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Items: 1 to 50 of 268

1.

Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs).

Rauch JN, Chen JJ, Sorum AW, Miller GM, Sharf T, See SK, Hsieh-Wilson LC, Kampmann M, Kosik KS.

Sci Rep. 2018 Apr 23;8(1):6382. doi: 10.1038/s41598-018-24904-z.

2.

Action potential propagation recorded from single axonal arbors using multielectrode arrays.

Tovar KR, Bridges DC, Wu B, Randall C, Audouard M, Jang J, Hansma PK, Kosik KS.

J Neurophysiol. 2018 Jul 1;120(1):306-320. doi: 10.1152/jn.00659.2017. Epub 2018 Apr 11.

PMID:
29641308
3.

Evolution of New miRNAs and Cerebro-Cortical Development.

Kosik KS, Nowakowski T.

Annu Rev Neurosci. 2018 Jul 8;41:119-137. doi: 10.1146/annurev-neuro-080317-061822. Epub 2018 Apr 4.

PMID:
29618285
4.

MEA Viewer: A high-performance interactive application for visualizing electrophysiological data.

Bridges DC, Tovar KR, Wu B, Hansma PK, Kosik KS.

PLoS One. 2018 Feb 9;13(2):e0192477. doi: 10.1371/journal.pone.0192477. eCollection 2018.

5.

iPhemap: an atlas of phenotype to genotype relationships of human iPSC models of neurological diseases.

Hollingsworth EW, Vaughn JE, Orack JC, Skinner C, Khouri J, Lizarraga SB, Hester ME, Watanabe F, Kosik KS, Imitola J.

EMBO Mol Med. 2017 Dec;9(12):1742-1762. doi: 10.15252/emmm.201708191.

6.

The Role of Chromatin Density in Cell Population Heterogeneity during Stem Cell Differentiation.

Golkaram M, Jang J, Hellander S, Kosik KS, Petzold LR.

Sci Rep. 2017 Oct 17;7(1):13307. doi: 10.1038/s41598-017-13731-3.

7.

A molecular signature for anastasis, recovery from the brink of apoptotic cell death.

Sun G, Guzman E, Balasanyan V, Conner CM, Wong K, Zhou HR, Kosik KS, Montell DJ.

J Cell Biol. 2017 Oct 2;216(10):3355-3368. doi: 10.1083/jcb.201706134. Epub 2017 Aug 2.

8.

Enhanced Neuronal Regeneration in the CAST/Ei Mouse Strain Is Linked to Expression of Differentiation Markers after Injury.

Lisi V, Singh B, Giroux M, Guzman E, Painter MW, Cheng YC, Huebner E, Coppola G, Costigan M, Woolf CJ, Kosik KS.

Cell Rep. 2017 Aug 1;20(5):1136-1147. doi: 10.1016/j.celrep.2017.07.010.

9.

RNA stores tau reversibly in complex coacervates.

Zhang X, Lin Y, Eschmann NA, Zhou H, Rauch JN, Hernandez I, Guzman E, Kosik KS, Han S.

PLoS Biol. 2017 Jul 6;15(7):e2002183. doi: 10.1371/journal.pbio.2002183. eCollection 2017 Jul.

10.

A microRNA-mRNA expression network during oral siphon regeneration in Ciona.

Spina EJ, Guzman E, Zhou H, Kosik KS, Smith WC.

Development. 2017 May 15;144(10):1787-1797. doi: 10.1242/dev.144097. Epub 2017 Apr 21.

11.

Life at Low Copy Number: How Dendrites Manage with So Few mRNAs.

Kosik KS.

Neuron. 2016 Dec 21;92(6):1168-1180. doi: 10.1016/j.neuron.2016.11.002. Review.

12.

Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability.

Silva MC, Cheng C, Mair W, Almeida S, Fong H, Biswas MHU, Zhang Z, Huang Y, Temple S, Coppola G, Geschwind DH, Karydas A, Miller BL, Kosik KS, Gao FB, Steen JA, Haggarty SJ.

Stem Cell Reports. 2016 Sep 13;7(3):325-340. doi: 10.1016/j.stemcr.2016.08.001. Epub 2016 Sep 1.

13.

A path toward understanding neurodegeneration.

Kosik KS, Sejnowski TJ, Raichle ME, Ciechanover A, Baltimore D.

Science. 2016 Aug 26;353(6302):872-3. doi: 10.1126/science.aai7622. No abstract available.

14.

MCP-1 and eotaxin-1 selectively and negatively associate with memory in MCI and Alzheimer's disease dementia phenotypes.

Bettcher BM, Fitch R, Wynn MJ, Lalli MA, Elofson J, Jastrzab L, Mitic L, Miller ZA, Rabinovici GD, Miller BL, Kao AW, Kosik KS, Kramer JH.

Alzheimers Dement (Amst). 2016 Jun 22;3:91-7. doi: 10.1016/j.dadm.2016.05.004. eCollection 2016.

15.

A Primate lncRNA Mediates Notch Signaling during Neuronal Development by Sequestering miRNA.

Rani N, Nowakowski TJ, Zhou H, Godshalk SE, Lisi V, Kriegstein AR, Kosik KS.

Neuron. 2016 Jun 15;90(6):1174-1188. doi: 10.1016/j.neuron.2016.05.005. Epub 2016 Jun 2.

16.

Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS.

Omura T, Omura K, Tedeschi A, Riva P, Painter MW, Rojas L, Martin J, Lisi V, Huebner EA, Latremoliere A, Yin Y, Barrett LB, Singh B, Lee S, Crisman T, Gao F, Li S, Kapur K, Geschwind DH, Kosik KS, Coppola G, He Z, Carmichael ST, Benowitz LI, Costigan M, Woolf CJ.

Neuron. 2016 May 4;90(3):662. doi: 10.1016/j.neuron.2016.04.025. No abstract available.

17.

Primary Cilium-Autophagy-Nrf2 (PAN) Axis Activation Commits Human Embryonic Stem Cells to a Neuroectoderm Fate.

Jang J, Wang Y, Lalli MA, Guzman E, Godshalk SE, Zhou H, Kosik KS.

Cell. 2016 Apr 7;165(2):410-20. doi: 10.1016/j.cell.2016.02.014. Epub 2016 Mar 24.

18.

Tracking Down Mutations Cell by Cell.

Kosik KS.

Neuron. 2016 Mar 16;89(6):1126-1127. doi: 10.1016/j.neuron.2016.02.042.

19.

Detection of Prokaryotic Genes in the Amphimedon queenslandica Genome.

Conaco C, Tsoulfas P, Sakarya O, Dolan A, Werren J, Kosik KS.

PLoS One. 2016 Mar 9;11(3):e0151092. doi: 10.1371/journal.pone.0151092. eCollection 2016.

20.

FLEXITau: Quantifying Post-translational Modifications of Tau Protein in Vitro and in Human Disease.

Mair W, Muntel J, Tepper K, Tang S, Biernat J, Seeley WW, Kosik KS, Mandelkow E, Steen H, Steen JA.

Anal Chem. 2016 Apr 5;88(7):3704-14. doi: 10.1021/acs.analchem.5b04509. Epub 2016 Mar 7.

21.

β-Secretase 1's Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice.

Piedrahita D, Castro-Alvarez JF, Boudreau RL, Villegas-Lanau A, Kosik KS, Gallego-Gomez JC, Cardona-Gómez GP.

Front Cell Neurosci. 2016 Jan 8;9:498. doi: 10.3389/fncel.2015.00498. eCollection 2015.

22.

Haploinsufficiency of BAZ1B contributes to Williams syndrome through transcriptional dysregulation of neurodevelopmental pathways.

Lalli MA, Jang J, Park JH, Wang Y, Guzman E, Zhou H, Audouard M, Bridges D, Tovar KR, Papuc SM, Tutulan-Cunita AC, Huang Y, Budisteanu M, Arghir A, Kosik KS.

Hum Mol Genet. 2016 Apr 1;25(7):1294-306. doi: 10.1093/hmg/ddw010. Epub 2016 Jan 10.

PMID:
26755828
23.

Developmental attenuation of N-methyl-D-aspartate receptor subunit expression by microRNAs.

Corbel C, Hernandez I, Wu B, Kosik KS.

Neural Dev. 2015 Sep 17;10:20. doi: 10.1186/s13064-015-0047-5.

24.

Tau-er of Power.

Kosik KS.

Cerebrum. 2015 May 1;2015:6. eCollection 2015 May-Jun. No abstract available.

25.

Whole-genome sequencing suggests a chemokine gene cluster that modifies age at onset in familial Alzheimer's disease.

Lalli MA, Bettcher BM, Arcila ML, Garcia G, Guzman C, Madrigal L, Ramirez L, Acosta-Uribe J, Baena A, Wojta KJ, Coppola G, Fitch R, de Both MD, Huentelman MJ, Reiman EM, Brunkow ME, Glusman G, Roach JC, Kao AW, Lopera F, Kosik KS.

Mol Psychiatry. 2015 Nov;20(11):1294-300. doi: 10.1038/mp.2015.131. Epub 2015 Sep 1.

26.

Genomic DISC1 Disruption in hiPSCs Alters Wnt Signaling and Neural Cell Fate.

Srikanth P, Han K, Callahan DG, Makovkina E, Muratore CR, Lalli MA, Zhou H, Boyd JD, Kosik KS, Selkoe DJ, Young-Pearse TL.

Cell Rep. 2015 Sep 1;12(9):1414-29. doi: 10.1016/j.celrep.2015.07.061. Epub 2015 Aug 20.

27.

Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS.

Omura T, Omura K, Tedeschi A, Riva P, Painter MW, Rojas L, Martin J, Lisi V, Huebner EA, Latremoliere A, Yin Y, Barrett LB, Singh B, Lee S, Crisman T, Gao F, Li S, Kapur K, Geschwind DH, Kosik KS, Coppola G, He Z, Carmichael ST, Benowitz LI, Costigan M, Woolf CJ.

Neuron. 2015 Jun 3;86(5):1215-27. doi: 10.1016/j.neuron.2015.05.005. Epub 2015 May 21.

28.

Tamoxifen inhibits CDK5 kinase activity by interacting with p35/p25 and modulates the pattern of tau phosphorylation.

Corbel C, Zhang B, Le Parc A, Baratte B, Colas P, Couturier C, Kosik KS, Landrieu I, Le Tilly V, Bach S.

Chem Biol. 2015 Apr 23;22(4):472-482. doi: 10.1016/j.chembiol.2015.03.009. Epub 2015 Apr 9.

29.

Personalized medicine for effective Alzheimer disease treatment.

Kosik KS.

JAMA Neurol. 2015 May;72(5):497-8. doi: 10.1001/jamaneurol.2014.3445. No abstract available.

PMID:
25730751
30.

The outer subventricular zone and primate-specific cortical complexification.

Dehay C, Kennedy H, Kosik KS.

Neuron. 2015 Feb 18;85(4):683-94. doi: 10.1016/j.neuron.2014.12.060. Review.

31.

Tau immunization: a cautionary tale?

Mably AJ, Kanmert D, Mc Donald JM, Liu W, Caldarone BJ, Lemere CA, O'Nuallain B, Kosik KS, Walsh DM.

Neurobiol Aging. 2015 Mar;36(3):1316-32. doi: 10.1016/j.neurobiolaging.2014.11.022. Epub 2014 Dec 30.

PMID:
25619661
32.

Homozygosity of the autosomal dominant Alzheimer disease presenilin 1 E280A mutation.

Kosik KS, Muñoz C, Lopez L, Arcila ML, García G, Madrigal L, Moreno S, Ríos Romenets S, Lopez H, Gutierrez M, Langbaum JB, Cho W, Suliman S, Tariot PN, Ho C, Reiman EM, Lopera F.

Neurology. 2015 Jan 13;84(2):206-8. doi: 10.1212/WNL.0000000000001130. Epub 2014 Dec 3. No abstract available.

33.

MOV10 and FMRP regulate AGO2 association with microRNA recognition elements.

Kenny PJ, Zhou H, Kim M, Skariah G, Khetani RS, Drnevich J, Arcila ML, Kosik KS, Ceman S.

Cell Rep. 2014 Dec 11;9(5):1729-1741. doi: 10.1016/j.celrep.2014.10.054. Epub 2014 Nov 20.

34.

Long- and short-term CDK5 knockdown prevents spatial memory dysfunction and tau pathology of triple transgenic Alzheimer's mice.

Castro-Alvarez JF, Uribe-Arias SA, Kosik KS, Cardona-Gómez GP.

Front Aging Neurosci. 2014 Sep 10;6:243. doi: 10.3389/fnagi.2014.00243. eCollection 2014.

35.

Synaptic dysregulation in a human iPS cell model of mental disorders.

Wen Z, Nguyen HN, Guo Z, Lalli MA, Wang X, Su Y, Kim NS, Yoon KJ, Shin J, Zhang C, Makri G, Nauen D, Yu H, Guzman E, Chiang CH, Yoritomo N, Kaibuchi K, Zou J, Christian KM, Cheng L, Ross CA, Margolis RL, Chen G, Kosik KS, Song H, Ming GL.

Nature. 2014 Nov 20;515(7527):414-8. doi: 10.1038/nature13716. Epub 2014 Aug 17.

36.

SMN regulates axonal local translation via miR-183/mTOR pathway.

Kye MJ, Niederst ED, Wertz MH, Gonçalves Ido C, Akten B, Dover KZ, Peters M, Riessland M, Neveu P, Wirth B, Kosik KS, Sardi SP, Monani UR, Passini MA, Sahin M.

Hum Mol Genet. 2014 Dec 1;23(23):6318-31. doi: 10.1093/hmg/ddu350. Epub 2014 Jul 4.

37.

A quantitative framework to evaluate modeling of cortical development by neural stem cells.

Stein JL, de la Torre-Ubieta L, Tian Y, Parikshak NN, Hernández IA, Marchetto MC, Baker DK, Lu D, Hinman CR, Lowe JK, Wexler EM, Muotri AR, Gage FH, Kosik KS, Geschwind DH.

Neuron. 2014 Jul 2;83(1):69-86. doi: 10.1016/j.neuron.2014.05.035.

38.

Parallel discovery of Alzheimer's therapeutics.

Lo AW, Ho C, Cummings J, Kosik KS.

Sci Transl Med. 2014 Jun 18;6(241):241cm5. doi: 10.1126/scitranslmed.3008228.

PMID:
24944190
39.

Nrf2, a regulator of the proteasome, controls self-renewal and pluripotency in human embryonic stem cells.

Jang J, Wang Y, Kim HS, Lalli MA, Kosik KS.

Stem Cells. 2014 Oct;32(10):2616-25. doi: 10.1002/stem.1764.

40.

Particle display: a quantitative screening method for generating high-affinity aptamers.

Wang J, Gong Q, Maheshwari N, Eisenstein M, Arcila ML, Kosik KS, Soh HT.

Angew Chem Int Ed Engl. 2014 May 5;53(19):4796-801. doi: 10.1002/anie.201309334. Epub 2014 Mar 18.

41.

Novel primate miRNAs coevolved with ancient target genes in germinal zone-specific expression patterns.

Arcila ML, Betizeau M, Cambronne XA, Guzman E, Doerflinger N, Bouhallier F, Zhou H, Wu B, Rani N, Bassett DS, Borello U, Huissoud C, Goodman RH, Dehay C, Kosik KS.

Neuron. 2014 Mar 19;81(6):1255-1262. doi: 10.1016/j.neuron.2014.01.017. Epub 2014 Feb 27.

42.

Staged miRNA re-regulation patterns during reprogramming.

Henzler CM, Li Z, Dang J, Arcila ML, Zhou H, Liu J, Chang KY, Bassett DS, Rana TM, Kosik KS.

Genome Biol. 2013 Dec 31;14(12):R149. doi: 10.1186/gb-2013-14-12-r149.

43.

Genetic correction of tauopathy phenotypes in neurons derived from human induced pluripotent stem cells.

Fong H, Wang C, Knoferle J, Walker D, Balestra ME, Tong LM, Leung L, Ring KL, Seeley WW, Karydas A, Kshirsagar MA, Boxer AL, Kosik KS, Miller BL, Huang Y.

Stem Cell Reports. 2013 Aug 29;1(3):226-34. doi: 10.1016/j.stemcr.2013.08.001. eCollection 2013.

44.

Origin of the PSEN1 E280A mutation causing early-onset Alzheimer's disease.

Lalli MA, Cox HC, Arcila ML, Cadavid L, Moreno S, Garcia G, Madrigal L, Reiman EM, Arcos-Burgos M, Bedoya G, Brunkow ME, Glusman G, Roach JC, Hood L, Kosik KS, Lopera F.

Alzheimers Dement. 2014 Oct;10(5 Suppl):S277-S283.e10. doi: 10.1016/j.jalz.2013.09.005. Epub 2013 Nov 13.

45.

Diseases: Study neuron networks to tackle Alzheimer's.

Kosik KS.

Nature. 2013 Nov 7;503(7474):31-2. No abstract available.

PMID:
24218661
46.

Statistical analysis of dendritic spine distributions in rat hippocampal cultures.

Jammalamadaka A, Banerjee S, Manjunath BS, Kosik KS.

BMC Bioinformatics. 2013 Oct 2;14:287. doi: 10.1186/1471-2105-14-287.

47.

Diaminothiazoles modify Tau phosphorylation and improve the tauopathy in mouse models.

Zhang X, Hernandez I, Rei D, Mair W, Laha JK, Cornwell ME, Cuny GD, Tsai LH, Steen JA, Kosik KS.

J Biol Chem. 2013 Jul 26;288(30):22042-56. doi: 10.1074/jbc.M112.436402. Epub 2013 Jun 4.

48.

Variants in triggering receptor expressed on myeloid cells 2 are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer's disease.

Giraldo M, Lopera F, Siniard AL, Corneveaux JJ, Schrauwen I, Carvajal J, Muñoz C, Ramirez-Restrepo M, Gaiteri C, Myers AJ, Caselli RJ, Kosik KS, Reiman EM, Huentelman MJ.

Neurobiol Aging. 2013 Aug;34(8):2077.e11-8. doi: 10.1016/j.neurobiolaging.2013.02.016. Epub 2013 Apr 9.

49.

MUC1* ligand, NM23-H1, is a novel growth factor that maintains human stem cells in a more naïve state.

Smagghe BJ, Stewart AK, Carter MG, Shelton LM, Bernier KJ, Hartman EJ, Calhoun AK, Hatziioannou VM, Lillacci G, Kirk BA, DiNardo BA, Kosik KS, Bamdad C.

PLoS One. 2013;8(3):e58601. doi: 10.1371/journal.pone.0058601. Epub 2013 Mar 7.

50.

Molecular biology: Circles reshape the RNA world.

Kosik KS.

Nature. 2013 Mar 21;495(7441):322-4. doi: 10.1038/nature11956. Epub 2013 Feb 27. No abstract available.

PMID:
23446351

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