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Items: 9


Myc Cooperates with Ras by Programming Inflammation and Immune Suppression.

Kortlever RM, Sodir NM, Wilson CH, Burkhart DL, Pellegrinet L, Brown Swigart L, Littlewood TD, Evan GI.

Cell. 2017 Nov 30;171(6):1301-1315.e14. doi: 10.1016/j.cell.2017.11.013.


A MYC-Driven Change in Mitochondrial Dynamics Limits YAP/TAZ Function in Mammary Epithelial Cells and Breast Cancer.

von Eyss B, Jaenicke LA, Kortlever RM, Royla N, Wiese KE, Letschert S, McDuffus LA, Sauer M, Rosenwald A, Evan GI, Kempa S, Eilers M.

Cancer Cell. 2015 Dec 14;28(6):743-757. doi: 10.1016/j.ccell.2015.10.013.


Selective activation of p53-mediated tumour suppression in high-grade tumours.

Junttila MR, Karnezis AN, Garcia D, Madriles F, Kortlever RM, Rostker F, Brown Swigart L, Pham DM, Seo Y, Evan GI, Martins CP.

Nature. 2010 Nov 25;468(7323):567-71. doi: 10.1038/nature09526.


Suppression of the p53-dependent replicative senescence response by lysophosphatidic acid signaling.

Kortlever RM, Brummelkamp TR, van Meeteren LA, Moolenaar WH, Bernards R.

Mol Cancer Res. 2008 Sep;6(9):1452-60. doi: 10.1158/1541-7786.MCR-08-0066. Epub 2008 Aug 22.


Transforming growth factor-beta requires its target plasminogen activator inhibitor-1 for cytostatic activity.

Kortlever RM, Nijwening JH, Bernards R.

J Biol Chem. 2008 Sep 5;283(36):24308-13. doi: 10.1074/jbc.M803341200. Epub 2008 Jul 9.


Senescence, wound healing and cancer: the PAI-1 connection.

Kortlever RM, Bernards R.

Cell Cycle. 2006 Dec;5(23):2697-703. Epub 2006 Dec 1.


Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence.

Kortlever RM, Higgins PJ, Bernards R.

Nat Cell Biol. 2006 Aug;8(8):877-84. Epub 2006 Jul 23.


TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescence.

Brummelkamp TR, Kortlever RM, Lingbeek M, Trettel F, MacDonald ME, van Lohuizen M, Bernards R.

J Biol Chem. 2002 Feb 22;277(8):6567-72. Epub 2001 Dec 17.

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