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Simple nutrients bypass the requirement for HLH-30 in coupling lysosomal nutrient sensing to survival.

Murphy JT, Liu H, Ma X, Shaver A, Egan BM, Oh C, Boyko A, Mazer T, Ang S, Khopkar R, Javaheri A, Kumar S, Jiang X, Ory D, Mani K, Matkovich SJ, Kornfeld K, Diwan A.

PLoS Biol. 2019 May 14;17(5):e3000245. doi: 10.1371/journal.pbio.3000245. eCollection 2019 May.


Lifespan Extension in C. elegans Caused by Bacterial Colonization of the Intestine and Subsequent Activation of an Innate Immune Response.

Kumar S, Egan BM, Kocsisova Z, Schneider DL, Murphy JT, Diwan A, Kornfeld K.

Dev Cell. 2019 Apr 8;49(1):100-117.e6. doi: 10.1016/j.devcel.2019.03.010.


Rapid population-wide declines in stem cell number and activity during reproductive aging in C. elegans.

Kocsisova Z, Kornfeld K, Schedl T.

Development. 2019 Apr 23;146(8). pii: dev173195. doi: 10.1242/dev.173195.


Cell Cycle Analysis in the C. elegans Germline with the Thymidine Analog EdU.

Kocsisova Z, Mohammad A, Kornfeld K, Schedl T.

J Vis Exp. 2018 Oct 22;(140). doi: 10.3791/58339.


The zinc transporter ZIPT-7.1 regulates sperm activation in nematodes.

Zhao Y, Tan CH, Krauchunas A, Scharf A, Dietrich N, Warnhoff K, Yuan Z, Druzhinina M, Gu SG, Miao L, Singson A, Ellis RE, Kornfeld K.

PLoS Biol. 2018 Jun 7;16(6):e2005069. doi: 10.1371/journal.pbio.2005069. eCollection 2018 Jun.


A pathway for low zinc homeostasis that is conserved in animals and acts in parallel to the pathway for high zinc homeostasis.

Dietrich N, Schneider DL, Kornfeld K.

Nucleic Acids Res. 2017 Nov 16;45(20):11658-11672. doi: 10.1093/nar/gkx762.


The Nuclear Receptor HIZR-1 Uses Zinc as a Ligand to Mediate Homeostasis in Response to High Zinc.

Warnhoff K, Roh HC, Kocsisova Z, Tan CH, Morrison A, Croswell D, Schneider DL, Kornfeld K.

PLoS Biol. 2017 Jan 17;15(1):e2000094. doi: 10.1371/journal.pbio.2000094. eCollection 2017 Jan.


Insights into zinc and cadmium biology in the nematode Caenorhabditis elegans.

Dietrich N, Tan CH, Cubillas C, Earley BJ, Kornfeld K.

Arch Biochem Biophys. 2016 Dec 1;611:120-133. doi: 10.1016/ Epub 2016 May 31. Review.


Angiotensin Converting Enzyme (ACE) Inhibitor Extends Caenorhabditis elegans Life Span.

Kumar S, Dietrich N, Kornfeld K.

PLoS Genet. 2016 Feb 26;12(2):e1005866. doi: 10.1371/journal.pgen.1005866. eCollection 2016 Feb.


New links between protein N-terminal acetylation, dauer diapause, and the insulin/IGF-1 signaling pathway in Caenorhabditis elegans.

Warnhoff K, Kornfeld K.

Worm. 2015 Mar 11;4(2):e1023498. doi: 10.1080/21624054.2015.1023498. eCollection 2015 Apr-Jun.


Corrigendum: Simple Copy Number Determination with Reference Query Pyrosequencing (RQPS).

Liu Z, Schneider DL, Kornfeld K, Kopan R.

Cold Spring Harb Protoc. 2015 Oct 1;2015(10):950. doi: 10.1101/pdb.corr090167. No abstract available.


Conversion of the LIN-1 ETS protein of Caenorhabditis elegans from a SUMOylated transcriptional repressor to a phosphorylated transcriptional activator.

Leight ER, Murphy JT, Fantz DA, Pepin D, Schneider DL, Ratliff TM, Mohammad DH, Herman MA, Kornfeld K.

Genetics. 2015 Mar;199(3):761-75. doi: 10.1534/genetics.114.172668. Epub 2015 Jan 7.


A modular system of DNA enhancer elements mediates tissue-specific activation of transcription by high dietary zinc in C. elegans.

Roh HC, Dimitrov I, Deshmukh K, Zhao G, Warnhoff K, Cabrera D, Tsai W, Kornfeld K.

Nucleic Acids Res. 2015 Jan;43(2):803-16. doi: 10.1093/nar/gku1360. Epub 2014 Dec 30.


Keep on laying eggs Mama, RNAi my reproductive aging blues away.

Kumar S, Kocsisova Z, Kornfeld K.

PLoS Genet. 2014 Dec 4;10(12):e1004808. doi: 10.1371/journal.pgen.1004808. eCollection 2014 Dec. No abstract available.


The DAF-16 FOXO transcription factor regulates natc-1 to modulate stress resistance in Caenorhabditis elegans, linking insulin/IGF-1 signaling to protein N-terminal acetylation.

Warnhoff K, Murphy JT, Kumar S, Schneider DL, Peterson M, Hsu S, Guthrie J, Robertson JD, Kornfeld K.

PLoS Genet. 2014 Oct 16;10(10):e1004703. doi: 10.1371/journal.pgen.1004703. eCollection 2014 Oct.


Mated progeny production is a biomarker of aging in Caenorhabditis elegans.

Pickett CL, Dietrich N, Chen J, Xiong C, Kornfeld K.

G3 (Bethesda). 2013 Dec 9;3(12):2219-32. doi: 10.1534/g3.113.008664.


ttm-1 encodes CDF transporters that excrete zinc from intestinal cells of C. elegans and act in a parallel negative feedback circuit that promotes homeostasis.

Roh HC, Collier S, Deshmukh K, Guthrie J, Robertson JD, Kornfeld K.

PLoS Genet. 2013 May;9(5):e1003522. doi: 10.1371/journal.pgen.1003522. Epub 2013 May 23.


Age-related degeneration of the egg-laying system promotes matricidal hatching in Caenorhabditis elegans.

Pickett CL, Kornfeld K.

Aging Cell. 2013 Aug;12(4):544-53. doi: 10.1111/acel.12079. Epub 2013 May 2.


Lysosome-related organelles in intestinal cells are a zinc storage site in C. elegans.

Roh HC, Collier S, Guthrie J, Robertson JD, Kornfeld K.

Cell Metab. 2012 Jan 4;15(1):88-99. doi: 10.1016/j.cmet.2011.12.003.


Identification of mutations that delay somatic or reproductive aging of Caenorhabditis elegans.

Hughes SE, Huang C, Kornfeld K.

Genetics. 2011 Sep;189(1):341-56. doi: 10.1534/genetics.111.130450. Epub 2011 Jul 12.


Histidine protects against zinc and nickel toxicity in Caenorhabditis elegans.

Murphy JT, Bruinsma JJ, Schneider DL, Collier S, Guthrie J, Chinwalla A, Robertson JD, Mardis ER, Kornfeld K.

PLoS Genet. 2011 Mar;7(3):e1002013. doi: 10.1371/journal.pgen.1002013. Epub 2011 Mar 24.


Simple copy number determination with reference query pyrosequencing (RQPS).

Liu Z, Schneider DL, Kornfeld K, Kopan R.

Cold Spring Harb Protoc. 2010 Sep 1;2010(9):pdb.prot5491. doi: 10.1101/pdb.prot5491. Erratum in: Cold Spring Harb Protoc. 2015 Oct;2015(10):950.


The CRAL/TRIO and GOLD domain protein TAP-1 regulates RAF-1 activation.

Johnson KG, Kornfeld K.

Dev Biol. 2010 May 15;341(2):464-71. doi: 10.1016/j.ydbio.2010.03.003. Epub 2010 Mar 15.


The cation diffusion facilitator gene cdf-2 mediates zinc metabolism in Caenorhabditis elegans.

Davis DE, Roh HC, Deshmukh K, Bruinsma JJ, Schneider DL, Guthrie J, Robertson JD, Kornfeld K.

Genetics. 2009 Aug;182(4):1015-33. doi: 10.1534/genetics.109.103614. Epub 2009 May 17.


The anticonvulsant ethosuximide disrupts sensory function to extend C. elegans lifespan.

Collins JJ, Evason K, Pickett CL, Schneider DL, Kornfeld K.

PLoS Genet. 2008 Oct;4(10):e1000230. doi: 10.1371/journal.pgen.1000230. Epub 2008 Oct 24.


The measurement and analysis of age-related changes in Caenorhabditis elegans.

Collins JJ, Huang C, Hughes S, Kornfeld K.

WormBook. 2008 Jan 24:1-21. doi: 10.1895/wormbook.1.137.1. Review.


Valproic acid extends Caenorhabditis elegans lifespan.

Evason K, Collins JJ, Huang C, Hughes S, Kornfeld K.

Aging Cell. 2008 Jun;7(3):305-17. doi: 10.1111/j.1474-9726.2008.00375.x. Epub 2008 Jan 29.


Genetic and pharmacological factors that influence reproductive aging in nematodes.

Hughes SE, Evason K, Xiong C, Kornfeld K.

PLoS Genet. 2007 Feb 16;3(2):e25. Epub 2006 Dec 28.


Pharmacology of delayed aging and extended lifespan of Caenorhabditis elegans.

Collins JJ, Evason K, Kornfeld K.

Exp Gerontol. 2006 Oct;41(10):1032-9. Epub 2006 Jul 26. Review.


Identification of cis-regulatory elements from the C. elegans Hox gene lin-39 required for embryonic expression and for regulation by the transcription factors LIN-1, LIN-31 and LIN-39.

Wagmaister JA, Miley GR, Morris CA, Gleason JE, Miller LM, Kornfeld K, Eisenmann DM.

Dev Biol. 2006 Sep 15;297(2):550-65. Epub 2006 May 19.


Effects of anticonvulsant drugs on life span.

Kornfeld K, Evason K.

Arch Neurol. 2006 Apr;63(4):491-6.


Sumoylation of LIN-1 promotes transcriptional repression and inhibition of vulval cell fates.

Leight ER, Glossip D, Kornfeld K.

Development. 2005 Mar;132(5):1047-56. Epub 2005 Feb 2.


Anticonvulsant medications extend worm life-span.

Evason K, Huang C, Yamben I, Covey DF, Kornfeld K.

Science. 2005 Jan 14;307(5707):258-62.


Identification of residues of the Caenorhabditis elegans LIN-1 ETS domain that are necessary for DNA binding and regulation of vulval cell fates.

Miley GR, Fantz D, Glossip D, Lu X, Saito RM, Palmer RE, Inoue T, Van Den Heuvel S, Sternberg PW, Kornfeld K.

Genetics. 2004 Aug;167(4):1697-709.


Measurements of age-related changes of physiological processes that predict lifespan of Caenorhabditis elegans.

Huang C, Xiong C, Kornfeld K.

Proc Natl Acad Sci U S A. 2004 May 25;101(21):8084-9. Epub 2004 May 12.


Identification of residues and domains of Raf important for function in vivo and in vitro.

Harding A, Hsu V, Kornfeld K, Hancock JF.

J Biol Chem. 2003 Nov 14;278(46):45519-27. Epub 2003 Sep 3.


Zinc ions and cation diffusion facilitator proteins regulate Ras-mediated signaling.

Bruinsma JJ, Jirakulaporn T, Muslin AJ, Kornfeld K.

Dev Cell. 2002 May;2(5):567-78.


Docking sites on substrate proteins direct extracellular signal-regulated kinase to phosphorylate specific residues.

Fantz DA, Jacobs D, Glossip D, Kornfeld K.

J Biol Chem. 2001 Jul 20;276(29):27256-65. Epub 2001 May 22.


Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase.

Jacobs D, Glossip D, Xing H, Muslin AJ, Kornfeld K.

Genes Dev. 1999 Jan 15;13(2):163-75.


The protein kinase KSR interacts with 14-3-3 protein and Raf.

Xing H, Kornfeld K, Muslin AJ.

Curr Biol. 1997 May 1;7(5):294-300.


Vulval development in Caenorhabditis elegans.

Kornfeld K.

Trends Genet. 1997 Feb;13(2):55-61. Review.


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