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The solute carriers ZIP8 and ZIP14 regulate manganese accumulation in brain microvascular endothelial cells and control brain manganese levels.

Steimle BL, Smith FM, Kosman DJ.

J Biol Chem. 2019 Nov 7. pii: jbc.RA119.009371. doi: 10.1074/jbc.RA119.009371. [Epub ahead of print]


Is brain iron trafficking part of the physiology of the amyloid precursor protein?

Bailey DK, Kosman DJ.

J Biol Inorg Chem. 2019 Oct 1. doi: 10.1007/s00775-019-01684-z. [Epub ahead of print]


Reply to Lahiri et al.: APPealing for a role in cellular iron efflux.

Kosman DJ.

J Biol Chem. 2019 Jun 14;294(24):9366. doi: 10.1074/jbc.RL119.009249. No abstract available.


Fluorescence resonance energy transfer links membrane ferroportin, hephaestin but not ferroportin, amyloid precursor protein complex with iron efflux.

Dlouhy AC, Bailey DK, Steimle BL, Parker HV, Kosman DJ.

J Biol Chem. 2019 Mar 15;294(11):4202-4214. doi: 10.1074/jbc.RA118.005142. Epub 2019 Jan 15.


Energy metabolism, oxygen flux, and iron in bacteria: The Mössbauer report.

Kosman DJ.

J Biol Chem. 2019 Jan 4;294(1):63-64. doi: 10.1074/jbc.H118.006703.


For Cryptococcus neoformans, responding to the copper status in a colonization niche is not just about copper.

Kosman DJ.

Mol Microbiol. 2018 Jun;108(5):463-466. doi: 10.1111/mmi.13963. Epub 2018 Apr 26.


The teleos of metallo-reduction and metallo-oxidation in eukaryotic iron and copper trafficking.

Kosman DJ.

Metallomics. 2018 Mar 1;10(3):370-377. doi: 10.1039/c8mt00015h. Epub 2018 Feb 27.


The Ferroxidase Hephaestin But Not Amyloid Precursor Protein is Required for Ferroportin-Supported Iron Efflux in Primary Hippocampal Neurons.

Ji C, Steimle BL, Bailey DK, Kosman DJ.

Cell Mol Neurobiol. 2018 May;38(4):941-954. doi: 10.1007/s10571-017-0568-z. Epub 2017 Nov 25.


Potassium and the K+/H+ Exchanger Kha1p Promote Binding of Copper to ApoFet3p Multi-copper Ferroxidase.

Wu X, Kim H, Seravalli J, Barycki JJ, Hart PJ, Gohara DW, Di Cera E, Jung WH, Kosman DJ, Lee J.

J Biol Chem. 2016 Apr 29;291(18):9796-806. doi: 10.1074/jbc.M115.700500. Epub 2016 Mar 10.


Paracoccidioides spp. ferrous and ferric iron assimilation pathways.

Bailão EF, Lima Pde S, Silva-Bailão MG, Bailão AM, Fernandes Gda R, Kosman DJ, Soares CM.

Front Microbiol. 2015 Aug 12;6:821. doi: 10.3389/fmicb.2015.00821. eCollection 2015.


Mechanisms and regulation of iron trafficking across the capillary endothelial cells of the blood-brain barrier.

McCarthy RC, Kosman DJ.

Front Mol Neurosci. 2015 Jul 14;8:31. doi: 10.3389/fnmol.2015.00031. eCollection 2015. Review.


Molecular mechanisms of non-transferrin-bound and transferring-bound iron uptake in primary hippocampal neurons.

Ji C, Kosman DJ.

J Neurochem. 2015 Jun;133(5):668-83. doi: 10.1111/jnc.13040. Epub 2015 Mar 10.


Iron transport across the blood-brain barrier: development, neurovascular regulation and cerebral amyloid angiopathy.

McCarthy RC, Kosman DJ.

Cell Mol Life Sci. 2015 Feb;72(4):709-27. doi: 10.1007/s00018-014-1771-4. Epub 2014 Oct 30. Review.


sAPP modulates iron efflux from brain microvascular endothelial cells by stabilizing the ferrous iron exporter ferroportin.

McCarthy RC, Park YH, Kosman DJ.

EMBO Rep. 2014 Jul;15(7):809-15. doi: 10.15252/embr.201338064. Epub 2014 May 27.


Glial cell ceruloplasmin and hepcidin differentially regulate iron efflux from brain microvascular endothelial cells.

McCarthy RC, Kosman DJ.

PLoS One. 2014 Feb 12;9(2):e89003. doi: 10.1371/journal.pone.0089003. eCollection 2014.


Ferroportin and exocytoplasmic ferroxidase activity are required for brain microvascular endothelial cell iron efflux.

McCarthy RC, Kosman DJ.

J Biol Chem. 2013 Jun 14;288(24):17932-40. doi: 10.1074/jbc.M113.455428. Epub 2013 May 2.


Modified reactivity toward O2 in first shell variants of Fet3p: geometric and electronic structure requirements for a functioning trinuclear copper cluster.

Kjaergaard CH, Qayyum MF, Augustine AJ, Ziegler L, Kosman DJ, Hodgson KO, Hedman B, Solomon EI.

Biochemistry. 2013 May 28;52(21):3702-11. doi: 10.1021/bi4002826. Epub 2013 May 15.


Mechanistic analysis of iron accumulation by endothelial cells of the BBB.

McCarthy RC, Kosman DJ.

Biometals. 2012 Aug;25(4):665-75. doi: 10.1007/s10534-012-9538-6. Epub 2012 Mar 21.


Gene length may contribute to graded transcriptional responses in the Drosophila embryo.

McHale P, Mizutani CM, Kosman D, MacKay DL, Belu M, Hermann A, McGinnis W, Bier E, Hwa T.

Dev Biol. 2011 Dec 1;360(1):230-40. doi: 10.1016/j.ydbio.2011.08.016. Epub 2011 Sep 3.


Transport: Plutonium's Trojan horse.

Kosman DJ.

Nat Chem Biol. 2011 Jul 18;7(8):498-9. doi: 10.1038/nchembio.616. No abstract available.


Functional characterization of the ferroxidase, permease high-affinity iron transport complex from Candida albicans.

Ziegler L, Terzulli A, Gaur R, McCarthy R, Kosman DJ.

Mol Microbiol. 2011 Jul;81(2):473-85. doi: 10.1111/j.1365-2958.2011.07704.x. Epub 2011 Jun 7.


NMR study of the exchange coupling in the trinuclear cluster of the multicopper oxidase Fet3p.

Zaballa ME, Ziegler L, Kosman DJ, Vila AJ.

J Am Chem Soc. 2010 Aug 18;132(32):11191-6. doi: 10.1021/ja1037148.


Core glycan in the yeast multicopper ferroxidase, Fet3p: a case study of N-linked glycosylation, protein maturation, and stability.

Ziegler L, Terzulli A, Sedlak E, Kosman DJ.

Protein Sci. 2010 Sep;19(9):1739-50. doi: 10.1002/pro.457.


Redox cycling in iron uptake, efflux, and trafficking.

Kosman DJ.

J Biol Chem. 2010 Aug 27;285(35):26729-35. doi: 10.1074/jbc.R110.113217. Epub 2010 Jun 3. Review.


Systematic perturbation of the trinuclear copper cluster in the multicopper oxidases: the role of active site asymmetry in its reduction of O2 to H2O.

Augustine AJ, Kjaergaard C, Qayyum M, Ziegler L, Kosman DJ, Hodgson KO, Hedman B, Solomon EI.

J Am Chem Soc. 2010 May 5;132(17):6057-67. doi: 10.1021/ja909143d.


Analysis of the high-affinity iron uptake system at the Chlamydomonas reinhardtii plasma membrane.

Terzulli A, Kosman DJ.

Eukaryot Cell. 2010 May;9(5):815-26. doi: 10.1128/EC.00310-09. Epub 2010 Mar 26.


Visualization of individual Scr mRNAs during Drosophila embryogenesis yields evidence for transcriptional bursting.

Paré A, Lemons D, Kosman D, Beaver W, Freund Y, McGinnis W.

Curr Biol. 2009 Dec 15;19(23):2037-42. doi: 10.1016/j.cub.2009.10.028.


Illustrating the steady-state condition and the single-molecule kinetic method with the NMDA receptor.

Kosman DJ.

Biochem Mol Biol Educ. 2009 Nov;37(6):333-8. doi: 10.1002/bmb.20327.


Multicopper oxidases: a workshop on copper coordination chemistry, electron transfer, and metallophysiology.

Kosman DJ.

J Biol Inorg Chem. 2010 Jan;15(1):15-28. doi: 10.1007/s00775-009-0590-9. Epub 2009 Oct 9. Review.


In vitro unfolding of yeast multicopper oxidase Fet3p variants reveals unique role of each metal site.

Sedlák E, Ziegler L, Kosman DJ, Wittung-Stafshede P.

Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19258-63. doi: 10.1073/pnas.0806431105. Epub 2008 Nov 25.


The Fox1 ferroxidase of Chlamydomonas reinhardtii: a new multicopper oxidase structural paradigm.

Terzulli AJ, Kosman DJ.

J Biol Inorg Chem. 2009 Feb;14(2):315-25. doi: 10.1007/s00775-008-0450-z. Epub 2008 Nov 21.


Iron source preference and regulation of iron uptake in Cryptococcus neoformans.

Jung WH, Sham A, Lian T, Singh A, Kosman DJ, Kronstad JW.

PLoS Pathog. 2008 Feb 8;4(2):e45. doi: 10.1371/journal.ppat.0040045.


Spectroscopic studies of perturbed T1 Cu sites in the multicopper oxidases Saccharomyces cerevisiae Fet3p and Rhus vernicifera laccase: allosteric coupling between the T1 and trinuclear Cu sites.

Augustine AJ, Kragh ME, Sarangi R, Fujii S, Liboiron BD, Stoj CS, Kosman DJ, Hodgson KO, Hedman B, Solomon EI.

Biochemistry. 2008 Feb 19;47(7):2036-45. doi: 10.1021/bi7020052. Epub 2008 Jan 16.


Characterization of the Drosophila segment determination morphome.

Surkova S, Kosman D, Kozlov K, Manu, Myasnikova E, Samsonova AA, Spirov A, Vanario-Alonso CE, Samsonova M, Reinitz J.

Dev Biol. 2008 Jan 15;313(2):844-62. Epub 2007 Nov 4.


Spectroscopic and kinetic studies of perturbed trinuclear copper clusters: the role of protons in reductive cleavage of the O-O bond in the multicopper oxidase Fet3p.

Augustine AJ, Quintanar L, Stoj CS, Kosman DJ, Solomon EI.

J Am Chem Soc. 2007 Oct 31;129(43):13118-26. Epub 2007 Oct 5.


The metalloreductase Fre6p in Fe-efflux from the yeast vacuole.

Singh A, Kaur N, Kosman DJ.

J Biol Chem. 2007 Sep 28;282(39):28619-26. Epub 2007 Aug 5.


Shall we dance? How a multicopper oxidase chooses its electron transfer partner.

Quintanar L, Stoj C, Taylor AB, Hart PJ, Kosman DJ, Solomon EI.

Acc Chem Res. 2007 Jun;40(6):445-52. Epub 2007 Apr 11.


Structure-function analysis of the cuprous oxidase activity in Fet3p from Saccharomyces cerevisiae.

Stoj CS, Augustine AJ, Solomon EI, Kosman DJ.

J Biol Chem. 2007 Mar 16;282(11):7862-8. Epub 2007 Jan 12.


Structural basis of the ferrous iron specificity of the yeast ferroxidase, Fet3p.

Stoj CS, Augustine AJ, Zeigler L, Solomon EI, Kosman DJ.

Biochemistry. 2006 Oct 24;45(42):12741-9.


Computational identification of Ftz/Ftz-F1 downstream target genes.

Bowler T, Kosman D, Licht JD, Pick L.

Dev Biol. 2006 Nov 1;299(1):78-90. Epub 2006 Jul 12.


Analysis of pattern precision shows that Drosophila segmentation develops substantial independence from gradients of maternal gene products.

Holloway DM, Harrison LG, Kosman D, Vanario-Alonso CE, Spirov AV.

Dev Dyn. 2006 Nov;235(11):2949-60.


Evidence for iron channeling in the Fet3p-Ftr1p high-affinity iron uptake complex in the yeast plasma membrane.

Kwok EY, Severance S, Kosman DJ.

Biochemistry. 2006 May 23;45(20):6317-27.


Assembly, activation, and trafficking of the Fet3p.Ftr1p high affinity iron permease complex in Saccharomyces cerevisiae.

Singh A, Severance S, Kaur N, Wiltsie W, Kosman DJ.

J Biol Chem. 2006 May 12;281(19):13355-64. Epub 2006 Mar 7.


An engineered bifunctional high affinity iron uptake protein in the yeast plasma membrane.

Kwok EY, Stoj CS, Severance S, Kosman DJ.

J Inorg Biochem. 2006 May;100(5-6):1053-60. Epub 2006 Jan 4.


The copper-iron connection in biology: structure of the metallo-oxidase Fet3p.

Taylor AB, Stoj CS, Ziegler L, Kosman DJ, Hart PJ.

Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15459-64. Epub 2005 Oct 17.


Role of aspartate 94 in the decay of the peroxide intermediate in the multicopper oxidase Fet3p.

Quintanar L, Stoj C, Wang TP, Kosman DJ, Solomon EI.

Biochemistry. 2005 Apr 26;44(16):6081-91.


A high-throughput method for quantifying gene expression data from early Drosophila embryos.

Janssens H, Kosman D, Vanario-Alonso CE, Jaeger J, Samsonova M, Reinitz J.

Dev Genes Evol. 2005 Jul;215(7):374-81. Epub 2005 Apr 15.


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