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Items: 1 to 50 of 57

1.

Identifying the murine mammary cell target of metformin exposure.

Shehata M, Kim H, Vellanki R, Waterhouse PD, Mahendralingam M, Casey AE, Koritzinsky M, Khokha R.

Commun Biol. 2019 May 20;2:192. doi: 10.1038/s42003-019-0439-x. eCollection 2019.

2.

ONECUT2 is a driver of neuroendocrine prostate cancer.

Guo H, Ci X, Ahmed M, Hua JT, Soares F, Lin D, Puca L, Vosoughi A, Xue H, Li E, Su P, Chen S, Nguyen T, Liang Y, Zhang Y, Xu X, Xu J, Sheahan AV, Ba-Alawi W, Zhang S, Mahamud O, Vellanki RN, Gleave M, Bristow RG, Haibe-Kains B, Poirier JT, Rudin CM, Tsao MS, Wouters BG, Fazli L, Feng FY, Ellis L, van der Kwast T, Berlin A, Koritzinsky M, Boutros PC, Zoubeidi A, Beltran H, Wang Y, He HH.

Nat Commun. 2019 Jan 17;10(1):278. doi: 10.1038/s41467-018-08133-6.

3.

The mTOR Targets 4E-BP1/2 Restrain Tumor Growth and Promote Hypoxia Tolerance in PTEN-driven Prostate Cancer.

Ding M, Van der Kwast TH, Vellanki RN, Foltz WD, McKee TD, Sonenberg N, Pandolfi PP, Koritzinsky M, Wouters BG.

Mol Cancer Res. 2018 Apr;16(4):682-695. doi: 10.1158/1541-7786.MCR-17-0696. Epub 2018 Feb 16.

4.

Targeting the CXCL12/CXCR4 pathway and myeloid cells to improve radiation treatment of locally advanced cervical cancer.

Lecavalier-Barsoum M, Chaudary N, Han K, Koritzinsky M, Hill R, Milosevic M.

Int J Cancer. 2018 Sep 1;143(5):1017-1028. doi: 10.1002/ijc.31297. Epub 2018 Mar 5. Review.

PMID:
29417588
5.

MATE2 Expression Is Associated with Cancer Cell Response to Metformin.

Chowdhury S, Yung E, Pintilie M, Muaddi H, Chaib S, Yeung M, Fusciello M, Sykes J, Pitcher B, Hagenkort A, McKee T, Vellanki R, Chen E, Bristow RG, Wouters BG, Koritzinsky M.

PLoS One. 2016 Dec 13;11(12):e0165214. doi: 10.1371/journal.pone.0165214. eCollection 2016.

6.

Molecular targeting of hypoxia in radiotherapy.

Rey S, Schito L, Koritzinsky M, Wouters BG.

Adv Drug Deliv Rev. 2017 Jan 15;109:45-62. doi: 10.1016/j.addr.2016.10.002. Epub 2016 Oct 19. Review.

PMID:
27771366
7.

From Solo in the Silo to Strategic Training Programs.

Koritzinsky M, Koch CA, Riley B, Beauchemin N, Johnston G, Johnston M, Koropatnick J, Loiselle CG, Maslowska M, McCormick C, Miller WH Jr, Mulligan L, Tsao MS.

CBE Life Sci Educ. 2016 Spring;15(1):le1. No abstract available.

8.

Hypoxia and Predicting Radiation Response.

Hill RP, Bristow RG, Fyles A, Koritzinsky M, Milosevic M, Wouters BG.

Semin Radiat Oncol. 2015 Oct;25(4):260-72. doi: 10.1016/j.semradonc.2015.05.004. Epub 2015 May 15. Review.

PMID:
26384274
9.

Metformin: A Novel Biological Modifier of Tumor Response to Radiation Therapy.

Koritzinsky M.

Int J Radiat Oncol Biol Phys. 2015 Oct 1;93(2):454-64. doi: 10.1016/j.ijrobp.2015.06.003. Review.

PMID:
26383681
10.

Identification of P450 Oxidoreductase as a Major Determinant of Sensitivity to Hypoxia-Activated Prodrugs.

Hunter FW, Young RJ, Shalev Z, Vellanki RN, Wang J, Gu Y, Joshi N, Sreebhavan S, Weinreb I, Goldstein DP, Moffat J, Ketela T, Brown KR, Koritzinsky M, Solomon B, Rischin D, Wilson WR, Wouters BG.

Cancer Res. 2015 Oct 1;75(19):4211-23. doi: 10.1158/0008-5472.CAN-15-1107. Epub 2015 Aug 21.

11.

The amino acid sensor GCN2 inhibits inflammatory responses to apoptotic cells promoting tolerance and suppressing systemic autoimmunity.

Ravishankar B, Liu H, Shinde R, Chaudhary K, Xiao W, Bradley J, Koritzinsky M, Madaio MP, McGaha TL.

Proc Natl Acad Sci U S A. 2015 Aug 25;112(34):10774-9. doi: 10.1073/pnas.1504276112. Epub 2015 Aug 10.

12.

Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER.

van den Beucken T, Koch E, Chu K, Rupaimoole R, Prickaerts P, Adriaens M, Voncken JW, Harris AL, Buffa FM, Haider S, Starmans MHW, Yao CQ, Ivan M, Ivan C, Pecot CV, Boutros PC, Sood AK, Koritzinsky M, Wouters BG.

Nat Commun. 2014 Oct 29;5:5203. doi: 10.1038/ncomms6203.

13.

Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium.

Pettersen EO, Ebbesen P, Gieling RG, Williams KJ, Dubois L, Lambin P, Ward C, Meehan J, Kunkler IH, Langdon SP, Ree AH, Flatmark K, Lyng H, Calzada MJ, Peso LD, Landazuri MO, Görlach A, Flamm H, Kieninger J, Urban G, Weltin A, Singleton DC, Haider S, Buffa FM, Harris AL, Scozzafava A, Supuran CT, Moser I, Jobst G, Busk M, Toustrup K, Overgaard J, Alsner J, Pouyssegur J, Chiche J, Mazure N, Marchiq I, Parks S, Ahmed A, Ashcroft M, Pastorekova S, Cao Y, Rouschop KM, Wouters BG, Koritzinsky M, Mujcic H, Cojocari D.

J Enzyme Inhib Med Chem. 2015;30(5):689-721. doi: 10.3109/14756366.2014.966704. Epub 2014 Oct 27. Review.

PMID:
25347767
14.

Hypoxia provokes base excision repair changes and a repair-deficient, mutator phenotype in colorectal cancer cells.

Chan N, Ali M, McCallum GP, Kumareswaran R, Koritzinsky M, Wouters BG, Wells PG, Gallinger S, Bristow RG.

Mol Cancer Res. 2014 Oct;12(10):1407-15. doi: 10.1158/1541-7786.MCR-14-0246. Epub 2014 Jul 16.

15.

Hypoxia signaling and the metastatic phenotype.

Mujcic H, Hill RP, Koritzinsky M, Wouters BG.

Curr Mol Med. 2014;14(5):565-79. Review.

PMID:
24894165
16.

A pilot 'window of opportunity' neoadjuvant study of metformin in localised prostate cancer.

Joshua AM, Zannella VE, Downes MR, Bowes B, Hersey K, Koritzinsky M, Schwab M, Hofmann U, Evans A, van der Kwast T, Trachtenberg J, Finelli A, Fleshner N, Sweet J, Pollak M.

Prostate Cancer Prostatic Dis. 2014 Sep;17(3):252-8. doi: 10.1038/pcan.2014.20. Epub 2014 May 27.

PMID:
24861559
17.

Post-transcriptional regulation of MRE11 expression in muscle-invasive bladder tumours.

Martin RM, Kerr M, Teo MT, Jevons SJ, Koritzinsky M, Wouters BG, Bhattarai S, Kiltie AE.

Oncotarget. 2014 Feb 28;5(4):993-1003.

18.

Two phases of disulfide bond formation have differing requirements for oxygen.

Koritzinsky M, Levitin F, van den Beucken T, Rumantir RA, Harding NJ, Chu KC, Boutros PC, Braakman I, Wouters BG.

J Cell Biol. 2013 Nov 25;203(4):615-27. doi: 10.1083/jcb.201307185. Epub 2013 Nov 18.

19.

Reprogramming metabolism with metformin improves tumor oxygenation and radiotherapy response.

Zannella VE, Dal Pra A, Muaddi H, McKee TD, Stapleton S, Sykes J, Glicksman R, Chaib S, Zamiara P, Milosevic M, Wouters BG, Bristow RG, Koritzinsky M.

Clin Cancer Res. 2013 Dec 15;19(24):6741-50. doi: 10.1158/1078-0432.CCR-13-1787. Epub 2013 Oct 18.

20.

Hypoxic activation of the PERK/eIF2α arm of the unfolded protein response promotes metastasis through induction of LAMP3.

Mujcic H, Nagelkerke A, Rouschop KM, Chung S, Chaudary N, Span PN, Clarke B, Milosevic M, Sykes J, Hill RP, Koritzinsky M, Wouters BG.

Clin Cancer Res. 2013 Nov 15;19(22):6126-37. doi: 10.1158/1078-0432.CCR-13-0526. Epub 2013 Sep 17.

21.

The roles of reactive oxygen species and autophagy in mediating the tolerance of tumor cells to cycling hypoxia.

Koritzinsky M, Wouters BG.

Semin Radiat Oncol. 2013 Oct;23(4):252-61. doi: 10.1016/j.semradonc.2013.05.006. Review.

PMID:
24012339
22.

Contributions of AMPK and p53 dependent signaling to radiation response in the presence of metformin.

Muaddi H, Chowdhury S, Vellanki R, Zamiara P, Koritzinsky M.

Radiother Oncol. 2013 Sep;108(3):446-50. doi: 10.1016/j.radonc.2013.06.014. Epub 2013 Jul 25.

PMID:
23891087
23.

New small molecule inhibitors of UPR activation demonstrate that PERK, but not IRE1α signaling is essential for promoting adaptation and survival to hypoxia.

Cojocari D, Vellanki RN, Sit B, Uehling D, Koritzinsky M, Wouters BG.

Radiother Oncol. 2013 Sep;108(3):541-7. doi: 10.1016/j.radonc.2013.06.005. Epub 2013 Jul 3.

PMID:
23830192
24.

PERK/eIF2α signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS.

Rouschop KM, Dubois LJ, Keulers TG, van den Beucken T, Lambin P, Bussink J, van der Kogel AJ, Koritzinsky M, Wouters BG.

Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4622-7. doi: 10.1073/pnas.1210633110. Epub 2013 Mar 7.

25.

The prognostic value of temporal in vitro and in vivo derived hypoxia gene-expression signatures in breast cancer.

Starmans MH, Chu KC, Haider S, Nguyen F, Seigneuric R, Magagnin MG, Koritzinsky M, Kasprzyk A, Boutros PC, Wouters BG, Lambin P.

Radiother Oncol. 2012 Mar;102(3):436-43. doi: 10.1016/j.radonc.2012.02.002. Epub 2012 Feb 20.

26.

Translational control is a major contributor to hypoxia induced gene expression.

van den Beucken T, Magagnin MG, Jutten B, Seigneuric R, Lambin P, Koritzinsky M, Wouters BG.

Radiother Oncol. 2011 Jun;99(3):379-84. doi: 10.1016/j.radonc.2011.05.058. Epub 2011 Jun 28.

27.

AMPK regulates metabolism and survival in response to ionizing radiation.

Zannella VE, Cojocari D, Hilgendorf S, Vellanki RN, Chung S, Wouters BG, Koritzinsky M.

Radiother Oncol. 2011 Jun;99(3):293-9. doi: 10.1016/j.radonc.2011.05.049. Epub 2011 Jun 27.

PMID:
21715037
28.

Deregulation of cap-dependent mRNA translation increases tumour radiosensitivity through reduction of the hypoxic fraction.

Rouschop KM, Dubois L, Schaaf MB, van den Beucken T, Lieuwes N, Keulers TG, Savelkouls KG, Bussink J, van der Kogel AJ, Koritzinsky M, Wouters BG.

Radiother Oncol. 2011 Jun;99(3):385-91. doi: 10.1016/j.radonc.2011.05.047. Epub 2011 Jun 12.

PMID:
21665307
29.

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5.

Rouschop KM, van den Beucken T, Dubois L, Niessen H, Bussink J, Savelkouls K, Keulers T, Mujcic H, Landuyt W, Voncken JW, Lambin P, van der Kogel AJ, Koritzinsky M, Wouters BG.

J Clin Invest. 2010 Jan;120(1):127-41. doi: 10.1172/JCI40027. Epub 2009 Dec 14.

30.

Hypoxic activation of the unfolded protein response (UPR) induces expression of the metastasis-associated gene LAMP3.

Mujcic H, Rzymski T, Rouschop KM, Koritzinsky M, Milani M, Harris AL, Wouters BG.

Radiother Oncol. 2009 Sep;92(3):450-9. doi: 10.1016/j.radonc.2009.08.017. Epub 2009 Aug 31.

PMID:
19726095
31.

Autophagy is required during cycling hypoxia to lower production of reactive oxygen species.

Rouschop KM, Ramaekers CH, Schaaf MB, Keulers TG, Savelkouls KG, Lambin P, Koritzinsky M, Wouters BG.

Radiother Oncol. 2009 Sep;92(3):411-6. doi: 10.1016/j.radonc.2009.06.029. Epub 2009 Jul 16.

PMID:
19616335
32.

Deficient carbonic anhydrase 9 expression in UPR-impaired cells is associated with reduced survival in an acidic microenvironment.

van den Beucken T, Ramaekers CH, Rouschop K, Koritzinsky M, Wouters BG.

Radiother Oncol. 2009 Sep;92(3):437-42. doi: 10.1016/j.radonc.2009.06.018. Epub 2009 Jul 15.

PMID:
19615771
33.

Hypoxia-induced expression of carbonic anhydrase 9 is dependent on the unfolded protein response.

van den Beucken T, Koritzinsky M, Niessen H, Dubois L, Savelkouls K, Mujcic H, Jutten B, Kopacek J, Pastorekova S, van der Kogel AJ, Lambin P, Voncken W, Rouschop KM, Wouters BG.

J Biol Chem. 2009 Sep 4;284(36):24204-12. doi: 10.1074/jbc.M109.006510. Epub 2009 Jun 29.

34.

Inhibition of 4E-BP1 sensitizes U87 glioblastoma xenograft tumors to irradiation by decreasing hypoxia tolerance.

Dubois L, Magagnin MG, Cleven AH, Weppler SA, Grenacher B, Landuyt W, Lieuwes N, Lambin P, Gorr TA, Koritzinsky M, Wouters BG.

Int J Radiat Oncol Biol Phys. 2009 Mar 15;73(4):1219-27. doi: 10.1016/j.ijrobp.2008.12.003.

PMID:
19251093
35.

Hypoxia signalling through mTOR and the unfolded protein response in cancer.

Wouters BG, Koritzinsky M.

Nat Rev Cancer. 2008 Nov;8(11):851-64. doi: 10.1038/nrc2501. Epub 2008 Oct 10. Review.

PMID:
18846101
36.

The mTOR target 4E-BP1 contributes to differential protein expression during normoxia and hypoxia through changes in mRNA translation efficiency.

Magagnin MG, van den Beucken T, Sergeant K, Lambin P, Koritzinsky M, Devreese B, Wouters BG.

Proteomics. 2008 Mar;8(5):1019-28. doi: 10.1002/pmic.200700551.

PMID:
18219697
37.

Chronic hypoxia decreases synthesis of homologous recombination proteins to offset chemoresistance and radioresistance.

Chan N, Koritzinsky M, Zhao H, Bindra R, Glazer PM, Powell S, Belmaaza A, Wouters B, Bristow RG.

Cancer Res. 2008 Jan 15;68(2):605-14. doi: 10.1158/0008-5472.CAN-07-5472.

38.

Hypoxia and regulation of messenger RNA translation.

Koritzinsky M, Wouters BG.

Methods Enzymol. 2007;435:247-73.

PMID:
17998058
39.

Dose- and time-dependent changes in gene expression in human glioma cells after low radiation doses.

Short SC, Buffa FM, Bourne S, Koritzinsky M, Wouters BG, Bentzen SM.

Radiat Res. 2007 Aug;168(2):199-208.

PMID:
17638411
40.

Proteomic analysis of gene expression following hypoxia and reoxygenation reveals proteins involved in the recovery from endoplasmic reticulum and oxidative stress.

Magagnin MG, Sergeant K, van den Beucken T, Rouschop KM, Jutten B, Seigneuric R, Lambin P, Devreese B, Koritzinsky M, Wouters BG.

Radiother Oncol. 2007 Jun;83(3):340-5. Epub 2007 May 24.

PMID:
17531340
41.

Phosphorylation of eIF2alpha is required for mRNA translation inhibition and survival during moderate hypoxia.

Koritzinsky M, Rouschop KM, van den Beucken T, Magagnin MG, Savelkouls K, Lambin P, Wouters BG.

Radiother Oncol. 2007 Jun;83(3):353-61. Epub 2007 May 24.

PMID:
17531337
42.

Regulation of Cited2 expression provides a functional link between translational and transcriptional responses during hypoxia.

van den Beucken T, Magagnin MG, Savelkouls K, Lambin P, Koritzinsky M, Wouters BG.

Radiother Oncol. 2007 Jun;83(3):346-52. Epub 2007 May 17.

PMID:
17499866
43.

Patterns of tumor oxygenation and their influence on the cellular hypoxic response and hypoxia-directed therapies.

Magagnin MG, Koritzinsky M, Wouters BG.

Drug Resist Updat. 2006 Aug-Oct;9(4-5):185-97. Epub 2006 Aug 22. Review.

PMID:
16926105
44.

Translational control of gene expression during hypoxia.

van den Beucken T, Koritzinsky M, Wouters BG.

Cancer Biol Ther. 2006 Jul;5(7):749-55. Epub 2006 Jul 1. Review.

PMID:
16861930
45.

Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control.

Koritzinsky M, Magagnin MG, van den Beucken T, Seigneuric R, Savelkouls K, Dostie J, Pyronnet S, Kaufman RJ, Weppler SA, Voncken JW, Lambin P, Koumenis C, Sonenberg N, Wouters BG.

EMBO J. 2006 Mar 8;25(5):1114-25. Epub 2006 Feb 9.

46.

ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth.

Bi M, Naczki C, Koritzinsky M, Fels D, Blais J, Hu N, Harding H, Novoa I, Varia M, Raleigh J, Scheuner D, Kaufman RJ, Bell J, Ron D, Wouters BG, Koumenis C.

EMBO J. 2005 Oct 5;24(19):3470-81. Epub 2005 Sep 8.

47.

The hypoxic proteome is influenced by gene-specific changes in mRNA translation.

Koritzinsky M, Seigneuric R, Magagnin MG, van den Beucken T, Lambin P, Wouters BG.

Radiother Oncol. 2005 Aug;76(2):177-86.

PMID:
16098621
48.

Control of the hypoxic response through regulation of mRNA translation.

Wouters BG, van den Beucken T, Magagnin MG, Koritzinsky M, Fels D, Koumenis C.

Semin Cell Dev Biol. 2005 Aug-Oct;16(4-5):487-501. Review.

PMID:
15896987
49.

Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance.

Erler JT, Cawthorne CJ, Williams KJ, Koritzinsky M, Wouters BG, Wilson C, Miller C, Demonacos C, Stratford IJ, Dive C.

Mol Cell Biol. 2004 Apr;24(7):2875-89.

50.

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