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Items: 1 to 50 of 259

1.

Inflammatory monocytes and NK cells play a crucial role in DNAM-1-dependent control of cytomegalovirus infection.

Lenac Rovis T, Kucan Brlic P, Kaynan N, Juranic Lisnic V, Brizic I, Jordan S, Tomic A, Kvestak D, Babic M, Tsukerman P, Colonna M, Koszinowski U, Messerle M, Mandelboim O, Krmpotic A, Jonjic S.

J Exp Med. 2016 Aug 22;213(9):1835-50. doi: 10.1084/jem.20151899. Epub 2016 Aug 8.

2.

Structural Basis of Vesicle Formation at the Inner Nuclear Membrane.

Hagen C, Dent KC, Zeev-Ben-Mordehai T, Grange M, Bosse JB, Whittle C, Klupp BG, Siebert CA, Vasishtan D, Bäuerlein FJ, Cheleski J, Werner S, Guttmann P, Rehbein S, Henzler K, Demmerle J, Adler B, Koszinowski U, Schermelleh L, Schneider G, Enquist LW, Plitzko JM, Mettenleiter TC, Grünewald K.

Cell. 2015 Dec 17;163(7):1692-701. doi: 10.1016/j.cell.2015.11.029.

3.

Nuclear herpesvirus capsid motility is not dependent on F-actin.

Bosse JB, Virding S, Thiberge SY, Scherer J, Wodrich H, Ruzsics Z, Koszinowski UH, Enquist LW.

MBio. 2014 Oct 7;5(5):e01909-14. doi: 10.1128/mBio.01909-14.

4.

A novel murine cytomegalovirus vaccine vector protects against Mycobacterium tuberculosis.

Beverley PC, Ruzsics Z, Hey A, Hutchings C, Boos S, Bolinger B, Marchi E, O'Hara G, Klenerman P, Koszinowski UH, Tchilian EZ.

J Immunol. 2014 Sep 1;193(5):2306-16. doi: 10.4049/jimmunol.1302523. Epub 2014 Jul 28.

5.

A modified screening system for loss-of-function and dominant negative alleles of essential MCMV genes.

Pogoda M, Bosse JB, Conzelmann KK, Koszinowski UH, Ruzsics Z.

PLoS One. 2014 Apr 14;9(4):e94918. doi: 10.1371/journal.pone.0094918. eCollection 2014.

6.

Metabolic labeling of newly transcribed RNA for high resolution gene expression profiling of RNA synthesis, processing and decay in cell culture.

Rädle B, Rutkowski AJ, Ruzsics Z, Friedel CC, Koszinowski UH, Dölken L.

J Vis Exp. 2013 Aug 8;(78). doi: 10.3791/50195.

7.

The viral chemokine MCK-2 of murine cytomegalovirus promotes infection as part of a gH/gL/MCK-2 complex.

Wagner FM, Brizic I, Prager A, Trsan T, Arapovic M, Lemmermann NA, Podlech J, Reddehase MJ, Lemnitzer F, Bosse JB, Gimpfl M, Marcinowski L, MacDonald M, Adler H, Koszinowski UH, Adler B.

PLoS Pathog. 2013;9(7):e1003493. doi: 10.1371/journal.ppat.1003493. Epub 2013 Jul 25.

8.

Natural killer cells are required for extramedullary hematopoiesis following murine cytomegalovirus infection.

Jordan S, Ruzsics Z, Mitrović M, Baranek T, Arapović J, Krmpotić A, Vivier E, Dalod M, Jonjić S, Dölken L, Koszinowski UH.

Cell Host Microbe. 2013 May 15;13(5):535-545. doi: 10.1016/j.chom.2013.04.007.

9.

Systemic and local infection routes govern different cellular dissemination pathways during gammaherpesvirus infection in vivo.

Vidy A, Sacher T, Adler H, Jordan S, Koszinowski UH, Ruzsics Z.

J Virol. 2013 Apr;87(8):4596-608. doi: 10.1128/JVI.03135-12. Epub 2013 Feb 13.

10.

Block of death-receptor apoptosis protects mouse cytomegalovirus from macrophages and is a determinant of virulence in immunodeficient hosts.

Ebermann L, Ruzsics Z, Guzmán CA, van Rooijen N, Casalegno-Garduño R, Koszinowski U, Čičin-Šain L.

PLoS Pathog. 2012;8(12):e1003062. doi: 10.1371/journal.ppat.1003062. Epub 2012 Dec 13.

11.

Mouse cytomegalovirus egress protein pM50 interacts with cellular endophilin-A2.

Lemnitzer F, Raschbichler V, Kolodziejczak D, Israel L, Imhof A, Bailer SM, Koszinowski U, Ruzsics Z.

Cell Microbiol. 2013 Feb;15(2):335-51. doi: 10.1111/cmi.12080. Epub 2012 Dec 24.

PMID:
23189961
12.

MHC class I cross-presentation by dendritic cells counteracts viral immune evasion.

Nopora K, Bernhard CA, Ried C, Castello AA, Murphy KM, Marconi P, Koszinowski U, Brocker T.

Front Immunol. 2012 Nov 26;3:348. doi: 10.3389/fimmu.2012.00348. eCollection 2012.

13.

Characterization of conserved region 2-deficient mutants of the cytomegalovirus egress protein pM53.

Pogoda M, Bosse JB, Wagner FM, Schauflinger M, Walther P, Koszinowski UH, Ruzsics Z.

J Virol. 2012 Dec;86(23):12512-24. doi: 10.1128/JVI.00471-12. Epub 2012 Sep 19.

14.

The polyomaviruses WUPyV and KIPyV: a retrospective quantitative analysis in patients undergoing hematopoietic stem cell transplantation.

Motamedi N, Mairhofer H, Nitschko H, Jäger G, Koszinowski UH.

Virol J. 2012 Sep 18;9:209. doi: 10.1186/1743-422X-9-209.

15.

Protection from inflammatory organ damage in a murine model of hemophagocytic lymphohistiocytosis using treatment with IL-18 binding protein.

Chiossone L, Audonnet S, Chetaille B, Chasson L, Farnarier C, Berda-Haddad Y, Jordan S, Koszinowski UH, Dalod M, Mazodier K, Novick D, Dinarello CA, Vivier E, Kaplanski G.

Front Immunol. 2012 Aug 8;3:239. doi: 10.3389/fimmu.2012.00239. eCollection 2012.

16.

A beta-herpesvirus with fluorescent capsids to study transport in living cells.

Bosse JB, Bauerfeind R, Popilka L, Marcinowski L, Taeglich M, Jung C, Striebinger H, von Einem J, Gaul U, Walther P, Koszinowski UH, Ruzsics Z.

PLoS One. 2012;7(7):e40585. doi: 10.1371/journal.pone.0040585. Epub 2012 Jul 11.

17.

Cytomegalovirus replicon-based regulation of gene expression in vitro and in vivo.

Mohr H, Mohr CA, Schneider MR, Scrivano L, Adler B, Kraner-Schreiber S, Schnieke A, Dahlhoff M, Wolf E, Koszinowski UH, Ruzsics Z.

PLoS Pathog. 2012;8(6):e1002728. doi: 10.1371/journal.ppat.1002728. Epub 2012 Jun 7.

18.

A cell free protein fragment complementation assay for monitoring the core interaction of the human cytomegalovirus nuclear egress complex.

Schnee M, Wagner FM, Koszinowski UH, Ruzsics Z.

Antiviral Res. 2012 Jul;95(1):12-8. doi: 10.1016/j.antiviral.2012.04.009. Epub 2012 May 9.

PMID:
22580129
19.

Degradation of cellular mir-27 by a novel, highly abundant viral transcript is important for efficient virus replication in vivo.

Marcinowski L, Tanguy M, Krmpotic A, Rädle B, Lisnić VJ, Tuddenham L, Chane-Woon-Ming B, Ruzsics Z, Erhard F, Benkartek C, Babic M, Zimmer R, Trgovcich J, Koszinowski UH, Jonjic S, Pfeffer S, Dölken L.

PLoS Pathog. 2012 Feb;8(2):e1002510. doi: 10.1371/journal.ppat.1002510. Epub 2012 Feb 9.

20.

Shedding light on the elusive role of endothelial cells in cytomegalovirus dissemination.

Sacher T, Andrassy J, Kalnins A, Dölken L, Jordan S, Podlech J, Ruzsics Z, Jauch KW, Reddehase MJ, Koszinowski UH.

PLoS Pathog. 2011 Nov;7(11):e1002366. doi: 10.1371/journal.ppat.1002366. Epub 2011 Nov 17.

21.

Virus progeny of murine cytomegalovirus bacterial artificial chromosome pSM3fr show reduced growth in salivary Glands due to a fixed mutation of MCK-2.

Jordan S, Krause J, Prager A, Mitrovic M, Jonjic S, Koszinowski UH, Adler B.

J Virol. 2011 Oct;85(19):10346-53. doi: 10.1128/JVI.00545-11. Epub 2011 Aug 3.

22.

Viral functions and immune modulation.

Koszinowski U.

Eur J Cell Biol. 2012 Jan;91(1):1. doi: 10.1016/j.ejcb.2011.05.009. Epub 2011 Jul 29. No abstract available.

PMID:
21802169
23.

M94 is essential for the secondary envelopment of murine cytomegalovirus.

Maninger S, Bosse JB, Lemnitzer F, Pogoda M, Mohr CA, von Einem J, Walther P, Koszinowski UH, Ruzsics Z.

J Virol. 2011 Sep;85(18):9254-67. doi: 10.1128/JVI.00443-11. Epub 2011 Jun 29.

24.

The role of cell types in cytomegalovirus infection in vivo.

Sacher T, Mohr CA, Weyn A, Schlichting C, Koszinowski UH, Ruzsics Z.

Eur J Cell Biol. 2012 Jan;91(1):70-7. doi: 10.1016/j.ejcb.2011.02.002. Epub 2011 Apr 13. Review.

PMID:
21492952
25.

HCMV spread and cell tropism are determined by distinct virus populations.

Scrivano L, Sinzger C, Nitschko H, Koszinowski UH, Adler B.

PLoS Pathog. 2011 Jan 13;7(1):e1001256. doi: 10.1371/journal.ppat.1001256.

26.

Human cytomegalovirus disrupts the major histocompatibility complex class I peptide-loading complex and inhibits tapasin gene transcription.

Halenius A, Hauka S, Dölken L, Stindt J, Reinhard H, Wiek C, Hanenberg H, Koszinowski UH, Momburg F, Hengel H.

J Virol. 2011 Apr;85(7):3473-85. doi: 10.1128/JVI.01923-10. Epub 2011 Jan 19.

27.

Recombinant mouse cytomegalovirus expressing a ligand for the NKG2D receptor is attenuated and has improved vaccine properties.

Slavuljica I, Busche A, Babić M, Mitrović M, Gašparović I, Cekinović D, Markova Car E, Pernjak Pugel E, Ciković A, Lisnić VJ, Britt WJ, Koszinowski U, Messerle M, Krmpotić A, Jonjić S.

J Clin Invest. 2010 Dec;120(12):4532-45. doi: 10.1172/JCI43961. Epub 2010 Nov 22.

28.

Cytomegalovirus microRNAs facilitate persistent virus infection in salivary glands.

Dölken L, Krmpotic A, Kothe S, Tuddenham L, Tanguy M, Marcinowski L, Ruzsics Z, Elefant N, Altuvia Y, Margalit H, Koszinowski UH, Jonjic S, Pfeffer S.

PLoS Pathog. 2010 Oct 14;6(10):e1001150. doi: 10.1371/journal.ppat.1001150.

29.

Dominant negative mutants of the murine cytomegalovirus M53 gene block nuclear egress and inhibit capsid maturation.

Popa M, Ruzsics Z, Lötzerich M, Dölken L, Buser C, Walther P, Koszinowski UH.

J Virol. 2010 Sep;84(18):9035-46. doi: 10.1128/JVI.00681-10. Epub 2010 Jul 7.

30.

Intact NKG2D-independent function of NK cells chronically stimulated with the NKG2D ligand Rae-1.

Champsaur M, Beilke JN, Ogasawara K, Koszinowski UH, Jonjic S, Lanier LL.

J Immunol. 2010 Jul 1;185(1):157-65. doi: 10.4049/jimmunol.1000397. Epub 2010 Jun 7.

31.

A spread-deficient cytomegalovirus for assessment of first-target cells in vaccination.

Mohr CA, Arapovic J, Mühlbach H, Panzer M, Weyn A, Dölken L, Krmpotic A, Voehringer D, Ruzsics Z, Koszinowski U, Sacher T.

J Virol. 2010 Aug;84(15):7730-42. doi: 10.1128/JVI.02696-09. Epub 2010 May 12.

32.

Systematic analysis of viral and cellular microRNA targets in cells latently infected with human gamma-herpesviruses by RISC immunoprecipitation assay.

Dölken L, Malterer G, Erhard F, Kothe S, Friedel CC, Suffert G, Marcinowski L, Motsch N, Barth S, Beitzinger M, Lieber D, Bailer SM, Hoffmann R, Ruzsics Z, Kremmer E, Pfeffer S, Zimmer R, Koszinowski UH, Grässer F, Meister G, Haas J.

Cell Host Microbe. 2010 Apr 22;7(4):324-34. doi: 10.1016/j.chom.2010.03.008.

33.

Virology. A vaccine monkey wrench?

Hengel H, Koszinowski UH.

Science. 2010 Apr 2;328(5974):51-2. doi: 10.1126/science.1188578. No abstract available.

PMID:
20360096
34.

The m74 gene product of murine cytomegalovirus (MCMV) is a functional homolog of human CMV gO and determines the entry pathway of MCMV.

Scrivano L, Esterlechner J, Mühlbach H, Ettischer N, Hagen C, Grünewald K, Mohr CA, Ruzsics Z, Koszinowski U, Adler B.

J Virol. 2010 May;84(9):4469-80. doi: 10.1128/JVI.02441-09. Epub 2010 Feb 24.

35.

Dominant-negative proteins in herpesviruses - from assigning gene function to intracellular immunization.

Mühlbach H, Mohr CA, Ruzsics Z, Koszinowski UH.

Viruses. 2009 Dec;1(3):420-40. doi: 10.3390/v1030420. Epub 2009 Oct 19.

36.

Virally infected mouse liver endothelial cells trigger CD8+ T-cell immunity.

Kern M, Popov A, Scholz K, Schumak B, Djandji D, Limmer A, Eggle D, Sacher T, Zawatzky R, Holtappels R, Reddehase MJ, Hartmann G, Debey-Pascher S, Diehl L, Kalinke U, Koszinowski U, Schultze J, Knolle PA.

Gastroenterology. 2010 Jan;138(1):336-46. doi: 10.1053/j.gastro.2009.08.057. Epub 2009 Sep 6.

PMID:
19737567
37.

Evolutionarily conserved herpesviral protein interaction networks.

Fossum E, Friedel CC, Rajagopala SV, Titz B, Baiker A, Schmidt T, Kraus T, Stellberger T, Rutenberg C, Suthram S, Bandyopadhyay S, Rose D, von Brunn A, Uhlmann M, Zeretzke C, Dong YA, Boulet H, Koegl M, Bailer SM, Koszinowski U, Ideker T, Uetz P, Zimmer R, Haas J.

PLoS Pathog. 2009 Sep;5(9):e1000570. doi: 10.1371/journal.ppat.1000570. Epub 2009 Sep 4.

38.

Conserved principles of mammalian transcriptional regulation revealed by RNA half-life.

Friedel CC, Dölken L, Ruzsics Z, Koszinowski UH, Zimmer R.

Nucleic Acids Res. 2009 Sep;37(17):e115. doi: 10.1093/nar/gkp542. Epub 2009 Jun 26.

39.

Differential susceptibility of RAE-1 isoforms to mouse cytomegalovirus.

Arapovic J, Lenac T, Antulov R, Polic B, Ruzsics Z, Carayannopoulos LN, Koszinowski UH, Krmpotic A, Jonjic S.

J Virol. 2009 Aug;83(16):8198-207. doi: 10.1128/JVI.02549-08. Epub 2009 Jun 3.

40.

Cytomegalovirus microRNAs.

Dölken L, Pfeffer S, Koszinowski UH.

Virus Genes. 2009 Jun;38(3):355-64. doi: 10.1007/s11262-009-0347-0. Epub 2009 Mar 17. Review.

PMID:
19291384
41.

Ly49P recognition of cytomegalovirus-infected cells expressing H2-Dk and CMV-encoded m04 correlates with the NK cell antiviral response.

Kielczewska A, Pyzik M, Sun T, Krmpotic A, Lodoen MB, Munks MW, Babic M, Hill AB, Koszinowski UH, Jonjic S, Lanier LL, Vidal SM.

J Exp Med. 2009 Mar 16;206(3):515-23. doi: 10.1084/jem.20080954. Epub 2009 Mar 2.

42.

High-resolution gene expression profiling for simultaneous kinetic parameter analysis of RNA synthesis and decay.

Dölken L, Ruzsics Z, Rädle B, Friedel CC, Zimmer R, Mages J, Hoffmann R, Dickinson P, Forster T, Ghazal P, Koszinowski UH.

RNA. 2008 Sep;14(9):1959-72. doi: 10.1261/rna.1136108. Epub 2008 Jul 24.

43.

Mutagenesis of the cytomegalovirus genome.

Ruzsics Z, Koszinowski UH.

Curr Top Microbiol Immunol. 2008;325:41-61. Review.

PMID:
18637499
44.

A mouse model for cytomegalovirus infection.

Brune W, Hengel H, Koszinowski UH.

Curr Protoc Immunol. 2001 Aug;Chapter 19:Unit 19.7. doi: 10.1002/0471142735.im1907s43.

PMID:
18432758
45.

The major virus-producing cell type during murine cytomegalovirus infection, the hepatocyte, is not the source of virus dissemination in the host.

Sacher T, Podlech J, Mohr CA, Jordan S, Ruzsics Z, Reddehase MJ, Koszinowski UH.

Cell Host Microbe. 2008 Apr 17;3(4):263-72. doi: 10.1016/j.chom.2008.02.014.

46.

Dissection of the antiviral NK cell response by MCMV mutants.

Jonjic S, Krmpotic A, Arapovic J, Koszinowski UH.

Methods Mol Biol. 2008;415:127-49. doi: 10.1007/978-1-59745-570-1_8.

PMID:
18370152
47.

Conditional gene expression systems to study herpesvirus biology in vivo.

Sacher T, Jordan S, Mohr CA, Vidy A, Weyn AM, Ruszics Z, Koszinowski UH.

Med Microbiol Immunol. 2008 Jun;197(2):269-76. doi: 10.1007/s00430-008-0086-1. Epub 2008 Mar 7. Review.

PMID:
18324415
48.

Cloning and sequencing of a highly productive, endotheliotropic virus strain derived from human cytomegalovirus TB40/E.

Sinzger C, Hahn G, Digel M, Katona R, Sampaio KL, Messerle M, Hengel H, Koszinowski U, Brune W, Adler B.

J Gen Virol. 2008 Feb;89(Pt 2):359-68. doi: 10.1099/vir.0.83286-0.

PMID:
18198366
49.

Proteins of the secretory pathway govern virus productivity during lytic gammaherpesvirus infection.

Mages J, Freimüller K, Lang R, Hatzopoulos AK, Guggemoos S, Koszinowski UH, Adler H.

J Cell Mol Med. 2008 Oct;12(5B):1974-89. doi: 10.1111/j.1582-4934.2008.00235.x. Epub 2008 Jan 11.

50.

UL74 of human cytomegalovirus contributes to virus release by promoting secondary envelopment of virions.

Jiang XJ, Adler B, Sampaio KL, Digel M, Jahn G, Ettischer N, Stierhof YD, Scrivano L, Koszinowski U, Mach M, Sinzger C.

J Virol. 2008 Mar;82(6):2802-12. doi: 10.1128/JVI.01550-07. Epub 2008 Jan 9.

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