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A BAX/BAK and cyclophilin D-independent intrinsic apoptosis pathway.

Zamorano S, Rojas-Rivera D, Lisbona F, Parra V, Court FA, Villegas R, Cheng EH, Korsmeyer SJ, Lavandero S, Hetz C.

PLoS One. 2012;7(6):e37782. doi: 10.1371/journal.pone.0037782. Epub 2012 Jun 12.


A pharmacologic inhibitor of the protease Taspase1 effectively inhibits breast and brain tumor growth.

Chen DY, Lee Y, Van Tine BA, Searleman AC, Westergard TD, Liu H, Tu HC, Takeda S, Dong Y, Piwnica-Worms DR, Oh KJ, Korsmeyer SJ, Hermone A, Gussio R, Shoemaker RH, Cheng EH, Hsieh JJ.

Cancer Res. 2012 Feb 1;72(3):736-46. doi: 10.1158/0008-5472.CAN-11-2584. Epub 2011 Dec 13.


p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis.

Kirsch DG, Santiago PM, di Tomaso E, Sullivan JM, Hou WS, Dayton T, Jeffords LB, Sodha P, Mercer KL, Cohen R, Takeuchi O, Korsmeyer SJ, Bronson RT, Kim CF, Haigis KM, Jain RK, Jacks T.

Science. 2010 Jan 29;327(5965):593-6. doi: 10.1126/science.1166202. Epub 2009 Dec 17. Erratum in: Science. 2011 Nov 11;334(6057):761.


The VDAC2-BAK rheostat controls thymocyte survival.

Ren D, Kim H, Tu HC, Westergard TD, Fisher JK, Rubens JA, Korsmeyer SJ, Hsieh JJ, Cheng EH.

Sci Signal. 2009 Aug 25;2(85):ra48. doi: 10.1126/scisignal.2000274.


Dual role of proapoptotic BAD in insulin secretion and beta cell survival.

Danial NN, Walensky LD, Zhang CY, Choi CS, Fisher JK, Molina AJ, Datta SR, Pitter KL, Bird GH, Wikstrom JD, Deeney JT, Robertson K, Morash J, Kulkarni A, Neschen S, Kim S, Greenberg ME, Corkey BE, Shirihai OS, Shulman GI, Lowell BB, Korsmeyer SJ.

Nat Med. 2008 Feb;14(2):144-53. doi: 10.1038/nm1717. Epub 2008 Jan 27.


Multiple signaling pathways promote B lymphocyte stimulator dependent B-cell growth and survival.

Woodland RT, Fox CJ, Schmidt MR, Hammerman PS, Opferman JT, Korsmeyer SJ, Hilbert DM, Thompson CB.

Blood. 2008 Jan 15;111(2):750-60. Epub 2007 Oct 17.


A spatially and temporally restricted mouse model of soft tissue sarcoma.

Kirsch DG, Dinulescu DM, Miller JB, Grimm J, Santiago PM, Young NP, Nielsen GP, Quade BJ, Chaber CJ, Schultz CP, Takeuchi O, Bronson RT, Crowley D, Korsmeyer SJ, Yoon SS, Hornicek FJ, Weissleder R, Jacks T.

Nat Med. 2007 Aug;13(8):992-7. Epub 2007 Aug 5.


Proapoptotic histone H1.2 induces CASP-3 and -7 activation by forming a protein complex with CYT c, APAF-1 and CASP-9.

Ruiz-Vela A, Korsmeyer SJ.

FEBS Lett. 2007 Jul 24;581(18):3422-8. Epub 2007 Jun 28.


Reactivation of the p53 tumor suppressor pathway by a stapled p53 peptide.

Bernal F, Tyler AF, Korsmeyer SJ, Walensky LD, Verdine GL.

J Am Chem Soc. 2007 Mar 7;129(9):2456-7. Epub 2007 Feb 7. No abstract available. Erratum in: J Am Chem Soc. 2007 Apr 25;129(16):5298.


A stapled BID BH3 helix directly binds and activates BAX.

Walensky LD, Pitter K, Morash J, Oh KJ, Barbuto S, Fisher J, Smith E, Verdine GL, Korsmeyer SJ.

Mol Cell. 2006 Oct 20;24(2):199-210.


A membrane-targeted BID BCL-2 homology 3 peptide is sufficient for high potency activation of BAX in vitro.

Oh KJ, Barbuto S, Pitter K, Morash J, Walensky LD, Korsmeyer SJ.

J Biol Chem. 2006 Dec 1;281(48):36999-7008. Epub 2006 Sep 20.


Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression.

Takeda S, Chen DY, Westergard TD, Fisher JK, Rubens JA, Sasagawa S, Kan JT, Korsmeyer SJ, Cheng EH, Hsieh JJ.

Genes Dev. 2006 Sep 1;20(17):2397-409.


PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum.

Lin SS, Bassik MC, Suh H, Nishino M, Arroyo JD, Hahn WC, Korsmeyer SJ, Roberts TM.

J Biol Chem. 2006 Aug 11;281(32):23003-12. Epub 2006 May 22.


Tuberin activates the proapoptotic molecule BAD.

Freilinger A, Rosner M, Krupitza G, Nishino M, Lubec G, Korsmeyer SJ, Hengstschläger M.

Oncogene. 2006 Oct 19;25(49):6467-79. Epub 2006 May 15.


Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha.

Hetz C, Bernasconi P, Fisher J, Lee AH, Bassik MC, Antonsson B, Brandt GS, Iwakoshi NN, Schinzel A, Glimcher LH, Korsmeyer SJ.

Science. 2006 Apr 28;312(5773):572-6.


BH3 peptidomimetics potently activate apoptosis and demonstrate single agent efficacy in neuroblastoma.

Goldsmith KC, Liu X, Dam V, Morgan BT, Shabbout M, Cnaan A, Letai A, Korsmeyer SJ, Hogarty MD.

Oncogene. 2006 Aug 3;25(33):4525-33. Epub 2006 Mar 27.


Uncleaved TFIIA is a substrate for taspase 1 and active in transcription.

Zhou H, Spicuglia S, Hsieh JJ, Mitsiou DJ, Høiby T, Veenstra GJ, Korsmeyer SJ, Stunnenberg HG.

Mol Cell Biol. 2006 Apr;26(7):2728-35.


Traumatic brain injury in mice deficient in Bid: effects on histopathology and functional outcome.

Bermpohl D, You Z, Korsmeyer SJ, Moskowitz MA, Whalen MJ.

J Cereb Blood Flow Metab. 2006 May;26(5):625-33.


Bax channel inhibitors prevent mitochondrion-mediated apoptosis and protect neurons in a model of global brain ischemia.

Hetz C, Vitte PA, Bombrun A, Rostovtseva TK, Montessuit S, Hiver A, Schwarz MK, Church DJ, Korsmeyer SJ, Martinou JC, Antonsson B.

J Biol Chem. 2005 Dec 30;280(52):42960-70. Epub 2005 Oct 11. Erratum in: J Biol Chem. 2012 Dec 28;287(53):44108.


p600, a unique protein required for membrane morphogenesis and cell survival.

Nakatani Y, Konishi H, Vassilev A, Kurooka H, Ishiguro K, Sawada J, Ikura T, Korsmeyer SJ, Qin J, Herlitz AM.

Proc Natl Acad Sci U S A. 2005 Oct 18;102(42):15093-8. Epub 2005 Oct 7. Erratum in: Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17882.


A role for proapoptotic BID in the DNA-damage response.

Zinkel SS, Hurov KE, Ong C, Abtahi FM, Gross A, Korsmeyer SJ.

Cell. 2005 Aug 26;122(4):579-91.


Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia.

Schinzel AC, Takeuchi O, Huang Z, Fisher JK, Zhou Z, Rubens J, Hetz C, Danial NN, Moskowitz MA, Korsmeyer SJ.

Proc Natl Acad Sci U S A. 2005 Aug 23;102(34):12005-10. Epub 2005 Aug 15.


Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease.

Takeuchi O, Fisher J, Suh H, Harada H, Malynn BA, Korsmeyer SJ.

Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11272-7. Epub 2005 Jul 29.


An inhibitor of Bcl-2 family proteins induces regression of solid tumours.

Oltersdorf T, Elmore SW, Shoemaker AR, Armstrong RC, Augeri DJ, Belli BA, Bruncko M, Deckwerth TL, Dinges J, Hajduk PJ, Joseph MK, Kitada S, Korsmeyer SJ, Kunzer AR, Letai A, Li C, Mitten MJ, Nettesheim DG, Ng S, Nimmer PM, O'Connor JM, Oleksijew A, Petros AM, Reed JC, Shen W, Tahir SK, Thompson CB, Tomaselli KJ, Wang B, Wendt MD, Zhang H, Fesik SW, Rosenberg SH.

Nature. 2005 Jun 2;435(7042):677-81. Epub 2005 May 15.


Proapoptotic BAX and BAK control multiple initiator caspases.

Ruiz-Vela A, Opferman JT, Cheng EH, Korsmeyer SJ.

EMBO Rep. 2005 Apr;6(4):379-85.


Oligomeric Bax is a component of the putative cytochrome c release channel MAC, mitochondrial apoptosis-induced channel.

Dejean LM, Martinez-Caballero S, Guo L, Hughes C, Teijido O, Ducret T, Ichas F, Korsmeyer SJ, Antonsson B, Jonas EA, Kinnally KW.

Mol Biol Cell. 2005 May;16(5):2424-32. Epub 2005 Mar 16.


The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival.

Mandal M, Borowski C, Palomero T, Ferrando AA, Oberdoerffer P, Meng F, Ruiz-Vela A, Ciofani M, Zuniga-Pflucker JC, Screpanti I, Look AT, Korsmeyer SJ, Rajewsky K, von Boehmer H, Aifantis I.

J Exp Med. 2005 Feb 21;201(4):603-14.


Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells.

Opferman JT, Iwasaki H, Ong CC, Suh H, Mizuno S, Akashi K, Korsmeyer SJ.

Science. 2005 Feb 18;307(5712):1101-4.


Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease.

Wang J, Iwasaki H, Krivtsov A, Febbo PG, Thorner AR, Ernst P, Anastasiadou E, Kutok JL, Kogan SC, Zinkel SS, Fisher JK, Hess JL, Golub TR, Armstrong SA, Akashi K, Korsmeyer SJ.

EMBO J. 2005 Jan 26;24(2):368-81. Epub 2005 Jan 6.


Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum.

Oakes SA, Scorrano L, Opferman JT, Bassik MC, Nishino M, Pozzan T, Korsmeyer SJ.

Proc Natl Acad Sci U S A. 2005 Jan 4;102(1):105-10. Epub 2004 Dec 21.


An Mll-dependent Hox program drives hematopoietic progenitor expansion.

Ernst P, Mabon M, Davidson AJ, Zon LI, Korsmeyer SJ.

Curr Biol. 2004 Nov 23;14(22):2063-9.


Conformational changes in BID, a pro-apoptotic BCL-2 family member, upon membrane binding. A site-directed spin labeling study.

Oh KJ, Barbuto S, Meyer N, Kim RS, Collier RJ, Korsmeyer SJ.

J Biol Chem. 2005 Jan 7;280(1):753-67. Epub 2004 Oct 21.


Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity.

Harada H, Quearry B, Ruiz-Vela A, Korsmeyer SJ.

Proc Natl Acad Sci U S A. 2004 Oct 26;101(43):15313-7. Epub 2004 Oct 14.


Untangling the web: mitochondrial fission and apoptosis.

Oakes SA, Korsmeyer SJ.

Dev Cell. 2004 Oct;7(4):460-2.


Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions.

Nam YJ, Mani K, Ashton AW, Peng CF, Krishnamurthy B, Hayakawa Y, Lee P, Korsmeyer SJ, Kitsis RN.

Mol Cell. 2004 Sep 24;15(6):901-12.


Antiapoptotic BCL-2 is required for maintenance of a model leukemia.

Letai A, Sorcinelli MD, Beard C, Korsmeyer SJ.

Cancer Cell. 2004 Sep;6(3):241-9.


Bax regulates c-Myc-induced mammary tumour apoptosis but not proliferation in MMTV-c-myc transgenic mice.

Jamerson MH, Johnson MD, Korsmeyer SJ, Furth PA, Dickson RB.

Br J Cancer. 2004 Oct 4;91(7):1372-9.


Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix.

Walensky LD, Kung AL, Escher I, Malia TJ, Barbuto S, Wright RD, Wagner G, Verdine GL, Korsmeyer SJ.

Science. 2004 Sep 3;305(5689):1466-70.


Expression of apoptosis inhibitor protein Mcl1 linked to neuroprotection in CNS neurons.

Mori M, Burgess DL, Gefrides LA, Foreman PJ, Opferman JT, Korsmeyer SJ, Cavalheiro EA, Naffah-Mazzacoratti MG, Noebels JL.

Cell Death Differ. 2004 Nov;11(11):1223-33.


BAD is a pro-survival factor prior to activation of its pro-apoptotic function.

Seo SY, Chen YB, Ivanovska I, Ranger AM, Hong SJ, Dawson VL, Korsmeyer SJ, Bellows DS, Fannjiang Y, Hardwick JM.

J Biol Chem. 2004 Oct 1;279(40):42240-9. Epub 2004 Jul 1.


Effects of cytochrome c on the mitochondrial apoptosis-induced channel MAC.

Guo L, Pietkiewicz D, Pavlov EV, Grigoriev SM, Kasianowicz JJ, Dejean LM, Korsmeyer SJ, Antonsson B, Kinnally KW.

Am J Physiol Cell Physiol. 2004 May;286(5):C1109-17. Epub 2003 Dec 24.


Definitive hematopoiesis requires the mixed-lineage leukemia gene.

Ernst P, Fisher JK, Avery W, Wade S, Foy D, Korsmeyer SJ.

Dev Cell. 2004 Mar;6(3):437-43.


Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis.

Bassik MC, Scorrano L, Oakes SA, Pozzan T, Korsmeyer SJ.

EMBO J. 2004 Mar 10;23(5):1207-16. Epub 2004 Mar 4.


Cell death: critical control points.

Danial NN, Korsmeyer SJ.

Cell. 2004 Jan 23;116(2):205-19. Review.


Switching mechanisms of cell death in mdm2- and mdm4-null mice by deletion of p53 downstream targets.

Chavez-Reyes A, Parant JM, Amelse LL, de Oca Luna RM, Korsmeyer SJ, Lozano G.

Cancer Res. 2003 Dec 15;63(24):8664-9.


FLT3 mutations in childhood acute lymphoblastic leukemia.

Armstrong SA, Mabon ME, Silverman LB, Li A, Gribben JG, Fox EA, Sallan SE, Korsmeyer SJ.

Blood. 2004 May 1;103(9):3544-6. Epub 2003 Dec 11.


Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1.

Opferman JT, Letai A, Beard C, Sorcinelli MD, Ong CC, Korsmeyer SJ.

Nature. 2003 Dec 11;426(6967):671-6.


Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression.

Hsieh JJ, Cheng EH, Korsmeyer SJ.

Cell. 2003 Oct 31;115(3):293-303.


Caspase regulation of genotoxin-induced neural precursor cell death.

D'Sa C, Klocke BJ, Cecconi F, Lindsten T, Thompson CB, Korsmeyer SJ, Flavell RA, Roth KA.

J Neurosci Res. 2003 Nov 1;74(3):435-45.


MLL-rearranged leukemias: insights from gene expression profiling.

Armstrong SA, Golub TR, Korsmeyer SJ.

Semin Hematol. 2003 Oct;40(4):268-73. Review.


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