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Items: 38

1.

Voltage-Gated Calcium Channels: Key Players in Sensory Coding in the Retina and the Inner Ear.

Pangrsic T, Singer JH, Koschak A.

Physiol Rev. 2018 Oct 1;98(4):2063-2096. doi: 10.1152/physrev.00030.2017. Review.

2.

Protein kinase N1 critically regulates cerebellar development and long-term function.

zur Nedden S, Eith R, Schwarzer C, Zanetti L, Seitter H, Fresser F, Koschak A, Cameron AJ, Parker PJ, Baier G, Baier-Bitterlich G.

J Clin Invest. 2018 May 1;128(5):2076-2088. doi: 10.1172/JCI96165. Epub 2018 Apr 16.

3.

Relevance of tissue specific subunit expression in channelopathies.

Seitter H, Koschak A.

Neuropharmacology. 2018 Apr;132:58-70. doi: 10.1016/j.neuropharm.2017.06.029. Epub 2017 Jun 29. Review.

PMID:
28669898
4.

Cell-type-specific tuning of Cav1.3 Ca(2+)-channels by a C-terminal automodulatory domain.

Scharinger A, Eckrich S, Vandael DH, Schönig K, Koschak A, Hecker D, Kaur G, Lee A, Sah A, Bartsch D, Benedetti B, Lieb A, Schick B, Singewald N, Sinnegger-Brauns MJ, Carbone E, Engel J, Striessnig J.

Front Cell Neurosci. 2015 Aug 24;9:309. doi: 10.3389/fncel.2015.00309. eCollection 2015.

5.

The Physiology, Pathology, and Pharmacology of Voltage-Gated Calcium Channels and Their Future Therapeutic Potential.

Zamponi GW, Striessnig J, Koschak A, Dolphin AC.

Pharmacol Rev. 2015 Oct;67(4):821-70. doi: 10.1124/pr.114.009654. Review.

6.

Gain-of-function nature of Cav1.4 L-type calcium channels alters firing properties of mouse retinal ganglion cells.

Knoflach D, Schicker K, Glösmann M, Koschak A.

Channels (Austin). 2015;9(5):298-306. doi: 10.1080/19336950.2015.1078040.

7.

A New Splicing Isoform of Cacna2d4 Mimicking the Effects of c.2451insC Mutation in the Retina: Novel Molecular and Electrophysiological Insights.

Bacchi N, Messina A, Burtscher V, Dassi E, Provenzano G, Bozzi Y, Demontis GC, Koschak A, Denti MA, Casarosa S.

Invest Ophthalmol Vis Sci. 2015 Jul;56(8):4846-56. doi: 10.1167/iovs.15-16410.

PMID:
26218913
8.

Spectrum of Cav1.4 dysfunction in congenital stationary night blindness type 2.

Burtscher V, Schicker K, Novikova E, Pöhn B, Stockner T, Kugler C, Singh A, Zeitz C, Lancelot ME, Audo I, Leroy BP, Freissmuth M, Herzig S, Matthes J, Koschak A.

Biochim Biophys Acta. 2014 Aug;1838(8):2053-65. doi: 10.1016/j.bbamem.2014.04.023. Epub 2014 May 4.

9.

Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.

Etemad S, Obermair GJ, Bindreither D, Benedetti A, Stanika R, Di Biase V, Burtscher V, Koschak A, Kofler R, Geley S, Wille A, Lusser A, Flockerzi V, Flucher BE.

J Neurosci. 2014 Jan 22;34(4):1446-61. doi: 10.1523/JNEUROSCI.3935-13.2014.

10.

Cav1.4 IT mouse as model for vision impairment in human congenital stationary night blindness type 2.

Knoflach D, Kerov V, Sartori SB, Obermair GJ, Schmuckermair C, Liu X, Sothilingam V, Garcia Garrido M, Baker SA, Glösmann M, Schicker K, Seeliger M, Lee A, Koschak A.

Channels (Austin). 2013 Nov-Dec;7(6):503-13. doi: 10.4161/chan.26368. Epub 2013 Sep 19.

11.

What can naturally occurring mutations tell us about Ca(v)1.x channel function?

Stockner T, Koschak A.

Biochim Biophys Acta. 2013 Jul;1828(7):1598-607. doi: 10.1016/j.bbamem.2012.11.026. Epub 2012 Dec 4. Review.

12.

Functional properties of a newly identified C-terminal splice variant of Cav1.3 L-type Ca2+ channels.

Bock G, Gebhart M, Scharinger A, Jangsangthong W, Busquet P, Poggiani C, Sartori S, Mangoni ME, Sinnegger-Brauns MJ, Herzig S, Striessnig J, Koschak A.

J Biol Chem. 2011 Dec 9;286(49):42736-48. doi: 10.1074/jbc.M111.269951. Epub 2011 Oct 13.

13.

Impact of gating modulation in CaV1.3 L-type calcium channels.

Koschak A.

Channels (Austin). 2010 Nov-Dec;4(6):523-5. Epub 2010 Nov 1. Review.

14.

Loss of Ca(v)1.3 (CACNA1D) function in a human channelopathy with bradycardia and congenital deafness.

Baig SM, Koschak A, Lieb A, Gebhart M, Dafinger C, Nürnberg G, Ali A, Ahmad I, Sinnegger-Brauns MJ, Brandt N, Engel J, Mangoni ME, Farooq M, Khan HU, Nürnberg P, Striessnig J, Bolz HJ.

Nat Neurosci. 2011 Jan;14(1):77-84. doi: 10.1038/nn.2694. Epub 2010 Dec 5.

PMID:
21131953
15.

Modulation of Cav1.3 Ca2+ channel gating by Rab3 interacting molecule.

Gebhart M, Juhasz-Vedres G, Zuccotti A, Brandt N, Engel J, Trockenbacher A, Kaur G, Obermair GJ, Knipper M, Koschak A, Striessnig J.

Mol Cell Neurosci. 2010 Jul;44(3):246-59. doi: 10.1016/j.mcn.2010.03.011. Epub 2010 Apr 2.

PMID:
20363327
16.

Channelopathies in Cav1.1, Cav1.3, and Cav1.4 voltage-gated L-type Ca2+ channels.

Striessnig J, Bolz HJ, Koschak A.

Pflugers Arch. 2010 Jul;460(2):361-74. doi: 10.1007/s00424-010-0800-x. Epub 2010 Mar 7. Review.

17.

Use-dependent block of voltage-gated Cav2.1 Ca2+ channels by petasins and eudesmol isomers.

Horak S, Koschak A, Stuppner H, Striessnig J.

J Pharmacol Exp Ther. 2009 Jul;330(1):220-6. doi: 10.1124/jpet.109.151183. Epub 2009 Apr 15.

PMID:
19369579
18.

Expression and 1,4-dihydropyridine-binding properties of brain L-type calcium channel isoforms.

Sinnegger-Brauns MJ, Huber IG, Koschak A, Wild C, Obermair GJ, Einzinger U, Hoda JC, Sartori SB, Striessnig J.

Mol Pharmacol. 2009 Feb;75(2):407-14. doi: 10.1124/mol.108.049981. Epub 2008 Nov 24.

PMID:
19029287
19.

Functional properties and modulation of extracellular epitope-tagged Ca(V)2.1 voltage-gated calcium channels.

Watschinger K, Horak SB, Schulze K, Obermair GJ, Wild C, Koschak A, Sinnegger-Brauns MJ, Tampé R, Striessnig J.

Channels (Austin). 2008 Nov-Dec;2(6):461-73. Epub 2008 Nov 15.

20.

Exploring the function and pharmacotherapeutic potential of voltage-gated Ca2+ channels with gene knockout models.

Striessnig J, Koschak A.

Channels (Austin). 2008 Jul-Aug;2(4):233-51. Epub 2008 Jul 11. Review. No abstract available.

PMID:
18719397
21.

Modulation of voltage- and Ca2+-dependent gating of CaV1.3 L-type calcium channels by alternative splicing of a C-terminal regulatory domain.

Singh A, Gebhart M, Fritsch R, Sinnegger-Brauns MJ, Poggiani C, Hoda JC, Engel J, Romanin C, Striessnig J, Koschak A.

J Biol Chem. 2008 Jul 25;283(30):20733-44. doi: 10.1074/jbc.M802254200. Epub 2008 May 15.

22.

Oestrogen directly inhibits the cardiovascular L-type Ca2+ channel Cav1.2.

Ullrich ND, Koschak A, MacLeod KT.

Biochem Biophys Res Commun. 2007 Sep 21;361(2):522-7. Epub 2007 Jul 23.

PMID:
17662243
23.

Molecular nature of anomalous L-type calcium channels in mouse cerebellar granule cells.

Koschak A, Obermair GJ, Pivotto F, Sinnegger-Brauns MJ, Striessnig J, Pietrobon D.

J Neurosci. 2007 Apr 4;27(14):3855-63.

24.

Role of voltage-gated L-type Ca2+ channel isoforms for brain function.

Striessnig J, Koschak A, Sinnegger-Brauns MJ, Hetzenauer A, Nguyen NK, Busquet P, Pelster G, Singewald N.

Biochem Soc Trans. 2006 Nov;34(Pt 5):903-9.

PMID:
17052224
25.

C-terminal modulator controls Ca2+-dependent gating of Ca(v)1.4 L-type Ca2+ channels.

Singh A, Hamedinger D, Hoda JC, Gebhart M, Koschak A, Romanin C, Striessnig J.

Nat Neurosci. 2006 Sep;9(9):1108-16. Epub 2006 Aug 20.

PMID:
16921373
26.

Effects of congenital stationary night blindness type 2 mutations R508Q and L1364H on Cav1.4 L-type Ca2+ channel function and expression.

Hoda JC, Zaghetto F, Singh A, Koschak A, Striessnig J.

J Neurochem. 2006 Mar;96(6):1648-58. Epub 2006 Feb 10.

28.

L-type Ca2+ channels in Ca2+ channelopathies.

Striessnig J, Hoda JC, Koschak A, Zaghetto F, Müllner C, Sinnegger-Brauns MJ, Wild C, Watschinger K, Trockenbacher A, Pelster G.

Biochem Biophys Res Commun. 2004 Oct 1;322(4):1341-6. Review.

PMID:
15336981
29.

Isoform-specific regulation of mood behavior and pancreatic beta cell and cardiovascular function by L-type Ca 2+ channels.

Sinnegger-Brauns MJ, Hetzenauer A, Huber IG, Renström E, Wietzorrek G, Berjukov S, Cavalli M, Walter D, Koschak A, Waldschütz R, Hering S, Bova S, Rorsman P, Pongs O, Singewald N, Striessnig J.

J Clin Invest. 2004 May;113(10):1430-9.

30.

Cav1.4alpha1 subunits can form slowly inactivating dihydropyridine-sensitive L-type Ca2+ channels lacking Ca2+-dependent inactivation.

Koschak A, Reimer D, Walter D, Hoda JC, Heinzle T, Grabner M, Striessnig J.

J Neurosci. 2003 Jul 9;23(14):6041-9.

31.

Synthesis, characterization, and application of cy-dye- and alexa-dye-labeled hongotoxin(1) analogues. The first high affinity fluorescence probes for voltage-gated K+ channels.

Pragl B, Koschak A, Trieb M, Obermair G, Kaufmann WA, Gerster U, Blanc E, Hahn C, Prinz H, Schütz G, Darbon H, Gruber HJ, Knaus HG.

Bioconjug Chem. 2002 May-Jun;13(3):416-25.

PMID:
12009929
32.

Functional consequences of P/Q-type Ca2+ channel Cav2.1 missense mutations associated with episodic ataxia type 2 and progressive ataxia.

Wappl E, Koschak A, Poteser M, Sinnegger MJ, Walter D, Eberhart A, Groschner K, Glossmann H, Kraus RL, Grabner M, Striessnig J.

J Biol Chem. 2002 Mar 1;277(9):6960-6. Epub 2001 Dec 12.

33.

alpha 1D (Cav1.3) subunits can form l-type Ca2+ channels activating at negative voltages.

Koschak A, Reimer D, Huber I, Grabner M, Glossmann H, Engel J, Striessnig J.

J Biol Chem. 2001 Jun 22;276(25):22100-6. Epub 2001 Apr 2.

34.

Three new familial hemiplegic migraine mutants affect P/Q-type Ca(2+) channel kinetics.

Kraus RL, Sinnegger MJ, Koschak A, Glossmann H, Stenirri S, Carrera P, Striessnig J.

J Biol Chem. 2000 Mar 31;275(13):9239-43.

35.

High-conductance calcium-activated potassium channels in rat brain: pharmacology, distribution, and subunit composition.

Wanner SG, Koch RO, Koschak A, Trieb M, Garcia ML, Kaczorowski GJ, Knaus HG.

Biochemistry. 1999 Apr 27;38(17):5392-400.

PMID:
10220326
36.

Subunit composition of brain voltage-gated potassium channels determined by hongotoxin-1, a novel peptide derived from Centruroides limbatus venom.

Koschak A, Bugianesi RM, Mitterdorfer J, Kaczorowski GJ, Garcia ML, Knaus HG.

J Biol Chem. 1998 Jan 30;273(5):2639-44.

37.

Complex subunit assembly of neuronal voltage-gated K+ channels. Basis for high-affinity toxin interactions and pharmacology.

Koch RO, Wanner SG, Koschak A, Hanner M, Schwarzer C, Kaczorowski GJ, Slaughter RS, Garcia ML, Knaus HG.

J Biol Chem. 1997 Oct 31;272(44):27577-81.

38.

[125I]Iberiotoxin-D19Y/Y36F, the first selective, high specific activity radioligand for high-conductance calcium-activated potassium channels.

Koschak A, Koch RO, Liu J, Kaczorowski GJ, Reinhart PH, Garcia ML, Knaus HG.

Biochemistry. 1997 Feb 18;36(7):1943-52.

PMID:
9048582

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