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Items: 14

1.

AG-348 (Mitapivat), an allosteric activator of red blood cell pyruvate kinase, increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes.

Rab MAE, van Oirschot BA, Kosinski PA, Hixon J, Johnson K, Chubukov V, Dang L, Pasterkamp G, van Straaten S, van Solinge WW, van Beers EJ, Kung C, van Wijk R.

Haematologica. 2020 Jan 23. pii: haematol.2019.238865. doi: 10.3324/haematol.2019.238865. [Epub ahead of print]

2.

Metabolic Profiling Using Stable Isotope Tracing Reveals Distinct Patterns of Glucose Utilization by Physiologically Activated CD8+ T Cells.

Ma EH, Verway MJ, Johnson RM, Roy DG, Steadman M, Hayes S, Williams KS, Sheldon RD, Samborska B, Kosinski PA, Kim H, Griss T, Faubert B, Condotta SA, Krawczyk CM, DeBerardinis RJ, Stewart KM, Richer MJ, Chubukov V, Roddy TP, Jones RG.

Immunity. 2019 Nov 19;51(5):856-870.e5. doi: 10.1016/j.immuni.2019.09.003. Epub 2019 Oct 10.

PMID:
31747582
3.

Phase 1 Single- and Multiple-Ascending-Dose Randomized Studies of the Safety, Pharmacokinetics, and Pharmacodynamics of AG-348, a First-in-Class Allosteric Activator of Pyruvate Kinase R, in Healthy Volunteers.

Yang H, Merica E, Chen Y, Cohen M, Goldwater R, Kosinski PA, Kung C, Yuan ZJ, Silverman L, Goldwasser M, Silver BA, Agresta S, Barbier AJ.

Clin Pharmacol Drug Dev. 2019 Feb;8(2):246-259. doi: 10.1002/cpdd.604. Epub 2018 Aug 9.

PMID:
30091852
4.

AG-348 enhances pyruvate kinase activity in red blood cells from patients with pyruvate kinase deficiency.

Kung C, Hixon J, Kosinski PA, Cianchetta G, Histen G, Chen Y, Hill C, Gross S, Si Y, Johnson K, DeLaBarre B, Luo Z, Gu Z, Yao G, Tang H, Fang C, Xu Y, Lv X, Biller S, Su SM, Yang H, Popovici-Muller J, Salituro F, Silverman L, Dang L.

Blood. 2017 Sep 14;130(11):1347-1356. doi: 10.1182/blood-2016-11-753525. Epub 2017 Jul 31.

5.

Heat shock protein 90 (HSP90) inhibitors activate the heat shock factor 1 (HSF1) stress response pathway and improve glucose regulation in diabetic mice.

Lee JH, Gao J, Kosinski PA, Elliman SJ, Hughes TE, Gromada J, Kemp DM.

Biochem Biophys Res Commun. 2013 Jan 18;430(3):1109-13. doi: 10.1016/j.bbrc.2012.12.029. Epub 2012 Dec 19.

PMID:
23261432
6.

Uncovering mechanisms of transcriptional regulations by systematic mining of cis regulatory elements with gene expression profiles.

Ma Q, Chirn GW, Szustakowski JD, Bakhtiarova A, Kosinski PA, Kemp D, Nirmala N.

BioData Min. 2008 Jul 17;1(1):4. doi: 10.1186/1756-0381-1-4.

7.

Dynamic resolution of functionally related gene sets in response to acute heat stress.

Szustakowski JD, Kosinski PA, Marrese CA, Lee JH, Elliman SJ, Nirmala N, Kemp DM.

BMC Mol Biol. 2007 Jun 5;8:46.

8.

Resveratrol inhibits firefly luciferase.

Bakhtiarova A, Taslimi P, Elliman SJ, Kosinski PA, Hubbard B, Kavana M, Kemp DM.

Biochem Biophys Res Commun. 2006 Dec 15;351(2):481-4. Epub 2006 Oct 18.

PMID:
17064666
9.

Identification of novel pathway regulation during myogenic differentiation.

Szustakowski JD, Lee JH, Marrese CA, Kosinski PA, Nirmala NR, Kemp DM.

Genomics. 2006 Jan;87(1):129-38. Epub 2005 Nov 21.

10.

Contribution of human bone marrow stem cells to individual skeletal myotubes followed by myogenic gene activation.

Lee JH, Kosinski PA, Kemp DM.

Exp Cell Res. 2005 Jul 1;307(1):174-82. Epub 2005 Apr 8.

PMID:
15922737
11.
12.

Differential regulation of HIF-1 alpha prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells.

Cioffi CL, Liu XQ, Kosinski PA, Garay M, Bowen BR.

Biochem Biophys Res Commun. 2003 Apr 11;303(3):947-53.

PMID:
12670503
13.
14.

Identification of a complex that binds to the CD154 3' untranslated region: implications for a role in message stability during T cell activation.

Barnhart B, Kosinski PA, Wang Z, Ford GS, Kiledjian M, Covey LR.

J Immunol. 2000 Oct 15;165(8):4478-86.

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