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Items: 44

1.

Di-aryl Sulfonamide Motif Adds π-Stacking Bulk in Negative Allosteric Modulators of the NMDA Receptor.

Summer SL, Kell SA, Zhu Z, Moore R, Liotta DC, Myers SJ, Koszalka GW, Traynelis SF, Menaldino DS.

ACS Med Chem Lett. 2019 Jan 4;10(3):248-254. doi: 10.1021/acsmedchemlett.8b00395. eCollection 2019 Mar 14.

PMID:
30891121
2.

Antiretroviral drug development for HIV: challenges for the future.

Boone LR, Koszalka GW.

Curr Opin Investig Drugs. 2010 Aug;11(8):863-67.

PMID:
21072979
3.

2007: a difficult year for HCV drug development.

Meanwell NA, Koszalka GW.

Curr Opin Investig Drugs. 2008 Feb;9(2):128-31. No abstract available.

PMID:
18246515
4.

Inhibition of virus entry: an antiviral mechanism of emerging prominence.

Koszalka GW, Meanwell NA.

Curr Opin Investig Drugs. 2006 Feb;7(2):106-8. No abstract available.

PMID:
16499279
5.

Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 2.

Freeman GA, Andrews Iii CW 3rd, Hopkins AL, Lowell GS, Schaller LT, Cowan JR, Gonzales SS, Koszalka GW, Hazen RJ, Boone LR, Ferris RG, Creech KL, Roberts GB, Short SA, Weaver K, Reynolds DJ, Milton J, Ren J, Stuart DI, Stammers DK, Chan JH.

J Med Chem. 2004 Nov 18;47(24):5923-36.

PMID:
15537347
6.

Pharmacokinetics of the thymidine analog 2'-fluoro-5-methyl-1-beta-D-arabinofuranosyluracil (FMAU) in tumor-bearing rats.

Bading JR, Shahinian AH, Vail A, Bathija P, Koszalka GW, Koda RT, Alauddin MM, Fissekis JD, Conti PS.

Nucl Med Biol. 2004 May;31(4):407-18.

PMID:
15093810
7.

Novel benzophenones as non-nucleoside reverse transcriptase inhibitors of HIV-1.

Chan JH, Freeman GA, Tidwell JH, Romines KR, Schaller LT, Cowan JR, Gonzales SS, Lowell GS, Andrews CW 3rd, Reynolds DJ, St Clair M, Hazen RJ, Ferris RG, Creech KL, Roberts GB, Short SA, Weaver K, Koszalka GW, Boone LR.

J Med Chem. 2004 Feb 26;47(5):1175-82.

PMID:
14971897
8.

Relating the structure, activity, and physical properties of ultrashort-acting benzodiazepine receptor agonists.

Pacofsky GJ, Stafford JA, Cox RF, Cowan JR, Dorsey GF Jr, Gonzales SS, Kaldor I, Koszalka GW, Lovell GG, McIntyre MS, Tidwell JH, Todd D, Whitesell G, Wiard RP, Feldman PL.

Bioorg Med Chem Lett. 2002 Nov 4;12(21):3219-22.

PMID:
12372538
9.

Identification and structure-activity studies of novel ultrashort-acting benzodiazepine receptor agonists.

Stafford JA, Pacofsky GJ, Cox RF, Cowan JR, Dorsey GF Jr, Gonzales SS, Jung DK, Koszalka GW, McIntyre MS, Tidwell JH, Wiard RP, Feldman PL.

Bioorg Med Chem Lett. 2002 Nov 4;12(21):3215-8.

PMID:
12372537
10.

Preclinical and toxicology studies of 1263W94, a potent and selective inhibitor of human cytomegalovirus replication.

Koszalka GW, Johnson NW, Good SS, Boyd L, Chamberlain SC, Townsend LB, Drach JC, Biron KK.

Antimicrob Agents Chemother. 2002 Aug;46(8):2373-80.

11.

Potent and selective inhibition of human cytomegalovirus replication by 1263W94, a benzimidazole L-riboside with a unique mode of action.

Biron KK, Harvey RJ, Chamberlain SC, Good SS, Smith AA 3rd, Davis MG, Talarico CL, Miller WH, Ferris R, Dornsife RE, Stanat SC, Drach JC, Townsend LB, Koszalka GW.

Antimicrob Agents Chemother. 2002 Aug;46(8):2365-72.

12.

Synthesis and antiviral evaluation of halogenated beta-D- and -L-erythrofuranosylbenzimidazoles.

Gudmundsson KS, Tidwell J, Lippa N, Koszalka GW, van Draanen N, Ptak RG, Drach JC, Townsend LB.

J Med Chem. 2000 Jun 15;43(12):2464-72.

PMID:
10882374
13.

Design, synthesis, and antiviral evaluation of 2-deoxy-D-ribosides of substituted benzimidazoles as potential agents for human cytomegalovirus infections.

Zou R, Kawashima E, Freeman GA, Koszalka GW, Drach JC, Townsend LB.

Nucleosides Nucleotides Nucleic Acids. 2000 Jan-Feb;19(1-2):125-53.

PMID:
10772706
14.

Synthesis and evaluation of a series of 2'-deoxy analogues of the antiviral agent 5,6-dichloro-2-isopropylamino-1-(beta-L-ribofuranosyl)-1H-benzimidazole (1263W94).

Chan JH, Chamberlain SD, Biron KK, Davis MG, Harvey RJ, Selleseth DW, Dornsife RE, Dark EH, Frick LW, Townsend LB, Drach JC, Koszalka GW.

Nucleosides Nucleotides Nucleic Acids. 2000 Jan-Feb;19(1-2):101-23. Erratum in: Nucleosides Nucleotides Nucleic Acids. 2002;21(1):109.

PMID:
10772705
15.

Studies designed to increase the stability and antiviral activity (HCMV) of the active benzimidazole nucleoside, TCRB.

Townsend LB, Gudmundsson KS, Daluge SM, Chen JJ, Zhu Z, Koszalka GW, Boyd L, Chamberlain SD, Freeman GA, Biron KK, Drach JC.

Nucleosides Nucleotides. 1999 Apr-May;18(4-5):509-19.

PMID:
10432642
16.

Design, synthesis, and antiviral activity of alpha-nucleosides: D- and L-isomers of lyxofuranosyl- and (5-deoxylyxofuranosyl)benzimidazoles.

Migawa MT, Girardet JL, Walker JA 2nd, Koszalka GW, Chamberlain SD, Drach JC, Townsend LB.

J Med Chem. 1998 Apr 9;41(8):1242-51.

PMID:
9575044
17.

The crystal structure of Escherichia coli purine nucleoside phosphorylase: a comparison with the human enzyme reveals a conserved topology.

Mao C, Cook WJ, Zhou M, Koszalka GW, Krenitsky TA, Ealick SE.

Structure. 1997 Oct 15;5(10):1373-83.

18.

Synthesis and antiviral activity of 2'-deoxy-4'-thio purine nucleosides.

Van Draanen NA, Freeman GA, Short SA, Harvey R, Jansen R, Szczech G, Koszalka GW.

J Med Chem. 1996 Jan 19;39(2):538-42.

PMID:
8558524
19.
20.

An enantiospecific synthesis of the human cytomegalovirus antiviral agent [(R)-3-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)-4- hydroxybutyl]phosphonic acid.

Chamberlain SD, Biron KK, Dornsife RE, Averett DR, Beauchamp L, Koszalka GW.

J Med Chem. 1994 Apr 29;37(9):1371-7.

PMID:
8176714
21.

Influence of stereochemistry on antiviral activities and resistance profiles of dideoxycytidine nucleosides.

Van Draanen NA, Tisdale M, Parry NR, Jansen R, Dornsife RE, Tuttle JV, Averett DR, Koszalka GW.

Antimicrob Agents Chemother. 1994 Apr;38(4):868-71.

22.

Varicella-zoster virus thymidine kinase. Characterization and substrate specificity.

Roberts GB, Fyfe JA, McKee SA, Rahim SG, Daluge SM, Almond MR, Rideout JL, Koszalka GW, Krenitsky TA.

Biochem Pharmacol. 1993 Dec 14;46(12):2209-18.

PMID:
8274154
23.

Novel 6-alkoxypurine 2',3'-dideoxynucleosides as inhibitors of the cytopathic effect of the human immunodeficiency virus.

Burns CL, St Clair MH, Frick LW, Spector T, Averett DR, English ML, Holmes TJ, Krenitsky TA, Koszalka GW.

J Med Chem. 1993 Feb 5;36(3):378-84.

PMID:
8426365
24.

6-Dimethylamino-9-(beta-D-arabinofuranosyl)-9H-purine: pharmacokinetics and antiviral activity in simian varicella virus-infected monkeys.

Soike KF, Huang JL, Lambe CU, Nelson DJ, Ellis MN, Krenitsky TA, Koszalka GW.

Antiviral Res. 1993 Jan;20(1):13-20.

PMID:
8457145
25.

Membrane permeation characteristics of 5'-modified thymidine analogs.

Domin BA, Mahony WB, Koszalka GW, Porter DJ, Hajian G, Zimmerman TP.

Mol Pharmacol. 1992 May;41(5):950-6.

PMID:
1588925
26.

Metabolism and pharmacokinetics of the anti-varicella-zoster virus agent 6-dimethylaminopurine arabinoside.

Lambe CU, Resetar A, Spector T, Koszalka GW, Nelson DJ.

Antimicrob Agents Chemother. 1992 Feb;36(2):353-60.

27.

6-N-substituted derivatives of adenine arabinoside as selective inhibitors of varicella-zoster virus.

Koszalka GW, Averett DR, Fyfe JA, Roberts GB, Spector T, Biron K, Krenitsky TA.

Antimicrob Agents Chemother. 1991 Jul;35(7):1437-43.

28.

Metabolic disposition and pharmacokinetics of the antiviral agent 6-methoxypurine arabinoside in rats and monkeys.

Burnette TC, Koszalka GW, Krenitsky TA, De Miranda P.

Antimicrob Agents Chemother. 1991 Jun;35(6):1165-73.

29.

6-Methoxypurine arabinoside as a selective and potent inhibitor of varicella-zoster virus.

Averett DR, Koszalka GW, Fyfe JA, Roberts GB, Purifoy DJ, Krenitsky TA.

Antimicrob Agents Chemother. 1991 May;35(5):851-7.

30.
31.

Three-dimensional structure of thymidine phosphorylase from Escherichia coli at 2.8 A resolution.

Walter MR, Cook WJ, Cole LB, Short SA, Koszalka GW, Krenitsky TA, Ealick SE.

J Biol Chem. 1990 Aug 15;265(23):14016-22.

32.

Purification and properties of inosine-guanosine phosphorylase from Escherichia coli K-12.

Koszalka GW, Vanhooke J, Short SA, Hall WW.

J Bacteriol. 1988 Aug;170(8):3493-8.

33.

Enzymatic enhancement of the catalytic rate of sulfhydryl oxidase.

Koszalka GW, Swaisgood HE, Horton HR.

Biochim Biophys Acta. 1987 Sep 24;915(2):321-9.

PMID:
3115296
34.

Crystallization and preliminary x-ray investigation of thymidine phosphorylase from Escherichia coli.

Cook WJ, Koszalka GW, Hall WW, Burns CL, Ealick SE.

J Biol Chem. 1987 Mar 15;262(8):3788-9.

35.

Crystallization and preliminary X-ray investigation of uridine phosphorylase from Escherichia coli.

Cook WJ, Koszalka GW, Hall WW, Narayana SV, Ealick SE.

J Biol Chem. 1987 Feb 25;262(6):2852-3.

36.

Imidazo[4,5-c]pyridines (3-deazapurines) and their nucleosides as immunosuppressive and antiinflammatory agents.

Krenitsky TA, Rideout JL, Chao EY, Koszalka GW, Gurney F, Crouch RC, Cohn NK, Wolberg G, Vinegar R.

J Med Chem. 1986 Jan;29(1):138-43.

PMID:
3941408
37.

5'-Methylthioadenosine (MTA) phosphorylase from promastigotes of Leishmania donovani.

Koszalka GW, Krenitsky TA.

Adv Exp Med Biol. 1986;195 Pt B:559-63. No abstract available.

PMID:
3094329
38.

Pyrazolo[3,4-d]pyrimidine ribonucleosides as anticoccidials. 2. Synthesis and activity of some nucleosides of 4-(alkylamino)-1H-pyrazolo[3, 4-d]pyrimidines.

Rideout JL, Krenitsky TA, Koszalka GW, Cohn NK, Chao EY, Elion GB, Latter VS, Williams RB.

J Med Chem. 1982 Sep;25(9):1040-4.

PMID:
7131482
39.

Pyrazolo[3,4-d]pyrimidine ribonucleosides as anticoccidials. 1. Synthesis and activity of some nucleosides of purines and 4-(alkylthio)pyrazolo[3,4-d]pyrimidines.

Krenitsky TA, Rideout JL, Koszalka GW, Inmon RB, Chao EY, Elion GB, Latter VS, Williams RB.

J Med Chem. 1982 Jan;25(1):32-5.

PMID:
7086819
40.

Purine nucleoside synthesis, an efficient method employing nucleoside phosphorylases.

Krenitsky TA, Koszalka GW, Tuttle JV.

Biochemistry. 1981 Jun 9;20(12):3615-21.

PMID:
6789872
41.
42.

Adenosine kinase from rabbit liver. II. Substrate and inhibitor specificity.

Miller RL, Adamczyk DL, Miller WH, Koszalka GW, Rideout JL, Beacham LM 3rd, Chao EY, Haggerty JJ, Krenitsky TA, Elion GB.

J Biol Chem. 1979 Apr 10;254(7):2346-52. No abstract available.

43.

Purine salvage enzymes in man and Leishmania donovani.

Krenitsky TA, Koszalka GW, Tuttle JV, Adamczyk DL, Elion GB, Marr JJ.

Adv Exp Med Biol. 1979;122B:51-6. No abstract available.

PMID:
121040
44.

Deoxycytidine kinase from calf thymus. Substrate and inhibitor specificity.

Krenitsky TA, Tuttle JV, Koszalka GW, Chen IS, Beacham LM 3rd, Rideout JL, Elion GB.

J Biol Chem. 1976 Jul 10;251(13):4055-61.

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