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Dimer-specific immunoprecipitation of active caspase-2 identifies TRAF proteins as novel activators.

Robeson AC, Lindblom KR, Wojton J, Kornbluth S, Matsuura K.

EMBO J. 2018 Jul 13;37(14). pii: e97072. doi: 10.15252/embj.201797072. Epub 2018 Jun 6.


Downregulation of the proapoptotic protein MOAP-1 by the UBR5 ubiquitin ligase and its role in ovarian cancer resistance to cisplatin.

Matsuura K, Huang NJ, Cocce K, Zhang L, Kornbluth S.

Oncogene. 2017 Mar 23;36(12):1698-1706. doi: 10.1038/onc.2016.336. Epub 2016 Oct 10.


A grafted ovarian fragment rescues host fertility after chemotherapy.

Batchvarov IS, Taylor RW, Bustamante-Marín X, Czerwinski M, Johnson ES, Kornbluth S, Capel B.

Mol Hum Reprod. 2016 Dec;22(12):842-851. Epub 2016 Oct 3.


Evaluation of eye, head and trunk coordination during target tracking tasks.

Gadotti IC, Elbaum L, Jung Y, Garbalosa V, Kornbluth S, Da Costa B, Maitra K, Brunt D.

Ergonomics. 2016 Nov;59(11):1420-1427. Epub 2016 Apr 6.


Mitotic phosphatase activity is required for MCC maintenance during the spindle checkpoint.

Foss KM, Robeson AC, Kornbluth S, Zhang L.

Cell Cycle. 2016;15(2):225-33. doi: 10.1080/15384101.2015.1121331.


Vertebrate Reproduction.

Kornbluth S, Fissore R.

Cold Spring Harb Perspect Biol. 2015 Oct 1;7(10):a006064. doi: 10.1101/cshperspect.a006064. Review.


Automated, quantitative analysis of histopathological staining in nuclei.

Henao R, Geradts J, Kurokawa M, Kornbluth S, Lucas JE.

AMIA Jt Summits Transl Sci Proc. 2014 Apr 7;2014:54-9. eCollection 2014.


Metabolic control of Ca2+/calmodulin-dependent protein kinase II (CaMKII)-mediated caspase-2 suppression by the B55β/protein phosphatase 2A (PP2A).

Huang B, Yang CS, Wojton J, Huang NJ, Chen C, Soderblom EJ, Zhang L, Kornbluth S.

J Biol Chem. 2014 Dec 26;289(52):35882-90. doi: 10.1074/jbc.M114.585844. Epub 2014 Nov 4.


Fatty acid synthase inhibition engages a novel caspase-2 regulatory mechanism to induce ovarian cancer cell death.

Yang CS, Matsuura K, Huang NJ, Robeson AC, Huang B, Zhang L, Kornbluth S.

Oncogene. 2015 Jun;34(25):3264-72. doi: 10.1038/onc.2014.271. Epub 2014 Aug 25.


Reduced lipoapoptosis, hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis.

Machado MV, Michelotti GA, Pereira Tde A, Boursier J, Kruger L, Swiderska-Syn M, Karaca G, Xie G, Guy CD, Bohinc B, Lindblom KR, Johnson E, Kornbluth S, Diehl AM.

Gut. 2015 Jul;64(7):1148-57. doi: 10.1136/gutjnl-2014-307362. Epub 2014 Jul 22.


Sally Kornbluth: Nature's incredible contraptions.

Kornbluth S, Sedwick C.

J Cell Biol. 2014 Jul 7;206(1):4-5. doi: 10.1083/jcb.2061pi. No abstract available.


The deubiquitinating enzyme DUBAI stabilizes DIAP1 to suppress Drosophila apoptosis.

Yang CS, Sinenko SA, Thomenius MJ, Robeson AC, Freel CD, Horn SR, Kornbluth S.

Cell Death Differ. 2014 Apr;21(4):604-11. doi: 10.1038/cdd.2013.184. Epub 2013 Dec 20.


Suppression of DNA-damage checkpoint signaling by Rsk-mediated phosphorylation of Mre11.

Chen C, Zhang L, Huang NJ, Huang B, Kornbluth S.

Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20605-10. doi: 10.1073/pnas.1306328110. Epub 2013 Dec 2.


Cellular mechanisms controlling caspase activation and function.

Parrish AB, Freel CD, Kornbluth S.

Cold Spring Harb Perspect Biol. 2013 Jun 1;5(6). pii: a008672. doi: 10.1101/cshperspect.a008672. Review.


A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53.

Kurokawa M, Kim J, Geradts J, Matsuura K, Liu L, Ran X, Xia W, Ribar TJ, Henao R, Dewhirst MW, Kim WJ, Lucas JE, Wang S, Spector NL, Kornbluth S.

Sci Signal. 2013 May 7;6(274):ra32. doi: 10.1126/scisignal.2003741.


Metabolomic profiling reveals a role for caspase-2 in lipoapoptosis.

Johnson ES, Lindblom KR, Robeson A, Stevens RD, Ilkayeva OR, Newgard CB, Kornbluth S, Andersen JL.

J Biol Chem. 2013 May 17;288(20):14463-75. doi: 10.1074/jbc.M112.437210. Epub 2013 Apr 3.


The tangled circuitry of metabolism and apoptosis.

Andersen JL, Kornbluth S.

Mol Cell. 2013 Feb 7;49(3):399-410. doi: 10.1016/j.molcel.2012.12.026. Review.


Engineering a BCR-ABL-activated caspase for the selective elimination of leukemic cells.

Kurokawa M, Ito T, Yang CS, Zhao C, Macintyre AN, Rizzieri DA, Rathmell JC, Deininger MW, Reya T, Kornbluth S.

Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2300-5. doi: 10.1073/pnas.1206551110. Epub 2013 Jan 16.


Ubiquitylation of p53 by the APC/C inhibitor Trim39.

Zhang L, Huang NJ, Chen C, Tang W, Kornbluth S.

Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):20931-6. doi: 10.1073/pnas.1212047110. Epub 2012 Dec 4.


Life, death, and the metabolically controlled protein acetylome.

Johnson ES, Kornbluth S.

Curr Opin Cell Biol. 2012 Dec;24(6):876-80. doi: 10.1016/ Epub 2012 Oct 23. Review.


Mcl-1 rescues a glitch in the matrix.

Andersen JL, Kornbluth S.

Nat Cell Biol. 2012 May 30;14(6):563-5. doi: 10.1038/ncb2511.


The Trim39 ubiquitin ligase inhibits APC/CCdh1-mediated degradation of the Bax activator MOAP-1.

Huang NJ, Zhang L, Tang W, Chen C, Yang CS, Kornbluth S.

J Cell Biol. 2012 Apr 30;197(3):361-7. doi: 10.1083/jcb.201108062. Epub 2012 Apr 23.


Establishing a framework for improving the quality of clinical and translational research.

Califf RM, Kornbluth S.

J Clin Oncol. 2012 May 10;30(14):1725-6. doi: 10.1200/JCO.2011.41.4458. Epub 2012 Apr 9. No abstract available.


Phosphatases driving mitosis: pushing the gas and lifting the brakes.

Johnson ES, Kornbluth S.

Prog Mol Biol Transl Sci. 2012;106:327-41. doi: 10.1016/B978-0-12-396456-4.00008-0. Review.


Rsk-mediated phosphorylation and 14-3-3ɛ binding of Apaf-1 suppresses cytochrome c-induced apoptosis.

Kim J, Parrish AB, Kurokawa M, Matsuura K, Freel CD, Andersen JL, Johnson CE, Kornbluth S.

EMBO J. 2012 Mar 7;31(5):1279-92. doi: 10.1038/emboj.2011.491. Epub 2012 Jan 13.


Climate-associated phenological advances in bee pollinators and bee-pollinated plants.

Bartomeus I, Ascher JS, Wagner D, Danforth BN, Colla S, Kornbluth S, Winfree R.

Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20645-9. doi: 10.1073/pnas.1115559108. Epub 2011 Dec 5.


A biotin switch-based proteomics approach identifies 14-3-3ζ as a target of Sirt1 in the metabolic regulation of caspase-2.

Andersen JL, Thompson JW, Lindblom KR, Johnson ES, Yang CS, Lilley LR, Freel CD, Moseley MA, Kornbluth S.

Mol Cell. 2011 Sep 2;43(5):834-42. doi: 10.1016/j.molcel.2011.07.028.


Meeting the (N-terminal) end with acetylation.

Andersen JL, Kornbluth S.

Cell. 2011 Aug 19;146(4):503-5. doi: 10.1016/j.cell.2011.07.024.


Mitochondrial fusion is regulated by Reaper to modulate Drosophila programmed cell death.

Thomenius M, Freel CD, Horn S, Krieser R, Abdelwahid E, Cannon R, Balasundaram S, White K, Kornbluth S.

Cell Death Differ. 2011 Oct;18(10):1640-50. doi: 10.1038/cdd.2011.26. Epub 2011 Apr 8.


Regulation of mitochondrial morphology by APC/CCdh1-mediated control of Drp1 stability.

Horn SR, Thomenius MJ, Johnson ES, Freel CD, Wu JQ, Coloff JL, Yang CS, Tang W, An J, Ilkayeva OR, Rathmell JC, Newgard CB, Kornbluth S.

Mol Biol Cell. 2011 Apr 15;22(8):1207-16. doi: 10.1091/mbc.E10-07-0567. Epub 2011 Feb 16.


Regulation of the ATM-activator protein Aven by CRM1-dependent nuclear export.

Esmaili AM, Johnson EL, Thaivalappil SS, Kuhn HM, Kornbluth S, Irusta PM.

Cell Cycle. 2010 Oct 1;9(19):3913-20. Epub 2010 Oct 25.


The engine driving the ship: metabolic steering of cell proliferation and death.

Buchakjian MR, Kornbluth S.

Nat Rev Mol Cell Biol. 2010 Oct;11(10):715-27. doi: 10.1038/nrm2972. Review.


Metabolic regulation of Drosophila apoptosis through inhibitory phosphorylation of Dronc.

Yang CS, Thomenius MJ, Gan EC, Tang W, Freel CD, Merritt TJ, Nutt LK, Kornbluth S.

EMBO J. 2010 Sep 15;29(18):3196-207. doi: 10.1038/emboj.2010.191. Epub 2010 Aug 10.


Stalling in mitosis and releasing the apoptotic brake.

Kurokawa M, Kornbluth S.

EMBO J. 2010 Jul 21;29(14):2255-7. doi: 10.1038/emboj.2010.150. No abstract available.


Emi2-mediated inhibition of E2-substrate ubiquitin transfer by the anaphase-promoting complex/cyclosome through a D-box-independent mechanism.

Tang W, Wu JQ, Chen C, Yang CS, Guo JY, Freel CD, Kornbluth S.

Mol Biol Cell. 2010 Aug 1;21(15):2589-97. doi: 10.1091/mbc.E09-08-0708. Epub 2010 Jun 9.


Women: diversity among leaders is there if you look.

Andrews NC, Kornbluth S, Stokke D.

Nature. 2010 Feb 4;463(7281):608. doi: 10.1038/463608d. No abstract available.


A cut above the other caspases.

Andersen JL, Kornbluth S.

Mol Cell. 2009 Sep 24;35(6):733-4. doi: 10.1016/j.molcel.2009.09.001.


Caspases and kinases in a death grip.

Kurokawa M, Kornbluth S.

Cell. 2009 Sep 4;138(5):838-54. doi: 10.1016/j.cell.2009.08.021. Review.


Features of programmed cell death in intact Xenopus oocytes and early embryos revealed by near-infrared fluorescence and real-time monitoring.

Johnson CE, Freel CD, Kornbluth S.

Cell Death Differ. 2010 Jan;17(1):170-9. doi: 10.1038/cdd.2009.120.


Restraint of apoptosis during mitosis through interdomain phosphorylation of caspase-2.

Andersen JL, Johnson CE, Freel CD, Parrish AB, Day JL, Buchakjian MR, Nutt LK, Thompson JW, Moseley MA, Kornbluth S.

EMBO J. 2009 Oct 21;28(20):3216-27. doi: 10.1038/emboj.2009.253. Epub 2009 Sep 3.


Protein phosphatase 2A-dependent dephosphorylation of replication protein A is required for the repair of DNA breaks induced by replication stress.

Feng J, Wakeman T, Yong S, Wu X, Kornbluth S, Wang XF.

Mol Cell Biol. 2009 Nov;29(21):5696-709. doi: 10.1128/MCB.00191-09. Epub 2009 Aug 24.


Metabolic control of oocyte apoptosis mediated by 14-3-3zeta-regulated dephosphorylation of caspase-2.

Nutt LK, Buchakjian MR, Gan E, Darbandi R, Yoon SY, Wu JQ, Miyamoto YJ, Gibbons JA, Andersen JL, Freel CD, Tang W, He C, Kurokawa M, Wang Y, Margolis SS, Fissore RA, Kornbluth S.

Dev Cell. 2009 Jun;16(6):856-66. doi: 10.1016/j.devcel.2009.04.005. Erratum in: Dev Cell. 2010 Jan 19;18(1):165. Gibbon, Jennifer A [corrected to Gibbons, Jennifer A].


PP1-mediated dephosphorylation of phosphoproteins at mitotic exit is controlled by inhibitor-1 and PP1 phosphorylation.

Wu JQ, Guo JY, Tang W, Yang CS, Freel CD, Chen C, Nairn AC, Kornbluth S.

Nat Cell Biol. 2009 May;11(5):644-51. doi: 10.1038/ncb1871. Epub 2009 Apr 26.


Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes.

Galluzzi L, Aaronson SA, Abrams J, Alnemri ES, Andrews DW, Baehrecke EH, Bazan NG, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Castedo M, Cidlowski JA, Ciechanover A, Cohen GM, De Laurenzi V, De Maria R, Deshmukh M, Dynlacht BD, El-Deiry WS, Flavell RA, Fulda S, Garrido C, Golstein P, Gougeon ML, Green DR, Gronemeyer H, Hajnóczky G, Hardwick JM, Hengartner MO, Ichijo H, Jäättelä M, Kepp O, Kimchi A, Klionsky DJ, Knight RA, Kornbluth S, Kumar S, Levine B, Lipton SA, Lugli E, Madeo F, Malomi W, Marine JC, Martin SJ, Medema JP, Mehlen P, Melino G, Moll UM, Morselli E, Nagata S, Nicholson DW, Nicotera P, Nuñez G, Oren M, Penninger J, Pervaiz S, Peter ME, Piacentini M, Prehn JH, Puthalakath H, Rabinovich GA, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Scorrano L, Simon HU, Steller H, Tschopp J, Tsujimoto Y, Vandenabeele P, Vitale I, Vousden KH, Youle RJ, Yuan J, Zhivotovsky B, Kroemer G.

Cell Death Differ. 2009 Aug;16(8):1093-107. doi: 10.1038/cdd.2009.44. Epub 2009 Apr 17. Review.


An essential role for the Glut1 PDZ-binding motif in growth factor regulation of Glut1 degradation and trafficking.

Wieman HL, Horn SR, Jacobs SR, Altman BJ, Kornbluth S, Rathmell JC.

Biochem J. 2009 Mar 1;418(2):345-67. doi: 10.1042/BJ20081422.


Across the meiotic divide - CSF activity in the post-Emi2/XErp1 era.

Wu JQ, Kornbluth S.

J Cell Sci. 2008 Nov 1;121(Pt 21):3509-14. doi: 10.1242/jcs.036855. Review.


A gel-free MS-based quantitative proteomic approach accurately measures cytochrome P450 protein concentrations in human liver microsomes.

Wang MZ, Wu JQ, Dennison JB, Bridges AS, Hall SD, Kornbluth S, Tidwell RR, Smith PC, Voyksner RD, Paine MF, Hall JE.

Proteomics. 2008 Oct;8(20):4186-96. doi: 10.1002/pmic.200800144.


Caspase cleavage is not for everyone.

Johnson CE, Kornbluth S.

Cell. 2008 Sep 5;134(5):720-1. doi: 10.1016/j.cell.2008.08.019.


Inhibition of apoptosome formation by suppression of Hsp90beta phosphorylation in tyrosine kinase-induced leukemias.

Kurokawa M, Zhao C, Reya T, Kornbluth S.

Mol Cell Biol. 2008 Sep;28(17):5494-506. doi: 10.1128/MCB.00265-08. Epub 2008 Jun 30.


Aven-dependent activation of ATM following DNA damage.

Guo JY, Yamada A, Kajino T, Wu JQ, Tang W, Freel CD, Feng J, Chau BN, Wang MZ, Margolis SS, Yoo HY, Wang XF, Dunphy WG, Irusta PM, Hardwick JM, Kornbluth S.

Curr Biol. 2008 Jul 8;18(13):933-42. doi: 10.1016/j.cub.2008.05.045. Epub 2008 Jun 19.

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