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Items: 1 to 50 of 279

1.

Conditioned Aversion and Neuroplasticity Induced by a Superagonist of Extrasynaptic GABAA Receptors: Correlation With Activation of the Oval BNST Neurons and CRF Mechanisms.

de Miguel E, Vekovischeva O, Elsilä LV, Panhelainen A, Kankuri E, Aitta-Aho T, Korpi ER.

Front Mol Neurosci. 2019 May 24;12:130. doi: 10.3389/fnmol.2019.00130. eCollection 2019.

2.

Attenuation of Novelty-Induced Hyperactivity of Gria1-/- Mice by Cannabidiol and Hippocampal Inhibitory Chemogenetics.

Aitta-Aho T, Maksimovic M, Dahl K, Sprengel R, Korpi ER.

Front Pharmacol. 2019 Mar 29;10:309. doi: 10.3389/fphar.2019.00309. eCollection 2019.

3.

Multiple actions of fenamates and other nonsteroidal anti-inflammatory drugs on GABAA receptors.

Mansikkamäki S, Sinkkonen ST, Korpi ER, Lüddens H.

Eur J Pharmacol. 2019 Jun 15;853:247-255. doi: 10.1016/j.ejphar.2019.03.039. Epub 2019 Mar 28.

PMID:
30930251
4.

Dopaminergic-GABAergic interplay and alcohol binge drinking.

Leggio GM, Di Marco R, Gulisano W, D'Ascenzo M, Torrisi SA, Geraci F, Lavanco G, Dahl K, Giurdanella G, Castorina A, Aitta-Aho T, Aceto G, Bucolo C, Puzzo D, Grassi C, Korpi ER, Drago F, Salomone S.

Pharmacol Res. 2019 Mar;141:384-391. doi: 10.1016/j.phrs.2019.01.022. Epub 2019 Jan 12.

PMID:
30648615
5.

GABAB receptor positive allosteric modulators with different efficacies affect neuroadaptation to and self-administration of alcohol and cocaine.

de Miguel E, Vekovischeva O, Kuokkanen K, Vesajoki M, Paasikoski N, Kaskinoro J, Myllymäki M, Lainiola M, Janhunen SK, Hyytiä P, Linden AM, Korpi ER.

Addict Biol. 2018 Nov 13. doi: 10.1111/adb.12688. [Epub ahead of print]

PMID:
30421860
6.

Normal extinction and reinstatement of morphine-induced conditioned place preference in the GluA1-KO mouse line.

Kiiskinen T, Korpi ER, Aitta-Aho T.

Behav Pharmacol. 2019 Aug;30(5):405-411. doi: 10.1097/FBP.0000000000000449.

PMID:
30376459
7.

Conditioned Reward of Opioids, but not Psychostimulants, is Impaired in GABA-A Receptor δ Subunit Knockout Mice.

Siivonen MS, de Miguel E, Aaltio J, Manner AK, Vahermo M, Yli-Kauhaluoma J, Linden AM, Aitta-Aho T, Korpi ER.

Basic Clin Pharmacol Toxicol. 2018 Nov;123(5):558-566. doi: 10.1111/bcpt.13043. Epub 2018 Jul 9.

PMID:
29781560
8.

Addiction-related interactions of pregabalin with morphine in mice and humans: reinforcing and inhibiting effects.

Vashchinkina E, Piippo O, Vekovischeva O, Krupitsky E, Ilyuk R, Neznanov N, Kazankov K, Zaplatkin I, Korpi ER.

Addict Biol. 2018 May;23(3):945-958. doi: 10.1111/adb.12538. Epub 2017 Jul 25.

PMID:
28741741
9.

Increased Motor-Impairing Effects of the Neuroactive Steroid Pregnanolone in Mice with Targeted Inactivation of the GABAA Receptor γ2 Subunit in the Cerebellum.

Leppä E, Linden AM, Aller MI, Wulff P, Vekovischeva O, Luscher B, Lüddens H, Wisden W, Korpi ER.

Front Pharmacol. 2016 Oct 27;7:403. eCollection 2016.

10.

Neurotoxicity of Ammonia.

Oja SS, Saransaari P, Korpi ER.

Neurochem Res. 2017 Mar;42(3):713-720. doi: 10.1007/s11064-016-2014-x. Epub 2016 Jul 28. Review.

PMID:
27465396
11.

Continuous delivery of naltrexone and nalmefene leads to tolerance in reducing alcohol drinking and to supersensitivity of brain opioid receptors.

Korpi ER, Linden AM, Hytönen HR, Paasikoski N, Vashchinkina E, Dudek M, Herr DR, Hyytiä P.

Addict Biol. 2017 Jul;22(4):1022-1035. doi: 10.1111/adb.12393. Epub 2016 Mar 15.

PMID:
26990998
12.

Mitochondrial respiratory dysfunction due to the conversion of substituted cathinones to methylbenzamides in SH-SY5Y cells.

den Hollander B, Sundström M, Pelander A, Siltanen A, Ojanperä I, Mervaala E, Korpi ER, Kankuri E.

Sci Rep. 2015 Oct 14;5:14924. doi: 10.1038/srep14924.

13.

Mechanisms of Action and Persistent Neuroplasticity by Drugs of Abuse.

Korpi ER, den Hollander B, Farooq U, Vashchinkina E, Rajkumar R, Nutt DJ, Hyytiä P, Dawe GS.

Pharmacol Rev. 2015 Oct;67(4):872-1004. doi: 10.1124/pr.115.010967. Review.

PMID:
26403687
14.

Paradoxical widespread c-Fos expression induced by a GABA agonist in the forebrain of transgenic mice with ectopic expression of the GABA(A) α6 subunit.

Hellsten KS, Linden AM, Korpi ER.

Neuroscience. 2015 May 7;293:123-35. doi: 10.1016/j.neuroscience.2015.02.052. Epub 2015 Mar 9.

PMID:
25766937
15.

GABAergic signalling in the immune system.

Barragan A, Weidner JM, Jin Z, Korpi ER, Birnir B.

Acta Physiol (Oxf). 2015 Apr;213(4):819-27. doi: 10.1111/apha.12467. Epub 2015 Mar 1. Review.

PMID:
25677654
16.

GABA-A and NMDA receptor subunit mRNA expression is altered in the caudate but not the putamen of the postmortem brains of alcoholics.

Bhandage AK, Jin Z, Bazov I, Kononenko O, Bakalkin G, Korpi ER, Birnir B.

Front Cell Neurosci. 2014 Dec 5;8:415. doi: 10.3389/fncel.2014.00415. eCollection 2014.

17.

Manganese-enhanced magnetic resonance imaging reveals differential long-term neuroadaptation after methamphetamine and the substituted cathinone 4-methylmethcathinone (mephedrone).

den Hollander B, Dudek M, Ojanperä I, Kankuri E, Hyytiä P, Korpi ER.

Int J Neuropsychopharmacol. 2014 Dec 7;18(6). pii: pyu106. doi: 10.1093/ijnp/pyu106.

18.

GABAA receptor drugs and neuronal plasticity in reward and aversion: focus on the ventral tegmental area.

Vashchinkina E, Panhelainen A, Aitta-Aho T, Korpi ER.

Front Pharmacol. 2014 Nov 25;5:256. doi: 10.3389/fphar.2014.00256. eCollection 2014.

19.

Reversal of novelty-induced hippocampal c-Fos expression in GluA1 subunit-deficient mice by chronic treatment targeting glutamatergic transmission.

Maksimovic M, Aitta-aho T, Korpi ER.

Eur J Pharmacol. 2014 Dec 15;745:36-45. doi: 10.1016/j.ejphar.2014.10.005. Epub 2014 Oct 18.

PMID:
25446922
20.

Expression of specific ionotropic glutamate and GABA-A receptor subunits is decreased in central amygdala of alcoholics.

Jin Z, Bhandage AK, Bazov I, Kononenko O, Bakalkin G, Korpi ER, Birnir B.

Front Cell Neurosci. 2014 Sep 16;8:288. doi: 10.3389/fncel.2014.00288. eCollection 2014.

21.

Chronic treatment with mood-stabilizers attenuates abnormal hyperlocomotion of GluA1-subunit deficient mice.

Maksimovic M, Vekovischeva OY, Aitta-aho T, Korpi ER.

PLoS One. 2014 Jun 16;9(6):e100188. doi: 10.1371/journal.pone.0100188. eCollection 2014.

22.

Keto amphetamine toxicity-focus on the redox reactivity of the cathinone designer drug mephedrone.

den Hollander B, Sundström M, Pelander A, Ojanperä I, Mervaala E, Korpi ER, Kankuri E.

Toxicol Sci. 2014 Sep;141(1):120-31. doi: 10.1093/toxsci/kfu108. Epub 2014 Jun 9.

23.

Gene expression alterations in the cerebellum and granule neurons of Cstb(-/-) mouse are associated with early synaptic changes and inflammation.

Joensuu T, Tegelberg S, Reinmaa E, Segerstråle M, Hakala P, Pehkonen H, Korpi ER, Tyynelä J, Taira T, Hovatta I, Kopra O, Lehesjoki AE.

PLoS One. 2014 Feb 27;9(2):e89321. doi: 10.1371/journal.pone.0089321. eCollection 2014.

24.

Selective increases of AMPA, NMDA, and kainate receptor subunit mRNAs in the hippocampus and orbitofrontal cortex but not in prefrontal cortex of human alcoholics.

Jin Z, Bhandage AK, Bazov I, Kononenko O, Bakalkin G, Korpi ER, Birnir B.

Front Cell Neurosci. 2014 Jan 29;8:11. doi: 10.3389/fncel.2014.00011. eCollection 2014.

25.

Neurosteroid Agonist at GABAA receptor induces persistent neuroplasticity in VTA dopamine neurons.

Vashchinkina E, Manner AK, Vekovischeva O, den Hollander B, Uusi-Oukari M, Aitta-Aho T, Korpi ER.

Neuropsychopharmacology. 2014 Feb;39(3):727-37. doi: 10.1038/npp.2013.258. Epub 2013 Sep 27.

26.

Reversal of novelty-induced hyperlocomotion and hippocampal c-Fos expression in GluA1 knockout male mice by the mGluR2/3 agonist LY354740.

Procaccini C, Maksimovic M, Aitta-Aho T, Korpi ER, Linden AM.

Neuroscience. 2013 Oct 10;250:189-200. doi: 10.1016/j.neuroscience.2013.07.010. Epub 2013 Jul 15.

PMID:
23867766
27.

Autoinactivation of the stargazin-AMPA receptor complex: subunit-dependency and independence from physical dissociation.

Semenov A, Möykkynen T, Coleman SK, Korpi ER, Keinänen K.

PLoS One. 2012;7(11):e49282. doi: 10.1371/journal.pone.0049282. Epub 2012 Nov 14.

28.

Long-term cognitive and neurochemical effects of "bath salt" designer drugs methylone and mephedrone.

den Hollander B, Rozov S, Linden AM, Uusi-Oukari M, Ojanperä I, Korpi ER.

Pharmacol Biochem Behav. 2013 Jan;103(3):501-9. doi: 10.1016/j.pbb.2012.10.006. Epub 2012 Oct 22.

PMID:
23099177
29.

Importance of GluA1 subunit-containing AMPA glutamate receptors for morphine state-dependency.

Aitta-aho T, Möykkynen TP, Panhelainen AE, Vekovischeva OY, Bäckström P, Korpi ER.

PLoS One. 2012;7(5):e38325. doi: 10.1371/journal.pone.0038325. Epub 2012 May 31.

30.

GABA site agonist gaboxadol induces addiction-predicting persistent changes in ventral tegmental area dopamine neurons but is not rewarding in mice or baboons.

Vashchinkina E, Panhelainen A, Vekovischeva OY, Aitta-aho T, Ebert B, Ator NA, Korpi ER.

J Neurosci. 2012 Apr 11;32(15):5310-20. doi: 10.1523/JNEUROSCI.4697-11.2012.

31.

Acute effects of ethanol on glutamate receptors.

Möykkynen T, Korpi ER.

Basic Clin Pharmacol Toxicol. 2012 Jul;111(1):4-13. doi: 10.1111/j.1742-7843.2012.00879.x. Epub 2012 Apr 21. Review.

32.

Selective Changes of GABA(A) Channel Subunit mRNAs in the Hippocampus and Orbitofrontal Cortex but not in Prefrontal Cortex of Human Alcoholics.

Jin Z, Bazov I, Kononenko O, Korpi ER, Bakalkin G, Birnir B.

Front Cell Neurosci. 2012 Jan 3;5:30. doi: 10.3389/fncel.2011.00030. eCollection 2011.

33.

Evidence for a role of inhibition of orexinergic neurons in the anxiolytic and sedative effects of diazepam: A c-Fos study.

Panhelainen AE, Korpi ER.

Pharmacol Biochem Behav. 2012 Mar;101(1):115-24. doi: 10.1016/j.pbb.2011.12.011. Epub 2011 Dec 21.

PMID:
22210490
34.

[Designer drugs in Finland].

Tacke U, den Hollander B, Simojoki K, Korpi ER, Pihlainen K, Alho H.

Duodecim. 2011;127(19):2027-36. Review. Finnish.

PMID:
22073534
35.

Removal of GABA(A) receptor γ2 subunits from parvalbumin neurons causes wide-ranging behavioral alterations.

Leppä E, Linden AM, Vekovischeva OY, Swinny JD, Rantanen V, Toppila E, Höger H, Sieghart W, Wulff P, Wisden W, Korpi ER.

PLoS One. 2011;6(9):e24159. doi: 10.1371/journal.pone.0024159. Epub 2011 Sep 2.

36.

Diazepam-induced neuronal plasticity attenuates locomotor responses to morphine and amphetamine challenges in mice.

Panhelainen AE, Vekovischeva OY, Aitta-Aho T, Rasanen I, Ojanperä I, Korpi ER.

Neuroscience. 2011 Sep 29;192:312-21. doi: 10.1016/j.neuroscience.2011.07.004. Epub 2011 Jul 18.

PMID:
21782898
37.

Actions of two GABAA receptor benzodiazepine-site ligands that are mediated via non-γ2-dependent modulation.

Leppä E, Linden AM, Rabe H, Vekovischeva OY, Wulff P, Lüddens H, Wisden W, Korpi ER.

Eur J Pharmacol. 2011 Sep;666(1-3):111-21. doi: 10.1016/j.ejphar.2011.05.011. Epub 2011 May 19.

PMID:
21616065
38.

Ro 15-4513 Antagonizes Alcohol-Induced Sedation in Mice Through αβγ2-type GABA(A) Receptors.

Linden AM, Schmitt U, Leppä E, Wulff P, Wisden W, Lüddens H, Korpi ER.

Front Neurosci. 2011 Jan 20;5:3. doi: 10.3389/fnins.2011.00003. eCollection 2011.

39.

Activity of BK(Ca) channel is modulated by membrane cholesterol content and association with Na+/K+-ATPase in human melanoma IGR39 cells.

Tajima N, Itokazu Y, Korpi ER, Somerharju P, Käkelä R.

J Biol Chem. 2011 Feb 18;286(7):5624-38. doi: 10.1074/jbc.M110.149898. Epub 2010 Dec 6.

40.

Excessive novelty-induced c-Fos expression and altered neurogenesis in the hippocampus of GluA1 knockout mice.

Procaccini C, Aitta-aho T, Jaako-Movits K, Zharkovsky A, Panhelainen A, Sprengel R, Linden AM, Korpi ER.

Eur J Neurosci. 2011 Jan;33(1):161-74. doi: 10.1111/j.1460-9568.2010.07485.x. Epub 2010 Nov 14.

PMID:
21073553
41.

Ligand-binding domain determines endoplasmic reticulum exit of AMPA receptors.

Coleman SK, Möykkynen T, Hinkkuri S, Vaahtera L, Korpi ER, Pentikäinen OT, Keinänen K.

J Biol Chem. 2010 Nov 12;285(46):36032-9. doi: 10.1074/jbc.M110.156943. Epub 2010 Sep 13.

42.

Human kisspeptins activate neuropeptide FF2 receptor.

Lyubimov Y, Engstrom M, Wurster S, Savola JM, Korpi ER, Panula P.

Neuroscience. 2010 Sep 29;170(1):117-22. doi: 10.1016/j.neuroscience.2010.06.058. Epub 2010 Jul 1.

PMID:
20600636
43.

Human locus coeruleus neurons express the GABA(A) receptor gamma2 subunit gene and produce benzodiazepine binding.

Hellsten KS, Sinkkonen ST, Hyde TM, Kleinman JE, Särkioja T, Maksimow A, Uusi-Oukari M, Korpi ER.

Neurosci Lett. 2010 Jun 21;477(2):77-81. doi: 10.1016/j.neulet.2010.04.035. Epub 2010 Apr 22.

44.

Regulation of GABA(A) receptor subunit expression by pharmacological agents.

Uusi-Oukari M, Korpi ER.

Pharmacol Rev. 2010 Mar;62(1):97-135. doi: 10.1124/pr.109.002063. Epub 2010 Feb 1. Review.

PMID:
20123953
45.

Analysis of the potential role of GluA4 carboxyl-terminus in PDZ interactions.

Coleman SK, Cai C, Kalkkinen N, Korpi ER, Keinänen K.

PLoS One. 2010 Jan 14;5(1):e8715. doi: 10.1371/journal.pone.0008715.

46.

Prototypic GABA(A) receptor agonist muscimol acts preferentially through forebrain high-affinity binding sites.

Chandra D, Halonen LM, Linden AM, Procaccini C, Hellsten K, Homanics GE, Korpi ER.

Neuropsychopharmacology. 2010 Mar;35(4):999-1007. doi: 10.1038/npp.2009.203. Epub 2009 Dec 23.

47.

Histamine and H3 receptor-dependent mechanisms regulate ethanol stimulation and conditioned place preference in mice.

Nuutinen S, Karlstedt K, Aitta-Aho T, Korpi ER, Panula P.

Psychopharmacology (Berl). 2010 Jan;208(1):75-86. doi: 10.1007/s00213-009-1710-5. Epub 2009 Nov 13.

PMID:
19911169
48.

Decompressive craniectomy for intracerebral hemorrhage.

Marinkovic I, Strbian D, Pedrono E, Vekovischeva OY, Shekhar S, Durukan A, Korpi ER, Abo-Ramadan U, Tatlisumak T.

Neurosurgery. 2009 Oct;65(4):780-6, 1 p following 786; discussion 786. doi: 10.1227/01.NEU.0000351775.30702.A9.

PMID:
19834384
49.

Ethanol increases desensitization of recombinant GluR-D AMPA receptor and TARP combinations.

Möykkynen TP, Coleman SK, Keinänen K, Lovinger DM, Korpi ER.

Alcohol. 2009 Jun;43(4):277-84. doi: 10.1016/j.alcohol.2009.04.005.

50.

Use of MGLUR2 and MGLUR3 knockout mice to explore in vivo receptor specificity of the MGLUR2/3 selective antagonist LY341495.

Linden AM, Johnson BG, Trokovic N, Korpi ER, Schoepp DD.

Neuropharmacology. 2009 Aug;57(2):172-82. doi: 10.1016/j.neuropharm.2009.05.002. Epub 2009 May 27.

PMID:
19477188

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