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Items: 1 to 50 of 52

1.

Altered surface expression of P2Y11 receptor with narcolepsy-associated mutations.

Dommer MW, Dreisig K, Kornum BR.

Pharmacol Rep. 2019 Oct;71(5):926-928. doi: 10.1016/j.pharep.2019.05.005. Epub 2019 May 14.

PMID:
31450027
2.

Narcolepsy - clinical spectrum, aetiopathophysiology, diagnosis and treatment.

Bassetti CLA, Adamantidis A, Burdakov D, Han F, Gay S, Kallweit U, Khatami R, Koning F, Kornum BR, Lammers GJ, Liblau RS, Luppi PH, Mayer G, Pollmächer T, Sakurai T, Sallusto F, Scammell TE, Tafti M, Dauvilliers Y.

Nat Rev Neurol. 2019 Sep;15(9):519-539. doi: 10.1038/s41582-019-0226-9. Epub 2019 Jul 19. Review.

PMID:
31324898
3.

CD8+ T cells from patients with narcolepsy and healthy controls recognize hypocretin neuron-specific antigens.

Pedersen NW, Holm A, Kristensen NP, Bjerregaard AM, Bentzen AK, Marquard AM, Tamhane T, Burgdorf KS, Ullum H, Jennum P, Knudsen S, Hadrup SR, Kornum BR.

Nat Commun. 2019 Feb 19;10(1):837. doi: 10.1038/s41467-019-08774-1.

4.

Type 1 narcolepsy is not present in 29 HPV-vaccinated individuals with subjective sleep complaints.

Torstensen EW, Brinth LS, Mehlsen J, Kornum BR, Jennum PJ.

Dan Med J. 2018 Nov;65(11). pii: A5510.

PMID:
30382019
5.

DNMT1 regulates expression of MHC class I in post-mitotic neurons.

Gustafsson JR, Katsioudi G, Degn M, Ejlerskov P, Issazadeh-Navikas S, Kornum BR.

Mol Brain. 2018 Jul 3;11(1):36. doi: 10.1186/s13041-018-0380-9.

6.

Human P2Y11 Expression Level Affects Human P2X7 Receptor-Mediated Cell Death.

Dreisig K, Sund L, Dommer MW, Kristensen NP, Boddum K, Viste R, Fredholm S, Odum N, Jäättelä M, Skov S, Kornum BR.

Front Immunol. 2018 Jun 8;9:1159. doi: 10.3389/fimmu.2018.01159. eCollection 2018.

7.

Flow cytometry analysis of T-cell subsets in cerebrospinal fluid of narcolepsy type 1 patients with long-lasting disease.

Moresco M, Lecciso M, Ocadlikova D, Filardi M, Melzi S, Kornum BR, Antelmi E, Pizza F, Mignot E, Curti A, Plazzi G.

Sleep Med. 2018 Apr;44:53-60. doi: 10.1016/j.sleep.2017.11.1150. Epub 2018 Jan 3.

PMID:
29530370
8.

N-terminal tagging of human P2X7 receptor disturbs calcium influx and dye uptake.

Dreisig K, Kristensen NP, Dommer MW, Jørgensen NR, Kornum BR.

Purinergic Signal. 2018 Mar;14(1):83-90. doi: 10.1007/s11302-017-9598-8. Epub 2017 Dec 30.

9.

Increased interferon-mediated immunity following in vitro and in vivo Modafinil treatment on peripheral immune cells.

Zager A, Brandão WN, Margatho RO, Cruz DSG, Peron JP, Tufik S, Andersen ML, Moresco M, Pizza F, Plazzi G, Kornum BR, Palermo-Neto J.

Prog Neuropsychopharmacol Biol Psychiatry. 2018 Feb 2;81:297-305. doi: 10.1016/j.pnpbp.2017.09.009. Epub 2017 Sep 15.

PMID:
28919446
10.

Absence of autoreactive CD4+ T-cells targeting HLA-DQA1*01:02/DQB1*06:02 restricted hypocretin/orexin epitopes in narcolepsy type 1 when detected by EliSpot.

Kornum BR, Burgdorf KS, Holm A, Ullum H, Jennum P, Knudsen S.

J Neuroimmunol. 2017 Aug 15;309:7-11. doi: 10.1016/j.jneuroim.2017.05.001. Epub 2017 May 4.

PMID:
28601291
11.

Sleep spindle density in narcolepsy.

Christensen JAE, Nikolic M, Hvidtfelt M, Kornum BR, Jennum P.

Sleep Med. 2017 Jun;34:40-49. doi: 10.1016/j.sleep.2017.02.022. Epub 2017 Mar 18.

PMID:
28522097
12.

Sleep-wake stability in narcolepsy patients with normal, low and unmeasurable hypocretin levels.

Hansen MH, Kornum BR, Jennum P.

Sleep Med. 2017 Jun;34:1-6. doi: 10.1016/j.sleep.2017.01.021. Epub 2017 Mar 14.

PMID:
28522076
13.

The wake-promoting drug Modafinil prevents motor impairment in sickness behavior induced by LPS in mice: Role for dopaminergic D1 receptor.

Zager A, Brandão WN, Margatho RO, Peron JP, Tufik S, Andersen ML, Kornum BR, Palermo-Neto J.

Prog Neuropsychopharmacol Biol Psychiatry. 2018 Feb 2;81:468-476. doi: 10.1016/j.pnpbp.2017.05.003. Epub 2017 May 9.

PMID:
28499899
14.

Narcolepsy.

Kornum BR, Knudsen S, Ollila HM, Pizza F, Jennum PJ, Dauvilliers Y, Overeem S.

Nat Rev Dis Primers. 2017 Feb 9;3:16100. doi: 10.1038/nrdp.2016.100. Review.

PMID:
28179647
15.

Novel method for evaluation of eye movements in patients with narcolepsy.

Christensen JAE, Kempfner L, Leonthin HL, Hvidtfelt M, Nikolic M, Kornum BR, Jennum P.

Sleep Med. 2017 May;33:171-180. doi: 10.1016/j.sleep.2016.10.016. Epub 2016 Dec 21.

PMID:
28087252
16.

Normal Morning Melanin-Concentrating Hormone Levels and No Association with Rapid Eye Movement or Non-Rapid Eye Movement Sleep Parameters in Narcolepsy Type 1 and Type 2.

Schrölkamp M, Jennum PJ, Gammeltoft S, Holm A, Kornum BR, Knudsen S.

J Clin Sleep Med. 2017 Feb 15;13(2):235-243. doi: 10.5664/jcsm.6454.

17.

Neurobasal media facilitates increased specificity of siRNA-mediated knockdown in primary cerebellar cultures.

Gustafsson JR, Katsioudi G, Issazadeh-Navikas S, Kornum BR.

J Neurosci Methods. 2016 Dec 1;274:116-124. doi: 10.1016/j.jneumeth.2016.10.001. Epub 2016 Oct 4.

PMID:
27717866
18.

Monozygotic twins discordant for narcolepsy type 1 and multiple sclerosis.

Jennum PJ, Kornum BR, Issa NM, Gammeltoft S, Tommerup N, Morling N, Tümer Z, Knudsen S.

Neurol Neuroimmunol Neuroinflamm. 2016 Jun 16;3(4):e249. doi: 10.1212/NXI.0000000000000249. eCollection 2016 Aug. No abstract available.

19.

A critical look at the function of the P2Y11 receptor.

Dreisig K, Kornum BR.

Purinergic Signal. 2016 Sep;12(3):427-37. doi: 10.1007/s11302-016-9514-7. Epub 2016 May 31. Review.

20.

Cerebrospinal Fluid Hypocretin-1 (Orexin-A) Level Fluctuates with Season and Correlates with Day Length.

Boddum K, Hansen MH, Jennum PJ, Kornum BR.

PLoS One. 2016 Mar 23;11(3):e0151288. doi: 10.1371/journal.pone.0151288. eCollection 2016.

21.

The European Narcolepsy Network (EU-NN) database.

Khatami R, Luca G, Baumann CR, Bassetti CL, Bruni O, Canellas F, Dauvilliers Y, Del Rio-Villegas R, Feketeova E, Ferri R, Geisler P, Högl B, Jennum P, Kornum BR, Lecendreux M, Martins-da-Silva A, Mathis J, Mayer G, Paiva T, Partinen M, Peraita-Adrados R, Plazzi G, Santamaria J, Sonka K, Riha R, Tafti M, Wierzbicka A, Young P, Lammers GJ, Overeem S; European Narcolepsy Network.

J Sleep Res. 2016 Jun;25(3):356-64. doi: 10.1111/jsr.12374. Epub 2016 Jan 26.

22.

An optimized method for measuring hypocretin-1 peptide in the mouse brain reveals differential circadian regulation of hypocretin-1 levels rostral and caudal to the hypothalamus.

Justinussen JL, Holm A, Kornum BR.

Neuroscience. 2015 Dec 3;310:354-61. doi: 10.1016/j.neuroscience.2015.09.050. Epub 2015 Sep 28.

PMID:
26415770
23.

Serum cytokine levels in Kleine-Levin syndrome.

Kornum BR, Rico T, Lin L, Huang YS, Arnulf I, Jennum P, Mignot E.

Sleep Med. 2015 Aug;16(8):961-5. doi: 10.1016/j.sleep.2015.02.540. Epub 2015 May 15.

PMID:
26116465
24.

Type 1 narcolepsy: a CD8(+) T cell-mediated disease?

Degn M, Kornum BR.

Ann N Y Acad Sci. 2015 Sep;1351:80-8. doi: 10.1111/nyas.12793. Epub 2015 Jun 10. Review.

PMID:
26096261
25.

Cerebrospinal fluid cytokine levels in type 1 narcolepsy patients very close to onset.

Kornum BR, Pizza F, Knudsen S, Plazzi G, Jennum P, Mignot E.

Brain Behav Immun. 2015 Oct;49:54-8. doi: 10.1016/j.bbi.2015.03.004. Epub 2015 Mar 11.

26.

EIF3G is associated with narcolepsy across ethnicities.

Holm A, Lin L, Faraco J, Mostafavi S, Battle A, Zhu X, Levinson DF, Han F, Gammeltoft S, Jennum P, Mignot E, Kornum BR.

Eur J Hum Genet. 2015 Nov;23(11):1573-80. doi: 10.1038/ejhg.2015.4. Epub 2015 Feb 11.

27.

HLA-DPB1 and HLA class I confer risk of and protection from narcolepsy.

Ollila HM, Ravel JM, Han F, Faraco J, Lin L, Zheng X, Plazzi G, Dauvilliers Y, Pizza F, Hong SC, Jennum P, Knudsen S, Kornum BR, Dong XS, Yan H, Hong H, Coquillard C, Mahlios J, Jolanki O, Einen M, Arnulf I, Högl B, Frauscher B, Crowe C, Partinen M, Huang YS, Bourgin P, Vaarala O, Désautels A, Montplaisir J, Mack SJ, Mindrinos M, Fernandez-Vina M, Mignot E.

Am J Hum Genet. 2015 Jan 8;96(1):136-46. doi: 10.1016/j.ajhg.2014.12.010. Erratum in: Am J Hum Genet. 2015 May 7;96(5):852. Lavault, Sophie [removed]; Arnulf, Isabelle [added].

28.

MiRNA profiles in cerebrospinal fluid from patients with central hypersomnias.

Holm A, Bang-Berthelsen CH, Knudsen S, Modvig S, Kornum BR, Gammeltoft S, Jennum PJ.

J Neurol Sci. 2014 Dec 15;347(1-2):199-204. doi: 10.1016/j.jns.2014.09.047. Epub 2014 Oct 2.

PMID:
25451005
29.

Does autoreactivity have a role in narcolepsy?

Partinen M, Kornum BR, Plazzi G, Jennum P, Julkunen I, Vaarala O.

Lancet Neurol. 2014 Nov;13(11):1072-1073. doi: 10.1016/S1474-4422(14)70168-1. No abstract available.

PMID:
25316012
30.

miRNA profiles in plasma from patients with sleep disorders reveal dysregulation of miRNAs in narcolepsy and other central hypersomnias.

Holm A, Bang-Berthelsen CH, Knudsen S, Kornum BR, Modvig S, Jennum P, Gammeltoft S.

Sleep. 2014 Sep 1;37(9):1525-33. doi: 10.5665/sleep.4004.

31.

Retraction of the research article: "CD4⁺ T cell autoimmunity to hypocretin/orexin and cross-reactivity to a 2009 H1N1 influenza A epitope in narcolepsy".

De la Herrán-Arita AK, Kornum BR, Mahlios J, Jiang W, Lin L, Hou T, Macaubas C, Einen M, Plazzi G, Crowe C, Newell EW, Davis MM, Mellins ED, Mignot E.

Sci Transl Med. 2014 Jul 30;6(247):247rt1. doi: 10.1126/scitranslmed.3009995. No abstract available.

PMID:
25080479
32.

Narcolepsy as an autoimmune disease: the role of H1N1 infection and vaccination.

Partinen M, Kornum BR, Plazzi G, Jennum P, Julkunen I, Vaarala O.

Lancet Neurol. 2014 Jun;13(6):600-13. doi: 10.1016/S1474-4422(14)70075-4. Review.

PMID:
24849861
33.

CD4+ T cell autoimmunity to hypocretin/orexin and cross-reactivity to a 2009 H1N1 influenza A epitope in narcolepsy.

De la Herrán-Arita AK, Kornum BR, Mahlios J, Jiang W, Lin L, Hou T, Macaubas C, Einen M, Plazzi G, Crowe C, Newell EW, Davis MM, Mellins ED, Mignot E.

Sci Transl Med. 2013 Dec 18;5(216):216ra176. doi: 10.1126/scitranslmed.3007762. Retraction in: De la Herrán-Arita AK, Kornum BR, Mahlios J, Jiang W, Lin L, Hou T, Macaubas C, Einen M, Plazzi G, Crowe C, Newell EW, Davis MM, Mellins ED, Mignot E. Sci Transl Med. 2014 Jul 30;6(247):247rt1.

PMID:
24353159
34.

[The association between narcolepsy and H1N1 influenza].

Kornum BR, Knudsen S, Gammeltoft S, Jennum P.

Ugeskr Laeger. 2013 Mar 18;175(12):815. Danish. No abstract available.

PMID:
23582821
35.

ImmunoChip study implicates antigen presentation to T cells in narcolepsy.

Faraco J, Lin L, Kornum BR, Kenny EE, Trynka G, Einen M, Rico TJ, Lichtner P, Dauvilliers Y, Arnulf I, Lecendreux M, Javidi S, Geisler P, Mayer G, Pizza F, Poli F, Plazzi G, Overeem S, Lammers GJ, Kemlink D, Sonka K, Nevsimalova S, Rouleau G, Desautels A, Montplaisir J, Frauscher B, Ehrmann L, Högl B, Jennum P, Bourgin P, Peraita-Adrados R, Iranzo A, Bassetti C, Chen WM, Concannon P, Thompson SD, Damotte V, Fontaine B, Breban M, Gieger C, Klopp N, Deloukas P, Wijmenga C, Hallmayer J, Onengut-Gumuscu S, Rich SS, Winkelmann J, Mignot E.

PLoS Genet. 2013;9(2):e1003270. doi: 10.1371/journal.pgen.1003270. Epub 2013 Feb 14.

36.

Predictors of hypocretin (orexin) deficiency in narcolepsy without cataplexy.

Andlauer O, Moore H 4th, Hong SC, Dauvilliers Y, Kanbayashi T, Nishino S, Han F, Silber MH, Rico T, Einen M, Kornum BR, Jennum P, Knudsen S, Nevsimalova S, Poli F, Plazzi G, Mignot E.

Sleep. 2012 Sep 1;35(9):1247-55F. doi: 10.5665/sleep.2080.

37.

Early IVIg treatment has no effect on post-H1N1 narcolepsy phenotype or hypocretin deficiency.

Knudsen S, Biering-Sørensen B, Kornum BR, Petersen ER, Ibsen JD, Gammeltoft S, Mignot E, Jennum PJ.

Neurology. 2012 Jul 3;79(1):102-3. doi: 10.1212/WNL.0b013e31825dce03. Epub 2012 Jun 20. No abstract available.

PMID:
22722630
38.

Mutations in DNMT1 cause autosomal dominant cerebellar ataxia, deafness and narcolepsy.

Winkelmann J, Lin L, Schormair B, Kornum BR, Faraco J, Plazzi G, Melberg A, Cornelio F, Urban AE, Pizza F, Poli F, Grubert F, Wieland T, Graf E, Hallmayer J, Strom TM, Mignot E.

Hum Mol Genet. 2012 May 15;21(10):2205-10. doi: 10.1093/hmg/dds035. Epub 2012 Feb 9.

39.

DQB1*06:02 allele-specific expression varies by allelic dosage, not narcolepsy status.

Weiner Lachmi K, Lin L, Kornum BR, Rico T, Lo B, Aran A, Mignot E.

Hum Immunol. 2012 Apr;73(4):405-10. doi: 10.1016/j.humimm.2012.01.004. Epub 2012 Jan 31.

40.

Narcolepsy with hypocretin/orexin deficiency, infections and autoimmunity of the brain.

Kornum BR, Faraco J, Mignot E.

Curr Opin Neurobiol. 2011 Dec;21(6):897-903. doi: 10.1016/j.conb.2011.09.003. Epub 2011 Sep 30. Review.

PMID:
21963829
41.

5-HT radioligands for human brain imaging with PET and SPECT.

Paterson LM, Kornum BR, Nutt DJ, Pike VW, Knudsen GM.

Med Res Rev. 2013 Jan;33(1):54-111. doi: 10.1002/med.20245. Epub 2011 Jun 14. Review.

42.

Common variants in P2RY11 are associated with narcolepsy.

Kornum BR, Kawashima M, Faraco J, Lin L, Rico TJ, Hesselson S, Axtell RC, Kuipers H, Weiner K, Hamacher A, Kassack MU, Han F, Knudsen S, Li J, Dong X, Winkelmann J, Plazzi G, Nevsimalova S, Hong SC, Honda Y, Honda M, Högl B, Ton TG, Montplaisir J, Bourgin P, Kemlink D, Huang YS, Warby S, Einen M, Eshragh JL, Miyagawa T, Desautels A, Ruppert E, Hesla PE, Poli F, Pizza F, Frauscher B, Jeong JH, Lee SP, Strohl KP, Longstreth WT Jr, Kvale M, Dobrovolna M, Ohayon MM, Nepom GT, Wichmann HE, Rouleau GA, Gieger C, Levinson DF, Gejman PV, Meitinger T, Peppard P, Young T, Jennum P, Steinman L, Tokunaga K, Kwok PY, Risch N, Hallmayer J, Mignot E.

Nat Genet. 2011 Jan;43(1):66-71. doi: 10.1038/ng.734. Epub 2010 Dec 19. Erratum in: Nat Genet. 2011 Oct;43(10):1040.

43.

Radiosynthesis and evaluation of 11C-CIMBI-5 as a 5-HT2A receptor agonist radioligand for PET.

Ettrup A, Palner M, Gillings N, Santini MA, Hansen M, Kornum BR, Rasmussen LK, Någren K, Madsen J, Begtrup M, Knudsen GM.

J Nucl Med. 2010 Nov;51(11):1763-70. doi: 10.2967/jnumed.109.074021. Epub 2010 Oct 18.

44.

An approach for serotonin depletion in pigs: effects on serotonin receptor binding.

Ettrup A, Kornum BR, Weikop P, Knudsen GM.

Synapse. 2011 Feb;65(2):136-45. doi: 10.1002/syn.20827.

PMID:
20560131
45.

Cognitive testing of pigs (Sus scrofa) in translational biobehavioral research.

Kornum BR, Knudsen GM.

Neurosci Biobehav Rev. 2011 Jan;35(3):437-51. doi: 10.1016/j.neubiorev.2010.05.004. Epub 2010 May 27. Review.

PMID:
20553757
46.

Adeno-associated viral vector serotypes 1 and 5 targeted to the neonatal rat and pig striatum induce widespread transgene expression in the forebrain.

Kornum BR, Stott SR, Mattsson B, Wisman L, Ettrup A, Hermening S, Knudsen GM, Kirik D.

Exp Neurol. 2010 Mar;222(1):70-85. doi: 10.1016/j.expneurol.2009.12.009. Epub 2009 Dec 16.

PMID:
20025873
47.

Species differences in blood-brain barrier transport of three positron emission tomography radioligands with emphasis on P-glycoprotein transport.

Syvänen S, Lindhe O, Palner M, Kornum BR, Rahman O, Långström B, Knudsen GM, Hammarlund-Udenaes M.

Drug Metab Dispos. 2009 Mar;37(3):635-43. doi: 10.1124/dmd.108.024745. Epub 2008 Dec 1.

PMID:
19047468
48.

Evaluation of the novel 5-HT4 receptor PET ligand [11C]SB207145 in the Göttingen minipig.

Kornum BR, Lind NM, Gillings N, Marner L, Andersen F, Knudsen GM.

J Cereb Blood Flow Metab. 2009 Jan;29(1):186-96. doi: 10.1038/jcbfm.2008.110. Epub 2008 Sep 17.

PMID:
18797470
49.

A novel spatial Delayed Non-Match to Sample (DNMS) task in the Göttingen minipig.

Nielsen TR, Kornum BR, Moustgaard A, Gade A, Lind NM, Knudsen GM.

Behav Brain Res. 2009 Jan 3;196(1):93-8. doi: 10.1016/j.bbr.2008.07.019. Epub 2008 Jul 25.

PMID:
18706937
50.

The effect of the inter-phase delay interval in the spontaneous object recognition test for pigs.

Kornum BR, Thygesen KS, Nielsen TR, Knudsen GM, Lind NM.

Behav Brain Res. 2007 Aug 6;181(2):210-7. Epub 2007 Apr 20.

PMID:
17524499

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