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Items: 1 to 50 of 59

1.

The planar cell polarity protein VANG-1/Vangl negatively regulates Wnt/β-catenin signaling through a Dvl dependent mechanism.

Mentink RA, Rella L, Radaszkiewicz TW, Gybel T, Betist MC, Bryja V, Korswagen HC.

PLoS Genet. 2018 Dec 7;14(12):e1007840. doi: 10.1371/journal.pgen.1007840. eCollection 2018 Dec.

2.

Spatial Transcriptomics of C. elegans Males and Hermaphrodites Identifies Sex-Specific Differences in Gene Expression Patterns.

Ebbing A, Vértesy Á, Betist MC, Spanjaard B, Junker JP, Berezikov E, van Oudenaarden A, Korswagen HC.

Dev Cell. 2018 Dec 17;47(6):801-813.e6. doi: 10.1016/j.devcel.2018.10.016. Epub 2018 Nov 8.

PMID:
30416013
3.

SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion.

McGough IJ, de Groot REA, Jellett AP, Betist MC, Varandas KC, Danson CM, Heesom KJ, Korswagen HC, Cullen PJ.

Nat Commun. 2018 Sep 13;9(1):3737. doi: 10.1038/s41467-018-06114-3.

4.

Temporal precision of regulated gene expression.

Gupta S, Varennes J, Korswagen HC, Mugler A.

PLoS Comput Biol. 2018 Jun 7;14(6):e1006201. doi: 10.1371/journal.pcbi.1006201. eCollection 2018 Jun.

5.

A Caenorhabditis elegans Zinc Finger Transcription Factor, ztf-6, Required for the Specification of a Dopamine Neuron-Producing Lineage.

Doitsidou M, Minevich G, Kroll JR, Soete G, Gowtham S, Korswagen HC, Sebastiaan van Zon J, Hobert O.

G3 (Bethesda). 2018 Jan 4;8(1):17-26. doi: 10.1534/g3.117.300132.

6.

The emerging role of retromer in neuroprotection.

McMillan KJ, Korswagen HC, Cullen PJ.

Curr Opin Cell Biol. 2017 Aug;47:72-82. doi: 10.1016/j.ceb.2017.02.004. Epub 2017 Apr 8. Review.

7.

The Caenorhabditis elegans Q neuroblasts: A powerful system to study cell migration at single-cell resolution in vivo.

Rella L, Fernandes Póvoa EE, Korswagen HC.

Genesis. 2016 Apr;54(4):198-211. doi: 10.1002/dvg.22931. Epub 2016 Mar 29. Review.

PMID:
26934462
8.

A Long Noncoding RNA on the Ribosome Is Required for Lifespan Extension.

Essers PB, Nonnekens J, Goos YJ, Betist MC, Viester MD, Mossink B, Lansu N, Korswagen HC, Jelier R, Brenkman AB, MacInnes AW.

Cell Rep. 2015 Jan 20;10(3):339-345. doi: 10.1016/j.celrep.2014.12.029. Epub 2015 Jan 15.

9.

Cell intrinsic modulation of Wnt signaling controls neuroblast migration in C. elegans.

Mentink RA, Middelkoop TC, Rella L, Ji N, Tang CY, Betist MC, van Oudenaarden A, Korswagen HC.

Dev Cell. 2014 Oct 27;31(2):188-201. doi: 10.1016/j.devcel.2014.08.008. Epub 2014 Oct 16.

10.

Development and migration of the C. elegans Q neuroblasts and their descendants.

Middelkoop TC, Korswagen HC.

WormBook. 2014 Oct 15:1-23. doi: 10.1895/wormbook.1.173.1. Review.

11.

Protein kinase CK2 is required for Wntless internalization and Wnt secretion.

de Groot RE, Rappel SB, Lorenowicz MJ, Korswagen HC.

Cell Signal. 2014 Dec;26(12):2601-5. doi: 10.1016/j.cellsig.2014.08.016. Epub 2014 Aug 27.

PMID:
25178265
12.

Huwe1-mediated ubiquitylation of dishevelled defines a negative feedback loop in the Wnt signaling pathway.

de Groot RE, Ganji RS, Bernatik O, Lloyd-Lewis B, Seipel K, Šedová K, Zdráhal Z, Dhople VM, Dale TC, Korswagen HC, Bryja V.

Sci Signal. 2014 Mar 18;7(317):ra26. doi: 10.1126/scisignal.2004985.

PMID:
24643799
13.

Distinct DNA binding sites contribute to the TCF transcriptional switch in C. elegans and Drosophila.

Bhambhani C, Ravindranath AJ, Mentink RA, Chang MV, Betist MC, Yang YX, Koushika SP, Korswagen HC, Cadigan KM.

PLoS Genet. 2014 Feb 6;10(2):e1004133. doi: 10.1371/journal.pgen.1004133. eCollection 2014 Feb.

14.

Feedback control of gene expression variability in the Caenorhabditis elegans Wnt pathway.

Ji N, Middelkoop TC, Mentink RA, Betist MC, Tonegawa S, Mooijman D, Korswagen HC, van Oudenaarden A.

Cell. 2013 Nov 7;155(4):869-80. doi: 10.1016/j.cell.2013.09.060.

15.

Retromer dependent recycling of the Wnt secretion factor Wls is dispensable for stem cell maintenance in the mammalian intestinal epithelium.

de Groot RE, Farin HF, Macůrková M, van Es JH, Clevers HC, Korswagen HC.

PLoS One. 2013 Oct 9;8(10):e76971. doi: 10.1371/journal.pone.0076971. eCollection 2013.

16.

Inhibition of late endosomal maturation restores Wnt secretion in Caenorhabditis elegans vps-29 retromer mutants.

Lorenowicz MJ, Macurkova M, Harterink M, Middelkoop TC, de Groot R, Betist MC, Korswagen HC.

Cell Signal. 2014 Jan;26(1):19-31. doi: 10.1016/j.cellsig.2013.09.013. Epub 2013 Sep 20.

PMID:
24056045
17.

Insulin/IGF-1-mediated longevity is marked by reduced protein metabolism.

Stout GJ, Stigter EC, Essers PB, Mulder KW, Kolkman A, Snijders DS, van den Broek NJ, Betist MC, Korswagen HC, Macinnes AW, Brenkman AB.

Mol Syst Biol. 2013 Jul 2;9:679. doi: 10.1038/msb.2013.35.

18.

RNA helicase DDX3 is a regulatory subunit of casein kinase 1 in Wnt-β-catenin signaling.

Cruciat CM, Dolde C, de Groot RE, Ohkawara B, Reinhard C, Korswagen HC, Niehrs C.

Science. 2013 Mar 22;339(6126):1436-41. doi: 10.1126/science.1231499. Epub 2013 Feb 14.

19.

Redox-dependent control of FOXO/DAF-16 by transportin-1.

Putker M, Madl T, Vos HR, de Ruiter H, Visscher M, van den Berg MC, Kaplan M, Korswagen HC, Boelens R, Vermeulen M, Burgering BM, Dansen TB.

Mol Cell. 2013 Feb 21;49(4):730-42. doi: 10.1016/j.molcel.2012.12.014. Epub 2013 Jan 17.

20.

Deconvolving the roles of Wnt ligands and receptors in sensing and amplification.

Tan RZ, Ji N, Mentink RA, Korswagen HC, van Oudenaarden A.

Mol Syst Biol. 2013;9:631. doi: 10.1038/msb.2012.64.

21.

Quantification of in vivo oxidative damage in Caenorhabditis elegans during aging by endogenous F3-isoprostane measurement.

Labuschagne CF, Stigter EC, Hendriks MM, Berger R, Rokach J, Korswagen HC, Brenkman AB.

Aging Cell. 2013 Apr;12(2):214-23. doi: 10.1111/acel.12043. Epub 2013 Jan 30.

22.

Wnt signaling in C. elegans.

Sawa H, Korswagen HC.

WormBook. 2013 Dec 9:1-30. doi: 10.1895/wormbook.1.7.2. Review.

23.

UNC-4 antagonizes Wnt signaling to regulate synaptic choice in the C. elegans motor circuit.

Schneider J, Skelton RL, Von Stetina SE, Middelkoop TC, van Oudenaarden A, Korswagen HC, Miller DM 3rd.

Development. 2012 Jun;139(12):2234-45. doi: 10.1242/dev.075184.

24.

Sorting nexins provide diversity for retromer-dependent trafficking events.

Cullen PJ, Korswagen HC.

Nat Cell Biol. 2011 Dec 22;14(1):29-37. doi: 10.1038/ncb2374. Review.

25.

The thrombospondin repeat containing protein MIG-21 controls a left-right asymmetric Wnt signaling response in migrating C. elegans neuroblasts.

Middelkoop TC, Williams L, Yang PT, Luchtenberg J, Betist MC, Ji N, van Oudenaarden A, Kenyon C, Korswagen HC.

Dev Biol. 2012 Jan 15;361(2):338-48. doi: 10.1016/j.ydbio.2011.10.029. Epub 2011 Oct 29.

26.

A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion.

Harterink M, Port F, Lorenowicz MJ, McGough IJ, Silhankova M, Betist MC, van Weering JRT, van Heesbeen RGHP, Middelkoop TC, Basler K, Cullen PJ, Korswagen HC.

Nat Cell Biol. 2011 Jul 3;13(8):914-923. doi: 10.1038/ncb2281.

27.

Neuroblast migration along the anteroposterior axis of C. elegans is controlled by opposing gradients of Wnts and a secreted Frizzled-related protein.

Harterink M, Kim DH, Middelkoop TC, Doan TD, van Oudenaarden A, Korswagen HC.

Development. 2011 Jul;138(14):2915-24. doi: 10.1242/dev.064733. Epub 2011 Jun 8.

28.

Caenorhabditis elegans chromatin-associated proteins SET-2 and ASH-2 are differentially required for histone H3 Lys 4 methylation in embryos and adult germ cells.

Xiao Y, Bedet C, Robert VJ, Simonet T, Dunkelbarger S, Rakotomalala C, Soete G, Korswagen HC, Strome S, Palladino F.

Proc Natl Acad Sci U S A. 2011 May 17;108(20):8305-10. doi: 10.1073/pnas.1019290108. Epub 2011 Apr 28.

29.

A case of cross-reactivity.

Korswagen HC.

Chem Biol. 2011 Apr 22;18(4):409-10. doi: 10.1016/j.chembiol.2011.04.003.

30.

Dissecting the Wnt secretion pathway: key questions on the modification and intracellular trafficking of Wnt proteins.

Harterink M, Korswagen HC.

Acta Physiol (Oxf). 2012 Jan;204(1):8-16. doi: 10.1111/j.1748-1716.2011.02287.x. Epub 2011 Apr 22. Review.

PMID:
21439025
31.

Wnt signalling requires MTM-6 and MTM-9 myotubularin lipid-phosphatase function in Wnt-producing cells.

Silhankova M, Port F, Harterink M, Basler K, Korswagen HC.

EMBO J. 2010 Dec 15;29(24):4094-105. doi: 10.1038/emboj.2010.278. Epub 2010 Nov 12.

32.

Expression patterns of intronic microRNAs in Caenorhabditis elegans.

Isik M, Korswagen HC, Berezikov E.

Silence. 2010 Feb 1;1(1):5. doi: 10.1186/1758-907X-1-5.

33.

Phosphatidylinositol 3-kinase signaling does not activate the wnt cascade.

Ng SS, Mahmoudi T, Danenberg E, Bejaoui I, de Lau W, Korswagen HC, Schutte M, Clevers H.

J Biol Chem. 2009 Dec 18;284(51):35308-13. doi: 10.1074/jbc.M109.078261.

34.

The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network.

Wassmer T, Attar N, Harterink M, van Weering JR, Traer CJ, Oakley J, Goud B, Stephens DJ, Verkade P, Korswagen HC, Cullen PJ.

Dev Cell. 2009 Jul;17(1):110-22. doi: 10.1016/j.devcel.2009.04.016.

35.

Sailing with the Wnt: charting the Wnt processing and secretion route.

Lorenowicz MJ, Korswagen HC.

Exp Cell Res. 2009 Oct 1;315(16):2683-9. doi: 10.1016/j.yexcr.2009.06.015. Epub 2009 Jun 24. Review.

PMID:
19559695
36.

Mammalian Wnt3a is released on lipoprotein particles.

Neumann S, Coudreuse DY, van der Westhuyzen DR, Eckhardt ER, Korswagen HC, Schmitz G, Sprong H.

Traffic. 2009 Mar;10(3):334-43. doi: 10.1111/j.1600-0854.2008.00872.x.

37.

Wnt signaling requires retromer-dependent recycling of MIG-14/Wntless in Wnt-producing cells.

Yang PT, Lorenowicz MJ, Silhankova M, Coudreuse DY, Betist MC, Korswagen HC.

Dev Cell. 2008 Jan;14(1):140-7. Epub 2007 Dec 20.

38.

Migration of neuronal cells along the anterior-posterior body axis of C. elegans: Wnts are in control.

Silhankova M, Korswagen HC.

Curr Opin Genet Dev. 2007 Aug;17(4):320-5. Epub 2007 Jul 20. Review.

PMID:
17644372
39.

C. elegans Disabled is required for cell-type specific endocytosis and is essential in animals lacking the AP-3 adaptor complex.

Holmes A, Flett A, Coudreuse D, Korswagen HC, Pettitt J.

J Cell Sci. 2007 Aug 1;120(Pt 15):2741-51. Epub 2007 Jul 17.

40.

Two functionally distinct Axin-like proteins regulate canonical Wnt signaling in C. elegans.

Oosterveen T, Coudreuse DY, Yang PT, Fraser E, Bergsma J, Dale TC, Korswagen HC.

Dev Biol. 2007 Aug 15;308(2):438-48. Epub 2007 Jun 6.

41.
42.

The making of Wnt: new insights into Wnt maturation, sorting and secretion.

Coudreuse D, Korswagen HC.

Development. 2007 Jan;134(1):3-12. Epub 2006 Nov 30. Review. No abstract available.

43.

Regulation of the Wnt/beta-catenin pathway by redox signaling.

Korswagen HC.

Dev Cell. 2006 Jun;10(6):687-8.

44.

Chemical genetics reveals an RGS/G-protein role in the action of a compound.

Fitzgerald K, Tertyshnikova S, Moore L, Bjerke L, Burley B, Cao J, Carroll P, Choy R, Doberstein S, Dubaquie Y, Franke Y, Kopczynski J, Korswagen H, Krystek SR, Lodge NJ, Plasterk R, Starrett J, Stouch T, Thalody G, Wayne H, van der Linden A, Zhang Y, Walker SG, Cockett M, Wardwell-Swanson J, Ross-Macdonald P, Kindt RM.

PLoS Genet. 2006 Apr;2(4):e57. Epub 2006 Apr 21.

45.

Wnt gradient formation requires retromer function in Wnt-producing cells.

Coudreuse DY, Roël G, Betist MC, Destrée O, Korswagen HC.

Science. 2006 May 12;312(5775):921-4. Epub 2006 Apr 27.

46.

Functional interaction between beta-catenin and FOXO in oxidative stress signaling.

Essers MA, de Vries-Smits LM, Barker N, Polderman PE, Burgering BM, Korswagen HC.

Science. 2005 May 20;308(5725):1181-4.

47.

Wnt activates the Tak1/Nemo-like kinase pathway.

Smit L, Baas A, Kuipers J, Korswagen H, van de Wetering M, Clevers H.

J Biol Chem. 2004 Apr 23;279(17):17232-40. Epub 2004 Feb 11.

48.

Hyperactivation of the G12-mediated signaling pathway in Caenorhabditis elegans induces a developmental growth arrest via protein kinase C.

van der Linden AM, Moorman C, Cuppen E, Korswagen HC, Plasterk RH.

Curr Biol. 2003 Mar 18;13(6):516-21.

49.
50.

The Axin-like protein PRY-1 is a negative regulator of a canonical Wnt pathway in C. elegans.

Korswagen HC, Coudreuse DY, Betist MC, van de Water S, Zivkovic D, Clevers HC.

Genes Dev. 2002 May 15;16(10):1291-302.

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