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Items: 1 to 50 of 87

1.

Identification of Acer2 as a First Susceptibility Gene for Lithium-Induced Nephrogenic Diabetes Insipidus in Mice.

de Groot T, Ebert LK, Christensen BM, Andralojc K, Cheval L, Doucet A, Mao C, Baumgarten R, Low BE, Sandhoff R, Wiles MV, Deen PMT, Korstanje R.

J Am Soc Nephrol. 2019 Sep 26. pii: ASN.2018050549. doi: 10.1681/ASN.2018050549. [Epub ahead of print]

PMID:
31558682
2.

Hepsin-mediated Processing of Uromodulin is Crucial for Salt-sensitivity and Thick Ascending Limb Homeostasis.

Olinger E, Lake J, Sheehan S, Schiano G, Takata T, Tokonami N, Debaix H, Consolato F, Rampoldi L, Korstanje R, Devuyst O.

Sci Rep. 2019 Aug 23;9(1):12287. doi: 10.1038/s41598-019-48300-3.

3.

Detection and Classification of Novel Renal Histologic Phenotypes Using Deep Neural Networks.

Sheehan S, Mawe S, Cianciolo RE, Korstanje R, Mahoney JM.

Am J Pathol. 2019 Sep;189(9):1786-1796. doi: 10.1016/j.ajpath.2019.05.019. Epub 2019 Jun 18.

PMID:
31220455
4.

Integration of heterogeneous functional genomics data in gerontology research to find genes and pathway underlying aging across species.

Bubier JA, Sutphin GL, Reynolds TJ, Korstanje R, Fuksman-Kumpa A, Baker EJ, Langston MA, Chesler EJ.

PLoS One. 2019 Apr 12;14(4):e0214523. doi: 10.1371/journal.pone.0214523. eCollection 2019.

5.

Genome assembly and gene expression in the American black bear provides new insights into the renal response to hibernation.

Srivastava A, Kumar Sarsani V, Fiddes I, Sheehan SM, Seger RL, Barter ME, Neptune-Bear S, Lindqvist C, Korstanje R.

DNA Res. 2019 Feb 1;26(1):37-44. doi: 10.1093/dnares/dsy036.

6.

A multi-tissue full lifespan epigenetic clock for mice.

Thompson MJ, Chwiałkowska K, Rubbi L, Lusis AJ, Davis RC, Srivastava A, Korstanje R, Churchill GA, Horvath S, Pellegrini M.

Aging (Albany NY). 2018 Oct 21;10(10):2832-2854. doi: 10.18632/aging.101590.

7.

Automatic glomerular identification and quantification of histological phenotypes using image analysis and machine learning.

Sheehan SM, Korstanje R.

Am J Physiol Renal Physiol. 2018 Dec 1;315(6):F1644-F1651. doi: 10.1152/ajprenal.00629.2017. Epub 2018 Sep 26.

PMID:
30256126
8.

FAR2 is associated with kidney disease in mice and humans.

Backer G, Eddy S, Sheehan SM, Takemon Y, Reznichenko A, Savage HS, Kretzler M, Korstanje R.

Physiol Genomics. 2018 Aug 1;50(8):543-552. doi: 10.1152/physiolgenomics.00118.2017. Epub 2018 Apr 13.

9.

Hierarchical analysis of RNA-seq reads improves the accuracy of allele-specific expression.

Raghupathy N, Choi K, Vincent MJ, Beane GL, Sheppard KS, Munger SC, Korstanje R, Pardo-Manual de Villena F, Churchill GA.

Bioinformatics. 2018 Jul 1;34(13):2177-2184. doi: 10.1093/bioinformatics/bty078.

10.

Lithium reduces blood glucose levels, but aggravates albuminuria in BTBR-ob/ob mice.

de Groot T, Damen L, Kosse L, Alsady M, Doty R, Baumgarten R, Sheehan S, van der Vlag J, Korstanje R, Deen PMT.

PLoS One. 2017 Dec 15;12(12):e0189485. doi: 10.1371/journal.pone.0189485. eCollection 2017.

11.

Lithium induces aerobic glycolysis and glutaminolysis in collecting duct principal cells.

Alsady M, de Groot T, Kortenoeven MLA, Carmone C, Neijman K, Bekkenkamp-Grovenstein M, Engelke U, Wevers R, Baumgarten R, Korstanje R, Deen PMT.

Am J Physiol Renal Physiol. 2018 Feb 1;314(2):F230-F239. doi: 10.1152/ajprenal.00297.2017. Epub 2017 Oct 25.

12.

Hearing loss without overt metabolic acidosis in ATP6V1B1 deficient MRL mice, a new genetic model for non-syndromic deafness with enlarged vestibular aqueducts.

Tian C, Gagnon LH, Longo-Guess C, Korstanje R, Sheehan SM, Ohlemiller KK, Schrader AD, Lett JM, Johnson KR.

Hum Mol Genet. 2017 Oct 1;26(19):3722-3735. doi: 10.1093/hmg/ddx257.

13.

Continuous Glucose Monitoring in Female NOD Mice Reveals Daily Rhythms and a Negative Correlation With Body Temperature.

Korstanje R, Ryan JL, Savage HS, Lyons BL, Kane KG, Sukoff Rizzo SJ.

Endocrinology. 2017 Sep 1;158(9):2707-2712. doi: 10.1210/en.2017-00266.

14.

Genetic variance is associated with susceptibility for cigarette smoke-induced DAMP release in mice.

Pouwels SD, Faiz A, den Boef LE, Gras R, van den Berge M, Boezen HM, Korstanje R, Ten Hacken NHT, van Oosterhout AJM, Heijink IH, Nawijn MC.

Am J Physiol Lung Cell Mol Physiol. 2017 Sep 1;313(3):L559-L580. doi: 10.1152/ajplung.00466.2016. Epub 2017 Jun 8.

15.

Caenorhabditis elegans orthologs of human genes differentially expressed with age are enriched for determinants of longevity.

Sutphin GL, Backer G, Sheehan S, Bean S, Corban C, Liu T, Peters MJ, van Meurs JBJ, Murabito JM, Johnson AD, Korstanje R; Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Gene Expression Working Group.

Aging Cell. 2017 Aug;16(4):672-682. doi: 10.1111/acel.12595. Epub 2017 Apr 12.

16.

APOBEC1 complementation factor (A1CF) is dispensable for C-to-U RNA editing in vivo.

Snyder EM, McCarty C, Mehalow A, Svenson KL, Murray SA, Korstanje R, Braun RE.

RNA. 2017 Apr;23(4):457-465. doi: 10.1261/rna.058818.116. Epub 2017 Jan 9.

17.

WORMHOLE: Novel Least Diverged Ortholog Prediction through Machine Learning.

Sutphin GL, Mahoney JM, Sheppard K, Walton DO, Korstanje R.

PLoS Comput Biol. 2016 Nov 3;12(11):e1005182. doi: 10.1371/journal.pcbi.1005182. eCollection 2016 Nov.

18.

Loss of Kynurenine 3-Mono-oxygenase Causes Proteinuria.

Korstanje R, Deutsch K, Bolanos-Palmieri P, Hanke N, Schroder P, Staggs L, Bräsen JH, Roberts IS, Sheehan S, Savage H, Haller H, Schiffer M.

J Am Soc Nephrol. 2016 Nov;27(11):3271-3277. Epub 2016 Mar 28.

19.

The transcriptional landscape of age in human peripheral blood.

Peters MJ, Joehanes R, Pilling LC, Schurmann C, Conneely KN, Powell J, Reinmaa E, Sutphin GL, Zhernakova A, Schramm K, Wilson YA, Kobes S, Tukiainen T; NABEC/UKBEC Consortium, Ramos YF, Göring HH, Fornage M, Liu Y, Gharib SA, Stranger BE, De Jager PL, Aviv A, Levy D, Murabito JM, Munson PJ, Huan T, Hofman A, Uitterlinden AG, Rivadeneira F, van Rooij J, Stolk L, Broer L, Verbiest MM, Jhamai M, Arp P, Metspalu A, Tserel L, Milani L, Samani NJ, Peterson P, Kasela S, Codd V, Peters A, Ward-Caviness CK, Herder C, Waldenberger M, Roden M, Singmann P, Zeilinger S, Illig T, Homuth G, Grabe HJ, Völzke H, Steil L, Kocher T, Murray A, Melzer D, Yaghootkar H, Bandinelli S, Moses EK, Kent JW, Curran JE, Johnson MP, Williams-Blangero S, Westra HJ, McRae AF, Smith JA, Kardia SL, Hovatta I, Perola M, Ripatti S, Salomaa V, Henders AK, Martin NG, Smith AK, Mehta D, Binder EB, Nylocks KM, Kennedy EM, Klengel T, Ding J, Suchy-Dicey AM, Enquobahrie DA, Brody J, Rotter JI, Chen YD, Houwing-Duistermaat J, Kloppenburg M, Slagboom PE, Helmer Q, den Hollander W, Bean S, Raj T, Bakhshi N, Wang QP, Oyston LJ, Psaty BM, Tracy RP, Montgomery GW, Turner ST, Blangero J, Meulenbelt I, Ressler KJ, Yang J, Franke L, Kettunen J, Visscher PM, Neely GG, Korstanje R, Hanson RL, Prokisch H, Ferrucci L, Esko T, Teumer A, van Meurs JB, Johnson AD.

Nat Commun. 2015 Oct 22;6:8570. doi: 10.1038/ncomms9570.

20.

A roadmap for the genetic analysis of renal aging.

Noordmans GA, Hillebrands JL, van Goor H, Korstanje R.

Aging Cell. 2015 Oct;14(5):725-33. doi: 10.1111/acel.12378. Epub 2015 Jul 29. Review.

21.

Aging Research Using Mouse Models.

Ackert-Bicknell CL, Anderson LC, Sheehan S, Hill WG, Chang B, Churchill GA, Chesler EJ, Korstanje R, Peters LL.

Curr Protoc Mouse Biol. 2015 Jun 1;5(2):95-133. doi: 10.1002/9780470942390.mo140195.

22.

Genetic Background is a Key Determinant of Glomerular Extracellular Matrix Composition and Organization.

Randles MJ, Woolf AS, Huang JL, Byron A, Humphries JD, Price KL, Kolatsi-Joannou M, Collinson S, Denny T, Knight D, Mironov A, Starborg T, Korstanje R, Humphries MJ, Long DA, Lennon R.

J Am Soc Nephrol. 2015 Dec;26(12):3021-34. doi: 10.1681/ASN.2014040419. Epub 2015 Apr 20.

23.

The role of platelet-activating factor in mesangial pathophysiology.

Reznichenko A, Korstanje R.

Am J Pathol. 2015 Apr;185(4):888-96. doi: 10.1016/j.ajpath.2014.11.025. Epub 2015 Feb 2. Review.

24.

Genetic variation associates with susceptibility for cigarette smoke-induced neutrophilia in mice.

Pouwels SD, Heijink IH, Brouwer U, Gras R, den Boef LE, Boezen HM, Korstanje R, van Oosterhout AJ, Nawijn MC.

Am J Physiol Lung Cell Mol Physiol. 2015 Apr 1;308(7):L693-709. doi: 10.1152/ajplung.00118.2014. Epub 2015 Jan 30.

25.

Accessing Data Resources in the Mouse Phenome Database for Genetic Analysis of Murine Life Span and Health Span.

Bogue MA, Peters LL, Paigen B, Korstanje R, Yuan R, Ackert-Bicknell C, Grubb SC, Churchill GA, Chesler EJ.

J Gerontol A Biol Sci Med Sci. 2016 Feb;71(2):170-7. doi: 10.1093/gerona/glu223. Epub 2014 Dec 22.

26.

Genetic analysis of intracapillary glomerular lipoprotein deposits in aging mice.

Noordmans GA, Huang Y, Savage H, van Dijk MC, Schaart G, van den Bergh Weerman MA, Heeringa P, Hillebrands JL, Korstanje R, van Goor H.

PLoS One. 2014 Oct 29;9(10):e111308. doi: 10.1371/journal.pone.0111308. eCollection 2014.

27.

Whole-genome sequence of the C57L/J mouse inbred strain.

Ananda G, Takemon Y, Hinerfeld D, Korstanje R.

G3 (Bethesda). 2014 Jul 21;4(9):1689-92. doi: 10.1534/g3.114.012997.

28.

Mutations in the gene that encodes the F-actin binding protein anillin cause FSGS.

Gbadegesin RA, Hall G, Adeyemo A, Hanke N, Tossidou I, Burchette J, Wu G, Homstad A, Sparks MA, Gomez J, Jiang R, Alonso A, Lavin P, Conlon P, Korstanje R, Stander MC, Shamsan G, Barua M, Spurney R, Singhal PC, Kopp JB, Haller H, Howell D, Pollak MR, Shaw AS, Schiffer M, Winn MP.

J Am Soc Nephrol. 2014 Sep;25(9):1991-2002. doi: 10.1681/ASN.2013090976. Epub 2014 Mar 27.

29.

Identification of novel genes associated with renal tertiary lymphoid organ formation in aging mice.

Huang Y, Caputo CR, Noordmans GA, Yazdani S, Monteiro LH, van den Born J, van Goor H, Heeringa P, Korstanje R, Hillebrands JL.

PLoS One. 2014 Mar 17;9(3):e91850. doi: 10.1371/journal.pone.0091850. eCollection 2014.

30.

A mouse Col4a4 mutation causing Alport glomerulosclerosis with abnormal collagen α3α4α5(IV) trimers.

Korstanje R, Caputo CR, Doty RA, Cook SA, Bronson RT, Davisson MT, Miner JH.

Kidney Int. 2014 Jun;85(6):1461-8. doi: 10.1038/ki.2013.493. Epub 2014 Feb 12.

31.

The role of mouse strain differences in the susceptibility to fibrosis: a systematic review.

Walkin L, Herrick SE, Summers A, Brenchley PE, Hoff CM, Korstanje R, Margetts PJ.

Fibrogenesis Tissue Repair. 2013 Sep 25;6(1):18. doi: 10.1186/1755-1536-6-18.

32.

Proprotein convertases in high-density lipoprotein metabolism.

Choi S, Korstanje R.

Biomark Res. 2013 Sep 18;1(1):27. doi: 10.1186/2050-7771-1-27.

33.

Genetic analysis of mesangial matrix expansion in aging mice and identification of Far2 as a candidate gene.

Noordmans GA, Caputo CR, Huang Y, Sheehan SM, Bulthuis M, Heeringa P, Hillebrands JL, van Goor H, Korstanje R.

J Am Soc Nephrol. 2013 Dec;24(12):1995-2001. doi: 10.1681/ASN.2012080838. Epub 2013 Sep 5.

34.

Knockdown of the hypertension-associated gene NOSTRIN alters glomerular barrier function in zebrafish (Danio rerio).

Kirsch T, Kaufeld J, Korstanje R, Hentschel DM, Staggs L, Bollig F, Beese M, Schroder P, Boehme L, Haller H, Schiffer M.

Hypertension. 2013 Oct;62(4):726-30. doi: 10.1161/HYPERTENSIONAHA.113.01882. Epub 2013 Aug 19.

PMID:
23959558
35.

Decreased APOE-containing HDL subfractions and cholesterol efflux capacity of serum in mice lacking Pcsk9.

Choi S, Aljakna A, Srivastava U, Peterson BR, Deng B, Prat A, Korstanje R.

Lipids Health Dis. 2013 Jul 24;12:112. doi: 10.1186/1476-511X-12-112.

36.

Albuminuria is associated with too few glomeruli and too much testosterone.

Long DA, Kolatsi-Joannou M, Price KL, Dessapt-Baradez C, Huang JL, Papakrivopoulou E, Hubank M, Korstanje R, Gnudi L, Woolf AS.

Kidney Int. 2013 Jun;83(6):1118-29. doi: 10.1038/ki.2013.45. Epub 2013 Feb 27.

37.

Recalculation of 23 mouse HDL QTL datasets improves accuracy and allows for better candidate gene analysis.

Ackert-Bicknell C, Paigen B, Korstanje R.

J Lipid Res. 2013 Apr;54(4):984-94. doi: 10.1194/jlr.M033035. Epub 2013 Feb 7.

38.

Pla2g12b and Hpn are genes identified by mouse ENU mutagenesis that affect HDL cholesterol.

Aljakna A, Choi S, Savage H, Hageman Blair R, Gu T, Svenson KL, Churchill GA, Hibbs M, Korstanje R.

PLoS One. 2012;7(8):e43139. doi: 10.1371/journal.pone.0043139. Epub 2012 Aug 17.

39.

Differences in health status affect susceptibility and mapping of genetic loci for atherosclerosis (fatty streak) in inbred mice.

Srivastava U, Paigen BJ, Korstanje R.

Arterioscler Thromb Vasc Biol. 2012 Oct;32(10):2380-6. doi: 10.1161/ATVBAHA.112.255703. Epub 2012 Jul 26.

40.

Transforming growth factor β-induced peritoneal fibrosis is mouse strain dependent.

Margetts PJ, Hoff C, Liu L, Korstanje R, Walkin L, Summers A, Herrick S, Brenchley P.

Nephrol Dial Transplant. 2013 Aug;28(8):2015-27. doi: 10.1093/ndt/gfs289. Epub 2012 Jul 10.

PMID:
22785109
41.

Genome-wide association mapping of quantitative traits in outbred mice.

Zhang W, Korstanje R, Thaisz J, Staedtler F, Harttman N, Xu L, Feng M, Yanas L, Yang H, Valdar W, Churchill GA, Dipetrillo K.

G3 (Bethesda). 2012 Feb;2(2):167-74. doi: 10.1534/g3.111.001792. Epub 2012 Feb 1.

42.

Rat Ace allele variation determines susceptibility to AngII-induced renal damage.

Kamilic J, Hamming I, Lely AT, Korstanje R, Schulze U, Poppinga WJ, Turner AJ, Clarke NE, van Goor H, Navis GJ.

J Renin Angiotensin Aldosterone Syst. 2011 Dec;12(4):420-9. doi: 10.1177/1470320311415886. Epub 2011 Jul 25.

43.

The mouse QTL map helps interpret human genome-wide association studies for HDL cholesterol.

Leduc MS, Lyons M, Darvishi K, Walsh K, Sheehan S, Amend S, Cox A, Orho-Melander M, Kathiresan S, Paigen B, Korstanje R.

J Lipid Res. 2011 Jun;52(6):1139-49. doi: 10.1194/jlr.M009175. Epub 2011 Mar 28.

44.

Genetic analysis of complex traits in the emerging Collaborative Cross.

Aylor DL, Valdar W, Foulds-Mathes W, Buus RJ, Verdugo RA, Baric RS, Ferris MT, Frelinger JA, Heise M, Frieman MB, Gralinski LE, Bell TA, Didion JD, Hua K, Nehrenberg DL, Powell CL, Steigerwalt J, Xie Y, Kelada SN, Collins FS, Yang IV, Schwartz DA, Branstetter LA, Chesler EJ, Miller DR, Spence J, Liu EY, McMillan L, Sarkar A, Wang J, Wang W, Zhang Q, Broman KW, Korstanje R, Durrant C, Mott R, Iraqi FA, Pomp D, Threadgill D, de Villena FP, Churchill GA.

Genome Res. 2011 Aug;21(8):1213-22. doi: 10.1101/gr.111310.110. Epub 2011 Mar 15.

45.

A Bayesian framework for inference of the genotype-phenotype map for segregating populations.

Hageman RS, Leduc MS, Korstanje R, Paigen B, Churchill GA.

Genetics. 2011 Apr;187(4):1163-70. doi: 10.1534/genetics.110.123273. Epub 2011 Jan 17.

46.

Genetic analysis of mouse strains with variable serum sodium concentrations identifies the Nalcn sodium channel as a novel player in osmoregulation.

Sinke AP, Caputo C, Tsaih SW, Yuan R, Ren D, Deen PM, Korstanje R.

Physiol Genomics. 2011 Mar 16;43(5):265-70. doi: 10.1152/physiolgenomics.00188.2010. Epub 2010 Dec 21.

47.

Uncovering genes and regulatory pathways related to urinary albumin excretion.

Hageman RS, Leduc MS, Caputo CR, Tsaih SW, Churchill GA, Korstanje R.

J Am Soc Nephrol. 2011 Jan;22(1):73-81. doi: 10.1681/ASN.2010050561. Epub 2010 Oct 28.

48.

Identification of the Mhc region as an asthma susceptibility locus in recombinant congenic mice.

Nawijn MC, Piavaux BJ, Jeurink PV, Gras R, Reinders MA, Stearns T, Foote S, Hylkema MN, Groot PC, Korstanje R, Oosterhout AJ.

Am J Respir Cell Mol Biol. 2011 Aug;45(2):295-303. doi: 10.1165/rcmb.2009-0369OC. Epub 2010 Oct 22.

49.

Untangling HDL quantitative trait loci on mouse chromosome 5 and identifying Scarb1 and Acads as the underlying genes.

Su Z, Leduc MS, Korstanje R, Paigen B.

J Lipid Res. 2010 Sep;51(9):2706-13. doi: 10.1194/jlr.M008110. Epub 2010 Jun 19.

50.

Combining QTL data for HDL cholesterol levels from two different species leads to smaller confidence intervals.

Cox A, Sheehan SM, Klöting I, Paigen B, Korstanje R.

Heredity (Edinb). 2010 Nov;105(5):426-32. doi: 10.1038/hdy.2010.75. Epub 2010 Jun 16.

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