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Communication between distinct subunit interfaces of the cohesin complex promotes its topological entrapment of DNA.

Guacci V, Chatterjee F, Robison B, Koshland DE.

Elife. 2019 Jun 4;8. pii: e46347. doi: 10.7554/eLife.46347.


Desiccation tolerance: an unusual window into stress biology.

Koshland D, Tapia H.

Mol Biol Cell. 2019 Mar 15;30(6):737-741. doi: 10.1091/mbc.E17-04-0257.


Intermediate step of cohesin's ATPase cycle allows cohesin to entrap DNA.

Çamdere GÖ, Carlborg KK, Koshland D.

Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):9732-9737. doi: 10.1073/pnas.1807213115. Epub 2018 Sep 10.


Genome-wide Map of R-Loop-Induced Damage Reveals How a Subset of R-Loops Contributes to Genomic Instability.

Costantino L, Koshland D.

Mol Cell. 2018 Aug 16;71(4):487-497.e3. doi: 10.1016/j.molcel.2018.06.037. Epub 2018 Aug 2.


Synergy between the small intrinsically disordered protein Hsp12 and trehalose sustain viability after severe desiccation.

Kim SX, Çamdere G, Hu X, Koshland D, Tapia H.

Elife. 2018 Jul 16;7. pii: e38337. doi: 10.7554/eLife.38337.


A role for the Smc3 hinge domain in the maintenance of sister chromatid cohesion.

Robison B, Guacci V, Koshland D.

Mol Biol Cell. 2018 Feb 1;29(3):339-355. doi: 10.1091/mbc.E17-08-0511. Epub 2017 Nov 29.


Cohesin Function in Cohesion, Condensation, and DNA Repair Is Regulated by Wpl1p via a Common Mechanism in Saccharomyces cerevisiae.

Bloom MS, Koshland D, Guacci V.

Genetics. 2018 Jan;208(1):111-124. doi: 10.1534/genetics.117.300537. Epub 2017 Nov 20.


Tardigrades Use Intrinsically Disordered Proteins to Survive Desiccation.

Boothby TC, Tapia H, Brozena AH, Piszkiewicz S, Smith AE, Giovannini I, Rebecchi L, Pielak GJ, Koshland D, Goldstein B.

Mol Cell. 2017 Mar 16;65(6):975-984.e5. doi: 10.1016/j.molcel.2017.02.018.


RNase H enables efficient repair of R-loop induced DNA damage.

Amon JD, Koshland D.

Elife. 2016 Dec 10;5. pii: e20533. doi: 10.7554/eLife.20533.


Differential roles of the RNases H in preventing chromosome instability.

Zimmer AD, Koshland D.

Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):12220-12225. Epub 2016 Oct 10.


Back to the Future: Mutant Hunts Are Still the Way To Go.

Winston F, Koshland D.

Genetics. 2016 Jul;203(3):1007-10. doi: 10.1534/genetics.115.180596.


S1-DRIP-seq identifies high expression and polyA tracts as major contributors to R-loop formation.

Wahba L, Costantino L, Tan FJ, Zimmer A, Koshland D.

Genes Dev. 2016 Jun 1;30(11):1327-38. doi: 10.1101/gad.280834.116.


Single-Molecule Imaging Reveals a Collapsed Conformational State for DNA-Bound Cohesin.

Stigler J, Çamdere GÖ, Koshland DE, Greene EC.

Cell Rep. 2016 May 3;15(5):988-998. doi: 10.1016/j.celrep.2016.04.003. Epub 2016 Apr 21.


The ATPases of cohesin interface with regulators to modulate cohesin-mediated DNA tethering.

Çamdere G, Guacci V, Stricklin J, Koshland D.

Elife. 2015 Nov 19;4. pii: e11315. doi: 10.7554/eLife.11315.


Interallelic complementation provides functional evidence for cohesin-cohesin interactions on DNA.

Eng T, Guacci V, Koshland D.

Mol Biol Cell. 2015 Nov 15;26(23):4224-35. doi: 10.1091/mbc.E15-06-0331. Epub 2015 Sep 16.


The Yin and Yang of R-loop biology.

Costantino L, Koshland D.

Curr Opin Cell Biol. 2015 Jun;34:39-45. doi: 10.1016/ Epub 2015 May 15. Review.


Increasing intracellular trehalose is sufficient to confer desiccation tolerance to Saccharomyces cerevisiae.

Tapia H, Young L, Fox D, Bertozzi CR, Koshland D.

Proc Natl Acad Sci U S A. 2015 May 12;112(19):6122-7. doi: 10.1073/pnas.1506415112. Epub 2015 Apr 27.


A conserved domain in the scc3 subunit of cohesin mediates the interaction with both mcd1 and the cohesin loader complex.

Orgil O, Matityahu A, Eng T, Guacci V, Koshland D, Onn I.

PLoS Genet. 2015 Mar 6;11(3):e1005036. doi: 10.1371/journal.pgen.1005036. eCollection 2015 Mar.


Trehalose is a versatile and long-lived chaperone for desiccation tolerance.

Tapia H, Koshland DE.

Curr Biol. 2014 Dec 1;24(23):2758-66. doi: 10.1016/j.cub.2014.10.005. Epub 2014 Nov 13.


A novel mechanism for the establishment of sister chromatid cohesion by the ECO1 acetyltransferase.

Guacci V, Stricklin J, Bloom MS, Guō X, Bhatter M, Koshland D.

Mol Biol Cell. 2015 Jan 1;26(1):117-33. doi: 10.1091/mbc.E14-08-1268. Epub 2014 Nov 5.


ROCC, a conserved region in cohesin's Mcd1 subunit, is essential for the proper regulation of the maintenance of cohesion and establishment of condensation.

Eng T, Guacci V, Koshland D.

Mol Biol Cell. 2014 Aug 15;25(16):2351-64. doi: 10.1091/mbc.E14-04-0929. Epub 2014 Jun 25.


The Rs of biology: R-loops and the regulation of regulators.

Wahba L, Koshland D.

Mol Cell. 2013 Jun 6;50(5):611-2. doi: 10.1016/j.molcel.2013.05.024.


TOR and RAS pathways regulate desiccation tolerance in Saccharomyces cerevisiae.

Welch AZ, Gibney PA, Botstein D, Koshland DE.

Mol Biol Cell. 2013 Jan;24(2):115-28. doi: 10.1091/mbc.E12-07-0524. Epub 2012 Nov 21.


DNA resection at chromosome breaks promotes genome stability by constraining non-allelic homologous recombination.

Tan FJ, Hoang ML, Koshland D.

PLoS Genet. 2012;8(3):e1002633. doi: 10.1371/journal.pgen.1002633. Epub 2012 Mar 29.


RNase H and multiple RNA biogenesis factors cooperate to prevent RNA:DNA hybrids from generating genome instability.

Wahba L, Amon JD, Koshland D, Vuica-Ross M.

Mol Cell. 2011 Dec 23;44(6):978-88. doi: 10.1016/j.molcel.2011.10.017.


Cohesin-independent segregation of sister chromatids in budding yeast.

Guacci V, Koshland D.

Mol Biol Cell. 2012 Feb;23(4):729-39. doi: 10.1091/mbc.E11-08-0696. Epub 2011 Dec 21.


Genetic analysis of desiccation tolerance in Sachharomyces cerevisiae.

Calahan D, Dunham M, DeSevo C, Koshland DE.

Genetics. 2011 Oct;189(2):507-19. doi: 10.1534/genetics.111.130369. Epub 2011 Aug 11.


In vitro assembly of physiological cohesin/DNA complexes.

Onn I, Koshland D.

Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12198-205. doi: 10.1073/pnas.1107504108. Epub 2011 Jun 13.


Competitive repair by naturally dispersed repetitive DNA during non-allelic homologous recombination.

Hoang ML, Tan FJ, Lai DC, Celniker SE, Hoskins RA, Dunham MJ, Zheng Y, Koshland D.

PLoS Genet. 2010 Dec 2;6(12):e1001228. doi: 10.1371/journal.pgen.1001228.


Genetic evidence that the acetylation of the Smc3p subunit of cohesin modulates its ATP-bound state to promote cohesion establishment in Saccharomyces cerevisiae.

Heidinger-Pauli JM, Onn I, Koshland D.

Genetics. 2010 Aug;185(4):1249-56. doi: 10.1534/genetics.110.116871. Epub 2010 May 24.


Systematic reduction of cohesin differentially affects chromosome segregation, condensation, and DNA repair.

Heidinger-Pauli JM, Mert O, Davenport C, Guacci V, Koshland D.

Curr Biol. 2010 May 25;20(10):957-63. doi: 10.1016/j.cub.2010.04.018. Epub 2010 May 6.


The zinc finger of Eco1 enhances its acetyltransferase activity during sister chromatid cohesion.

Onn I, Guacci V, Koshland DE.

Nucleic Acids Res. 2009 Oct;37(18):6126-34. doi: 10.1093/nar/gkp656. Epub 2009 Aug 19.


Telomere behavior in a hybrid yeast.

Martin OC, DeSevo CG, Guo BZ, Koshland DE, Dunham MJ, Zheng Y.

Cell Res. 2009 Jul;19(7):910-2. doi: 10.1038/cr.2009.65. No abstract available.


Distinct targets of the Eco1 acetyltransferase modulate cohesion in S phase and in response to DNA damage.

Heidinger-Pauli JM, Unal E, Koshland D.

Mol Cell. 2009 May 15;34(3):311-21. doi: 10.1016/j.molcel.2009.04.008.


A molecular determinant for the establishment of sister chromatid cohesion.

Unal E, Heidinger-Pauli JM, Kim W, Guacci V, Onn I, Gygi SP, Koshland DE.

Science. 2008 Jul 25;321(5888):566-9. doi: 10.1126/science.1157880.


Sister chromatid cohesion: a simple concept with a complex reality.

Onn I, Heidinger-Pauli JM, Guacci V, Unal E, Koshland DE.

Annu Rev Cell Dev Biol. 2008;24:105-29. doi: 10.1146/annurev.cellbio.24.110707.175350. Review.


The kleisin subunit of cohesin dictates damage-induced cohesion.

Heidinger-Pauli JM, Unal E, Guacci V, Koshland D.

Mol Cell. 2008 Jul 11;31(1):47-56. doi: 10.1016/j.molcel.2008.06.005.


Cohesin interaction with centromeric minichromosomes shows a multi-complex rod-shaped structure.

Surcel A, Koshland D, Ma H, Simpson RT.

PLoS One. 2008 Jun 11;3(6):e2453. doi: 10.1371/journal.pone.0002453.


Philosophy of science. The Cha-Cha-Cha Theory of Scientific Discovery.

Koshland DE Jr.

Science. 2007 Aug 10;317(5839):761-2. No abstract available.


DNA double-strand breaks trigger genome-wide sister-chromatid cohesion through Eco1 (Ctf7).

Unal E, Heidinger-Pauli JM, Koshland D.

Science. 2007 Jul 13;317(5835):245-8. Erratum in: Science. 2007 Dec 14;318(5857):1722.


A multi-step pathway for the establishment of sister chromatid cohesion.

Milutinovich M, Unal E, Ward C, Skibbens RV, Koshland D.

PLoS Genet. 2007 Jan 19;3(1):e12. Epub 2006 Dec 8.


Insights into the serine protease mechanism from atomic resolution structures of trypsin reaction intermediates.

Radisky ES, Lee JM, Lu CJ, Koshland DE Jr.

Proc Natl Acad Sci U S A. 2006 May 2;103(18):6835-40. Epub 2006 Apr 24.


Rings, bracelet or snaps: fashionable alternatives for Smc complexes.

Huang CE, Milutinovich M, Koshland D.

Philos Trans R Soc Lond B Biol Sci. 2005 Mar 29;360(1455):537-42. Review.


Role of the intramolecular hydrogen bond network in the inhibitory power of chymotrypsin inhibitor 2.

Radisky ES, Lu CJ, Kwan G, Koshland DE Jr.

Biochemistry. 2005 May 10;44(18):6823-30.


DNA damage response pathway uses histone modification to assemble a double-strand break-specific cohesin domain.

Unal E, Arbel-Eden A, Sattler U, Shroff R, Lichten M, Haber JE, Koshland D.

Mol Cell. 2004 Dec 22;16(6):991-1002.


Crazy, but correct.

Koshland DE Jr.

Nature. 2004 Nov 25;432(7016):447. No abstract available.


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