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Items: 1 to 50 of 115

1.

Metabolic characterization of isocitrate dehydrogenase (IDH) mutant and IDH wildtype gliomaspheres uncovers cell type-specific vulnerabilities.

Garrett M, Sperry J, Braas D, Yan W, Le TM, Mottahedeh J, Ludwig K, Eskin A, Qin Y, Levy R, Breunig JJ, Pajonk F, Graeber TG, Radu CG, Christofk H, Prins RM, Lai A, Liau LM, Coppola G, Kornblum HI.

Cancer Metab. 2018 Apr 17;6:4. doi: 10.1186/s40170-018-0177-4. eCollection 2018.

2.

Building Bonds: Cancer Stem Cells Depend on Their Progeny to Drive Tumor Progression.

Muthukrishnan SD, Alvarado AG, Kornblum HI.

Cell Stem Cell. 2018 Apr 5;22(4):473-474. doi: 10.1016/j.stem.2018.03.008.

PMID:
29625062
3.

D-2-Hydroxyglutarate Is Necessary and Sufficient for Isocitrate Dehydrogenase 1 Mutant-Induced MIR148A Promoter Methylation.

Li T, Cox CD, Ozer BH, Nguyen NT, Nguyen HN, Lai TJ, Li S, Liu F, Kornblum HI, Liau LM, Nghiemphu PL, Cloughesy TF, Lai A.

Mol Cancer Res. 2018 Jun;16(6):947-960. doi: 10.1158/1541-7786.MCR-17-0367. Epub 2018 Mar 15.

PMID:
29545476
4.

Microtubins: a novel class of small synthetic microtubule targeting drugs that inhibit cancer cell proliferation.

Senese S, Lo YC, Gholkar AA, Li CM, Huang Y, Mottahedeh J, Kornblum HI, Damoiseaux R, Torres JZ.

Oncotarget. 2017 Oct 19;8(61):104007-104021. doi: 10.18632/oncotarget.21945. eCollection 2017 Nov 28.

5.

A molecular cascade modulates MAP1B and confers resistance to mTOR inhibition in human glioblastoma.

Laks DR, Oses-Prieto JA, Alvarado AG, Nakashima J, Chand S, Azzam DB, Gholkar AA, Sperry J, Ludwig K, Condro MC, Nazarian S, Cardenas A, Shih MYS, Damoiseaux R, France B, Orozco N, Visnyei K, Crisman TJ, Gao F, Torres JZ, Coppola G, Burlingame AL, Kornblum HI.

Neuro Oncol. 2018 May 18;20(6):764-775. doi: 10.1093/neuonc/nox215.

6.

Cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma.

Mai WX, Gosa L, Daniels VW, Ta L, Tsang JE, Higgins B, Gilmore WB, Bayley NA, Harati MD, Lee JT, Yong WH, Kornblum HI, Bensinger SJ, Mischel PS, Rao PN, Clark PM, Cloughesy TF, Letai A, Nathanson DA.

Nat Med. 2017 Nov;23(11):1342-1351. doi: 10.1038/nm.4418. Epub 2017 Oct 9.

7.

ATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways.

Le TM, Poddar S, Capri JR, Abt ER, Kim W, Wei L, Uong NT, Cheng CM, Braas D, Nikanjam M, Rix P, Merkurjev D, Zaretsky J, Kornblum HI, Ribas A, Herschman HR, Whitelegge J, Faull KF, Donahue TR, Czernin J, Radu CG.

Nat Commun. 2017 Aug 14;8(1):241. doi: 10.1038/s41467-017-00221-3.

8.

Targeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase EZH2.

Wang J, Cheng P, Pavlyukov MS, Yu H, Zhang Z, Kim SH, Minata M, Mohyeldin A, Xie W, Chen D, Goidts V, Frett B, Hu W, Li H, Shin YJ, Lee Y, Nam DH, Kornblum HI, Wang M, Nakano I.

J Clin Invest. 2017 Aug 1;127(8):3075-3089. doi: 10.1172/JCI89092. Epub 2017 Jul 24.

9.

Molecular markers in glioma.

Ludwig K, Kornblum HI.

J Neurooncol. 2017 Sep;134(3):505-512. doi: 10.1007/s11060-017-2379-y. Epub 2017 Feb 23. Review.

PMID:
28233083
10.

Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity.

Turner KM, Deshpande V, Beyter D, Koga T, Rusert J, Lee C, Li B, Arden K, Ren B, Nathanson DA, Kornblum HI, Taylor MD, Kaushal S, Cavenee WK, Wechsler-Reya R, Furnari FB, Vandenberg SR, Rao PN, Wahl GM, Bafna V, Mischel PS.

Nature. 2017 Mar 2;543(7643):122-125. doi: 10.1038/nature21356. Epub 2017 Feb 8.

11.

Identification of an Efficient Gene Expression Panel for Glioblastoma Classification.

Crisman TJ, Zelaya I, Laks DR, Zhao Y, Kawaguchi R, Gao F, Kornblum HI, Coppola G.

PLoS One. 2016 Nov 17;11(11):e0164649. doi: 10.1371/journal.pone.0164649. eCollection 2016.

12.

Inhibition of Nucleotide Synthesis Targets Brain Tumor Stem Cells in a Subset of Glioblastoma.

Laks DR, Ta L, Crisman TJ, Gao F, Coppola G, Radu CG, Nathanson DA, Kornblum HI.

Mol Cancer Ther. 2016 Jun;15(6):1271-8. doi: 10.1158/1535-7163.MCT-15-0982. Epub 2016 Mar 29.

13.

Large-scale assessment of the gliomasphere model system.

Laks DR, Crisman TJ, Shih MY, Mottahedeh J, Gao F, Sperry J, Garrett MC, Yong WH, Cloughesy TF, Liau LM, Lai A, Coppola G, Kornblum HI.

Neuro Oncol. 2016 Oct;18(10):1367-78. doi: 10.1093/neuonc/now045. Epub 2016 Apr 25.

14.

Neural Stem Cells (NSCs) and Proteomics.

Shoemaker LD, Kornblum HI.

Mol Cell Proteomics. 2016 Feb;15(2):344-54. doi: 10.1074/mcp.O115.052704. Epub 2015 Oct 22. Review.

15.

MELK-a conserved kinase: functions, signaling, cancer, and controversy.

Ganguly R, Mohyeldin A, Thiel J, Kornblum HI, Beullens M, Nakano I.

Clin Transl Med. 2015 Mar 7;4:11. doi: 10.1186/s40169-014-0045-y. eCollection 2015.

16.

Maternal inflammation contributes to brain overgrowth and autism-associated behaviors through altered redox signaling in stem and progenitor cells.

Le Belle JE, Sperry J, Ngo A, Ghochani Y, Laks DR, López-Aranda M, Silva AJ, Kornblum HI.

Stem Cell Reports. 2014 Nov 11;3(5):725-34. doi: 10.1016/j.stemcr.2014.09.004. Epub 2014 Oct 11.

17.

Traumatic brain injury reveals novel cell lineage relationships within the subventricular zone.

Thomsen GM, Le Belle JE, Harnisch JA, Mc Donald WS, Hovda DA, Sofroniew MV, Kornblum HI, Harris NG.

Stem Cell Res. 2014 Jul;13(1):48-60. doi: 10.1016/j.scr.2014.04.013. Epub 2014 Apr 28.

18.

Maternal embryonic leucine zipper kinase: key kinase for stem cell phenotype in glioma and other cancers.

Ganguly R, Hong CS, Smith LG, Kornblum HI, Nakano I.

Mol Cancer Ther. 2014 Jun;13(6):1393-8. doi: 10.1158/1535-7163.MCT-13-0764. Epub 2014 May 2. Review.

19.

Multi-kinase inhibitor C1 triggers mitotic catastrophe of glioma stem cells mainly through MELK kinase inhibition.

Minata M, Gu C, Joshi K, Nakano-Okuno M, Hong C, Nguyen CH, Kornblum HI, Molla A, Nakano I.

PLoS One. 2014 Apr 16;9(4):e92546. doi: 10.1371/journal.pone.0092546. eCollection 2014.

20.

Asparagine depletion potentiates the cytotoxic effect of chemotherapy against brain tumors.

Panosyan EH, Wang Y, Xia P, Lee WN, Pak Y, Laks DR, Lin HJ, Moore TB, Cloughesy TF, Kornblum HI, Lasky JL 3rd.

Mol Cancer Res. 2014 May;12(5):694-702. doi: 10.1158/1541-7786.MCR-13-0576. Epub 2014 Feb 6.

21.

Exome sequencing identifies de novo gain of function missense mutation in KCND2 in identical twins with autism and seizures that slows potassium channel inactivation.

Lee H, Lin MC, Kornblum HI, Papazian DM, Nelson SF.

Hum Mol Genet. 2014 Jul 1;23(13):3481-9. doi: 10.1093/hmg/ddu056. Epub 2014 Feb 5.

22.

Targeted therapy resistance mediated by dynamic regulation of extrachromosomal mutant EGFR DNA.

Nathanson DA, Gini B, Mottahedeh J, Visnyei K, Koga T, Gomez G, Eskin A, Hwang K, Wang J, Masui K, Paucar A, Yang H, Ohashi M, Zhu S, Wykosky J, Reed R, Nelson SF, Cloughesy TF, James CD, Rao PN, Kornblum HI, Heath JR, Cavenee WK, Furnari FB, Mischel PS.

Science. 2014 Jan 3;343(6166):72-6. doi: 10.1126/science.1241328. Epub 2013 Dec 5.

23.

De-repression of PDGFRβ transcription promotes acquired resistance to EGFR tyrosine kinase inhibitors in glioblastoma patients.

Akhavan D, Pourzia AL, Nourian AA, Williams KJ, Nathanson D, Babic I, Villa GR, Tanaka K, Nael A, Yang H, Dang J, Vinters HV, Yong WH, Flagg M, Tamanoi F, Sasayama T, James CD, Kornblum HI, Cloughesy TF, Cavenee WK, Bensinger SJ, Mischel PS.

Cancer Discov. 2013 May;3(5):534-47. doi: 10.1158/2159-8290.CD-12-0502. Epub 2013 Mar 26.

24.

MELK-dependent FOXM1 phosphorylation is essential for proliferation of glioma stem cells.

Joshi K, Banasavadi-Siddegowda Y, Mo X, Kim SH, Mao P, Kig C, Nardini D, Sobol RW, Chow LM, Kornblum HI, Waclaw R, Beullens M, Nakano I.

Stem Cells. 2013 Jun;31(6):1051-63. doi: 10.1002/stem.1358.

25.

Identification of retinol binding protein 1 promoter hypermethylation in isocitrate dehydrogenase 1 and 2 mutant gliomas.

Chou AP, Chowdhury R, Li S, Chen W, Kim AJ, Piccioni DE, Selfridge JM, Mody RR, Chang S, Lalezari S, Lin J, Sanchez DE, Wilson RW, Garrett MC, Harry B, Mottahedeh J, Nghiemphu PL, Kornblum HI, Mischel PS, Prins RM, Yong WH, Cloughesy T, Nelson SF, Liau LM, Lai A.

J Natl Cancer Inst. 2012 Oct 3;104(19):1458-69. doi: 10.1093/jnci/djs357. Epub 2012 Sep 3.

26.

Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopy.

Pope WB, Prins RM, Albert Thomas M, Nagarajan R, Yen KE, Bittinger MA, Salamon N, Chou AP, Yong WH, Soto H, Wilson N, Driggers E, Jang HG, Su SM, Schenkein DP, Lai A, Cloughesy TF, Kornblum HI, Wu H, Fantin VR, Liau LM.

J Neurooncol. 2012 Mar;107(1):197-205. doi: 10.1007/s11060-011-0737-8. Epub 2011 Oct 21.

27.

Autocrine endothelin-3/endothelin receptor B signaling maintains cellular and molecular properties of glioblastoma stem cells.

Liu Y, Ye F, Yamada K, Tso JL, Zhang Y, Nguyen DH, Dong Q, Soto H, Choe J, Dembo A, Wheeler H, Eskin A, Schmid I, Yong WH, Mischel PS, Cloughesy TF, Kornblum HI, Nelson SF, Liau LM, Tso CL.

Mol Cancer Res. 2011 Dec;9(12):1668-85. doi: 10.1158/1541-7786.MCR-10-0563. Epub 2011 Oct 19.

28.

CD44v6 regulates growth of brain tumor stem cells partially through the AKT-mediated pathway.

Jijiwa M, Demir H, Gupta S, Leung C, Joshi K, Orozco N, Huang T, Yildiz VO, Shibahara I, de Jesus JA, Yong WH, Mischel PS, Fernandez S, Kornblum HI, Nakano I.

PLoS One. 2011;6(9):e24217. doi: 10.1371/journal.pone.0024217. Epub 2011 Sep 6.

29.

A molecular screening approach to identify and characterize inhibitors of glioblastoma stem cells.

Visnyei K, Onodera H, Damoiseaux R, Saigusa K, Petrosyan S, De Vries D, Ferrari D, Saxe J, Panosyan EH, Masterman-Smith M, Mottahedeh J, Bradley KA, Huang J, Sabatti C, Nakano I, Kornblum HI.

Mol Cancer Ther. 2011 Oct;10(10):1818-28. doi: 10.1158/1535-7163.MCT-11-0268. Epub 2011 Aug 22.

30.

Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway.

Nakano I, Joshi K, Visnyei K, Hu B, Watanabe M, Lam D, Wexler E, Saigusa K, Nakamura Y, Laks DR, Mischel PS, Viapiano M, Kornblum HI.

Neuro Oncol. 2011 Jun;13(6):622-34. doi: 10.1093/neuonc/nor023. Epub 2011 May 9.

31.

Proliferative neural stem cells have high endogenous ROS levels that regulate self-renewal and neurogenesis in a PI3K/Akt-dependant manner.

Le Belle JE, Orozco NM, Paucar AA, Saxe JP, Mottahedeh J, Pyle AD, Wu H, Kornblum HI.

Cell Stem Cell. 2011 Jan 7;8(1):59-71. doi: 10.1016/j.stem.2010.11.028.

32.

MicroRNA profiling reveals two distinct p53-related human pluripotent stem cell states.

Neveu P, Kye MJ, Qi S, Buchholz DE, Clegg DO, Sahin M, Park IH, Kim KS, Daley GQ, Kornblum HI, Shraiman BI, Kosik KS.

Cell Stem Cell. 2010 Dec 3;7(6):671-81. doi: 10.1016/j.stem.2010.11.012.

33.

Brain tumor stem cells as therapeutic targets in models of glioma.

Laks DR, Visnyei K, Kornblum HI.

Yonsei Med J. 2010 Sep;51(5):633-40. doi: 10.3349/ymj.2010.51.5.633. Review.

34.

A microfluidic platform for systems pathology: multiparameter single-cell signaling measurements of clinical brain tumor specimens.

Sun J, Masterman-Smith MD, Graham NA, Jiao J, Mottahedeh J, Laks DR, Ohashi M, DeJesus J, Kamei K, Lee KB, Wang H, Yu ZT, Lu YT, Hou S, Li K, Liu M, Zhang N, Wang S, Angenieux B, Panosyan E, Samuels ER, Park J, Williams D, Konkankit V, Nathanson D, van Dam RM, Phelps ME, Wu H, Liau LM, Mischel PS, Lazareff JA, Kornblum HI, Yong WH, Graeber TG, Tseng HR.

Cancer Res. 2010 Aug 1;70(15):6128-38. doi: 10.1158/0008-5472.CAN-10-0076. Epub 2010 Jul 14.

35.

Clinical outcome in pediatric glial and embryonal brain tumors correlates with in vitro multi-passageable neurosphere formation.

Panosyan EH, Laks DR, Masterman-Smith M, Mottahedeh J, Yong WH, Cloughesy TF, Lazareff JA, Mischel PS, Moore TB, Kornblum HI.

Pediatr Blood Cancer. 2010 Oct;55(4):644-51. doi: 10.1002/pbc.22627.

36.

A multipronged approach to the identification and study of an important oncogene in GBM.

Kornblum HI.

Cancer Cell. 2010 May 18;17(5):417-8. doi: 10.1016/j.ccr.2010.04.019.

37.

Hydrogel matrix to support stem cell survival after brain transplantation in stroke.

Zhong J, Chan A, Morad L, Kornblum HI, Fan G, Carmichael ST.

Neurorehabil Neural Repair. 2010 Sep;24(7):636-44. doi: 10.1177/1545968310361958. Epub 2010 Apr 27.

38.

Identification of differentially expressed proteins in murine embryonic and postnatal cortical neural progenitors.

Shoemaker LD, Orozco NM, Geschwind DH, Whitelegge JP, Faull KF, Kornblum HI.

PLoS One. 2010 Feb 9;5(2):e9121. doi: 10.1371/journal.pone.0009121.

39.

Induction of Nrf2 and xCT are involved in the action of the neuroprotective antibiotic ceftriaxone in vitro.

Lewerenz J, Albrecht P, Tien ML, Henke N, Karumbayaram S, Kornblum HI, Wiedau-Pazos M, Schubert D, Maher P, Methner A.

J Neurochem. 2009 Oct;111(2):332-43. doi: 10.1111/j.1471-4159.2009.06347.x. Epub 2009 Aug 18.

40.

Methods for analysis of brain tumor stem cell and neural stem cell self-renewal.

Nakano I, Kornblum HI.

Methods Mol Biol. 2009;568:37-56. doi: 10.1007/978-1-59745-280-9_4.

PMID:
19582420
41.

Endogenous Wnt signaling maintains neural progenitor cell potency.

Wexler EM, Paucer A, Kornblum HI, Palmer TD, Geschwind DH.

Stem Cells. 2009 May;27(5):1130-41. doi: 10.1002/stem.36. Erratum in: Stem Cells. 2009 Oct;27(10):2636. Plamer, Theodore D [corrected to Palmer, Theodore D].

42.

Neurosphere formation is an independent predictor of clinical outcome in malignant glioma.

Laks DR, Masterman-Smith M, Visnyei K, Angenieux B, Orozco NM, Foran I, Yong WH, Vinters HV, Liau LM, Lazareff JA, Mischel PS, Cloughesy TF, Horvath S, Kornblum HI.

Stem Cells. 2009 Apr;27(4):980-7. doi: 10.1002/stem.15.

43.

Directed differentiation of human-induced pluripotent stem cells generates active motor neurons.

Karumbayaram S, Novitch BG, Patterson M, Umbach JA, Richter L, Lindgren A, Conway AE, Clark AT, Goldman SA, Plath K, Wiedau-Pazos M, Kornblum HI, Lowry WE.

Stem Cells. 2009 Apr;27(4):806-11. doi: 10.1002/stem.31.

44.

Human embryonic stem cell-derived motor neurons expressing SOD1 mutants exhibit typical signs of motor neuron degeneration linked to ALS.

Karumbayaram S, Kelly TK, Paucar AA, Roe AJ, Umbach JA, Charles A, Goldman SA, Kornblum HI, Wiedau-Pazos M.

Dis Model Mech. 2009 Mar-Apr;2(3-4):189-95. doi: 10.1242/dmm.002113. Epub 2009 Feb 23.

45.

Pten deletion in adult neural stem/progenitor cells enhances constitutive neurogenesis.

Gregorian C, Nakashima J, Le Belle J, Ohab J, Kim R, Liu A, Smith KB, Groszer M, Garcia AD, Sofroniew MV, Carmichael ST, Kornblum HI, Liu X, Wu H.

J Neurosci. 2009 Feb 11;29(6):1874-86. doi: 10.1523/JNEUROSCI.3095-08.2009.

46.

Cell lineage and regional identity of cultured spinal cord neural stem cells and comparison to brain-derived neural stem cells.

Kelly TK, Karsten SL, Geschwind DH, Kornblum HI.

PLoS One. 2009;4(1):e4213. doi: 10.1371/journal.pone.0004213. Epub 2009 Jan 16.

47.

BMPing off glioma stem cells.

Nakano I, Saigusa K, Kornblum HI.

Cancer Cell. 2008 Jan;13(1):3-4. doi: 10.1016/j.ccr.2007.12.018.

48.

Disruption of the PACAP gene promotes medulloblastoma in ptc1 mutant mice.

Lelievre V, Seksenyan A, Nobuta H, Yong WH, Chhith S, Niewiadomski P, Cohen JR, Dong H, Flores A, Liau LM, Kornblum HI, Scott MP, Waschek JA.

Dev Biol. 2008 Jan 1;313(1):359-70. Epub 2007 Nov 26.

49.

A phenotypic small-molecule screen identifies an orphan ligand-receptor pair that regulates neural stem cell differentiation.

Saxe JP, Wu H, Kelly TK, Phelps ME, Sun YE, Kornblum HI, Huang J.

Chem Biol. 2007 Sep;14(9):1019-30.

50.

Detection of a microRNA signal in an in vivo expression set of mRNAs.

Liu T, Papagiannakopoulos T, Puskar K, Qi S, Santiago F, Clay W, Lao K, Lee Y, Nelson SF, Kornblum HI, Doyle F, Petzold L, Shraiman B, Kosik KS.

PLoS One. 2007 Aug 29;2(8):e804.

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