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Items: 45

1.

Prediction of drug interaction between oral adsorbent AST-120 and concomitant drugs based on the in vitro dissolution and in vivo absorption behavior of the drugs.

Koya Y, Uchida S, Machi Y, Shobu Y, Namiki N, Kotegawa T.

Eur J Clin Pharmacol. 2016 Nov;72(11):1353-1361. Epub 2016 Aug 5.

2.

The Pharmacokinetic Exposure to Fexofenadine is Volume-Dependently Reduced in Healthy Subjects Following Oral Administration With Apple Juice.

Luo J, Imai H, Ohyama T, Hashimoto S, Hasunuma T, Inoue Y, Kotegawa T, Ohashi K, Uemura N.

Clin Transl Sci. 2016 Aug;9(4):201-6. doi: 10.1111/cts.12400. Epub 2016 May 19.

3.

[Early Postoperative Outcomes and Evaluation of Hemodynamics after Mitral Valve Replacement with Epic Mitral Bioprosthesis].

Kanda K, Kotegawa T, Kawatsu S, Takahashi G, Yoshioka I, Fujiwara H, Adachi O, Akiyama M, Kumagai K, Kawamoto S, Saiki Y.

Kyobu Geka. 2015 Nov;68(12):961-6. Japanese.

PMID:
26555907
4.

Determination of domperidone in human plasma using high performance liquid chromatography with fluorescence detection for clinical application.

Yoshizato T, Tsutsumi K, Kotegawa T, Imai H, Nakano S.

J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Jun 15;961:86-90. doi: 10.1016/j.jchromb.2014.05.004. Epub 2014 May 14.

PMID:
24869944
5.

The effect of experimentally induced sleep disturbance on the pharmacokinetics of lorazepam in healthy volunteers.

Kotegawa T, Tsutsumi K, Imai H, Ohashi K, Nakano S.

Int J Clin Pharmacol Ther. 2014 Jun;52(6):519-24. doi: 10.5414/CP202084.

PMID:
24755136
6.

[Determination of triazolam and midazolam in human plasma using gas chromatography with microelectron capture detection for clinical application].

Tsutsumi K, Iwao M, Kotegawa T, Imai H, Ohashi K, Nakano S.

Yakugaku Zasshi. 2014;134(1):119-25. Japanese.

7.

Determination of celiprolol in human plasma using high performance liquid chromatography with fluorescence detection for clinical application.

Itohda A, Tsutsumi K, Imai H, Iwao M, Kotegawa T, Ohashi K.

J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Sep 1;904:88-92. doi: 10.1016/j.jchromb.2012.07.026. Epub 2012 Jul 31.

PMID:
22889991
8.

Effect of renal impairment on the pharmacokinetics of memantine.

Moritoyo T, Hasunuma T, Harada K, Tateishi T, Watanabe M, Kotegawa T, Nagai M, Kumagai Y, Fujitani T, Okura T, Fukuoka T, Miyoshi K, Matsuura B, Furukawa S, Kobori T, Moritoyo H, Nishikawa N, Tsujii T, Iwaki H, Nakamura M, Makino S, Ohnuma K, Yuji K, Hashimoto M, Takasu M, Hashizume Y, You K, Matsumura T, Tanaka Y, Matsumoto N, Nakamura J, Miura J, Akizawa T, Kitazawa K, Shibata T, Kuroki A, Honda H, Mukai M, Ohashi K, Morimoto T, Imai H, Okudaira T, Sato F, Imanaga J, Tanaka K, Nomoto M.

J Pharmacol Sci. 2012;119(4):324-9. Epub 2012 Jul 21.

9.

Effects of dosing interval on the pharmacokinetic and pharmacodynamic interactions between the oral adsorbent AST-120 and triazolam in humans.

Kotegawa T, Tsutsumi K, Morita H, Imai H, Morita M, Yoshizato T, Ohyama T, Uchida S, Watanabe H, Namiki N, Ohashi K.

Eur J Clin Pharmacol. 2012 Dec;68(12):1605-10. doi: 10.1007/s00228-012-1301-y. Epub 2012 May 30.

PMID:
22644342
10.

Apple juice greatly reduces systemic exposure to atenolol.

Jeon H, Jang IJ, Lee S, Ohashi K, Kotegawa T, Ieiri I, Cho JY, Yoon SH, Shin SG, Yu KS, Lim KS.

Br J Clin Pharmacol. 2013 Jan;75(1):172-9. doi: 10.1111/j.1365-2125.2012.04324.x.

11.

Itraconazole and domperidone: a placebo-controlled drug interaction study.

Yoshizato T, Kotegawa T, Imai H, Tsutsumi K, Imanaga J, Ohyama T, Ohashi K.

Eur J Clin Pharmacol. 2012 Sep;68(9):1287-94. doi: 10.1007/s00228-012-1258-x. Epub 2012 Mar 15.

PMID:
22418831
12.

Duration of drug interactions: putative time courses after mechanism-based inhibition or induction of CYPs.

Imai H, Kotegawa T, Ohashi K.

Expert Rev Clin Pharmacol. 2011 Jul;4(4):409-11. doi: 10.1586/ecp.11.30. No abstract available.

PMID:
22114850
13.

The effects of the SLCO2B1 c.1457C > T polymorphism and apple juice on the pharmacokinetics of fexofenadine and midazolam in humans.

Imanaga J, Kotegawa T, Imai H, Tsutsumi K, Yoshizato T, Ohyama T, Shirasaka Y, Tamai I, Tateishi T, Ohashi K.

Pharmacogenet Genomics. 2011 Feb;21(2):84-93.

PMID:
21280267
14.

The recovery time-course of CYP3A after induction by St John's wort administration.

Imai H, Kotegawa T, Tsutsumi K, Morimoto T, Eshima N, Nakano S, Ohashi K.

Br J Clin Pharmacol. 2008 May;65(5):701-7. doi: 10.1111/j.1365-2125.2008.03120.x. Epub 2008 Feb 20.

15.

Effect of the treatment period with erythromycin on cytochrome P450 3A activity in humans.

Okudaira T, Kotegawa T, Imai H, Tsutsumi K, Nakano S, Ohashi K.

J Clin Pharmacol. 2007 Jul;47(7):871-6.

PMID:
17585116
16.

[Communication skills for pharmaceutical care].

Kotegawa T.

Yakugaku Zasshi. 2007 Feb;127(2):237-44. Review. Japanese.

17.

Effect of St. John's wort on the pharmacokinetics of theophylline in healthy volunteers.

Morimoto T, Kotegawa T, Tsutsumi K, Ohtani Y, Imai H, Nakano S.

J Clin Pharmacol. 2004 Jan;44(1):95-101.

PMID:
14681347
18.

The effect of itraconazole on the pharmacokinetics and pharmacodynamics of bromazepam in healthy volunteers.

Oda M, Kotegawa T, Tsutsumi K, Ohtani Y, Kuwatani K, Nakano S.

Eur J Clin Pharmacol. 2003 Nov;59(8-9):615-9. Epub 2003 Sep 27.

PMID:
14517708
19.

The effect of erythromycin and clarithromycin on the pharmacokinetics of intravenous digoxin in healthy volunteers.

Tsutsumi K, Kotegawa T, Kuranari M, Otani Y, Morimoto T, Matsuki S, Nakano S.

J Clin Pharmacol. 2002 Oct;42(10):1159-64.

PMID:
12362931
20.

In vitro, pharmacokinetic, and pharmacodynamic interactions of ketoconazole and midazolam in the rat.

Kotegawa T, Laurijssens BE, Von Moltke LL, Cotreau MM, Perloff MD, Venkatakrishnan K, Warrington JS, Granda BW, Harmatz JS, Greenblatt DJ.

J Pharmacol Exp Ther. 2002 Sep;302(3):1228-37.

PMID:
12183684
21.
22.

The effect of pregnancy on cytochrome P4501A2, xanthine oxidase, and N-acetyltransferase activities in humans.

Tsutsumi K, Kotegawa T, Matsuki S, Tanaka Y, Ishii Y, Kodama Y, Kuranari M, Miyakawa I, Nakano S.

Clin Pharmacol Ther. 2001 Aug;70(2):121-5.

PMID:
11503005
23.

Drug interaction between cimetidine and timolol ophthalmic solution: effect on heart rate and intraocular pressure in healthy Japanese volunteers.

Ishii Y, Nakamura K, Tsutsumi K, Kotegawa T, Nakano S, Nakatsuka K.

J Clin Pharmacol. 2000 Feb;40(2):193-9.

PMID:
10664926
24.

Midazolam and triazolam biotransformation in mouse and human liver microsomes: relative contribution of CYP3A and CYP2C isoforms.

Perloff MD, von Moltke LL, Court MH, Kotegawa T, Shader RI, Greenblatt DJ.

J Pharmacol Exp Ther. 2000 Feb;292(2):618-28.

PMID:
10640299
25.

Pharmacokinetic changes of theophylline and amikacin through the menstrual cycle in healthy women.

Matsuki S, Kotegawa T, Tsutsumi K, Nakamura K, Nakano S.

J Clin Pharmacol. 1999 Dec;39(12):1256-62.

PMID:
10586391
26.

Pharmacokinetics and electroencephalographic effects of ketoconazole in the rat.

Kotegawa T, Laurijssens BE, Durol AL, Greenblatt DJ.

Biopharm Drug Dispos. 1999 Jan;20(1):49-52.

PMID:
10086837
27.

Influences of urinary pH on ciprofloxacin pharmacokinetics in humans and antimicrobial activity in vitro versus those of sparfloxacin.

Kamberi M, Tsutsumi K, Kotegawa T, Kawano K, Nakamura K, Niki Y, Nakano S.

Antimicrob Agents Chemother. 1999 Mar;43(3):525-9.

28.

Sparfloxacin pharmacokinetics in healthy volunteers: the influence of acidification and alkalinization.

Kamberi M, Kotegawa T, Tsutsumi K, Nakamura K, Nakano S.

Eur J Clin Pharmacol. 1998 Oct;54(8):633-7.

PMID:
9860151
29.

Interaction between timolol eyedrops and oral nicardipine or oral diltiazem in healthy Japanese subjects.

Yatsuka YI, Tsutsumi K, Kotegawa T, Nakamura K, Nakano S, Nakatsuka K.

Eur J Clin Pharmacol. 1998 Apr;54(2):149-54.

PMID:
9626919
30.

Determination of ciprofloxacin in plasma and urine by HPLC with ultraviolet detection.

Kamberi M, Tsutsumi K, Kotegawa T, Nakamura K, Nakano S.

Clin Chem. 1998 Jun;44(6 Pt 1):1251-5.

31.

Short-term effects of nicardipine and propranolol on ocular and systemic hemodynamics in healthy Japanese subjects.

Yatsuka YI, Matsukubo S, Tsutsumi K, Kotegawa T, Nakamura K, Nakano S, Nakatsuka K.

J Clin Pharmacol. 1998 Jan;38(1):68-73.

PMID:
9597562
32.
33.

Temporal variation in the effects of ophthalmic timolol on cardiovascular and respiratory functions in healthy men.

Umetsuki MH, Kotegawa T, Nakamura K, Nakano S, Nakatsuka K.

J Clin Pharmacol. 1997 Jan;37(1):58-63.

PMID:
9048274
34.

Pharmacokinetics of a new thromboxane A2 receptor antagonist, S-1452, and its effect on platelet aggregation in healthy volunteers.

Fujimura A, Shiga T, Kumagai Y, Ohashi K, Ebihara A, Kotegawa T.

J Clin Pharmacol. 1996 May;36(5):409-13.

PMID:
8739019
35.

Effect of food intake on pharmacokinetics and effects of a new thromboxane A2 receptor antagonist, S-1452.

Fujimura A, Shiga T, Kumagai Y, Ohashi K, Ebihara A, Kotegawa T.

Eur J Clin Pharmacol. 1996;50(4):311-4.

PMID:
8803525
36.

Ophthalmic artery flow velocity after physical exercise in healthy men.

Yatsuka Y, Matsukubo S, Tsutsumi K, Kotegawa T, Nakamura K, Nakano S.

Jpn J Ophthalmol. 1996;40(1):103-10.

PMID:
8739507
37.

Effects of opioid peptides on the electrical activity of preoptic and hypothalamic neurons in the quail brain.

Furukawa Y, Kotegawa T, Tsutsui K.

J Exp Zool. 1995 Oct 1;273(2):96-103.

PMID:
7595282
38.

Isolation and characterization of opioid peptides in the avian brain.

Kotegawa T, Takahashi T, Tsutsui K, Ikeda T, Minakata H, Nomoto K.

J Exp Zool. 1995 Oct 1;273(2):87-95.

PMID:
7595281
39.

[The variability of blood velocity in the ophthalmic artery with color Doppler imaging].

Yatsuka Y, Matsukubo S, Tsutsumi K, Kotegawa T, Nakamura K, Nakano S, Furushima M, Matsuo K, Nakatsuka K, Yoshimatu S, et al.

Nippon Ganka Gakkai Zasshi. 1995 Jul;99(7):849-54. Japanese.

PMID:
7661050
40.

Comparison of the pharmacokinetics, pharmacodynamics, and safety of oral (Catapres) and transdermal (M-5041T) clonidine in healthy subjects.

Fujimura A, Ebihara A, Ohashi K, Shiga T, Kumagai Y, Nakashima H, Kotegawa T.

J Clin Pharmacol. 1994 Mar;34(3):260-5.

PMID:
8021335
41.

Pharmacokinetics and pharmacodynamics of a new transdermal clonidine, M-5041T, in healthy subjects.

Fujimura A, Ebihara A, Shiga T, Kumagai Y, Ohashi K, Nakashima H, Kotegawa T.

J Clin Pharmacol. 1993 Dec;33(12):1192-200.

PMID:
8126254
42.

Influence of application site of a new transdermal clonidine, M-5041T, on its pharmacokinetics and pharmacodynamics in healthy subjects.

Ebihara A, Fujimura A, Ohashi K, Shiga T, Kumagai Y, Nakashima H, Kotegawa T.

J Clin Pharmacol. 1993 Dec;33(12):1188-91.

PMID:
8126253
43.

Influence of food on the absorption of beta-methyldigoxin.

Tsutsumi K, Nakashima H, Kotegawa T, Nakano S.

J Clin Pharmacol. 1992 Feb;32(2):157-62.

PMID:
1613126
45.

Influence of indomethacin on a reduction in forearm blood flow induced by propranolol in healthy subjects.

Sugimoto K, Fujimura A, Kumagai Y, Kotegawa T, Ebihara A.

J Clin Pharmacol. 1989 Apr;29(4):307-10.

PMID:
2656774

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