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Impact of Diabetes and Low Body Mass Index on Tuberculosis Treatment Outcomes.

Kornfeld H, Sahukar SB, Procter-Gray E, Kumar NP, West K, Kane K, Natarajan M, Li W, Babu S, Viswanathan V.

Clin Infect Dis. 2020 Jan 19. pii: ciaa054. doi: 10.1093/cid/ciaa054. [Epub ahead of print]


Systemic RAGE ligands are upregulated in tuberculosis individuals with diabetes co-morbidity and modulated by anti-tuberculosis treatment and metformin therapy.

Kumar NP, Moideen K, Nancy A, Viswanathan V, Shruthi BS, Sivakumar S, Hissar S, Kornfeld H, Babu S.

BMC Infect Dis. 2019 Dec 9;19(1):1039. doi: 10.1186/s12879-019-4648-1.


Plasma chemokines are biomarkers of disease severity, higher bacterial burden and delayed sputum culture conversion in pulmonary tuberculosis.

Kumar NP, Moideen K, Nancy A, Viswanathan V, Shruthi BS, Sivakumar S, Natarajan M, Kornfeld H, Babu S.

Sci Rep. 2019 Dec 3;9(1):18217. doi: 10.1038/s41598-019-54803-w.


A Common NLRC4 Gene Variant Associates With Inflammation and Pulmonary Function in Human Immunodeficiency Virus and Tuberculosis.

Ravimohan S, Maenetje P, Auld SC, Ncube I, Mlotshwa M, Chase W, Tiemessen CT, Vangu MD, Wallis RS, Churchyard G, Weissman D, Kornfeld H, Bisson GP.

Clin Infect Dis. 2019 Nov 22. pii: ciz898. doi: 10.1093/cid/ciz898. [Epub ahead of print]


Plasma Eicosanoid Levels in Tuberculosis and Tuberculosis-Diabetes Co-morbidity Are Associated With Lung Pathology and Bacterial Burden.

Pavan Kumar N, Moideen K, Nancy A, Viswanathan V, Shruthi BS, Shanmugam S, Hissar S, Kornfeld H, Babu S.

Front Cell Infect Microbiol. 2019 Oct 1;9:335. doi: 10.3389/fcimb.2019.00335. eCollection 2019.


Declines in Lung Function After Antiretroviral Therapy Initiation in Adults With Human Immunodeficiency Virus and Tuberculosis: A Potential Manifestation of Respiratory Immune Reconstitution Inflammatory Syndrome.

Auld SC, Maenetje P, Ravimohan S, Weissman D, Ncube I, Mlotshwa M, Ratsela N, Chase W, Vangu MD, Wallis R, Churchyard G, Kornfeld H, Bisson GP.

Clin Infect Dis. 2019 Sep 25. pii: ciz733. doi: 10.1093/cid/ciz733. [Epub ahead of print]


Heterogeneity in the cytokine profile of tuberculosis - diabetes co-morbidity.

Kumar NP, Moideen K, Nancy A, Viswanathan V, Shruthi BS, Sivakumar S, Natarajan M, Kornfeld H, Babu S.

Cytokine. 2020 Jan;125:154824. doi: 10.1016/j.cyto.2019.154824. Epub 2019 Aug 28.


Tuberculosis and diabetes: from bench to bedside and back.

Martinez N, Kornfeld H.

Int J Tuberc Lung Dis. 2019 Jun 1;23(6):669-677. doi: 10.5588/ijtld.18.0805.


mTORC2/Akt activation in adipocytes is required for adipose tissue inflammation in tuberculosis.

Martinez N, Cheng CY, Ketheesan N, Cullen A, Tang Y, Lum J, West K, Poidinger M, Guertin DA, Singhal A, Kornfeld H.

EBioMedicine. 2019 Jul;45:314-327. doi: 10.1016/j.ebiom.2019.06.052. Epub 2019 Jul 4.


Persistent inflammation during anti-tuberculosis treatment with diabetes comorbidity.

Kumar NP, Fukutani KF, Shruthi BS, Alves T, Silveira-Mattos PS, Rocha MS, West K, Natarajan M, Viswanathan V, Babu S, Andrade BB, Kornfeld H.

Elife. 2019 Jul 4;8. pii: e46477. doi: 10.7554/eLife.46477.


Lung injury on antiretroviral therapy in adults with HIV/TB.

Ravimohan S, Auld SC, Maenetje P, Ratsela N, Mlotshwa M, Ncube I, Smith JP, Vangu MD, Sebe M, Kossenkov A, Weissman D, Wallis RS, Churchyard G, Kornfeld H, Bisson GP.

Clin Infect Dis. 2019 Jun 26. pii: ciz560. doi: 10.1093/cid/ciz560. [Epub ahead of print]


The temporal and financial benefit of intraoperative breast specimen imaging: A pilot study of the Kubtec MOZART.

Kornfeld HW, Mulder LL, Spivey TL, Cortina CS, Madrigrano A, Kopkash KA.

Breast J. 2019 Jul;25(4):766-768. doi: 10.1111/tbj.13337. Epub 2019 May 13. No abstract available.


Reduced prevalence of latent tuberculosis infection in diabetes patients using metformin and statins.

Magee MJ, Salindri AD, Kornfeld H, Singhal A.

Eur Respir J. 2019 Mar 14;53(3). pii: 1801695. doi: 10.1183/13993003.01695-2018. Print 2019 Mar. No abstract available.


Elevated circulating levels of monocyte activation markers among tuberculosis patients with diabetes co-morbidity.

Kumar NP, Moideen K, Bhootra Y, Nancy A, Viswanathan V, Shruthi BS, Sivakumar S, Natarajan M, Kornfeld H, Babu S.

Immunology. 2019 Mar;156(3):249-258. doi: 10.1111/imm.13023. Epub 2018 Dec 10.


Convergence of non-communicable diseases and tuberculosis: a two-way street?

Magee MJ, Salindri AD, Gujral UP, Auld SC, Bao J, Haw JS, Lin HH, Kornfeld H.

Int J Tuberc Lung Dis. 2018 Nov 1;22(11):1258-1268. doi: 10.5588/ijtld.18.0045. Review.


Perioperative Considerations for the Patient with Opioid Use Disorder on Buprenorphine, Methadone, or Naltrexone Maintenance Therapy.

Harrison TK, Kornfeld H, Aggarwal AK, Lembke A.

Anesthesiol Clin. 2018 Sep;36(3):345-359. doi: 10.1016/j.anclin.2018.04.002. Epub 2018 Jul 11. Review.


IL-16/miR-125a axis controls neutrophil recruitment in pristane-induced lung inflammation.

Smith S, Wu PW, Seo JJ, Fernando T, Jin M, Contreras J, Montano EN, Gabhann JN, Cunningham K, Widaa A, McCarthy EM, Molloy ES, Kearns G, Murphy CC, Kong W, Björkbacka H, Kornfeld H, Forbess L, Venuturupalli S, Ishimori M, Wallace D, Weisman MH, Jefferies CA.

JCI Insight. 2018 Aug 9;3(15). pii: 120798. doi: 10.1172/jci.insight.120798. eCollection 2018 Aug 9.


Empirical treatment with non-anti-tuberculosis antibiotics decreased microbiological detection in cervical tuberculous lymphadenitis.

Dai Y, Wen Z, Ye T, Deng G, Zhang M, Deng Q, Yang Q, Shan W, Kornfeld H, Cai Y, Chen X.

Diagn Microbiol Infect Dis. 2018 Nov;92(3):245-249. doi: 10.1016/j.diagmicrobio.2018.06.008. Epub 2018 Jun 20.


Elevated levels of matrix metalloproteinases reflect severity and extent of disease in tuberculosis-diabetes co-morbidity and are predominantly reversed following standard anti-tuberculosis or metformin treatment.

Kumar NP, Moideen K, Viswanathan V, Shruthi BS, Sivakumar S, Menon PA, Kornfeld H, Babu S.

BMC Infect Dis. 2018 Jul 25;18(1):345. doi: 10.1186/s12879-018-3246-y.


Enlisting the Host to Fight TB.

Kornfeld H, Singhal A.

Chest. 2018 Jun;153(6):1292-1293. doi: 10.1016/j.chest.2018.01.011. No abstract available.


A dual purpose for household contact investigations: preventing TB disease and improving diabetes outcomes.

Magee MJ, Gandhi NR, Kornfeld H.

Int J Tuberc Lung Dis. 2018 Jun 1;22(6):594-595. doi: 10.5588/ijtld.18.0262. No abstract available.


Indicators for prediction of Mycobacterium tuberculosis positivity detected with bronchoalveolar lavage fluid.

Liu X, Hou XF, Gao L, Deng GF, Zhang MX, Deng QY, Ye TS, Yang QT, Zhou BP, Wen ZH, Liu HY, Kornfeld H, Chen XC.

Infect Dis Poverty. 2018 Mar 24;7(1):22. doi: 10.1186/s40249-018-0403-x.


Tuberculosis and lung damage: from epidemiology to pathophysiology.

Ravimohan S, Kornfeld H, Weissman D, Bisson GP.

Eur Respir Rev. 2018 Feb 28;27(147). pii: 170077. doi: 10.1183/16000617.0077-2017. Print 2018 Mar 31. Review.


Heightened circulating levels of antimicrobial peptides in tuberculosis-Diabetes co-morbidity and reversal upon treatment.

Kumar NP, Moideen K, Viswanathan V, Sivakumar S, Menon PA, Kornfeld H, Babu S.

PLoS One. 2017 Sep 14;12(9):e0184753. doi: 10.1371/journal.pone.0184753. eCollection 2017.


Host sirtuin 1 regulates mycobacterial immunopathogenesis and represents a therapeutic target against tuberculosis.

Cheng CY, Gutierrez NM, Marzuki MB, Lu X, Foreman TW, Paleja B, Lee B, Balachander A, Chen J, Tsenova L, Kurepina N, Teng KWW, West K, Mehra S, Zolezzi F, Poidinger M, Kreiswirth B, Kaushal D, Kornfeld H, Newell EW, Singhal A.

Sci Immunol. 2017 Mar;2(9). pii: eaaj1789. doi: 10.1126/sciimmunol.aaj1789. Epub 2017 Mar 24.


Systems Immunology of Diabetes-Tuberculosis Comorbidity Reveals Signatures of Disease Complications.

Prada-Medina CA, Fukutani KF, Pavan Kumar N, Gil-Santana L, Babu S, Lichtenstein F, West K, Sivakumar S, Menon PA, Viswanathan V, Andrade BB, Nakaya HI, Kornfeld H.

Sci Rep. 2017 May 17;7(1):1999. doi: 10.1038/s41598-017-01767-4.


"The Impact of Mycobacterium tuberculosis Immune Evasion on Protective Immunity: Implications for TB Vaccine Design" - Meeting report.

Boggiano C, Eichelberg K, Ramachandra L, Shea J, Ramakrishnan L, Behar S, Ernst JD, Porcelli SA, Maeurer M, Kornfeld H.

Vaccine. 2017 Jun 14;35(27):3433-3440. doi: 10.1016/j.vaccine.2017.04.007. Epub 2017 May 2.


Defining a Research Agenda to Address the Converging Epidemics of Tuberculosis and Diabetes: Part 2: Underlying Biologic Mechanisms.

Ronacher K, van Crevel R, Critchley JA, Bremer AA, Schlesinger LS, Kapur A, Basaraba R, Kornfeld H, Restrepo BI.

Chest. 2017 Jul;152(1):174-180. doi: 10.1016/j.chest.2017.02.032. Epub 2017 Apr 20. Review.


Defining a Research Agenda to Address the Converging Epidemics of Tuberculosis and Diabetes: Part 1: Epidemiology and Clinical Management.

Critchley JA, Restrepo BI, Ronacher K, Kapur A, Bremer AA, Schlesinger LS, Basaraba R, Kornfeld H, van Crevel R.

Chest. 2017 Jul;152(1):165-173. doi: 10.1016/j.chest.2017.04.155. Epub 2017 Apr 20. Review.


Modulation of dendritic cell and monocyte subsets in tuberculosis-diabetes co-morbidity upon standard tuberculosis treatment.

Kumar NP, Moideen K, Sivakumar S, Menon PA, Viswanathan V, Kornfeld H, Babu S.

Tuberculosis (Edinb). 2016 Dec;101:191-200. doi: 10.1016/ Epub 2016 Oct 11.


NK-CD11c+ Cell Crosstalk in Diabetes Enhances IL-6-Mediated Inflammation during Mycobacterium tuberculosis Infection.

Cheekatla SS, Tripathi D, Venkatasubramanian S, Nathella PK, Paidipally P, Ishibashi M, Welch E, Tvinnereim AR, Ikebe M, Valluri VL, Babu S, Kornfeld H, Vankayalapati R.

PLoS Pathog. 2016 Oct 26;12(10):e1005972. doi: 10.1371/journal.ppat.1005972. eCollection 2016 Oct.


Tuberculosis-diabetes co-morbidity is characterized by heightened systemic levels of circulating angiogenic factors.

Kumar NP, Moideen K, Sivakumar S, Menon PA, Viswanathan V, Kornfeld H, Babu S.

J Infect. 2017 Jan;74(1):10-21. doi: 10.1016/j.jinf.2016.08.021. Epub 2016 Oct 4.


Tuberculosis Susceptibility and Vaccine Protection Are Independently Controlled by Host Genotype.

Smith CM, Proulx MK, Olive AJ, Laddy D, Mishra BB, Moss C, Gutierrez NM, Bellerose MM, Barreira-Silva P, Phuah JY, Baker RE, Behar SM, Kornfeld H, Evans TG, Beamer G, Sassetti CM.

mBio. 2016 Sep 20;7(5). pii: e01516-16. doi: 10.1128/mBio.01516-16.


Impaired Recognition of Mycobacterium tuberculosis by Alveolar Macrophages From Diabetic Mice.

Martinez N, Ketheesan N, West K, Vallerskog T, Kornfeld H.

J Infect Dis. 2016 Dec 1;214(11):1629-1637. Epub 2016 Sep 13.


Effect of standard tuberculosis treatment on naive, memory and regulatory T-cell homeostasis in tuberculosis-diabetes co-morbidity.

Kumar NP, Moideen K, Viswanathan V, Kornfeld H, Babu S.

Immunology. 2016 Sep;149(1):87-97. doi: 10.1111/imm.12632. Epub 2016 Jul 26.


Defects in early cell recruitment contribute to the increased susceptibility to respiratory Klebsiella pneumoniae infection in diabetic mice.

Martinez N, Ketheesan N, Martens GW, West K, Lien E, Kornfeld H.

Microbes Infect. 2016 Oct;18(10):649-655. doi: 10.1016/j.micinf.2016.05.007. Epub 2016 May 30.


Glucose Metabolism Disorder Is Associated with Pulmonary Tuberculosis in Individuals with Respiratory Symptoms from Brazil.

Almeida-Junior JL, Gil-Santana L, Oliveira CA, Castro S, Cafezeiro AS, Daltro C, Netto EM, Kornfeld H, Andrade BB.

PLoS One. 2016 Apr 14;11(4):e0153590. doi: 10.1371/journal.pone.0153590. eCollection 2016.


High Prevalence and Heterogeneity of Diabetes in Patients With TB in South India: A Report from the Effects of Diabetes on Tuberculosis Severity (EDOTS) Study.

Kornfeld H, West K, Kane K, Kumpatla S, Zacharias RR, Martinez-Balzano C, Li W, Viswanathan V.

Chest. 2016 Jun;149(6):1501-8. doi: 10.1016/j.chest.2016.02.675. Epub 2016 Mar 10.


A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling.

Ní Cheallaigh C, Sheedy FJ, Harris J, Muñoz-Wolf N, Lee J, West K, McDermott EP, Smyth A, Gleeson LE, Coleman M, Martinez N, Hearnden CH, Tynan GA, Carroll EC, Jones SA, Corr SC, Bernard NJ, Hughes MM, Corcoran SE, O'Sullivan M, Fallon CM, Kornfeld H, Golenbock D, Gordon SV, O'Neill LA, Lavelle EC, Keane J.

Immunity. 2016 Feb 16;44(2):368-79. doi: 10.1016/j.immuni.2016.01.019.


Diabetes Is Associated with Worse Clinical Presentation in Tuberculosis Patients from Brazil: A Retrospective Cohort Study.

Gil-Santana L, Almeida-Junior JL, Oliveira CA, Hickson LS, Daltro C, Castro S, Kornfeld H, Netto EM, Andrade BB.

PLoS One. 2016 Jan 11;11(1):e0146876. doi: 10.1371/journal.pone.0146876. eCollection 2016.


Discriminating Active Tuberculosis from Latent Tuberculosis Infection by flow cytometric measurement of CD161-expressing T cells.

Yang Q, Xu Q, Chen Q, Li J, Zhang M, Cai Y, Liu H, Zhou Y, Deng G, Deng Q, Zhou B, Kornfeld H, Chen X.

Sci Rep. 2015 Dec 8;5:17918. doi: 10.1038/srep17918.


Differential adjuvant activities of TLR7 and TLR9 agonists inversely correlate with nitric oxide and PGE2 production.

Lee J, Martinez N, West K, Kornfeld H.

PLoS One. 2015 Apr 13;10(4):e0123165. doi: 10.1371/journal.pone.0123165. eCollection 2015.


Bacillary replication and macrophage necrosis are determinants of neutrophil recruitment in tuberculosis.

Repasy T, Martinez N, Lee J, West K, Li W, Kornfeld H.

Microbes Infect. 2015 Aug;17(8):564-74. doi: 10.1016/j.micinf.2015.03.013. Epub 2015 Apr 7.


Cell death and autophagy in tuberculosis.

Moraco AH, Kornfeld H.

Semin Immunol. 2014 Dec;26(6):497-511. doi: 10.1016/j.smim.2014.10.001. Epub 2014 Oct 17. Review.


Coincident pre-diabetes is associated with dysregulated cytokine responses in pulmonary tuberculosis.

Kumar NP, Banurekha VV, Nair D, Sridhar R, Kornfeld H, Nutman TB, Babu S.

PLoS One. 2014 Nov 13;9(11):e112108. doi: 10.1371/journal.pone.0112108. eCollection 2014.


IP-10 and MIG are compartmentalized at the site of disease during pleural and meningeal tuberculosis and are decreased after antituberculosis treatment.

Yang Q, Cai Y, Zhao W, Wu F, Zhang M, Luo K, Zhang Y, Liu H, Zhou B, Kornfeld H, Chen X.

Clin Vaccine Immunol. 2014 Dec;21(12):1635-44. doi: 10.1128/CVI.00499-14. Epub 2014 Oct 1.


Chromatin decondensation and T cell hyperresponsiveness in diabetes-associated hyperglycemia.

Martinez N, Vallerskog T, West K, Nunes-Alves C, Lee J, Martens GW, Behar SM, Kornfeld H.

J Immunol. 2014 Nov 1;193(9):4457-68. doi: 10.4049/jimmunol.1401125. Epub 2014 Sep 22.


Heterochromatin position effects on circularized sex chromosomes cause filicidal embryonic lethality in Drosophila melanogaster.

Ferree PM, Gomez K, Rominger P, Howard D, Kornfeld H, Barbash DA.

Genetics. 2014 Apr;196(4):1001-5. doi: 10.1534/genetics.113.161075. Epub 2014 Jan 29.


Diabetes and immunity to tuberculosis.

Martinez N, Kornfeld H.

Eur J Immunol. 2014 Mar;44(3):617-26. doi: 10.1002/eji.201344301. Epub 2014 Feb 16. Review.


Gamma interferon immunospot assay of pleural effusion mononuclear cells for diagnosis of tuberculous pleurisy.

Liao M, Yang Q, Zhang J, Zhang M, Deng Q, Liu H, Graner MW, Kornfeld H, Zhou B, Chen X.

Clin Vaccine Immunol. 2014 Mar;21(3):347-53. doi: 10.1128/CVI.00680-13. Epub 2014 Jan 3.

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