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Items: 1 to 50 of 175

1.

Synthetic phosphodiester-linked 4-amino-4-deoxy-L-arabinose derivatives demonstrate ArnT is an inverting aminoarabinosyl transferase.

Olagnon C, Feria JM, Grünwald-Gruber C, Blaukopf M, Valvano M, Kosma P.

Chembiochem. 2019 Jun 24. doi: 10.1002/cbic.201900349. [Epub ahead of print]

PMID:
31233657
2.

ADP heptose, a novel pathogen-associated molecular pattern identified in Helicobacter pylori.

Pfannkuch L, Hurwitz R, Traulsen J, Sigulla J, Poeschke M, Matzner L, Kosma P, Schmid M, Meyer TF.

FASEB J. 2019 Aug;33(8):9087-9099. doi: 10.1096/fj.201802555R. Epub 2019 Jun 21.

3.

Synthesis of an Undecasaccharide Featuring an Oligomannosidic Heptasaccharide and a Bacterial Kdo-lipid A Backbone for Eliciting Neutralizing Antibodies to Mammalian Oligomannose on the HIV-1 Envelope Spike.

Trattnig N, Blaukopf M, Bruxelle JF, Pantophlet R, Kosma P.

J Am Chem Soc. 2019 May 15;141(19):7946-7954. doi: 10.1021/jacs.9b02872. Epub 2019 Apr 30.

4.

Subtle Changes in the Combining Site of the Chlamydiaceae-Specific mAb S25-23 Increase the Antibody-Carbohydrate Binding Affinity by an Order of Magnitude.

Haji-Ghassemi O, Müller-Loennies S, Brooks CL, MacKenzie CR, Caveney N, Van Petegem F, Brade L, Kosma P, Brade H, Evans SV.

Biochemistry. 2019 Feb 12;58(6):714-726. doi: 10.1021/acs.biochem.8b00318. Epub 2019 Jan 10.

PMID:
30571096
5.

Comparative Antigenicity of Thiourea and Adipic Amide Linked Neoglycoconjugates Containing Modified Oligomannose Epitopes for the Carbohydrate-Specific anti-HIV Antibody 2G12.

Trattnig N, Mayrhofer P, Kunert R, Mach L, Pantophlet R, Kosma P.

Bioconjug Chem. 2019 Jan 16;30(1):70-82. doi: 10.1021/acs.bioconjchem.8b00731. Epub 2018 Dec 28.

6.

Insights into Heptosyltransferase I Catalysis and Inhibition through the Structure of Its Ternary Complex.

Blaukopf M, Worrall L, Kosma P, Strynadka NCJ, Withers SG.

Structure. 2018 Oct 2;26(10):1399-1407.e5. doi: 10.1016/j.str.2018.07.001. Epub 2018 Aug 16.

PMID:
30122450
7.

Structural basis of cell wall anchoring by SLH domains in Paenibacillus alvei.

Blackler RJ, López-Guzmán A, Hager FF, Janesch B, Martinz G, Gagnon SML, Haji-Ghassemi O, Kosma P, Messner P, Schäffer C, Evans SV.

Nat Commun. 2018 Aug 7;9(1):3120. doi: 10.1038/s41467-018-05471-3.

8.

Functional Characterization of Enzymatic Steps Involved in Pyruvylation of Bacterial Secondary Cell Wall Polymer Fragments.

Hager FF, López-Guzmán A, Krauter S, Blaukopf M, Polter M, Brockhausen I, Kosma P, Schäffer C.

Front Microbiol. 2018 Jun 27;9:1356. doi: 10.3389/fmicb.2018.01356. eCollection 2018.

9.

Lipoteichoic acid mediates binding of a Lactobacillus S-layer protein.

Bönisch E, Oh YJ, Anzengruber J, Hager FF, López-Guzmán A, Zayni S, Hinterdorfer P, Kosma P, Messner P, Duda KA, Schäffer C.

Glycobiology. 2018 Mar 1;28(3):148-158. doi: 10.1093/glycob/cwx102.

10.

Bacterially derived synthetic mimetics of mammalian oligomannose prime antibody responses that neutralize HIV infectivity.

Pantophlet R, Trattnig N, Murrell S, Lu N, Chau D, Rempel C, Wilson IA, Kosma P.

Nat Commun. 2017 Nov 17;8(1):1601. doi: 10.1038/s41467-017-01640-y.

11.

2,4,5-Trihydroxy-3-methylacetophenone: A Cellulosic Chromophore as a Case Study of Aromaticity.

Zwirchmayr NS, Elder T, Bacher M, Hofinger-Horvath A, Kosma P, Rosenau T.

ACS Omega. 2017 Nov 15;2(11):7929-7935. doi: 10.1021/acsomega.7b00874. eCollection 2017 Nov 30.

12.

Synthesis of a Pentasaccharide Fragment Related to the Inner Core Region of Rhizobial and Agrobacterial Lipopolysaccharides.

Trattnig N, Farcet JB, Gritsch P, Christler A, Pantophlet R, Kosma P.

J Org Chem. 2017 Dec 1;82(23):12346-12358. doi: 10.1021/acs.joc.7b02172. Epub 2017 Oct 26.

13.

ALPK1- and TIFA-Dependent Innate Immune Response Triggered by the Helicobacter pylori Type IV Secretion System.

Zimmermann S, Pfannkuch L, Al-Zeer MA, Bartfeld S, Koch M, Liu J, Rechner C, Soerensen M, Sokolova O, Zamyatina A, Kosma P, Mäurer AP, Glowinski F, Pleissner KP, Schmid M, Brinkmann V, Karlas A, Naumann M, Rother M, Machuy N, Meyer TF.

Cell Rep. 2017 Sep 5;20(10):2384-2395. doi: 10.1016/j.celrep.2017.08.039.

14.

Synthesis of 3-O- and 4-O-(2-aminoethylphosphono) derivatives of methyl l-glycero-α-d-manno-heptopyranoside.

Walter M, Kohout C, Blaukopf M, Kosma P.

Monatsh Chem. 2017;148(1):111-119. doi: 10.1007/s00706-016-1868-6. Epub 2016 Dec 8.

15.

Stereoselective Synthesis of α- and β-l-Ara4N Glycosyl H-Phosphonates and a Neoglycoconjugate Comprising Glycosyl Phosphodiester Linked β-l-Ara4N.

Hollaus R, Kosma P, Zamyatina A.

Org Lett. 2017 Jan 6;19(1):78-81. doi: 10.1021/acs.orglett.6b03358. Epub 2016 Dec 23.

16.

Genome Analysis and Characterisation of the Exopolysaccharide Produced by Bifidobacterium longum subsp. longum 35624™.

Altmann F, Kosma P, O'Callaghan A, Leahy S, Bottacini F, Molloy E, Plattner S, Schiavi E, Gleinser M, Groeger D, Grant R, Rodriguez Perez N, Healy S, Svehla E, Windwarder M, Hofinger A, O'Connell Motherway M, Akdis CA, Xu J, Roper J, van Sinderen D, O'Mahony L.

PLoS One. 2016 Sep 22;11(9):e0162983. doi: 10.1371/journal.pone.0162983. eCollection 2016.

17.

"Hypermethylation" of anthranilic acid-labeled sugars confers the selectivity required for liquid chromatography-mass spectrometry.

Windwarder M, Figl R, Svehla E, Mócsai RT, Farcet JB, Staudacher E, Kosma P, Altmann F.

Anal Biochem. 2016 Dec 1;514:24-31. doi: 10.1016/j.ab.2016.09.008. Epub 2016 Sep 14.

PMID:
27640150
18.

Reaction of Oxidized Polysialic Acid and a Diaminooxy Linker: Characterization and Process Optimization Using Nuclear Magnetic Resonance Spectroscopy.

Ray GJ, Siekmann J, Scheinecker R, Zhang Z, Gerasimov MV, Szabo CM, Kosma P.

Bioconjug Chem. 2016 Sep 21;27(9):2071-80. doi: 10.1021/acs.bioconjchem.6b00336. Epub 2016 Sep 9.

PMID:
27506297
19.

Correction to Complete Structural Elucidation of an Oxidized Polysialic Acid Drug Intermediate by Nuclear Magnetic Resonance Spectroscopy.

Ray GJ, Ravenscroft N, Siekmann J, Zhang Z, Sanders P, Shaligram U, Szabo CM, Kosma P.

Bioconjug Chem. 2016 Aug 17;27(8):1958. doi: 10.1021/acs.bioconjchem.6b00335. Epub 2016 Jul 22. No abstract available.

PMID:
27447785
20.

Predictors of RSV LRTI Hospitalization in Infants Born at 33 to 35 Weeks Gestational Age: A Large Multinational Study (PONI).

Straňák Z, Saliba E, Kosma P, Posfay-Barbe K, Yunis K, Farstad T, Unnebrink K, van Wyk J, Wegzyn C, Notario G, Kalus S, Campbell FJ.

PLoS One. 2016 Jun 16;11(6):e0157446. doi: 10.1371/journal.pone.0157446. eCollection 2016.

21.

Scope and Limitations of 3-Iodo-Kdo Fluoride-Based Glycosylation Chemistry using N-Acetyl Glucosamine Acceptors.

Pokorny B, Kosma P.

ChemistryOpen. 2015 Jul 29;4(6):722-8. doi: 10.1002/open.201500126. eCollection 2015 Dec.

22.

Progress in Kdo-glycoside chemistry.

Kosma P.

Tetrahedron Lett. 2016 May 18;57(20):2133-2142.

23.

Development of a multifunctional aminoxy-based fluorescent linker for glycan immobilization and analysis.

Jiménez-Castells C, Stanton R, Yan S, Kosma P, Wilson IB.

Glycobiology. 2016 Dec;26(12):1297-1307. Epub 2016 May 24.

24.

Cellobiohydrolases Produce Different Oligosaccharides from Chitosan.

Tegl G, Öhlknecht C, Vielnascher R, Rollett A, Hofinger-Horvath A, Kosma P, Guebitz GM.

Biomacromolecules. 2016 Jun 13;17(6):2284-92. doi: 10.1021/acs.biomac.6b00547. Epub 2016 May 31.

PMID:
27214513
25.

Transferase Activity of Lactobacillal and Bifidobacterial β-Galactosidases with Various Sugars as Galactosyl Acceptors.

Arreola SL, Intanon M, Wongputtisin P, Kosma P, Haltrich D, Nguyen TH.

J Agric Food Chem. 2016 Mar 30;64(12):2604-11. doi: 10.1021/acs.jafc.5b06009. Epub 2016 Mar 21.

26.

Evaluation of a di-O-methylated glycan as a potential antigenic target for the serodiagnosis of human toxocariasis.

Elefant GR, Roldán WH, Seeböck A, Kosma P.

Parasite Immunol. 2016 Apr;38(4):236-43. doi: 10.1111/pim.12311.

27.

Synthesis of 5-O-oligoglucosyl extended α-(2→4)-Kdo disaccharides corresponding to inner core fragments of Moraxellaceae lipopolysaccharides.

Pokorny B, Kosma P.

Carbohydr Res. 2016 Mar 3;422:5-12. doi: 10.1016/j.carres.2015.12.009. Epub 2016 Jan 5.

28.

Unraveling the B. pseudomallei Heptokinase WcbL: From Structure to Drug Discovery.

Vivoli M, Isupov MN, Nicholas R, Hill A, Scott AE, Kosma P, Prior JL, Harmer NJ.

Chem Biol. 2015 Dec 17;22(12):1622-32. doi: 10.1016/j.chembiol.2015.10.015.

29.

Structural Basis for Antibody Recognition of Lipid A: INSIGHTS TO POLYSPECIFICITY TOWARD SINGLE-STRANDED DNA.

Haji-Ghassemi O, Müller-Loennies S, Rodriguez T, Brade L, Kosma P, Brade H, Evans SV.

J Biol Chem. 2015 Aug 7;290(32):19629-40. doi: 10.1074/jbc.M115.657874. Epub 2015 Jun 17.

30.

Theoretical study on the effects of a 4,6-O-diacetal protecting group on the stability of ion pairs from D-mannopyranosyl and D-glucopyranosyl triflates.

Hosoya T, Kosma P, Rosenau T.

Carbohydr Res. 2015 Jun 26;411:64-9. doi: 10.1016/j.carres.2015.03.010. Epub 2015 Mar 24.

PMID:
25981459
31.

Chemical synthesis of Burkholderia Lipid A modified with glycosyl phosphodiester-linked 4-amino-4-deoxy-β-L-arabinose and its immunomodulatory potential.

Hollaus R, Ittig S, Hofinger A, Haegman M, Beyaert R, Kosma P, Zamyatina A.

Chemistry. 2015 Mar 2;21(10):4102-14. doi: 10.1002/chem.201406058. Epub 2015 Jan 28.

32.

UDP-sulfoquinovose formation by Sulfolobus acidocaldarius.

Zolghadr B, Gasselhuber B, Windwarder M, Pabst M, Kracher D, Kerndl M, Zayni S, Hofinger-Horvath A, Ludwig R, Haltrich D, Oostenbrink C, Obinger C, Kosma P, Messner P, Schäffer C.

Extremophiles. 2015 Mar;19(2):451-67. doi: 10.1007/s00792-015-0730-9. Epub 2015 Jan 21.

33.

Contact ion pairs and solvent-separated ion pairs from D-mannopyranosyl and D-glucopyranosyl triflates.

Hosoya T, Kosma P, Rosenau T.

Carbohydr Res. 2015 Jan 12;401:127-31. doi: 10.1016/j.carres.2014.10.013. Epub 2014 Oct 27.

PMID:
25497129
34.

First and stereoselective synthesis of an α-(2→5)-linked disaccharide of 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo).

Pokorny B, Kosma P.

Org Lett. 2015 Jan 2;17(1):110-3. doi: 10.1021/ol5033128. Epub 2014 Dec 12.

35.

A novel method to analyze the degree of acetylation in biopolymers.

Zweckmair T, Becker M, Ahn K, Hettegger H, Kosma P, Rosenau T, Potthast A.

J Chromatogr A. 2014 Dec 12;1372C:212-220. doi: 10.1016/j.chroma.2014.10.082. Epub 2014 Oct 31.

PMID:
25465018
36.

Anti-endotoxic activity and structural basis for human MD-2·TLR4 antagonism of tetraacylated lipid A mimetics based on βGlcN(1↔1)αGlcN scaffold.

Garate JA, Stöckl J, Fernández-Alonso Mdel C, Artner D, Haegman M, Oostenbrink C, Jiménez-Barbero J, Beyaert R, Heine H, Kosma P, Zamyatina A.

Innate Immun. 2015 Jul;21(5):490-503. doi: 10.1177/1753425914550426. Epub 2014 Nov 13.

37.

Synthesis of chlamydia lipopolysaccharide haptens through the use of α-specific 3-iodo-Kdo fluoride glycosyl donors.

Pokorny B, Kosma P.

Chemistry. 2015 Jan 2;21(1):305-13. doi: 10.1002/chem.201405424. Epub 2014 Oct 29.

38.

Development of αGlcN(1↔1)αMan-based lipid A mimetics as a novel class of potent Toll-like receptor 4 agonists.

Adanitsch F, Ittig S, Stöckl J, Oblak A, Haegman M, Jerala R, Beyaert R, Kosma P, Zamyatina A.

J Med Chem. 2014 Oct 9;57(19):8056-71. doi: 10.1021/jm500946r. Epub 2014 Sep 25.

39.

Theoretical foundation for the presence of oxacarbenium ions in chemical glycoside synthesis.

Hosoya T, Takano T, Kosma P, Rosenau T.

J Org Chem. 2014 Sep 5;79(17):7889-94. doi: 10.1021/jo501012s. Epub 2014 Aug 18.

PMID:
25105663
40.

Two β-galactosidases from the human isolate Bifidobacterium breve DSM 20213: molecular cloning and expression, biochemical characterization and synthesis of galacto-oligosaccharides.

Arreola SL, Intanon M, Suljic J, Kittl R, Pham NH, Kosma P, Haltrich D, Nguyen TH.

PLoS One. 2014 Aug 4;9(8):e104056. doi: 10.1371/journal.pone.0104056. eCollection 2014.

41.

Synthesis of zwitterionic 1,1'-glycosylphosphodiester: a partial structure of galactosamine-modified Francisella lipid A.

Baum D, Kosma P, Zamyatina A.

Org Lett. 2014 Jul 18;16(14):3772-5. doi: 10.1021/ol501639c. Epub 2014 Jul 8.

42.
43.

Groove-type recognition of chlamydiaceae-specific lipopolysaccharide antigen by a family of antibodies possessing an unusual variable heavy chain N-linked glycan.

Haji-Ghassemi O, Müller-Loennies S, Saldova R, Muniyappa M, Brade L, Rudd PM, Harvey DJ, Kosma P, Brade H, Evans SV.

J Biol Chem. 2014 Jun 13;289(24):16644-61. doi: 10.1074/jbc.M113.528224. Epub 2014 Mar 28.

44.

Complete structural elucidation of an oxidized polysialic acid drug intermediate by nuclear magnetic resonance spectroscopy.

Ray GJ, Ravenscroft N, Siekmann J, Zhang Z, Sanders P, Shaligram U, Szabo CM, Kosma P.

Bioconjug Chem. 2014 Apr 16;25(4):665-76. doi: 10.1021/bc400456g. Epub 2014 Mar 28. Erratum in: Bioconjug Chem. 2016 Aug 17;27(8):1958.

PMID:
24679150
46.

Bacterial cell-envelope glycoconjugates.

Messner P, Schäffer C, Kosma P.

Adv Carbohydr Chem Biochem. 2013;69:209-72. doi: 10.1016/B978-0-12-408093-5.00006-X. Review.

47.

Respiratory infections in preterm infants and subsequent asthma: a cohort study.

Montgomery S, Bahmanyar S, Brus O, Hussein O, Kosma P, Palme-Kilander C.

BMJ Open. 2013 Oct 29;3(10):e004034. doi: 10.1136/bmjopen-2013-004034.

48.

Conformationally constrained lipid A mimetics for exploration of structural basis of TLR4/MD-2 activation by lipopolysaccharide.

Artner D, Oblak A, Ittig S, Garate JA, Horvat S, Arrieumerlou C, Hofinger A, Oostenbrink C, Jerala R, Kosma P, Zamyatina A.

ACS Chem Biol. 2013 Nov 15;8(11):2423-32. doi: 10.1021/cb4003199. Epub 2013 Sep 26.

50.

4-({(Z)-5-[(Z)-3-Eth-oxy-4-hy-droxy-benzyl-idene]-3-methyl-4-oxo-1,3-thia-zolidin-2-yl-idene}amino)-benzoic acid dimethyl-formamide monosolvate.

Kosma P, Selzer E, Mereiter K.

Acta Crystallogr Sect E Struct Rep Online. 2012 Dec 1;68(Pt 12):o3417-8. doi: 10.1107/S1600536812047307. Epub 2012 Nov 24.

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