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Items: 25


RGS6 and RGS7 Discriminate between the Highly Similar Gαi and Gαo Proteins Using a Two-Tiered Specificity Strategy.

Israeli R, Asli A, Avital-Shacham M, Kosloff M.

J Mol Biol. 2019 Aug 9;431(17):3302-3311. doi: 10.1016/j.jmb.2019.05.037. Epub 2019 May 30.


Structural design principles that underlie the multi-specific interactions of Gαq with dissimilar partners.

Navot S, Kosloff M.

Sci Rep. 2019 May 3;9(1):6898. doi: 10.1038/s41598-019-43395-0.


Author Correction: RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells.

Qutob N, Masuho I, Alon M, Emmanuel R, Cohen I, Di Pizio A, Madore J, Elkahloun A, Ziv T, Levy R, Gartner JJ, Hill VK, Lin JC, Hevroni Y, Greenberg P, Brodezki A, Rosenberg SA, Kosloff M, Hayward NK, Admon A, Niv MY, Scolyer RA, Martemyanov KA, Samuels Y.

Sci Rep. 2019 Mar 9;9(1):4523. doi: 10.1038/s41598-018-37932-6.


Residue-level determinants of angiopoietin-2 interactions with its receptor Tie2.

Bakhman A, Rabinovich E, Shlamkovich T, Papo N, Kosloff M.

Proteins. 2019 Mar;87(3):185-197. doi: 10.1002/prot.25638. Epub 2018 Dec 21.


Structural motifs in the RGS RZ subfamily combine to attenuate interactions with Gα subunits.

Salem-Mansour D, Asli A, Avital-Shacham M, Kosloff M.

Biochem Biophys Res Commun. 2018 Sep 18;503(4):2736-2741. doi: 10.1016/j.bbrc.2018.08.033. Epub 2018 Aug 13.


Neofunctionalization in Ligand Binding Sites of Ant Olfactory Receptors.

Saad R, Cohanim AB, Kosloff M, Privman E.

Genome Biol Evol. 2018 Sep 1;10(9):2490-2500. doi: 10.1093/gbe/evy131.


Interplay between negative and positive design elements in Gα helical domains of G proteins determines interaction specificity toward RGS2.

Kasom M, Gharra S, Sadiya I, Avital-Shacham M, Kosloff M.

Biochem J. 2018 Jul 26;475(14):2293-2304. doi: 10.1042/BCJ20180285.


"Disruptor" residues in the regulator of G protein signaling (RGS) R12 subfamily attenuate the inactivation of Gα subunits.

Asli A, Sadiya I, Avital-Shacham M, Kosloff M.

Sci Signal. 2018 Jun 12;11(534). pii: eaan3677. doi: 10.1126/scisignal.aan3677.


Refinement of the endogenous epitope tagging technology allows the identification of a novel NRAS binding partner in melanoma.

Alon M, Emmanuel R, Qutob N, Bakhman A, Peshti V, Brodezki A, Bassan D, Kosloff M, Samuels Y.

Pigment Cell Melanoma Res. 2018 Sep;31(5):641-648. doi: 10.1111/pcmr.12705. Epub 2018 May 16.


RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells.

Qutob N, Masuho I, Alon M, Emmanuel R, Cohen I, Di Pizio A, Madore J, Elkahloun A, Ziv T, Levy R, Gartner JJ, Hill VK, Lin JC, Hevroni Y, Greenberg P, Brodezki A, Rosenberg SA, Kosloff M, Hayward NK, Admon A, Niv MY, Scolyer RA, Martemyanov KA, Samuels Y.

Sci Rep. 2018 Jan 12;8(1):653. doi: 10.1038/s41598-017-18851-4. Erratum in: Sci Rep. 2019 Mar 9;9(1):4523.


Engineering a monomeric variant of macrophage colony-stimulating factor (M-CSF) that antagonizes the c-FMS receptor.

Zur Y, Rosenfeld L, Bakhman A, Ilic S, Hayun H, Shahar A, Akabayov B, Kosloff M, Levaot N, Papo N.

Biochem J. 2017 Jul 20;474(15):2601-2617. doi: 10.1042/BCJ20170276.


Identifying Residues that Determine SCF Molecular-Level Interactions through a Combination of Experimental and In silico Analyses.

Rabinovich E, Heyne M, Bakhman A, Kosloff M, Shifman JM, Papo N.

J Mol Biol. 2017 Jan 6;429(1):97-114. doi: 10.1016/j.jmb.2016.11.018. Epub 2016 Nov 25.


Regulator of G-protein signaling-21 (RGS21) is an inhibitor of bitter gustatory signaling found in lingual and airway epithelia.

Cohen SP, Buckley BK, Kosloff M, Garland AL, Bosch DE, Cheng G Jr, Radhakrishna H, Brown MD, Willard FS, Arshavsky VY, Tarran R, Siderovski DP, Kimple AJ.

J Biol Chem. 2012 Dec 7;287(50):41706-19. doi: 10.1074/jbc.M112.423806. Epub 2012 Oct 24.


Compartmentalization and Ca2+ buffering are essential for prevention of light-induced retinal degeneration.

Weiss S, Kohn E, Dadon D, Katz B, Peters M, Lebendiker M, Kosloff M, Colley NJ, Minke B.

J Neurosci. 2012 Oct 17;32(42):14696-708. doi: 10.1523/JNEUROSCI.2456-12.2012.


Cooperative phosphoinositide and peptide binding by PSD-95/discs large/ZO-1 (PDZ) domain of polychaetoid, Drosophila zonulin.

Ivarsson Y, Wawrzyniak AM, Wuytens G, Kosloff M, Vermeiren E, Raport M, Zimmermann P.

J Biol Chem. 2011 Dec 30;286(52):44669-78. doi: 10.1074/jbc.M111.285734. Epub 2011 Oct 27.


Integrating energy calculations with functional assays to decipher the specificity of G protein-RGS protein interactions.

Kosloff M, Travis AM, Bosch DE, Siderovski DP, Arshavsky VY.

Nat Struct Mol Biol. 2011 Jun 19;18(7):846-53. doi: 10.1038/nsmb.2068.


PLoS Computational Biology conference postcards from ISMB 2010.

Chalancon G, Kosloff M, Osmanbeyoglu HU, Saraswathi S.

PLoS Comput Biol. 2010 Nov 11;6(11):e1002000. doi: 10.1371/journal.pcbi.1002000. No abstract available.


Electrostatic and lipid anchor contributions to the interaction of transducin with membranes: mechanistic implications for activation and translocation.

Kosloff M, Alexov E, Arshavsky VY, Honig B.

J Biol Chem. 2008 Nov 7;283(45):31197-207. doi: 10.1074/jbc.M803799200. Epub 2008 Sep 9.


Sequence-similar, structure-dissimilar protein pairs in the PDB.

Kosloff M, Kolodny R.

Proteins. 2008 May 1;71(2):891-902.


Comparative structural analysis of a novel glutathioneS-transferase (ATU5508) from Agrobacterium tumefaciens at 2.0 A resolution.

Kosloff M, Han GW, Krishna SS, Schwarzenbacher R, Fasnacht M, Elsliger MA, Abdubek P, Agarwalla S, Ambing E, Astakhova T, Axelrod HL, Canaves JM, Carlton D, Chiu HJ, Clayton T, DiDonato M, Duan L, Feuerhelm J, Grittini C, Grzechnik SK, Hale J, Hampton E, Haugen J, Jaroszewski L, Jin KK, Johnson H, Klock HE, Knuth MW, Koesema E, Kreusch A, Kuhn P, Levin I, McMullan D, Miller MD, Morse AT, Moy K, Nigoghossian E, Okach L, Oommachen S, Page R, Paulsen J, Quijano K, Reyes R, Rife CL, Sims E, Spraggon G, Sridhar V, Stevens RC, van den Bedem H, Velasquez J, White A, Wolf G, Xu Q, Hodgson KO, Wooley J, Deacon AM, Godzik A, Lesley SA, Wilson IA.

Proteins. 2006 Nov 15;65(3):527-37.


GTPase catalysis by Ras and other G-proteins: insights from Substrate Directed SuperImposition.

Kosloff M, Selinger Z.

J Mol Biol. 2003 Aug 29;331(5):1157-70.


Regulation of light-dependent Gqalpha translocation and morphological changes in fly photoreceptors.

Kosloff M, Elia N, Joel-Almagor T, Timberg R, Zars TD, Hyde DR, Minke B, Selinger Z.

EMBO J. 2003 Feb 3;22(3):459-68.


Structural homology discloses a bifunctional structural motif at the N-termini of G alpha proteins.

Kosloff M, Elia N, Selinger Z.

Biochemistry. 2002 Dec 10;41(49):14518-23.


Substrate assisted catalysis -- application to G proteins.

Kosloff M, Selinger Z.

Trends Biochem Sci. 2001 Mar;26(3):161-6. Review.


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