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Hypocalcemia-Induced Slowing of Human Sinus Node Pacemaking.

Loewe A, Lutz Y, Nairn D, Fabbri A, Nagy N, Toth N, Ye X, Fuertinger DH, Genovesi S, Kotanko P, Raimann JG, Severi S.

Biophys J. 2019 Jul 30. pii: S0006-3495(19)30626-5. doi: 10.1016/j.bpj.2019.07.037. [Epub ahead of print]


A Multi-Compartment Model Capturing the Pharmacokinetics of the Calcimimetic Cinacalcet.

Schappacher-Tilp G, Fuertinger DH, Kotanko P.

Cell Physiol Biochem. 2019;53(2):429-438. doi: 10.33594/000000148.


Association of Extreme Heat Events With Hospital Admission or Mortality Among Patients With End-Stage Renal Disease.

Remigio RV, Jiang C, Raimann J, Kotanko P, Usvyat L, Maddux FW, Kinney P, Sapkota A.

JAMA Netw Open. 2019 Aug 2;2(8):e198904. doi: 10.1001/jamanetworkopen.2019.8904.


The effect of increased frequency of hemodialysis on vitamin C concentrations: an ancillary study of the randomized Frequent Hemodialysis Network (FHN) daily trial.

Raimann JG, Abbas SR, Liu L, Larive B, Beck G, Kotanko P, Levin NW, Handelman G; FHN Trial.

BMC Nephrol. 2019 May 17;20(1):179. doi: 10.1186/s12882-019-1311-4.


A mathematical model of parathyroid gland biology.

Schappacher-Tilp G, Cherif A, Fuertinger DH, Bushinsky D, Kotanko P.

Physiol Rep. 2019 Apr;7(7):e14045. doi: 10.14814/phy2.14045.


The promise of bioimpedance for volume management in American dialysis patients: An unfulfilled opportunity.

Kotanko P.

Semin Dial. 2019 May;32(3):223-224. doi: 10.1111/sdi.12790. Epub 2019 Mar 29.


Prediction of Mortality and Hospitalization Risk Using Nutritional Indicators and Their Changes Over Time in a Large Prevalent Hemodialysis Cohort.

Wong MMY, Thijssen S, Wang Y, Usvyat LA, Xiao Q, Kotanko P, Maddux FW.

J Ren Nutr. 2019 Mar 6. pii: S1051-2276(19)30031-7. doi: 10.1053/j.jrn.2019.01.013. [Epub ahead of print]


Removal of Protein-Bound Uremic Toxins during Hemodialysis Using a Binding Competitor.

Madero M, Cano KB, Campos I, Tao X, Maheshwari V, Brown J, Cornejo B, Handelman G, Thijssen S, Kotanko P.

Clin J Am Soc Nephrol. 2019 Mar 7;14(3):394-402. doi: 10.2215/CJN.05240418. Epub 2019 Feb 12.


In silico comparison of protein-bound uremic toxin removal by hemodialysis, hemodiafiltration, membrane adsorption, and binding competition.

Maheshwari V, Thijssen S, Tao X, Fuertinger DH, Kappel F, Kotanko P.

Sci Rep. 2019 Jan 29;9(1):909. doi: 10.1038/s41598-018-37195-1.


Sodium and water handling during hemodialysis: new pathophysiologic insights and management approaches for improving outcomes in end-stage kidney disease.

Canaud B, Kooman J, Selby NM, Taal M, Francis S, Kopperschmidt P, Maierhofer A, Kotanko P, Titze J.

Kidney Int. 2019 Feb;95(2):296-309. doi: 10.1016/j.kint.2018.09.024. Review.


Preface - Advances in CKD 2019.

Kotanko P, Rosales LM, Ronco C.

Blood Purif. 2019;47(1-3):197-198. doi: 10.1159/000495158. Epub 2019 Jan 9. No abstract available.


Diagnostic performance of salivary urea nitrogen dipstick to detect and monitor acute kidney disease in patients with malaria.

Calice-Silva V, Sacomboio E, Raimann JG, Evans R, Dos Santos Sebastião C, Tchivango AT, Kotanko P, Levin N, Pecoits-Filho R.

Malar J. 2018 Dec 18;17(1):477. doi: 10.1186/s12936-018-2627-4.


Increased Mortality Associated with Higher Pre-Dialysis Serum Sodium Variability: Results of the International MONitoring Dialysis Outcome Initiative.

Ye X, Kooman JP, van der Sande FM, Canaud B, Stuard S, Etter M, Xu X, Marelli C, Guinsburg A, Power A, Usvyat LA, Wang Y, Kotanko P, Raimann JG; for the MONDO Initiative.

Am J Nephrol. 2019;49(1):1-10. doi: 10.1159/000495354. Epub 2018 Dec 13.


Tracking Arteriovenous Fistula Maturation: A Novel Approach.

Rosales LM, Zhang H, Mateo M, Chan B, Campos I, Harbord N, Thijssen S, Kotanko P.

Blood Purif. 2019;47(1-3):240-245. doi: 10.1159/000494742. Epub 2018 Dec 6.


Association of Central Venous Oxygen Saturation Variability and Mortality in Hemodialysis Patients.

Zhang H, Campos I, Chan L, Meyring-Wösten A, Tapia Silva LM, Rivera Fuentes L, Preciado P, Thijssen S, Kooman JP, van der Sande FM, Kotanko P.

Blood Purif. 2019;47(1-3):246-253. doi: 10.1159/000494630. Epub 2018 Dec 6.


Dialysate Calcium Levels: Do They Matter?

van der Sande FM, Ter Meulen KJA, Kotanko P, Kooman JP.

Blood Purif. 2019;47(1-3):230-235. doi: 10.1159/000494584. Epub 2018 Dec 5. Review.


Cycles, Arrows and Turbulence: Time Patterns in Renal Disease, a Path from Epidemiology to Personalized Medicine?

Kooman JP, Usvyat LA, Dekker MJE, Maddux DW, Raimann JG, van der Sande FM, Ye X, Wang Y, Kotanko P.

Blood Purif. 2019;47(1-3):171-184. doi: 10.1159/000494827. Epub 2018 Nov 16. Review.


A Cross-Sectional Study of Growth and Metabolic Bone Disease in a Pediatric Global Cohort Undergoing Chronic Hemodialysis.

Hussein R, Alvarez-Elías AC, Topping A, Raimann JG, Filler G, Yousif D, Kotanko P, Usvyat LA, Medeiros M, Pecoits-Filho R, Canaud B, Stuard S, Xiaoqi X, Etter M, Díaz-González de Ferris ME; MONDO Consortium.

J Pediatr. 2018 Nov;202:171-178.e3. doi: 10.1016/j.jpeds.2018.07.033. Epub 2018 Sep 26.



Maddux DW, Usvyat LA, Blanchard T, Jiao Y, Kotanko P, van der Sande FM, Kooman JP, Maddux FW.

Perit Dial Int. 2018 Sep 25. pii: pdi.2017.00252. doi: 10.3747/pdi.2017.00252. [Epub ahead of print]


All-cause mortality in relation to changes in relative blood volume during hemodialysis.

Preciado P, Zhang H, Thijssen S, Kooman JP, van der Sande FM, Kotanko P.

Nephrol Dial Transplant. 2018 Sep 18. doi: 10.1093/ndt/gfy286. [Epub ahead of print]


Interactions Between Malnutrition, Inflammation, and Fluid Overload and Their Associations With Survival in Prevalent Hemodialysis Patients.

Dekker MJE, Konings C, Canaud B, van der Sande FM, Stuard S, Raimann JG, Öztürk E, Usvyat L, Kotanko P, Kooman JP.

J Ren Nutr. 2018 Nov;28(6):435-444. doi: 10.1053/j.jrn.2018.06.005. Epub 2018 Aug 23.


Reliability and agreement of sodium (23Na) MRI in calf muscle and skin of healthy subjects from the US.

Dyke JP, Meyring-Wösten A, Zhao Y, Linz P, Thijssen S, Kotanko P.

Clin Imaging. 2018 Nov - Dec;52:100-105. doi: 10.1016/j.clinimag.2018.07.010. Epub 2018 Jul 20.


Indoxyl Sulfate, a Uremic Toxin, Stimulates Reactive Oxygen Species Production and Erythrocyte Cell Death Supposedly by an Organic Anion Transporter 2 (OAT2) and NADPH Oxidase Activity-Dependent Pathways.

Dias GF, Bonan NB, Steiner TM, Tozoni SS, Rodrigues S, Nakao LS, Kuntsevich V, Pecoits Filho R, Kotanko P, Moreno-Amaral AN.

Toxins (Basel). 2018 Jul 5;10(7). pii: E280. doi: 10.3390/toxins10070280.


A model of vascular refilling with inflammation.

Paguio VME, Kappel F, Kotanko P.

Math Biosci. 2018 Sep;303:101-114. doi: 10.1016/j.mbs.2018.06.007. Epub 2018 Jun 27.


Lipid levels are inversely associated with infectious and all-cause mortality: international MONDO study results.

Kaysen GA, Ye X, Raimann JG, Wang Y, Topping A, Usvyat LA, Stuard S, Canaud B, van der Sande FM, Kooman JP, Kotanko P; Monitoring Dialysis Outcomes (MONDO) Initiative.

J Lipid Res. 2018 Aug;59(8):1519-1528. doi: 10.1194/jlr.P084277. Epub 2018 Jun 12.


Pre-dialysis fluid status, pre-dialysis systolic blood pressure and outcome in prevalent haemodialysis patients: results of an international cohort study on behalf of the MONDO initiative.

Dekker M, Konings C, Canaud B, Carioni P, Guinsburg A, Madero M, van der Net J, Raimann J, van der Sande F, Stuard S, Usvyat L, Wang Y, Xu X, Kotanko P, Kooman J.

Nephrol Dial Transplant. 2018 Nov 1;33(11):2027-2034. doi: 10.1093/ndt/gfy095.


Hemodialysis: A model for extreme physiology in a vulnerable patient population.

Kooman JP, Katzarski K, van der Sande FM, Leunissen KM, Kotanko P.

Semin Dial. 2018 Sep;31(5):500-506. doi: 10.1111/sdi.12704. Epub 2018 Apr 19. Review.


Prediction of hemoglobin levels in individual hemodialysis patients by means of a mathematical model of erythropoiesis.

Fuertinger DH, Kappel F, Zhang H, Thijssen S, Kotanko P.

PLoS One. 2018 Apr 18;13(4):e0195918. doi: 10.1371/journal.pone.0195918. eCollection 2018.


Effects of dialysate to serum sodium (Na+) alignment in chronic hemodialysis (HD) patients: retrospective cohort study from a quality improvement project.

Raimann JG, Ficociello LH, Usvyat LA, Zhang H, Pacelli L, Moore S, Sheppard P, Xiao Q, Wang Y, Mullon C, Balter P, Sullivan T, Kotanko P.

BMC Nephrol. 2018 Apr 2;19(1):75. doi: 10.1186/s12882-018-0870-0.


Acute Kidney Injury in Sub-Sahara Africa: A Single-Center Experience from Khartoum, Sudan.

Yousif DE, Topping AR, Osman MF, Raimann JG, Osman EM, Kotanko P, Abboud OI.

Blood Purif. 2018;45(1-3):201-207. doi: 10.1159/000485214. Epub 2018 Jan 26.


Association between Heights of Dialysis Patients and Outcomes: Results from a Retrospective Cohort Study of the International MONitoring Dialysis Outcomes (MONDO) Database Initiative.

Patel S, Topping A, Ye X, Zhang H, Canaud B, Carioni P, Marelli C, Guinsburg A, Power A, Duncan N, Kooman J, van der Sande F, Usvyat LA, Wang Y, Xu X, Kotanko P, Raimann JG; the MONDO Initiative.

Blood Purif. 2018;45(1-3):245-253. doi: 10.1159/000485162. Epub 2018 Jan 26.


Relationships between Neighborhood Walkability and Objectively Measured Physical Activity Levels in Hemodialysis Patients.

Han M, Ye X, Preciado P, Williams S, Campos I, Bonner M, Young C, Marsh D, Larkin JW, Usvyat LA, Maddux FW, Pecoits-Filho R, Kotanko P.

Blood Purif. 2018;45(1-3):236-244. doi: 10.1159/000485161. Epub 2018 Jan 26.


The Association of Weekly pre-Hemodialysis Systolic Blood Pressure and Following Week Mortality.

Maddux D, Usvyat LA, Xu D, Wang Y, Kotanko P, van der Sande FM, Kooman JP, Maddux FW.

Kidney Blood Press Res. 2018;43(1):88-97. doi: 10.1159/000487105. Epub 2018 Jan 31.


The Virtual Anemia Trial: An Assessment of Model-Based In Silico Clinical Trials of Anemia Treatment Algorithms in Patients With Hemodialysis.

Fuertinger DH, Topping A, Kappel F, Thijssen S, Kotanko P.

CPT Pharmacometrics Syst Pharmacol. 2018 Apr;7(4):219-227. doi: 10.1002/psp4.12276. Epub 2018 Jan 31.


Intradialytic hypertension is associated with low intradialytic arterial oxygen saturation.

Meyring-Wösten A, Luo Y, Zhang H, Preciado P, Thijssen S, Wang Y, Kotanko P.

Nephrol Dial Transplant. 2018 Jun 1;33(6):1040-1045. doi: 10.1093/ndt/gfx309.


Effect of Change in Fluid Status Evaluated by Bioimpedance Techniques on Body Composition in Hemodialysis Patients.

Abbas SR, Thijssen S, Penne EL, Raimann JG, Liu L, Sipahioglu MH, Seibert E, Wang Y, Chen Y, Xiao Q, Levin NW, Kotanko P, Zhu F.

J Ren Nutr. 2018 May;28(3):183-190. doi: 10.1053/j.jrn.2017.09.002. Epub 2017 Nov 20.


Clinical parameters before and after the transition to dialysis.

Maddux DW, Usvyat LA, Ketchersid T, Jiao Y, Blanchard TC, Kotanko P, van der Sande FM, Kooman JP, Maddux FW.

Hemodial Int. 2018 Apr;22(2):235-244. doi: 10.1111/hdi.12603. Epub 2017 Nov 17. Erratum in: Hemodial Int. 2018 Oct;22(4):534.


Diagnostic Performance of a Saliva Urea Nitrogen Dipstick to Detect Kidney Disease in Malawi.

Evans R, Calice-Silva V, Raimann JG, Hemmila U, Craik A, Mtekateka M, Hamilton F, Kawale Z, Dobbie H, Dreyer G, Levin N, Kotanko P, Pecoits-Filho R; International Society of Nephrology (ISN) 0by25 Initiative.

Kidney Int Rep. 2016 Dec 31;2(2):219-227. doi: 10.1016/j.ekir.2016.12.006. eCollection 2017 Mar.


Performance of the Surprise Question Compared to Prediction Models in Hemodialysis Patients: A Prospective Study.

Malhotra R, Tao X, Wang Y, Chen Y, Apruzzese RH, Balter P, Xiao Q, Usvyat LA, Kotanko P, Thijssen S.

Am J Nephrol. 2017;46(5):390-396. doi: 10.1159/000481920. Epub 2017 Nov 7.


An in silico method to predict net calcium transfer during hemodialysis.

Maheshwari V, Cherif A, Fuertinger D, Schappacher-Tilp G, Preciado P, Thijssen S, Bushinsky DA, Kotanko P.

Conf Proc IEEE Eng Med Biol Soc. 2017 Jul;2017:2740-2743. doi: 10.1109/EMBC.2017.8037424.


Estimation of peripheral blood volume and interstitial volume in hemodialysis patients using bioimpedance techniques.

Fansan Zhu, Kotanko P, Levin NW.

Conf Proc IEEE Eng Med Biol Soc. 2017 Jul;2017:1389-1392. doi: 10.1109/EMBC.2017.8037092.


Meta-analysis and commentary: Preemptive correction of arteriovenous access stenosis.

Raimann JG, Waldron L, Koh E, Miller GA, Sor MH, Gray RJ, Kotanko P.

Hemodial Int. 2018 Apr;22(2):279-280. doi: 10.1111/hdi.12614. Epub 2017 Oct 3. No abstract available.


Dynamics of Nutritional Competence in the Last Year Before Death in a Large Cohort of US Hemodialysis Patients.

Ye X, Dekker MJE, Maddux FW, Kotanko P, Konings CJAM, Raimann JG, van der Sande FM, Usvyat LA, Kooman JP, Thijssen S.

J Ren Nutr. 2017 Nov;27(6):412-420. doi: 10.1053/j.jrn.2017.06.006. Epub 2017 Sep 21.


Association between intradialytic central venous oxygen saturation and ultrafiltration volume in chronic hemodialysis patients.

Zhang H, Chan L, Meyring-Wösten A, Campos I, Preciado P, Kooman JP, van der Sande FM, Fuertinger D, Thijssen S, Kotanko P.

Nephrol Dial Transplant. 2018 Sep 1;33(9):1636-1642. doi: 10.1093/ndt/gfx271.


A novel mathematical model of protein-bound uremic toxin kinetics during hemodialysis.

Maheshwari V, Thijssen S, Tao X, Fuertinger D, Kappel F, Kotanko P.

Sci Rep. 2017 Sep 4;7(1):10371. doi: 10.1038/s41598-017-10981-z.


Intradialytic Central Venous Oxygen Saturation is Associated with Clinical Outcomes in Hemodialysis Patients.

Chan L, Zhang H, Meyring-Wösten A, Campos I, Fuertinger D, Thijssen S, Kotanko P.

Sci Rep. 2017 Aug 17;7(1):8581. doi: 10.1038/s41598-017-09233-x.


Impact of the Karnofsky Performance Status on Survival and its Dynamics During the Terminal Year of Peritoneal Dialysis Patients.

Modesto AP, Usvyat L, Calice-Silva V, Spigolon DN, Figueiredo AE, de Moraes TP, Olandoski M, Shimakura SE, Barreti P, Kotanko P, Pecoits-Filho R.

Perit Dial Int. 2018 Jan-Feb;38(1):24-29. doi: 10.3747/pdi.2015.00241. Epub 2017 Aug 1.


The impact of dialysis modality and membrane characteristics on intradialytic hypotension.

Patel S, Raimann JG, Kotanko P.

Semin Dial. 2017 Nov;30(6):518-531. doi: 10.1111/sdi.12636. Epub 2017 Jul 13. Review.


Inflammation and premature aging in advanced chronic kidney disease.

Kooman JP, Dekker MJ, Usvyat LA, Kotanko P, van der Sande FM, Schalkwijk CG, Shiels PG, Stenvinkel P.

Am J Physiol Renal Physiol. 2017 Oct 1;313(4):F938-F950. doi: 10.1152/ajprenal.00256.2017. Epub 2017 Jul 12. Review.


To cool, or too cool: Is reducing dialysate temperature the optimal approach to preventing intradialytic hypotension?

Larkin JW, Reviriego-Mendoza MM, Usvyat LA, Kotanko P, Maddux FW.

Semin Dial. 2017 Nov;30(6):501-508. doi: 10.1111/sdi.12628. Epub 2017 Jun 30.


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