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Items: 1 to 50 of 107

1.

Pathogenic Escherichia coli Hijacks GTPase-Activated p21-Activated Kinase for Actin Pedestal Formation.

Singh V, Davidson A, Hume PJ, Koronakis V.

MBio. 2019 Aug 20;10(4). pii: e01876-19. doi: 10.1128/mBio.01876-19.

2.

Corrigendum: Antibiotic Resistance Mediated by the MacB ABC Transporter Family: A Structural and Functional Perspective.

Greene NP, Kaplan E, Crow A, Koronakis V.

Front Microbiol. 2018 Sep 28;9:2318. doi: 10.3389/fmicb.2018.02318. eCollection 2018.

3.

Insights into bacterial lipoprotein trafficking from a structure of LolA bound to the LolC periplasmic domain.

Kaplan E, Greene NP, Crow A, Koronakis V.

Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):E7389-E7397. doi: 10.1073/pnas.1806822115. Epub 2018 Jul 16.

4.

Antibiotic Resistance Mediated by the MacB ABC Transporter Family: A Structural and Functional Perspective.

Greene NP, Kaplan E, Crow A, Koronakis V.

Front Microbiol. 2018 May 28;9:950. doi: 10.3389/fmicb.2018.00950. eCollection 2018. Review. Erratum in: Front Microbiol. 2018 Sep 28;9:2318.

5.

Structure and mechanotransmission mechanism of the MacB ABC transporter superfamily.

Crow A, Greene NP, Kaplan E, Koronakis V.

Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):12572-12577. doi: 10.1073/pnas.1712153114. Epub 2017 Nov 6.

6.

Swiss Army Pathogen: The Salmonella Entry Toolkit.

Hume PJ, Singh V, Davidson AC, Koronakis V.

Front Cell Infect Microbiol. 2017 Aug 9;7:348. doi: 10.3389/fcimb.2017.00348. eCollection 2017. Review.

7.

Arf GTPase interplay with Rho GTPases in regulation of the actin cytoskeleton.

Singh V, Davidson AC, Hume PJ, Humphreys D, Koronakis V.

Small GTPases. 2019 Nov;10(6):411-418. doi: 10.1080/21541248.2017.1329691. Epub 2017 Nov 3.

8.

MYO6 is targeted by Salmonella virulence effectors to trigger PI3-kinase signaling and pathogen invasion into host cells.

Brooks AB, Humphreys D, Singh V, Davidson AC, Arden SD, Buss F, Koronakis V.

Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):3915-3920. doi: 10.1073/pnas.1616418114. Epub 2017 Mar 27.

9.

Inhibition of WAVE Regulatory Complex Activation by a Bacterial Virulence Effector Counteracts Pathogen Phagocytosis.

Humphreys D, Singh V, Koronakis V.

Cell Rep. 2016 Oct 11;17(3):697-707. doi: 10.1016/j.celrep.2016.09.039.

10.

Structures of Gate Loop Variants of the AcrB Drug Efflux Pump Bound by Erythromycin Substrate.

Ababou A, Koronakis V.

PLoS One. 2016 Jul 12;11(7):e0159154. doi: 10.1371/journal.pone.0159154. eCollection 2016.

11.

Structure of a bacterial toxin-activating acyltransferase.

Greene NP, Crow A, Hughes C, Koronakis V.

Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):E3058-66. doi: 10.1073/pnas.1503832112. Epub 2015 May 27.

12.

The Arf GTPase-activating protein family is exploited by Salmonella enterica serovar Typhimurium to invade nonphagocytic host cells.

Davidson AC, Humphreys D, Brooks AB, Hume PJ, Koronakis V.

MBio. 2015 Feb 10;6(1). pii: e02253-14. doi: 10.1128/mBio.02253-14.

13.

Structure of the periplasmic adaptor protein from a major facilitator superfamily (MFS) multidrug efflux pump.

Hinchliffe P, Greene NP, Paterson NG, Crow A, Hughes C, Koronakis V.

FEBS Lett. 2014 Aug 25;588(17):3147-53. doi: 10.1016/j.febslet.2014.06.055. Epub 2014 Jul 1.

14.

WAVE regulatory complex activation.

Hume PJ, Humphreys D, Koronakis V.

Methods Enzymol. 2014;540:363-79. doi: 10.1016/B978-0-12-397924-7.00020-0.

PMID:
24630117
15.

Arf6 coordinates actin assembly through the WAVE complex, a mechanism usurped by Salmonella to invade host cells.

Humphreys D, Davidson AC, Hume PJ, Makin LE, Koronakis V.

Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):16880-5. doi: 10.1073/pnas.1311680110. Epub 2013 Oct 1.

16.

Structure of an atypical periplasmic adaptor from a multidrug efflux pump of the spirochete Borrelia burgdorferi.

Greene NP, Hinchliffe P, Crow A, Ababou A, Hughes C, Koronakis V.

FEBS Lett. 2013 Sep 17;587(18):2984-8. doi: 10.1016/j.febslet.2013.06.056. Epub 2013 Jul 10.

17.

Structure and operation of bacterial tripartite pumps.

Hinchliffe P, Symmons MF, Hughes C, Koronakis V.

Annu Rev Microbiol. 2013;67:221-42. doi: 10.1146/annurev-micro-092412-155718. Epub 2013 Jun 26. Review.

PMID:
23808339
18.

The Drosophila Arf1 homologue Arf79F is essential for lamellipodium formation.

Humphreys D, Liu T, Davidson AC, Hume PJ, Koronakis V.

J Cell Sci. 2012 Dec 1;125(Pt 23):5630-5. doi: 10.1242/jcs.108092. Epub 2012 Sep 19.

19.

Salmonella virulence effector SopE and Host GEF ARNO cooperate to recruit and activate WAVE to trigger bacterial invasion.

Humphreys D, Davidson A, Hume PJ, Koronakis V.

Cell Host Microbe. 2012 Feb 16;11(2):129-39. doi: 10.1016/j.chom.2012.01.006.

20.

The bacterial cytoskeleton modulates motility, type 3 secretion, and colonization in Salmonella.

Bulmer DM, Kharraz L, Grant AJ, Dean P, Morgan FJ, Karavolos MH, Doble AC, McGhie EJ, Koronakis V, Daniel RA, Mastroeni P, Khan CM.

PLoS Pathog. 2012 Jan;8(1):e1002500. doi: 10.1371/journal.ppat.1002500. Epub 2012 Jan 26.

21.

WAVE regulatory complex activation by cooperating GTPases Arf and Rac1.

Koronakis V, Hume PJ, Humphreys D, Liu T, Hørning O, Jensen ON, McGhie EJ.

Proc Natl Acad Sci U S A. 2011 Aug 30;108(35):14449-54. doi: 10.1073/pnas.1107666108. Epub 2011 Aug 15.

22.

Structures of sequential open states in a symmetrical opening transition of the TolC exit duct.

Pei XY, Hinchliffe P, Symmons MF, Koronakis E, Benz R, Hughes C, Koronakis V.

Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):2112-7. doi: 10.1073/pnas.1012588108. Epub 2011 Jan 18.

23.

Enteropathogenic Escherichia coli recruits the cellular inositol phosphatase SHIP2 to regulate actin-pedestal formation.

Smith K, Humphreys D, Hume PJ, Koronakis V.

Cell Host Microbe. 2010 Jan 21;7(1):13-24. doi: 10.1016/j.chom.2009.12.004.

24.

LuxS-based quorum sensing does not affect the ability of Salmonella enterica serovar Typhimurium to express the SPI-1 type 3 secretion system, induce membrane ruffles, or invade epithelial cells.

Perrett CA, Karavolos MH, Humphrey S, Mastroeni P, Martinez-Argudo I, Spencer H, Bulmer D, Winzer K, McGhie E, Koronakis V, Williams P, Khan CM, Jepson MA.

J Bacteriol. 2009 Dec;191(23):7253-9. doi: 10.1128/JB.00727-09. Epub 2009 Sep 25.

25.

The assembled structure of a complete tripartite bacterial multidrug efflux pump.

Symmons MF, Bokma E, Koronakis E, Hughes C, Koronakis V.

Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):7173-8. doi: 10.1073/pnas.0900693106. Epub 2009 Apr 2.

26.

The Salmonella effector SptP dephosphorylates host AAA+ ATPase VCP to promote development of its intracellular replicative niche.

Humphreys D, Hume PJ, Koronakis V.

Cell Host Microbe. 2009 Mar 19;5(3):225-33. doi: 10.1016/j.chom.2009.01.010.

27.

Salmonella takes control: effector-driven manipulation of the host.

McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V.

Curr Opin Microbiol. 2009 Feb;12(1):117-24. doi: 10.1016/j.mib.2008.12.001. Epub 2009 Jan 20. Review.

28.

Clustering transfers the translocated Escherichia coli receptor into lipid rafts to stimulate reversible activation of c-Fyn.

Hayward RD, Hume PJ, Humphreys D, Phillips N, Smith K, Koronakis V.

Cell Microbiol. 2009 Mar;11(3):433-41. doi: 10.1111/j.1462-5822.2008.01265.x. Epub 2008 Nov 7.

PMID:
19016778
29.

Mimicry is the sincerest form of flattery?

Hume PJ, Koronakis V.

Cell Host Microbe. 2008 Nov 13;4(5):411-2. doi: 10.1016/j.chom.2008.10.006.

30.

Repetitive N-WASP-binding elements of the enterohemorrhagic Escherichia coli effector EspF(U) synergistically activate actin assembly.

Campellone KG, Cheng HC, Robbins D, Siripala AD, McGhie EJ, Hayward RD, Welch MD, Rosen MK, Koronakis V, Leong JM.

PLoS Pathog. 2008 Oct;4(10):e1000191. doi: 10.1371/journal.ppat.1000191. Epub 2008 Oct 31.

31.

Deciphering interplay between Salmonella invasion effectors.

Cain RJ, Hayward RD, Koronakis V.

PLoS Pathog. 2008 Apr 4;4(4):e1000037. doi: 10.1371/journal.ppat.1000037.

33.

A periplasmic coiled-coil interface underlying TolC recruitment and the assembly of bacterial drug efflux pumps.

Lobedanz S, Bokma E, Symmons MF, Koronakis E, Hughes C, Koronakis V.

Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4612-7. Epub 2007 Mar 5.

34.

Directed evolution of a bacterial efflux pump: adaptation of the E. coli TolC exit duct to the Pseudomonas MexAB translocase.

Bokma E, Koronakis E, Lobedanz S, Hughes C, Koronakis V.

FEBS Lett. 2006 Oct 2;580(22):5339-43. Epub 2006 Sep 12.

35.

Flexibility in a drug transport accessory protein: molecular dynamics simulations of MexA.

Vaccaro L, Koronakis V, Sansom MS.

Biophys J. 2006 Jul 15;91(2):558-64. Epub 2006 Apr 28.

36.

Exploiting pathogenic Escherichia coli to model transmembrane receptor signalling.

Hayward RD, Leong JM, Koronakis V, Campellone KG.

Nat Rev Microbiol. 2006 May;4(5):358-70. Review.

PMID:
16582930
37.

Pathogens reWritE Rho's rules.

Hayward RD, Koronakis V.

Cell. 2006 Jan 13;124(1):15-7. Review.

38.

Cholesterol binding by the bacterial type III translocon is essential for virulence effector delivery into mammalian cells.

Hayward RD, Cain RJ, McGhie EJ, Phillips N, Garner MJ, Koronakis V.

Mol Microbiol. 2005 May;56(3):590-603.

39.

Three's company: component structures bring a closer view of tripartite drug efflux pumps.

Eswaran J, Koronakis E, Higgins MK, Hughes C, Koronakis V.

Curr Opin Struct Biol. 2004 Dec;14(6):741-7. Review.

PMID:
15582398
40.
41.

Structure of the ligand-blocked periplasmic entrance of the bacterial multidrug efflux protein TolC.

Higgins MK, Eswaran J, Edwards P, Schertler GF, Hughes C, Koronakis V.

J Mol Biol. 2004 Sep 17;342(3):697-702.

PMID:
15342230
42.

Interactions underlying assembly of the Escherichia coli AcrAB-TolC multidrug efflux system.

Touzé T, Eswaran J, Bokma E, Koronakis E, Hughes C, Koronakis V.

Mol Microbiol. 2004 Jul;53(2):697-706.

43.

Structure of the periplasmic component of a bacterial drug efflux pump.

Higgins MK, Bokma E, Koronakis E, Hughes C, Koronakis V.

Proc Natl Acad Sci U S A. 2004 Jul 6;101(27):9994-9. Epub 2004 Jun 28.

44.

Phosphorylation of the enteropathogenic E. coli receptor by the Src-family kinase c-Fyn triggers actin pedestal formation.

Phillips N, Hayward RD, Koronakis V.

Nat Cell Biol. 2004 Jul;6(7):618-25. Epub 2004 Jun 27.

PMID:
15220932
45.

Structure and function of TolC: the bacterial exit duct for proteins and drugs.

Koronakis V, Eswaran J, Hughes C.

Annu Rev Biochem. 2004;73:467-89. Review.

PMID:
15189150
46.

Control of actin turnover by a salmonella invasion protein.

McGhie EJ, Hayward RD, Koronakis V.

Mol Cell. 2004 Feb 27;13(4):497-510.

47.

Self-association of EPEC intimin mediated by the beta-barrel-containing anchor domain: a role in clustering of the Tir receptor.

Touzé T, Hayward RD, Eswaran J, Leong JM, Koronakis V.

Mol Microbiol. 2004 Jan;51(1):73-87.

48.

TolC--the bacterial exit duct for proteins and drugs.

Koronakis V.

FEBS Lett. 2003 Nov 27;555(1):66-71. Review.

49.

The purified Shigella IpaB and Salmonella SipB translocators share biochemical properties and membrane topology.

Hume PJ, McGhie EJ, Hayward RD, Koronakis V.

Mol Microbiol. 2003 Jul;49(2):425-39.

50.

Locking TolC entrance helices to prevent protein translocation by the bacterial type I export apparatus.

Eswaran J, Hughes C, Koronakis V.

J Mol Biol. 2003 Mar 21;327(2):309-15.

PMID:
12628238

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