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Nuclear herpesvirus capsid motility is not dependent on F-actin.

Bosse JB, Virding S, Thiberge SY, Scherer J, Wodrich H, Ruzsics Z, Koszinowski UH, Enquist LW.

mBio. 2014 Oct 7;5(5):e01909-14. doi: 10.1128/mBio.01909-14.


A novel murine cytomegalovirus vaccine vector protects against Mycobacterium tuberculosis.

Beverley PC, Ruzsics Z, Hey A, Hutchings C, Boos S, Bolinger B, Marchi E, O'Hara G, Klenerman P, Koszinowski UH, Tchilian EZ.

J Immunol. 2014 Sep 1;193(5):2306-16. doi: 10.4049/jimmunol.1302523. Epub 2014 Jul 28.


A modified screening system for loss-of-function and dominant negative alleles of essential MCMV genes.

Pogoda M, Bosse JB, Conzelmann KK, Koszinowski UH, Ruzsics Z.

PLoS One. 2014 Apr 14;9(4):e94918. doi: 10.1371/journal.pone.0094918. eCollection 2014.


Metabolic labeling of newly transcribed RNA for high resolution gene expression profiling of RNA synthesis, processing and decay in cell culture.

Rädle B, Rutkowski AJ, Ruzsics Z, Friedel CC, Koszinowski UH, Dölken L.

J Vis Exp. 2013 Aug 8;(78). doi: 10.3791/50195.


The viral chemokine MCK-2 of murine cytomegalovirus promotes infection as part of a gH/gL/MCK-2 complex.

Wagner FM, Brizic I, Prager A, Trsan T, Arapovic M, Lemmermann NA, Podlech J, Reddehase MJ, Lemnitzer F, Bosse JB, Gimpfl M, Marcinowski L, MacDonald M, Adler H, Koszinowski UH, Adler B.

PLoS Pathog. 2013;9(7):e1003493. doi: 10.1371/journal.ppat.1003493. Epub 2013 Jul 25.


Natural killer cells are required for extramedullary hematopoiesis following murine cytomegalovirus infection.

Jordan S, Ruzsics Z, Mitrović M, Baranek T, Arapović J, Krmpotić A, Vivier E, Dalod M, Jonjić S, Dölken L, Koszinowski UH.

Cell Host Microbe. 2013 May 15;13(5):535-545. doi: 10.1016/j.chom.2013.04.007.


Systemic and local infection routes govern different cellular dissemination pathways during gammaherpesvirus infection in vivo.

Vidy A, Sacher T, Adler H, Jordan S, Koszinowski UH, Ruzsics Z.

J Virol. 2013 Apr;87(8):4596-608. doi: 10.1128/JVI.03135-12. Epub 2013 Feb 13.


Characterization of conserved region 2-deficient mutants of the cytomegalovirus egress protein pM53.

Pogoda M, Bosse JB, Wagner FM, Schauflinger M, Walther P, Koszinowski UH, Ruzsics Z.

J Virol. 2012 Dec;86(23):12512-24. doi: 10.1128/JVI.00471-12. Epub 2012 Sep 19.


The polyomaviruses WUPyV and KIPyV: a retrospective quantitative analysis in patients undergoing hematopoietic stem cell transplantation.

Motamedi N, Mairhofer H, Nitschko H, Jäger G, Koszinowski UH.

Virol J. 2012 Sep 18;9:209. doi: 10.1186/1743-422X-9-209.


Protection from inflammatory organ damage in a murine model of hemophagocytic lymphohistiocytosis using treatment with IL-18 binding protein.

Chiossone L, Audonnet S, Chetaille B, Chasson L, Farnarier C, Berda-Haddad Y, Jordan S, Koszinowski UH, Dalod M, Mazodier K, Novick D, Dinarello CA, Vivier E, Kaplanski G.

Front Immunol. 2012 Aug 8;3:239. doi: 10.3389/fimmu.2012.00239. eCollection 2012.


A beta-herpesvirus with fluorescent capsids to study transport in living cells.

Bosse JB, Bauerfeind R, Popilka L, Marcinowski L, Taeglich M, Jung C, Striebinger H, von Einem J, Gaul U, Walther P, Koszinowski UH, Ruzsics Z.

PLoS One. 2012;7(7):e40585. doi: 10.1371/journal.pone.0040585. Epub 2012 Jul 11.


Cytomegalovirus replicon-based regulation of gene expression in vitro and in vivo.

Mohr H, Mohr CA, Schneider MR, Scrivano L, Adler B, Kraner-Schreiber S, Schnieke A, Dahlhoff M, Wolf E, Koszinowski UH, Ruzsics Z.

PLoS Pathog. 2012;8(6):e1002728. doi: 10.1371/journal.ppat.1002728. Epub 2012 Jun 7.


A cell free protein fragment complementation assay for monitoring the core interaction of the human cytomegalovirus nuclear egress complex.

Schnee M, Wagner FM, Koszinowski UH, Ruzsics Z.

Antiviral Res. 2012 Jul;95(1):12-8. doi: 10.1016/j.antiviral.2012.04.009. Epub 2012 May 9.


Degradation of cellular mir-27 by a novel, highly abundant viral transcript is important for efficient virus replication in vivo.

Marcinowski L, Tanguy M, Krmpotic A, Rädle B, Lisnić VJ, Tuddenham L, Chane-Woon-Ming B, Ruzsics Z, Erhard F, Benkartek C, Babic M, Zimmer R, Trgovcich J, Koszinowski UH, Jonjic S, Pfeffer S, Dölken L.

PLoS Pathog. 2012 Feb;8(2):e1002510. doi: 10.1371/journal.ppat.1002510. Epub 2012 Feb 9.


Shedding light on the elusive role of endothelial cells in cytomegalovirus dissemination.

Sacher T, Andrassy J, Kalnins A, Dölken L, Jordan S, Podlech J, Ruzsics Z, Jauch KW, Reddehase MJ, Koszinowski UH.

PLoS Pathog. 2011 Nov;7(11):e1002366. doi: 10.1371/journal.ppat.1002366. Epub 2011 Nov 17.


Virus progeny of murine cytomegalovirus bacterial artificial chromosome pSM3fr show reduced growth in salivary Glands due to a fixed mutation of MCK-2.

Jordan S, Krause J, Prager A, Mitrovic M, Jonjic S, Koszinowski UH, Adler B.

J Virol. 2011 Oct;85(19):10346-53. doi: 10.1128/JVI.00545-11. Epub 2011 Aug 3.


M94 is essential for the secondary envelopment of murine cytomegalovirus.

Maninger S, Bosse JB, Lemnitzer F, Pogoda M, Mohr CA, von Einem J, Walther P, Koszinowski UH, Ruzsics Z.

J Virol. 2011 Sep;85(18):9254-67. doi: 10.1128/JVI.00443-11. Epub 2011 Jun 29.


The role of cell types in cytomegalovirus infection in vivo.

Sacher T, Mohr CA, Weyn A, Schlichting C, Koszinowski UH, Ruzsics Z.

Eur J Cell Biol. 2012 Jan;91(1):70-7. doi: 10.1016/j.ejcb.2011.02.002. Epub 2011 Apr 13. Review.


HCMV spread and cell tropism are determined by distinct virus populations.

Scrivano L, Sinzger C, Nitschko H, Koszinowski UH, Adler B.

PLoS Pathog. 2011 Jan 13;7(1):e1001256. doi: 10.1371/journal.ppat.1001256.


Human cytomegalovirus disrupts the major histocompatibility complex class I peptide-loading complex and inhibits tapasin gene transcription.

Halenius A, Hauka S, Dölken L, Stindt J, Reinhard H, Wiek C, Hanenberg H, Koszinowski UH, Momburg F, Hengel H.

J Virol. 2011 Apr;85(7):3473-85. doi: 10.1128/JVI.01923-10. Epub 2011 Jan 19.


Cytomegalovirus microRNAs facilitate persistent virus infection in salivary glands.

Dölken L, Krmpotic A, Kothe S, Tuddenham L, Tanguy M, Marcinowski L, Ruzsics Z, Elefant N, Altuvia Y, Margalit H, Koszinowski UH, Jonjic S, Pfeffer S.

PLoS Pathog. 2010 Oct 14;6(10):e1001150. doi: 10.1371/journal.ppat.1001150.


Dominant negative mutants of the murine cytomegalovirus M53 gene block nuclear egress and inhibit capsid maturation.

Popa M, Ruzsics Z, Lötzerich M, Dölken L, Buser C, Walther P, Koszinowski UH.

J Virol. 2010 Sep;84(18):9035-46. doi: 10.1128/JVI.00681-10. Epub 2010 Jul 7.


Intact NKG2D-independent function of NK cells chronically stimulated with the NKG2D ligand Rae-1.

Champsaur M, Beilke JN, Ogasawara K, Koszinowski UH, Jonjic S, Lanier LL.

J Immunol. 2010 Jul 1;185(1):157-65. doi: 10.4049/jimmunol.1000397. Epub 2010 Jun 7.


Systematic analysis of viral and cellular microRNA targets in cells latently infected with human gamma-herpesviruses by RISC immunoprecipitation assay.

Dölken L, Malterer G, Erhard F, Kothe S, Friedel CC, Suffert G, Marcinowski L, Motsch N, Barth S, Beitzinger M, Lieber D, Bailer SM, Hoffmann R, Ruzsics Z, Kremmer E, Pfeffer S, Zimmer R, Koszinowski UH, Grässer F, Meister G, Haas J.

Cell Host Microbe. 2010 Apr 22;7(4):324-34. doi: 10.1016/j.chom.2010.03.008.


Virology. A vaccine monkey wrench?

Hengel H, Koszinowski UH.

Science. 2010 Apr 2;328(5974):51-2. doi: 10.1126/science.1188578. No abstract available.


Dominant-negative proteins in herpesviruses - from assigning gene function to intracellular immunization.

Mühlbach H, Mohr CA, Ruzsics Z, Koszinowski UH.

Viruses. 2009 Dec;1(3):420-40. doi: 10.3390/v1030420. Epub 2009 Oct 19.


Conserved principles of mammalian transcriptional regulation revealed by RNA half-life.

Friedel CC, Dölken L, Ruzsics Z, Koszinowski UH, Zimmer R.

Nucleic Acids Res. 2009 Sep;37(17):e115. doi: 10.1093/nar/gkp542. Epub 2009 Jun 26.


Differential susceptibility of RAE-1 isoforms to mouse cytomegalovirus.

Arapovic J, Lenac T, Antulov R, Polic B, Ruzsics Z, Carayannopoulos LN, Koszinowski UH, Krmpotic A, Jonjic S.

J Virol. 2009 Aug;83(16):8198-207. doi: 10.1128/JVI.02549-08. Epub 2009 Jun 3.


Cytomegalovirus microRNAs.

Dölken L, Pfeffer S, Koszinowski UH.

Virus Genes. 2009 Jun;38(3):355-64. doi: 10.1007/s11262-009-0347-0. Epub 2009 Mar 17. Review.


Ly49P recognition of cytomegalovirus-infected cells expressing H2-Dk and CMV-encoded m04 correlates with the NK cell antiviral response.

Kielczewska A, Pyzik M, Sun T, Krmpotic A, Lodoen MB, Munks MW, Babic M, Hill AB, Koszinowski UH, Jonjic S, Lanier LL, Vidal SM.

J Exp Med. 2009 Mar 16;206(3):515-23. doi: 10.1084/jem.20080954. Epub 2009 Mar 2.


High-resolution gene expression profiling for simultaneous kinetic parameter analysis of RNA synthesis and decay.

Dölken L, Ruzsics Z, Rädle B, Friedel CC, Zimmer R, Mages J, Hoffmann R, Dickinson P, Forster T, Ghazal P, Koszinowski UH.

RNA. 2008 Sep;14(9):1959-72. doi: 10.1261/rna.1136108. Epub 2008 Jul 24.


Mutagenesis of the cytomegalovirus genome.

Ruzsics Z, Koszinowski UH.

Curr Top Microbiol Immunol. 2008;325:41-61. Review.


A mouse model for cytomegalovirus infection.

Brune W, Hengel H, Koszinowski UH.

Curr Protoc Immunol. 2001 Aug;Chapter 19:Unit 19.7. doi: 10.1002/0471142735.im1907s43.


The major virus-producing cell type during murine cytomegalovirus infection, the hepatocyte, is not the source of virus dissemination in the host.

Sacher T, Podlech J, Mohr CA, Jordan S, Ruzsics Z, Reddehase MJ, Koszinowski UH.

Cell Host Microbe. 2008 Apr 17;3(4):263-72. doi: 10.1016/j.chom.2008.02.014.


Dissection of the antiviral NK cell response by MCMV mutants.

Jonjic S, Krmpotic A, Arapovic J, Koszinowski UH.

Methods Mol Biol. 2008;415:127-49. doi: 10.1007/978-1-59745-570-1_8.


Conditional gene expression systems to study herpesvirus biology in vivo.

Sacher T, Jordan S, Mohr CA, Vidy A, Weyn AM, Ruszics Z, Koszinowski UH.

Med Microbiol Immunol. 2008 Jun;197(2):269-76. doi: 10.1007/s00430-008-0086-1. Epub 2008 Mar 7. Review.


Proteins of the secretory pathway govern virus productivity during lytic gammaherpesvirus infection.

Mages J, Freimüller K, Lang R, Hatzopoulos AK, Guggemoos S, Koszinowski UH, Adler H.

J Cell Mol Med. 2008 Oct;12(5B):1974-89. doi: 10.1111/j.1582-4934.2008.00235.x. Epub 2008 Jan 11.


Dominant-negative FADD rescues the in vivo fitness of a cytomegalovirus lacking an antiapoptotic viral gene.

Cicin-Sain L, Ruzsics Z, Podlech J, Bubić I, Menard C, Jonjić S, Reddehase MJ, Koszinowski UH.

J Virol. 2008 Mar;82(5):2056-64. Epub 2007 Dec 19.


Targeted deletion of regions rich in immune-evasive genes from the cytomegalovirus genome as a novel vaccine strategy.

Cicin-Sain L, Bubić I, Schnee M, Ruzsics Z, Mohr C, Jonjić S, Koszinowski UH.

J Virol. 2007 Dec;81(24):13825-34. Epub 2007 Oct 3.


Natural killer cells promote early CD8 T cell responses against cytomegalovirus.

Robbins SH, Bessou G, Cornillon A, Zucchini N, Rupp B, Ruzsics Z, Sacher T, Tomasello E, Vivier E, Koszinowski UH, Dalod M.

PLoS Pathog. 2007 Aug 24;3(8):e123.


Engineering of cytomegalovirus genomes for recombinant live herpesvirus vaccines.

Mohr CA, Cîcîn-Saîn L, Wagner M, Sacher T, Schnee M, Ruzsics Z, Koszinowski UH.

Int J Med Microbiol. 2008 Jan;298(1-2):115-25. Epub 2007 Aug 16. Review.


Random screening for dominant-negative mutants of the cytomegalovirus nuclear egress protein M50.

Rupp B, Ruzsics Z, Buser C, Adler B, Walther P, Koszinowski UH.

J Virol. 2007 Jun;81(11):5508-17. Epub 2007 Mar 21.


Viral interference with B7-1 costimulation: a new role for murine cytomegalovirus fc receptor-1.

Mintern JD, Klemm EJ, Wagner M, Paquet ME, Napier MD, Kim YM, Koszinowski UH, Ploegh HL.

J Immunol. 2006 Dec 15;177(12):8422-31.


Common and specific properties of herpesvirus UL34/UL31 protein family members revealed by protein complementation assay.

Schnee M, Ruzsics Z, Bubeck A, Koszinowski UH.

J Virol. 2006 Dec;80(23):11658-66. Epub 2006 Sep 27.


Coordinated function of murine cytomegalovirus genes completely inhibits CTL lysis.

Pinto AK, Munks MW, Koszinowski UH, Hill AB.

J Immunol. 2006 Sep 1;177(5):3225-34.


The herpesviral Fc receptor fcr-1 down-regulates the NKG2D ligands MULT-1 and H60.

Lenac T, Budt M, Arapovic J, Hasan M, Zimmermann A, Simic H, Krmpotic A, Messerle M, Ruzsics Z, Koszinowski UH, Hengel H, Jonjic S.

J Exp Med. 2006 Aug 7;203(8):1843-50. Epub 2006 Jul 10.


Functional domains of murine cytomegalovirus nuclear egress protein M53/p38.

Lötzerich M, Ruzsics Z, Koszinowski UH.

J Virol. 2006 Jan;80(1):73-84.


Frequent coinfection of cells explains functional in vivo complementation between cytomegalovirus variants in the multiply infected host.

Cicin-Sain L, Podlech J, Messerle M, Reddehase MJ, Koszinowski UH.

J Virol. 2005 Aug;79(15):9492-502.


Viruses know it all: new insights into IFN networks.

Hengel H, Koszinowski UH, Conzelmann KK.

Trends Immunol. 2005 Jul;26(7):396-401. Review.


Development of bovine herpesvirus 4 as an expression vector using bacterial artificial chromosome cloning.

Gillet L, Daix V, Donofrio G, Wagner M, Koszinowski UH, China B, Ackermann M, Markine-Goriaynoff N, Vanderplasschen A.

J Gen Virol. 2005 Apr;86(Pt 4):907-17.


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