querbes W, De S, Qin J, Frank-Kamenetsky M, Jayaprakash KN, Jayaraman M, Rajeev KG, Cantley WL, Dorkin JR, Butler JS, Qin L, Racie T, Sprague A, Fava E, Zeigerer A, Hope MJ, Zerial M, Sah DW, Fitzgerald K, Tracy MA, Manoharan M, Koteliansky V, Fougerolles Ad, Maier MA.

Mol Ther. 2010 Jul;18(7):1357-64. doi: 10.1038/mt.2010.85. Epub 2010 May 11.

46.

Lipid-like materials for low-dose, in vivo gene silencing.

Love KT, Mahon KP, Levins CG, Whitehead KA, Querbes W, Dorkin JR, Qin J, Cantley W, Qin LL, Racie T, Frank-Kamenetsky M, Yip KN, Alvarez R, Sah DW, de Fougerolles A, Fitzgerald K, Koteliansky V, Akinc A, Langer R, Anderson DG.

Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):1864-9. doi: 10.1073/pnas.0910603106. Epub 2010 Jan 11. Erratum in: Proc Natl Acad Sci U S A. 2010 May 25;107(21):9915.

47.

Development of lipidoid-siRNA formulations for systemic delivery to the liver.

Akinc A, Goldberg M, Qin J, Dorkin JR, Gamba-Vitalo C, Maier M, Jayaprakash KN, Jayaraman M, Rajeev KG, Manoharan M, Koteliansky V, Röhl I, Leshchiner ES, Langer R, Anderson DG.

Mol Ther. 2009 May;17(5):872-9. doi: 10.1038/mt.2009.36. Epub 2009 Mar 3.

48.

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts.

Thum T, Gross C, Fiedler J, Fischer T, Kissler S, Bussen M, Galuppo P, Just S, Rottbauer W, Frantz S, Castoldi M, Soutschek J, Koteliansky V, Rosenwald A, Basson MA, Licht JD, Pena JT, Rouhanifard SH, Muckenthaler MU, Tuschl T, Martin GR, Bauersachs J, Engelhardt S.

Nature. 2008 Dec 18;456(7224):980-4. doi: 10.1038/nature07511. Epub 2008 Nov 30.

PMID:
19043405
49.

Host scavenger receptor SR-BI plays a dual role in the establishment of malaria parasite liver infection.

Rodrigues CD, Hannus M, Prudêncio M, Martin C, Gonçalves LA, Portugal S, Epiphanio S, Akinc A, Hadwiger P, Jahn-Hofmann K, Röhl I, van Gemert GJ, Franetich JF, Luty AJ, Sauerwein R, Mazier D, Koteliansky V, Vornlocher HP, Echeverri CJ, Mota MM.

Cell Host Microbe. 2008 Sep 11;4(3):271-82. doi: 10.1016/j.chom.2008.07.012.

50.

Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates.

Frank-Kamenetsky M, Grefhorst A, Anderson NN, Racie TS, Bramlage B, Akinc A, Butler D, Charisse K, Dorkin R, Fan Y, Gamba-Vitalo C, Hadwiger P, Jayaraman M, John M, Jayaprakash KN, Maier M, Nechev L, Rajeev KG, Read T, Röhl I, Soutschek J, Tan P, Wong J, Wang G, Zimmermann T, de Fougerolles A, Vornlocher HP, Langer R, Anderson DG, Manoharan M, Koteliansky V, Horton JD, Fitzgerald K.

Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11915-20. doi: 10.1073/pnas.0805434105. Epub 2008 Aug 11.

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