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Items: 30


Anchorage-independent growth conditions reveal a differential SOS2 dependence for transformation and survival in RAS-mutant cancer cells.

Sheffels E, Sealover NE, Theard PL, Kortum RL.

Small GTPases. 2019 May 7:1-12. doi: 10.1080/21541248.2019.1611168. [Epub ahead of print]


Oncogenic RAS isoforms show a hierarchical requirement for the guanine nucleotide exchange factor SOS2 to mediate cell transformation.

Sheffels E, Sealover NE, Wang C, Kim DH, Vazirani IA, Lee E, M Terrell E, Morrison DK, Luo J, Kortum RL.

Sci Signal. 2018 Sep 4;11(546). pii: eaar8371. doi: 10.1126/scisignal.aar8371.


FOXP3 renders activated human regulatory T cells resistant to restimulation-induced cell death by suppressing SAP expression.

Katz G, Voss K, Yan TF, Kim YC, Kortum RL, Scott DW, Snow AL.

Cell Immunol. 2018 May;327:54-61. doi: 10.1016/j.cellimm.2018.02.007. Epub 2018 Feb 12.


KIT Suppresses BRAFV600E-Mutant Melanoma by Attenuating Oncogenic RAS/MAPK Signaling.

Neiswender JV, Kortum RL, Bourque C, Kasheta M, Zon LI, Morrison DK, Ceol CJ.

Cancer Res. 2017 Nov 1;77(21):5820-5830. doi: 10.1158/0008-5472.CAN-17-0473. Epub 2017 Sep 25.


Unexpected Cartilage Phenotype in CD4-Cre-Conditional SOS-Deficient Mice.

Guittard G, Gallardo DL, Li W, Melis N, Lui JC, Kortum RL, Shakarishvili NG, Huh S, Baron J, Weigert R, Kramer JA, Samelson LE, Sommers CL.

Front Immunol. 2017 Mar 23;8:343. doi: 10.3389/fimmu.2017.00343. eCollection 2017.


Path Forward for RAF Therapies: Inhibition of Monomers and Dimers.

Kortum RL, Morrison DK.

Cancer Cell. 2015 Sep 14;28(3):279-81. doi: 10.1016/j.ccell.2015.08.006.


The linker for activation of T cells (LAT) signaling hub: from signaling complexes to microclusters.

Balagopalan L, Kortum RL, Coussens NP, Barr VA, Samelson LE.

J Biol Chem. 2015 Oct 30;290(44):26422-9. doi: 10.1074/jbc.R115.665869. Epub 2015 Sep 9. Review.


miR-155 Controls Lymphoproliferation in LAT Mutant Mice by Restraining T-Cell Apoptosis via SHIP-1/mTOR and PAK1/FOXO3/BIM Pathways.

Rouquette-Jazdanian AK, Kortum RL, Li W, Merrill RK, Nguyen PH, Samelson LE, Sommers CL.

PLoS One. 2015 Jun 29;10(6):e0131823. doi: 10.1371/journal.pone.0131823. eCollection 2015.


Enhanced T-cell activation and differentiation in lymphocytes from transgenic mice expressing ubiquitination-resistant 2KR LAT molecules.

Rodriguez-Peña AB, Gomez-Rodriguez J, Kortum RL, Palmer DC, Yu Z, Guittard GC, Wohlfert EA, Silver PB, Misplon JA, Sommers CL, Feigenbaum L, Epstein SL, Caspi RR, Belkaid Y, Restifo NP, Samelson LE, Balagopalan L.

Gene Ther. 2015 Oct;22(10):781-92. doi: 10.1038/gt.2015.48. Epub 2015 Jun 18.


Absence of both Sos-1 and Sos-2 in peripheral CD4(+) T cells leads to PI3K pathway activation and defects in migration.

Guittard G, Kortum RL, Balagopalan L, Çuburu N, Nguyen P, Sommers CL, Samelson LE.

Eur J Immunol. 2015 Aug;45(8):2389-95. doi: 10.1002/eji.201445226. Epub 2015 Jun 5.


Caveolin-1 is required for kinase suppressor of Ras 1 (KSR1)-mediated extracellular signal-regulated kinase 1/2 activation, H-RasV12-induced senescence, and transformation.

Kortum RL, Fernandez MR, Costanzo-Garvey DL, Johnson HJ, Fisher KW, Volle DJ, Lewis RE.

Mol Cell Biol. 2014 Sep 15;34(18):3461-72. doi: 10.1128/MCB.01633-13. Epub 2014 Jul 7.


The ability of Sos1 to oligomerize the adaptor protein LAT is separable from its guanine nucleotide exchange activity in vivo.

Kortum RL, Balagopalan L, Alexander CP, Garcia J, Pinski JM, Merrill RK, Nguyen PH, Li W, Agarwal I, Akpan IO, Sommers CL, Samelson LE.

Sci Signal. 2013 Nov 12;6(301):ra99. doi: 10.1126/scisignal.2004494.


Functional redundancy of Sos1 and Sos2 for lymphopoiesis and organismal homeostasis and survival.

Baltanás FC, Pérez-Andrés M, Ginel-Picardo A, Diaz D, Jimeno D, Liceras-Boillos P, Kortum RL, Samelson LE, Orfao A, Santos E.

Mol Cell Biol. 2013 Nov;33(22):4562-78. doi: 10.1128/MCB.01026-13. Epub 2013 Sep 16.


miRNA signature of mouse helper T cell hyper-proliferation.

Sommers CL, Rouquette-Jazdanian AK, Robles AI, Kortum RL, Merrill RK, Li W, Nath N, Wohlfert E, Sixt KM, Belkaid Y, Samelson LE.

PLoS One. 2013 Jun 25;8(6):e66709. doi: 10.1371/journal.pone.0066709. Print 2013.


Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells.

Kortum RL, Rouquette-Jazdanian AK, Samelson LE.

Trends Immunol. 2013 Jun;34(6):259-68. doi: 10.1016/ Epub 2013 Mar 15. Review.


Cutting edge: cell surface linker for activation of T cells is recruited to microclusters and is active in signaling.

Balagopalan L, Barr VA, Kortum RL, Park AK, Samelson LE.

J Immunol. 2013 Apr 15;190(8):3849-53. doi: 10.4049/jimmunol.1202760. Epub 2013 Mar 13.


A phospholipase C-γ1-independent, RasGRP1-ERK-dependent pathway drives lymphoproliferative disease in linker for activation of T cells-Y136F mutant mice.

Kortum RL, Rouquette-Jazdanian AK, Miyaji M, Merrill RK, Markegard E, Pinski JM, Wesselink A, Nath NN, Alexander CP, Li W, Kedei N, Roose JP, Blumberg PM, Samelson LE, Sommers CL.

J Immunol. 2013 Jan 1;190(1):147-58. doi: 10.4049/jimmunol.1201458. Epub 2012 Dec 3.


LAT-independent Erk activation via Bam32-PLC-γ1-Pak1 complexes: GTPase-independent Pak1 activation.

Rouquette-Jazdanian AK, Sommers CL, Kortum RL, Morrison DK, Samelson LE.

Mol Cell. 2012 Oct 26;48(2):298-312. doi: 10.1016/j.molcel.2012.08.011. Epub 2012 Sep 13.


Deconstructing Ras signaling in the thymus.

Kortum RL, Sommers CL, Pinski JM, Alexander CP, Merrill RK, Li W, Love PE, Samelson LE.

Mol Cell Biol. 2012 Jul;32(14):2748-59. doi: 10.1128/MCB.00317-12. Epub 2012 May 14.


Targeted Sos1 deletion reveals its critical role in early T-cell development.

Kortum RL, Sommers CL, Alexander CP, Pinski JM, Li W, Grinberg A, Lee J, Love PE, Samelson LE.

Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12407-12. doi: 10.1073/pnas.1104295108. Epub 2011 Jul 11.


Kinase suppressor of ras 1 (KSR1) regulates PGC1α and estrogen-related receptor α to promote oncogenic Ras-dependent anchorage-independent growth.

Fisher KW, Das B, Kortum RL, Chaika OV, Lewis RE.

Mol Cell Biol. 2011 Jun;31(12):2453-61. doi: 10.1128/MCB.05255-11. Epub 2011 Apr 25.


KSR2 is an essential regulator of AMP kinase, energy expenditure, and insulin sensitivity.

Costanzo-Garvey DL, Pfluger PT, Dougherty MK, Stock JL, Boehm M, Chaika O, Fernandez MR, Fisher K, Kortum RL, Hong EG, Jun JY, Ko HJ, Schreiner A, Volle DJ, Treece T, Swift AL, Winer M, Chen D, Wu M, Leon LR, Shaw AS, McNeish J, Kim JK, Morrison DK, Tschöp MH, Lewis RE.

Cell Metab. 2009 Nov;10(5):366-78. doi: 10.1016/j.cmet.2009.09.010.


Genetic evidence for the role of Erk activation in a lymphoproliferative disease of mice.

Miyaji M, Kortum RL, Surana R, Li W, Woolard KD, Simpson RM, Samelson LE, Sommers CL.

Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14502-7. doi: 10.1073/pnas.0903894106. Epub 2009 Aug 10.


Priming the pump: adhesion enhances T cell antigen receptor-induced signaling.

Kortum RL, Samelson LE.

Immunity. 2009 Jan 16;30(1):3-5. doi: 10.1016/j.immuni.2008.12.007.


The molecular scaffold kinase suppressor of Ras 1 is a modifier of RasV12-induced and replicative senescence.

Kortum RL, Johnson HJ, Costanzo DL, Volle DJ, Razidlo GL, Fusello AM, Shaw AS, Lewis RE.

Mol Cell Biol. 2006 Mar;26(6):2202-14.


The molecular scaffold kinase suppressor of Ras 1 (KSR1) regulates adipogenesis.

Kortum RL, Costanzo DL, Haferbier J, Schreiner SJ, Razidlo GL, Wu MH, Volle DJ, Mori T, Sakaue H, Chaika NV, Chaika OV, Lewis RE.

Mol Cell Biol. 2005 Sep;25(17):7592-604.


Expression of kinase suppressor of Ras1 enhances cisplatin-induced extracellular signal-regulated kinase activation and cisplatin sensitivity.

Kim M, Yan Y, Kortum RL, Stoeger SM, Sgagias MK, Lee K, Lewis RE, Cowan KH.

Cancer Res. 2005 May 15;65(10):3986-92.


Phosphorylation regulates KSR1 stability, ERK activation, and cell proliferation.

Razidlo GL, Kortum RL, Haferbier JL, Lewis RE.

J Biol Chem. 2004 Nov 12;279(46):47808-14. Epub 2004 Sep 13.


Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP.

Matheny SA, Chen C, Kortum RL, Razidlo GL, Lewis RE, White MA.

Nature. 2004 Jan 15;427(6971):256-60.


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