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Items: 1 to 50 of 58

1.

A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis.

Zou Y, Palte MJ, Deik AA, Li H, Eaton JK, Wang W, Tseng YY, Deasy R, Kost-Alimova M, Dančík V, Leshchiner ES, Viswanathan VS, Signoretti S, Choueiri TK, Boehm JS, Wagner BK, Doench JG, Clish CB, Clemons PA, Schreiber SL.

Nat Commun. 2019 Apr 8;10(1):1617. doi: 10.1038/s41467-019-09277-9.

2.

Discovering metabolic disease gene interactions by correlated effects on cellular morphology.

Jiao Y, Ahmed U, Sim MFM, Bejar A, Zhang X, Talukder MMU, Rice R, Flannick J, Podgornaia AI, Reilly DF, Engreitz JM, Kost-Alimova M, Hartland K, Mercader JM, Georges S, Wagh V, Tadin-Strapps M, Doench JG, Edwardson JM, Rochford JJ, Rosen ED, Majithia AR.

Mol Metab. 2019 Jun;24:108-119. doi: 10.1016/j.molmet.2019.03.001. Epub 2019 Mar 13.

3.

Genome-Wide Interrogation of Human Cancers Identifies EGLN1 Dependency in Clear Cell Ovarian Cancers.

Price C, Gill S, Ho ZV, Davidson SM, Merkel E, McFarland JM, Leung L, Tang A, Kost-Alimova M, Tsherniak A, Jonas O, Vazquez F, Hahn WC.

Cancer Res. 2019 May 15;79(10):2564-2579. doi: 10.1158/0008-5472.CAN-18-2674. Epub 2019 Mar 21.

PMID:
30898838
4.

Cell Painting, a high-content image-based assay for morphological profiling using multiplexed fluorescent dyes.

Bray MA, Singh S, Han H, Davis CT, Borgeson B, Hartland C, Kost-Alimova M, Gustafsdottir SM, Gibson CC, Carpenter AE.

Nat Protoc. 2016 Sep;11(9):1757-74. doi: 10.1038/nprot.2016.105. Epub 2016 Aug 25.

5.

Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting.

Aguirre AJ, Meyers RM, Weir BA, Vazquez F, Zhang CZ, Ben-David U, Cook A, Ha G, Harrington WF, Doshi MB, Kost-Alimova M, Gill S, Xu H, Ali LD, Jiang G, Pantel S, Lee Y, Goodale A, Cherniack AD, Oh C, Kryukov G, Cowley GS, Garraway LA, Stegmaier K, Roberts CW, Golub TR, Meyerson M, Root DE, Tsherniak A, Hahn WC.

Cancer Discov. 2016 Aug;6(8):914-29. doi: 10.1158/2159-8290.CD-16-0154. Epub 2016 Jun 3.

6.

Development of novel cellular histone-binding and chromatin-displacement assays for bromodomain drug discovery.

Zhan Y, Kost-Alimova M, Shi X, Leo E, Bardenhagen JP, Shepard HE, Appikonda S, Vangamudi B, Zhao S, Tieu TN, Jiang S, Heffernan TP, Marszalek JR, Toniatti C, Draetta G, Tyler J, Barton M, Jones P, Palmer WS, Geck Do MK, Andersen JN.

Epigenetics Chromatin. 2015 Sep 21;8:37. doi: 10.1186/s13072-015-0026-4. eCollection 2015.

7.

The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies.

Vangamudi B, Paul TA, Shah PK, Kost-Alimova M, Nottebaum L, Shi X, Zhan Y, Leo E, Mahadeshwar HS, Protopopov A, Futreal A, Tieu TN, Peoples M, Heffernan TP, Marszalek JR, Toniatti C, Petrocchi A, Verhelle D, Owen DR, Draetta G, Jones P, Palmer WS, Sharma S, Andersen JN.

Cancer Res. 2015 Sep 15;75(18):3865-3878. doi: 10.1158/0008-5472.CAN-14-3798. Epub 2015 Jul 2.

8.

Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor.

Palmer WS, Poncet-Montange G, Liu G, Petrocchi A, Reyna N, Subramanian G, Theroff J, Yau A, Kost-Alimova M, Bardenhagen JP, Leo E, Shepard HE, Tieu TN, Shi X, Zhan Y, Zhao S, Barton MC, Draetta G, Toniatti C, Jones P, Geck Do M, Andersen JN.

J Med Chem. 2016 Feb 25;59(4):1440-54. doi: 10.1021/acs.jmedchem.5b00405. Epub 2015 Jul 6.

9.

Utilizing murine inducible telomerase alleles in the studies of tissue degeneration/regeneration and cancer.

Shingu T, Jaskelioff M, Yuan L, Ding Z, Protopopov A, Kost-Alimova M, Hu J.

J Vis Exp. 2015 Apr 13;(98). doi: 10.3791/52599.

10.

Telomere dysfunction suppresses multiple endocrine neoplasia in mice.

Lee JH, Anver M, Kost-Alimova M, Protopopov A, DePinho RA, Rane SG.

Genes Cancer. 2014 Sep;5(9-10):306-19.

11.

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function.

Viale A, Pettazzoni P, Lyssiotis CA, Ying H, Sánchez N, Marchesini M, Carugo A, Green T, Seth S, Giuliani V, Kost-Alimova M, Muller F, Colla S, Nezi L, Genovese G, Deem AK, Kapoor A, Yao W, Brunetto E, Kang Y, Yuan M, Asara JM, Wang YA, Heffernan TP, Kimmelman AC, Wang H, Fleming JB, Cantley LC, DePinho RA, Draetta GF.

Nature. 2014 Oct 30;514(7524):628-32. doi: 10.1038/nature13611. Epub 2014 Aug 10.

12.

Role of telomere dysfunction in cardiac failure in Duchenne muscular dystrophy.

Mourkioti F, Kustan J, Kraft P, Day JW, Zhao MM, Kost-Alimova M, Protopopov A, DePinho RA, Bernstein D, Meeker AK, Blau HM.

Nat Cell Biol. 2013 Aug;15(8):895-904. doi: 10.1038/ncb2790. Epub 2013 Jul 7.

13.

Telomerase reactivation following telomere dysfunction yields murine prostate tumors with bone metastases.

Ding Z, Wu CJ, Jaskelioff M, Ivanova E, Kost-Alimova M, Protopopov A, Chu GC, Wang G, Lu X, Labrot ES, Hu J, Wang W, Xiao Y, Zhang H, Zhang J, Zhang J, Gan B, Perry SR, Jiang S, Li L, Horner JW, Wang YA, Chin L, DePinho RA.

Cell. 2012 Mar 2;148(5):896-907. doi: 10.1016/j.cell.2012.01.039. Epub 2012 Feb 16.

14.

Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer.

Hu J, Hwang SS, Liesa M, Gan B, Sahin E, Jaskelioff M, Ding Z, Ying H, Boutin AT, Zhang H, Johnson S, Ivanova E, Kost-Alimova M, Protopopov A, Wang YA, Shirihai OS, Chin L, DePinho RA.

Cell. 2012 Feb 17;148(4):651-63. doi: 10.1016/j.cell.2011.12.028.

15.

Lenalidomide targets clonogenic side population in multiple myeloma: pathophysiologic and clinical implications.

Jakubikova J, Adamia S, Kost-Alimova M, Klippel S, Cervi D, Daley JF, Cholujova D, Kong SY, Leiba M, Blotta S, Ooi M, Delmore J, Laubach J, Richardson PG, Sedlak J, Anderson KC, Mitsiades CS.

Blood. 2011 Apr 28;117(17):4409-19. doi: 10.1182/blood-2010-02-267344. Epub 2011 Feb 14.

16.

Telomere dysfunction induces metabolic and mitochondrial compromise.

Sahin E, Colla S, Liesa M, Moslehi J, Müller FL, Guo M, Cooper M, Kotton D, Fabian AJ, Walkey C, Maser RS, Tonon G, Foerster F, Xiong R, Wang YA, Shukla SA, Jaskelioff M, Martin ES, Heffernan TP, Protopopov A, Ivanova E, Mahoney JE, Kost-Alimova M, Perry SR, Bronson R, Liao R, Mulligan R, Shirihai OS, Chin L, DePinho RA.

Nature. 2011 Feb 17;470(7334):359-65. doi: 10.1038/nature09787. Epub 2011 Feb 9. Erratum in: Nature. 2011 Jul 14;475(7355):254.

17.

Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice.

Jaskelioff M, Muller FL, Paik JH, Thomas E, Jiang S, Adams AC, Sahin E, Kost-Alimova M, Protopopov A, Cadiñanos J, Horner JW, Maratos-Flier E, Depinho RA.

Nature. 2011 Jan 6;469(7328):102-6. doi: 10.1038/nature09603. Epub 2010 Nov 28.

18.

Horizontal transfer of tumor DNA to endothelial cells in vivo.

Ehnfors J, Kost-Alimova M, Persson NL, Bergsmedh A, Castro J, Levchenko-Tegnebratt T, Yang L, Panaretakis T, Holmgren L.

Cell Death Differ. 2009 May;16(5):749-57. doi: 10.1038/cdd.2009.7. Epub 2009 Feb 13.

19.

Microdissection molecular copy-number counting (microMCC)--unlocking cancer archives with digital PCR.

McCaughan F, Darai-Ramqvist E, Bankier AT, Konfortov BA, Foster N, George PJ, Rabbitts TH, Kost-Alimova M, Rabbitts PH, Dear PH.

J Pathol. 2008 Nov;216(3):307-16. doi: 10.1002/path.2413.

PMID:
18773450
20.

Segmental duplications and evolutionary plasticity at tumor chromosome break-prone regions.

Darai-Ramqvist E, Sandlund A, Müller S, Klein G, Imreh S, Kost-Alimova M.

Genome Res. 2008 Mar;18(3):370-9. doi: 10.1101/gr.7010208. Epub 2008 Jan 29.

21.

Mandatory chromosomal segment balance in aneuploid tumor cells.

Kost-Alimova M, Darai-Ramqvist E, Yau WL, Sandlund A, Fedorova L, Yang Y, Kholodnyuk I, Cheng Y, Li Lung M, Stanbridge E, Klein G, Imreh S.

BMC Cancer. 2007 Jan 26;7:21.

22.

Array-CGH and multipoint FISH to decode complex chromosomal rearrangements.

Darai-Ramqvist E, Diaz de Ståhl T, Sandlund A, Mantripragada K, Klein G, Dumanski J, Imreh S, Kost-Alimova M.

BMC Genomics. 2006 Dec 29;7:330.

23.

Multipoint interphase FISH in childhood T-acute lymphoblastic leukemia detects subpopulations that carry different chromosome 3 aberrations.

Haltrich I, Kost-Alimova M, Kovács G, Dobos M, Klein G, Fekete G, Imreh S.

Cancer Genet Cytogenet. 2007 Jan 1;172(1):54-60.

PMID:
17175380
24.

Modeling non-random deletions in cancer.

Kost-Alimova M, Imreh S.

Semin Cancer Biol. 2007 Feb;17(1):19-30. Epub 2006 Nov 17. Review.

PMID:
17174104
25.

CHCHD7-PLAG1 and TCEA1-PLAG1 gene fusions resulting from cryptic, intrachromosomal 8q rearrangements in pleomorphic salivary gland adenomas.

Asp J, Persson F, Kost-Alimova M, Stenman G.

Genes Chromosomes Cancer. 2006 Sep;45(9):820-8.

PMID:
16736500
26.

Down regulation of 3p genes, LTF, SLC38A3 and DRR1, upon growth of human chromosome 3-mouse fibrosarcoma hybrids in severe combined immunodeficiency mice.

Kholodnyuk ID, Kozireva S, Kost-Alimova M, Kashuba V, Klein G, Imreh S.

Int J Cancer. 2006 Jul 1;119(1):99-107.

27.

Multipoint interphase FISH analysis of chromosome 3 abnormalities in 28 childhood AML patients.

Haltrich I, Kost-Alimova M, Kovács G, Klein G, Fekete G, Imreh S.

Eur J Haematol. 2006 Feb;76(2):124-33.

PMID:
16405433
28.

Jumping translocation of 17q11 approximately qter and 3q25 approximately q28 duplication in a variant Philadelphia t(9;14;22)(q34;q32;q11) in a childhood chronic myelogenous leukemia.

Haltrich I, Kost-Alimova M, Kovács G, Kriván G, Tamáska J, Klein G, Fekete G, Imreh S.

Cancer Genet Cytogenet. 2006 Jan 1;164(1):74-80.

PMID:
16364767
29.

[Identification of 3q21q26 syndrome by "multipoint" interphase FISH analyses in childhood myeloid leukemia].

Haltrich I, Kost-Alimova M, Kovács G, Kriván G, Dobos M, Imreh S, Fekete G.

Magy Onkol. 2005;49(2):141-7. Epub 2005 Oct 24. Hungarian.

30.

CGH analysis of familial non-BRCA1/BRCA2 breast tumors and mutation screening of a candidate locus on chromosome 17q11.2-12.

Maguire P, Holmberg K, Kost-Alimova M, Imreh S, Skoog L, Lindblom A.

Int J Mol Med. 2005 Jul;16(1):135-41.

PMID:
15942690
31.

Evolutionarily plastic regions at human 3p21.3 coincide with tumor breakpoints identified by the "elimination test".

Darai E, Kost-Alimova M, Kiss H, Kansoul H, Klein G, Imreh S.

Genomics. 2005 Jul;86(1):1-12.

PMID:
15913951
33.

Coincidence of synteny breakpoints with malignancy-related deletions on human chromosome 3.

Kost-Alimova M, Kiss H, Fedorova L, Yang Y, Dumanski JP, Klein G, Imreh S.

Proc Natl Acad Sci U S A. 2003 May 27;100(11):6622-7. Epub 2003 May 8.

34.

Consistent downregulation of human lactoferrin gene, in the common eliminated region 1 on 3p21.3, following tumor growth in severe combined immunodeficient (SCID) mice.

Yang Y, Li J, Szeles A, Imreh MP, Kost-Alimova M, Kiss H, Kholodnyuk I, Fedorova L, Darai E, Klein G, Imreh S.

Cancer Lett. 2003 Mar 10;191(2):155-64.

PMID:
12618328
35.

Comparative human/murine sequence analysis of the common eliminated region 1 from human 3p21.3.

Kiss H, Darai E, Kiss C, Kost-Alimova M, Klein G, Dumanski JP, Imreh S.

Mamm Genome. 2002 Nov;13(11):646-55.

PMID:
12461651
36.
37.

Detailed chromosomal and radiation hybrid mapping in the proximal part of rat Chromosome 10 and gene order comparison with mouse and human.

Behboudi A, Roshani L, Kost-Alimova M, Sjöstrand E, Montelius-Alatalo K, Röhme D, Klinga-Levan K, Ståhl F.

Mamm Genome. 2002 Jun;13(6):302-9.

PMID:
12115033
38.

Optimisation of the degenerate oligonucleotide primed PCR (DOP-PCR) for capillary thermocycler.

Kiss C, Kost-Alimova M, Klein G, Szekely L.

Biomol Eng. 2002 Jun;19(1):31-4.

PMID:
12103363
39.

The microcell hybrid-based "elimination test" identifies a 1-Mb putative tumor-suppressor region at 3p22.2-p22.1 centromeric to the homozygous deletion region detected in lung cancer.

Kholodnyuk ID, Kost-Alimova M, Yang Y, Kiss H, Fedorova L, Klein G, Imreh S.

Genes Chromosomes Cancer. 2002 Jul;34(3):341-4.

PMID:
12007195
40.

Human wig-1, a p53 target gene that encodes a growth inhibitory zinc finger protein.

Hellborg F, Qian W, Mendez-Vidal C, Asker C, Kost-Alimova M, Wilhelm M, Imreh S, Wiman KG.

Oncogene. 2001 Sep 6;20(39):5466-74.

41.

The position of t(11;22)(q23;q11) constitutional translocation breakpoint is conserved among its carriers.

Tapia-Páez I, Kost-Alimova M, Hu P, Roe BA, Blennow E, Fedorova L, Imreh S, Dumanski JP.

Hum Genet. 2001 Aug;109(2):167-77.

PMID:
11511922
42.

The LZTFL1 gene is a part of a transcriptional map covering 250 kb within the common eliminated region 1 (C3CER1) in 3p21.3.

Kiss H, Kedra D, Kiss C, Kost-Alimova M, Yang Y, Klein G, Imreh S, Dumanski JP.

Genomics. 2001 Apr 1;73(1):10-9.

PMID:
11352561
44.

Similar regions of human chromosome 3 are eliminated from or retained in human/human and human/mouse microcell hybrids during tumor growth in severe combined immunodeficient (SCID) mice.

Yang Y, Kost-Alimova M, Ingvarsson S, Qianhui Q, Kiss H, Szeles A, Kholodnyuk I, Cuthbert A, Klein G, Imreh S.

Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):1136-41.

45.

Fine mapping of the constitutional translocation t(11;22)(q23;q11).

Tapia-Páez I, O'Brien KP, Kost-Alimova M, Sahlén S, Kedra D, Bruder CE, Andersson B, Roe BA, Hu P, Imreh S, Blennow E, Dumanski JP.

Hum Genet. 2000 May;106(5):506-16.

PMID:
10914680
46.

Combined LOH/CGH analysis proves the existence of interstitial 3p deletions in renal cell carcinoma.

Alimov A, Kost-Alimova M, Liu J, Li C, Bergerheim U, Imreh S, Klein G, Zabarovsky ER.

Oncogene. 2000 Mar 9;19(11):1392-9.

47.

A novel gene containing LIM domains (LIMD1) is located within the common eliminated region 1 (C3CER1) in 3p21.3.

Kiss H, Kedra D, Yang Y, Kost-Alimova M, Kiss C, O'Brien KP, Fransson I, Klein G, Imreh S, Dumanski JP.

Hum Genet. 1999 Dec;105(6):552-9.

PMID:
10647888
48.

A 1-Mb PAC contig spanning the common eliminated region 1 (CER1) in microcell hybrid-derived SCID tumors.

Yang Y, Kiss H, Kost-Alimova M, Kedra D, Fransson I, Seroussi E, Li J, Szeles A, Kholodnyuk I, Imreh MP, Fodor K, Hadlaczky G, Klein G, Dumanski JP, Imreh S.

Genomics. 1999 Dec 1;62(2):147-55.

PMID:
10610706
49.

Analysis of NotI linking clones isolated from human chromosome 3 specific libraries.

Kashuba VI, Gizatullin RZ, Protopopov AI, Li J, Vorobieva NV, Fedorova L, Zabarovska VI, Muravenko OV, Kost-Alimova M, Domninsky DA, Kiss C, Allikmets R, Zakharyev VM, Braga EA, Sumegi J, Lerman M, Wahlestedt C, Zelenin AV, Sheer D, Winberg G, Grafodatsky A, Kisselev LL, Klein G, Zabarovsky ER.

Gene. 1999 Nov 1;239(2):259-71.

PMID:
10548727
50.

TOM1 genes map to human chromosome 22q13.1 and mouse chromosome 8C1 and encode proteins similar to the endosomal proteins HGS and STAM.

Seroussi E, Kedra D, Kost-Alimova M, Sandberg-Nordqvist AC, Fransson I, Jacobs JF, Fu Y, Pan HQ, Roe BA, Imreh S, Dumanski JP.

Genomics. 1999 May 1;57(3):380-8.

PMID:
10329004

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