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Items: 24


Effects of the Tobacco Carcinogens N'-Nitrosonornicotine and Dibenzo[a,l]pyrene Individually and in Combination on DNA Damage in Human Oral Leukoplakia and on Mutagenicity and Mutation Profiles in lacI Mouse Tongue.

Guttenplan JB, Chen KM, Sun YW, Shalaby NAE, Kosinska W, Desai D, Gowda K, Amin S, El-Bayoumy K.

Chem Res Toxicol. 2019 Sep 16;32(9):1893-1899. doi: 10.1021/acs.chemrestox.9b00257. Epub 2019 Sep 3.


E-cigarette Aerosol Condensate Enhances Metabolism of Benzo(a)pyrene to Genotoxic Products, and Induces CYP1A1 and CYP1B1, Likely by Activation of the Aryl Hydrocarbon Receptor.

Sun YW, Kosinska W, Guttenplan JB.

Int J Environ Res Public Health. 2019 Jul 11;16(14). pii: E2468. doi: 10.3390/ijerph16142468.


Effects of Black Raspberry on Dibenzo[a,l]Pyrene Diol Epoxide Induced DNA Adducts, Mutagenesis, and Tumorigenesis in the Mouse Oral Cavity.

Chen KM, Guttenplan JB, Sun YW, Cooper T, Shalaby NAE, Kosinska W, Benitez G, Aliaga C, Zhu J, Liao J, Gowda K, Amin S, Stoner G, El-Bayoumy K.

Cancer Prev Res (Phila). 2018 Mar;11(3):157-164. doi: 10.1158/1940-6207.CAPR-17-0278. Epub 2017 Nov 20.


Effects of Black Raspberry Extract and Berry Compounds on Repair of DNA Damage and Mutagenesis Induced by Chemical and Physical Agents in Human Oral Leukoplakia and Rat Oral Fibroblasts.

Guttenplan JB, Chen KM, Sun YW, Lajara B, Shalaby NAE, Kosinska W, Benitez G, Gowda K, Amin S, Stoner G, El-Bayoumy K.

Chem Res Toxicol. 2017 Dec 18;30(12):2159-2164. doi: 10.1021/acs.chemrestox.7b00242. Epub 2017 Nov 15.


Effects of Black Raspberry Extract and Protocatechuic Acid on Carcinogen-DNA Adducts and Mutagenesis, and Oxidative Stress in Rat and Human Oral Cells.

Guttenplan JB, Chen KM, Sun YW, Kosinska W, Zhou Y, Kim SA, Sung Y, Gowda K, Amin S, Stoner GD, El-Bayoumy K.

Cancer Prev Res (Phila). 2016 Aug;9(8):704-12. doi: 10.1158/1940-6207.CAPR-16-0003. Epub 2016 Jun 7.


Mechanisms of oral carcinogenesis induced by dibenzo[a,l]pyrene: an environmental pollutant and a tobacco smoke constituent.

Chen KM, Guttenplan JB, Zhang SM, Aliaga C, Cooper TK, Sun YW, DelTondo J, Kosinska W, Sharma AK, Jiang K, Bruggeman R, Ahn K, Amin S, El-Bayoumy K.

Int J Cancer. 2013 Sep 15;133(6):1300-9. doi: 10.1002/ijc.28152. Epub 2013 Apr 22.


Mechanisms underlying the varied mammary carcinogenicity of the environmental pollutant 6-nitrochrysene and its metabolites (-)-[R,R]- and (+)-[S,S]-1,2-dihydroxy-1,2-dihydro-6-nitrochrysene in the rat.

Sun YW, Guttenplan JB, Cooper T, Krzeminski J, Aliaga C, Boyiri T, Kosinska W, Zhao ZL, Chen KM, Berg A, Amin S, El-Bayoumy K.

Chem Res Toxicol. 2013 Apr 15;26(4):547-54. doi: 10.1021/tx300478z. Epub 2013 Mar 28.


Carnosol, a constituent of Zyflamend, inhibits aryl hydrocarbon receptor-mediated activation of CYP1A1 and CYP1B1 transcription and mutagenesis.

Mohebati A, Guttenplan JB, Kochhar A, Zhao ZL, Kosinska W, Subbaramaiah K, Dannenberg AJ.

Cancer Prev Res (Phila). 2012 Apr;5(4):593-602. doi: 10.1158/1940-6207.CAPR-12-0002. Epub 2012 Feb 28.


Tissue-specific mutagenesis by N-butyl-N-(4-hydroxybutyl)nitrosamine as the basis for urothelial carcinogenesis.

He Z, Kosinska W, Zhao ZL, Wu XR, Guttenplan JB.

Mutat Res. 2012 Feb 18;742(1-2):92-5. doi: 10.1016/j.mrgentox.2011.11.015. Epub 2011 Dec 4.


Mutagenesis and carcinogenesis induced by dibenzo[a,l]pyrene in the mouse oral cavity: a potential new model for oral cancer.

Guttenplan JB, Kosinska W, Zhao ZL, Chen KM, Aliaga C, DelTondo J, Cooper T, Sun YW, Zhang SM, Jiang K, Bruggeman R, Sharma AK, Amin S, Ahn K, El-Bayoumy K.

Int J Cancer. 2012 Jun 15;130(12):2783-90. doi: 10.1002/ijc.26344. Epub 2011 Nov 19.


Concentration dependent effects of tobacco particulates from different types of cigarettes on expression of drug metabolizing proteins, and benzo(a)pyrene metabolism in primary normal human oral epithelial cells.

Sacks PG, Zhao ZL, Kosinska W, Fleisher KE, Gordon T, Guttenplan JB.

Food Chem Toxicol. 2011 Sep;49(9):2348-55. doi: 10.1016/j.fct.2011.06.037. Epub 2011 Jun 21.


Effects of potential dietary inhibitors of endogenous DNA damage on mutagenesis and lipid peroxidation in lacZ mice.

Kosinska W, Khmelnitsky M, Kim JH, Zhao ZL, Guttenplan JB.

Environ Mol Mutagen. 2011 Jul;52(6):502-9. doi: 10.1002/em.20648. Epub 2011 Apr 27.


Effects of 1,4-phenylenebis(methylene)selenocyanate on mutagenesis and p53 protein expression in the tongue of lacI rats treated with 4-nitroquinoline-N-oxide.

Guttenplan J, Chen KM, Khmelnitsky M, Kosinska W, Hennessy J, Bruggeman R, Desai D, Amin S, Sun YW, Spratt TE, El-Bayoumy K.

Mutat Res. 2007 Dec 1;634(1-2):146-55. Epub 2007 Jul 17.


Comparative mutational profiles of the environmental mammary carcinogen, 6-nitrochrysene and its metabolites in a lacI mammary epithelial cell line.

Guttenplan JB, Zhao ZL, Kosinska W, Norman RG, Krzeminski J, Sun YW, Amin S, El-Bayoumy K.

Carcinogenesis. 2007 Nov;28(11):2391-7. Epub 2007 Jun 29.


Mutagenic activity of 4-hydroxyestradiol, but not 2-hydroxyestradiol, in BB rat2 embryonic cells, and the mutational spectrum of 4-hydroxyestradiol.

Zhao Z, Kosinska W, Khmelnitsky M, Cavalieri EL, Rogan EG, Chakravarti D, Sacks PG, Guttenplan JB.

Chem Res Toxicol. 2006 Mar;19(3):475-9.


Tautomeric equilibria in relation to pi-electron delocalization.

Raczyńska ED, Kosińska W, Ośmiałowski B, Gawinecki R.

Chem Rev. 2005 Oct;105(10):3561-612. Review. No abstract available.


Mutational spectrum of bleomycin in lacZ mouse kidney: a possible model for mutational spectrum of reactive oxygen species.

Guttenplan JB, Khmelnitsky M, Haesevoets R, Kosinska W.

Mutat Res. 2004 Oct 4;554(1-2):185-92.


Mammary carcinogenesis and molecular analysis of in vivo cII gene mutations in the mammary tissue of female transgenic rats treated with the environmental pollutant 6-nitrochrysene.

Boyiri T, Guttenplan J, Khmelnitsky M, Kosinska W, Lin JM, Desai D, Amin S, Pittman B, El-Bayoumy K.

Carcinogenesis. 2004 Apr;25(4):637-43. Epub 2003 Dec 4.


Comparative mutagenicities of bleomycin and ferric-nitrilotriacetate in lacZ mice.

Kosinska W, Pelle E, von Pressentin Md, Chen M, Guttenplan JB.

Cancer Lett. 2002 Dec 10;187(1-2):41-6. Erratum in: Cancer Lett. 2004 Mar 18;205(2):229.


Effects of 1,4-phenylenebis(methylene)selenocyanate (p-XSC) and vitamin E on 4-nitroquinoline-N-oxide (4-NQO)-induced mutagenesis in lacZ mouse upper aerodigestive tissue.

Guttenplan JB, Kosinska W, von Pressentin Md, Rosa J, El-Bayoumy K.

Mutat Res. 2002 Jun 27;518(1):85-93. Erratum in: Mutat Res. 2002 Nov 26;521(1-2):209..


Effects of a lycopene-rich diet on spontaneous and benzo[a]pyrene-induced mutagenesis in prostate, colon and lungs of the lacZ mouse.

Guttenplan JB, Chen M, Kosinska W, Thompson S, Zhao Z, Cohen LA.

Cancer Lett. 2001 Mar 10;164(1):1-6.


Mutagenesis induced by oral carcinogens in lacZ mouse (MutaMouse) tongue and other oral tissues.

von Pressentin MM, Kosinska W, Guttenplan JB.

Carcinogenesis. 1999 Nov;20(11):2167-70.


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