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Sp3-cificity of TNF-α expression promotes the Smac mimetic-mediated killing of cancer cells.

Beug ST, Korneluk RG, LaCasse EC.

Mol Cell Oncol. 2019 May 8;6(4):1607456. doi: 10.1080/23723556.2019.1607456. eCollection 2019.


Targeted ablation of the cellular inhibitor of apoptosis 1 (cIAP1) attenuates denervation-induced skeletal muscle atrophy.

Lala-Tabbert N, Lejmi-Mrad R, Timusk K, Fukano M, Holbrook J, St-Jean M, LaCasse EC, Korneluk RG.

Skelet Muscle. 2019 May 24;9(1):13. doi: 10.1186/s13395-019-0201-6.


The transcription factor SP3 drives TNF-α expression in response to Smac mimetics.

Beug ST, Cheung HH, Sanda T, St-Jean M, Beauregard CE, Mamady H, Baird SD, LaCasse EC, Korneluk RG.

Sci Signal. 2019 Jan 29;12(566). pii: eaat9563. doi: 10.1126/scisignal.aat9563.


Combination of IAP Antagonists and TNF-α-Armed Oncolytic Viruses Induce Tumor Vascular Shutdown and Tumor Regression.

Beug ST, Pichette SJ, St-Jean M, Holbrook J, Walker DE, LaCasse EC, Korneluk RG.

Mol Ther Oncolytics. 2018 Jun 21;10:28-39. doi: 10.1016/j.omto.2018.06.002. eCollection 2018 Sep 28.


Publisher Correction: Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma.

Beug ST, Beauregard CE, Healy C, Sanda T, St-Jean M, Chabot J, Walker DE, Mohan A, Earl N, Lun X, Senger DL, Robbins SM, Staeheli P, Forsyth PA, Alain T, LaCasse EC, Korneluk RG.

Nat Commun. 2018 Jul 18;9:16231. doi: 10.1038/ncomms16231.


Differentiated macrophages acquire a pro-inflammatory and cell death-resistant phenotype due to increasing XIAP and p38-mediated inhibition of RipK1.

Rijal D, Ariana A, Wight A, Kim K, Alturki NA, Aamir Z, Ametepe ES, Korneluk RG, Tiedje C, Menon MB, Gaestel M, McComb S, Sad S.

J Biol Chem. 2018 Jul 27;293(30):11913-11927. doi: 10.1074/jbc.RA118.003614. Epub 2018 Jun 13.


Triad3a induces the degradation of early necrosome to limit RipK1-dependent cytokine production and necroptosis.

Alturki NA, McComb S, Ariana A, Rijal D, Korneluk RG, Sun SC, Alnemri E, Sad S.

Cell Death Dis. 2018 May 22;9(6):592. doi: 10.1038/s41419-018-0672-0.


Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma.

Beug ST, Beauregard CE, Healy C, Sanda T, St-Jean M, Chabot J, Walker DE, Mohan A, Earl N, Lun X, Senger DL, Robbins SM, Staeheli P, Forsyth PA, Alain T, LaCasse EC, Korneluk RG.

Nat Commun. 2017 Feb 15;8. doi: 10.1038/ncomms14278. Erratum in: Nat Commun. 2018 Jul 18;9:16231.


Oncolytic virus synergizes with Smac mimetic compounds to induce rhabdomyosarcoma cell death in a syngeneic murine model.

Dobson CC, Naing T, Beug ST, Faye MD, Chabot J, St-Jean M, Walker DE, LaCasse EC, Stojdl DF, Korneluk RG, Holcik M.

Oncotarget. 2017 Jan 10;8(2):3495-3508. doi: 10.18632/oncotarget.13849.


Combinatorial cancer immunotherapy strategies with proapoptotic small-molecule IAP antagonists.

Beug ST, Conrad DP, Alain T, Korneluk RG, Lacasse EC.

Int J Dev Biol. 2015;59(1-3):141-7. doi: 10.1387/ijdb.150084el. Review.


Combinatorial cancer immunotherapy strategies with proapoptotic small-molecule IAP antagonists.

Beug ST, Conrad DP, Alain T, Korneluk RG, Lacasse EC.

Int J Dev Biol. 2015 May 21. [Epub ahead of print]


The inhibitors of apoptosis (IAPs): Over 20 years of research into life and death.

LaCasse EC, Beug ST, Korneluk RG.

Semin Cell Dev Biol. 2015 Mar;39:70-1. doi: 10.1016/j.semcdb.2015.04.002. No abstract available.


Smac mimetics combined with innate immune stimuli create the perfect cytokine storm to kill tumor cells.

Beug ST, LaCasse EC, Korneluk RG.

Oncoimmunology. 2014 Apr 29;3:e28541. eCollection 2014.


IGF2BP1 controls cell death and drug resistance in rhabdomyosarcomas by regulating translation of cIAP1.

Faye MD, Beug ST, Graber TE, Earl N, Xiang X, Wild B, Langlois S, Michaud J, Cowan KN, Korneluk RG, Holcik M.

Oncogene. 2015 Mar 19;34(12):1532-41. doi: 10.1038/onc.2014.90. Epub 2014 Apr 7.


Role of the TWEAK-Fn14-cIAP1-NF-κB Signaling Axis in the Regulation of Myogenesis and Muscle Homeostasis.

Enwere EK, Lacasse EC, Adam NJ, Korneluk RG.

Front Immunol. 2014 Feb 5;5:34. doi: 10.3389/fimmu.2014.00034. eCollection 2014. Review.


Smac mimetics and innate immune stimuli synergize to promote tumor death.

Beug ST, Tang VA, LaCasse EC, Cheung HH, Beauregard CE, Brun J, Nuyens JP, Earl N, St-Jean M, Holbrook J, Dastidar H, Mahoney DJ, Ilkow C, Le Boeuf F, Bell JC, Korneluk RG.

Nat Biotechnol. 2014 Feb;32(2):182-90. doi: 10.1038/nbt.2806. Epub 2014 Jan 26.


Loss of cIAP1 attenuates soleus muscle pathology and improves diaphragm function in mdx mice.

Enwere EK, Boudreault L, Holbrook J, Timusk K, Earl N, LaCasse E, Renaud JM, Korneluk RG.

Hum Mol Genet. 2013 Mar 1;22(5):867-78. doi: 10.1093/hmg/dds493. Epub 2012 Nov 25.


TWEAK and cIAP1 regulate myoblast fusion through the noncanonical NF-κB signaling pathway.

Enwere EK, Holbrook J, Lejmi-Mrad R, Vineham J, Timusk K, Sivaraj B, Isaac M, Uehling D, Al-awar R, LaCasse E, Korneluk RG.

Sci Signal. 2012 Oct 16;5(246):ra75. doi: 10.1126/scisignal.2003086.


Modulation of immune signalling by inhibitors of apoptosis.

Beug ST, Cheung HH, LaCasse EC, Korneluk RG.

Trends Immunol. 2012 Nov;33(11):535-45. doi: 10.1016/ Epub 2012 Jul 24. Review.


cIAP1 and cIAP2 limit macrophage necroptosis by inhibiting Rip1 and Rip3 activation.

McComb S, Cheung HH, Korneluk RG, Wang S, Krishnan L, Sad S.

Cell Death Differ. 2012 Nov;19(11):1791-801. doi: 10.1038/cdd.2012.59. Epub 2012 May 11.


SMG1 and NIK regulate apoptosis induced by Smac mimetic compounds.

Cheung HH, St Jean M, Beug ST, Lejmi-Mrad R, LaCasse E, Baird SD, Stojdl DF, Screaton RA, Korneluk RG.

Cell Death Dis. 2011 Apr 14;2:e146. doi: 10.1038/cddis.2011.25.


XIAP inhibition of β-cell apoptosis reduces the number of islets required to restore euglycemia in a syngeneic islet transplantation model.

Plesner A, Soukhatcheva G, Korneluk RG, Verchere CB.

Islets. 2010 Jan-Feb;2(1):18-23. doi: 10.4161/isl.2.1.9997.


Smac mimetic compounds potentiate interleukin-1beta-mediated cell death.

Cheung HH, Beug ST, St Jean M, Brewster A, Kelly NL, Wang S, Korneluk RG.

J Biol Chem. 2010 Dec 24;285(52):40612-23. doi: 10.1074/jbc.M110.183616. Epub 2010 Oct 18.


Tumor suppressor XIAP-Associated factor 1 (XAF1) cooperates with tumor necrosis factor-related apoptosis-inducing ligand to suppress colon cancer growth and trigger tumor regression.

Tu SP, Sun YW, Cui JT, Zou B, Lin MC, Gu Q, Jiang SH, Kung HF, Korneluk RG, Wong BC.

Cancer. 2010 Mar 1;116(5):1252-63. doi: 10.1002/cncr.24814. Erratum in: Cancer. 2012 Mar 1;118(5):1470.


Down-regulation of c-FLIP Enhances death of cancer cells by smac mimetic compound.

Cheung HH, Mahoney DJ, Lacasse EC, Korneluk RG.

Cancer Res. 2009 Oct 1;69(19):7729-38. doi: 10.1158/0008-5472.CAN-09-1794. Epub 2009 Sep 22.


Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2.

Bertrand MJ, Doiron K, Labbé K, Korneluk RG, Barker PA, Saleh M.

Immunity. 2009 Jun 19;30(6):789-801. doi: 10.1016/j.immuni.2009.04.011. Epub 2009 May 21.


Restoration of XAF1 expression induces apoptosis and inhibits tumor growth in gastric cancer.

Tu SP, Liston P, Cui JT, Lin MC, Jiang XH, Yang Y, Gu Q, Jiang SH, Lum CT, Kung HF, Korneluk RG, Wong BC.

Int J Cancer. 2009 Aug 1;125(3):688-97. doi: 10.1002/ijc.24282.


Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK.

Zarnegar BJ, Wang Y, Mahoney DJ, Dempsey PW, Cheung HH, He J, Shiba T, Yang X, Yeh WC, Mak TW, Korneluk RG, Cheng G.

Nat Immunol. 2008 Dec;9(12):1371-8. doi: 10.1038/ni.1676. Epub 2008 Nov 9.


IAP-targeted therapies for cancer.

LaCasse EC, Mahoney DJ, Cheung HH, Plenchette S, Baird S, Korneluk RG.

Oncogene. 2008 Oct 20;27(48):6252-75. doi: 10.1038/onc.2008.302. Review.


Over-expression of X-linked inhibitor of apoptosis protein slows presbycusis in C57BL/6J mice.

Wang J, Menchenton T, Yin S, Yu Z, Bance M, Morris DP, Moore CS, Korneluk RG, Robertson GS.

Neurobiol Aging. 2010 Jul;31(7):1238-49. doi: 10.1016/j.neurobiolaging.2008.07.016. Epub 2008 Aug 27.


Both cIAP1 and cIAP2 regulate TNFalpha-mediated NF-kappaB activation.

Mahoney DJ, Cheung HH, Mrad RL, Plenchette S, Simard C, Enwere E, Arora V, Mak TW, Lacasse EC, Waring J, Korneluk RG.

Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11778-83. doi: 10.1073/pnas.0711122105. Epub 2008 Aug 12.


Increased X-linked inhibitor of apoptosis protein (XIAP) expression exacerbates experimental autoimmune encephalomyelitis (EAE).

Moore CS, Hebb AL, Blanchard MM, Crocker CE, Liston P, Korneluk RG, Robertson GS.

J Neuroimmunol. 2008 Oct 15;203(1):79-93. doi: 10.1016/j.jneuroim.2008.06.030.


The RING domain of cIAP1 mediates the degradation of RING-bearing inhibitor of apoptosis proteins by distinct pathways.

Cheung HH, Plenchette S, Kern CJ, Mahoney DJ, Korneluk RG.

Mol Biol Cell. 2008 Jul;19(7):2729-40. doi: 10.1091/mbc.E08-01-0107. Epub 2008 Apr 23.


Analysis of trinucleotide repeats in myotonic dystrophy.

Surh LC, Mahadevan M, Korneluk RG.

Curr Protoc Hum Genet. 2001 May;Chapter 9:Unit 9.6. doi: 10.1002/0471142905.hg0906s01.


The role of XAF1 in cancer.

Plenchette S, Cheung HH, Fong WG, LaCasse EC, Korneluk RG.

Curr Opin Investig Drugs. 2007 Jun;8(6):469-76. Review.


Degradation of survivin by the X-linked inhibitor of apoptosis (XIAP)-XAF1 complex.

Arora V, Cheung HH, Plenchette S, Micali OC, Liston P, Korneluk RG.

J Biol Chem. 2007 Sep 7;282(36):26202-9. Epub 2007 Jul 5.


The inhibitors of apoptosis (IAPs) as cancer targets.

Hunter AM, LaCasse EC, Korneluk RG.

Apoptosis. 2007 Sep;12(9):1543-68. Review.


Silencing of the XAF1 gene by promoter hypermethylation in cancer cells and reactivation to TRAIL-sensitization by IFN-beta.

Micali OC, Cheung HH, Plenchette S, Hurley SL, Liston P, LaCasse EC, Korneluk RG.

BMC Cancer. 2007 Mar 21;7:52.


XIAP protection of photoreceptors in animal models of retinitis pigmentosa.

Leonard KC, Petrin D, Coupland SG, Baker AN, Leonard BC, LaCasse EC, Hauswirth WW, Korneluk RG, Tsilfidis C.

PLoS One. 2007 Mar 21;2(3):e314.


Searching for IRES.

Baird SD, Turcotte M, Korneluk RG, Holcik M.

RNA. 2006 Oct;12(10):1755-85. Epub 2006 Sep 6. Review.


Detachment-induced upregulation of XIAP and cIAP2 delays anoikis of intestinal epithelial cells.

Liu Z, Li H, Wu X, Yoo BH, Yan SR, Stadnyk AW, Sasazuki T, Shirasawa S, LaCasse EC, Korneluk RG, Rosen KV.

Oncogene. 2006 Dec 14;25(59):7680-90. Epub 2006 Jun 26.


X-linked inhibitor of apoptosis antagonism: strategies in cancer treatment.

Cheung HH, LaCasse EC, Korneluk RG.

Clin Cancer Res. 2006 Jun 1;12(11 Pt 1):3238-42. Review. No abstract available.


Involvement of caspase-2 and caspase-9 in endoplasmic reticulum stress-induced apoptosis: a role for the IAPs.

Cheung HH, Lynn Kelly N, Liston P, Korneluk RG.

Exp Cell Res. 2006 Jul 15;312(12):2347-57. Epub 2006 Apr 4.


Abnormalities of cell structures in tumors: apoptosis in tumors.

Cheung HH, Arora V, Korneluk RG.

EXS. 2006;(96):201-21. Review.


Inhibitor of apoptosis protein cIAP2 is essential for lipopolysaccharide-induced macrophage survival.

Conte D, Holcik M, Lefebvre CA, Lacasse E, Picketts DJ, Wright KE, Korneluk RG.

Mol Cell Biol. 2006 Jan;26(2):699-708.


XIAP-mediated neuroprotection in retinal ischemia.

Renwick J, Narang MA, Coupland SG, Xuan JY, Baker AN, Brousseau J, Petrin D, Munger R, Leonard BC, Hauswirth WW, Korneluk RG, Tsilfidis C.

Gene Ther. 2006 Feb;13(4):339-47.


XIAP overexpression in human islets prevents early posttransplant apoptosis and reduces the islet mass needed to treat diabetes.

Emamaullee JA, Rajotte RV, Liston P, Korneluk RG, Lakey JR, Shapiro AM, Elliott JF.

Diabetes. 2005 Sep;54(9):2541-8.


The X-linked inhibitor of apoptosis protein enhances survival of murine islet allografts.

Plesner A, Liston P, Tan R, Korneluk RG, Verchere CB.

Diabetes. 2005 Sep;54(9):2533-40.


ras Oncogene triggers up-regulation of cIAP2 and XIAP in intestinal epithelial cells: epidermal growth factor receptor-dependent and -independent mechanisms of ras-induced transformation.

Liu Z, Li H, Derouet M, Filmus J, LaCasse EC, Korneluk RG, Kerbel RS, Rosen KV.

J Biol Chem. 2005 Nov 11;280(45):37383-92. Epub 2005 Aug 22.


XIAP overexpression in islet beta-cells enhances engraftment and minimizes hypoxia-reperfusion injury.

Emamaullee J, Liston P, Korneluk RG, Shapiro AM, Elliott JF.

Am J Transplant. 2005 Jun;5(6):1297-305. Review.

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