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Items: 1 to 50 of 108


Wilms' tumor 1 drives fibroproliferation and myofibroblast transformation in severe fibrotic lung disease.

Sontake V, Kasam RK, Sinner D, Korfhagen TR, Reddy GB, White ES, Jegga AG, Madala SK.

JCI Insight. 2018 Aug 23;3(16). pii: 121252. doi: 10.1172/jci.insight.121252. eCollection 2018 Aug 23.


Endothelial immune activation programmes cell-fate decisions and angiogenesis by inducing angiogenesis regulator DLL4 through TLR4-ERK-FOXC2 signalling.

Xia S, Menden HL, Korfhagen TR, Kume T, Sampath V.

J Physiol. 2018 Apr 15;596(8):1397-1417. doi: 10.1113/JP275453. Epub 2018 Mar 2.


Airway epithelial SPDEF integrates goblet cell differentiation and pulmonary Th2 inflammation.

Rajavelu P, Chen G, Xu Y, Kitzmiller JA, Korfhagen TR, Whitsett JA.

J Clin Invest. 2015 May;125(5):2021-31. doi: 10.1172/JCI79422. Epub 2015 Apr 13.


Inhibition of the αvβ6 integrin leads to limited alteration of TGF-α-induced pulmonary fibrosis.

Madala SK, Korfhagen TR, Schmidt S, Davidson C, Edukulla R, Ikegami M, Violette SM, Weinreb PH, Sheppard D, Hardie WD.

Am J Physiol Lung Cell Mol Physiol. 2014 Apr 15;306(8):L726-35. doi: 10.1152/ajplung.00357.2013. Epub 2014 Feb 7.


Dual targeting of MEK and PI3K pathways attenuates established and progressive pulmonary fibrosis.

Madala SK, Edukulla R, Phatak M, Schmidt S, Davidson C, Acciani TH, Korfhagen TR, Medvedovic M, Lecras TD, Wagner K, Hardie WD.

PLoS One. 2014 Jan 27;9(1):e86536. doi: 10.1371/journal.pone.0086536. eCollection 2014.


Foxa3 induces goblet cell metaplasia and inhibits innate antiviral immunity.

Chen G, Korfhagen TR, Karp CL, Impey S, Xu Y, Randell SH, Kitzmiller J, Maeda Y, Haitchi HM, Sridharan A, Senft AP, Whitsett JA.

Am J Respir Crit Care Med. 2014 Feb 1;189(3):301-13. doi: 10.1164/rccm.201306-1181OC.


Persistence of LPS-induced lung inflammation in surfactant protein-C-deficient mice.

Glasser SW, Maxfield MD, Ruetschilling TL, Akinbi HT, Baatz JE, Kitzmiller JA, Page K, Xu Y, Bao EL, Korfhagen TR.

Am J Respir Cell Mol Biol. 2013 Nov;49(5):845-54. doi: 10.1165/rcmb.2012-0374OC.


Genetic replacement of surfactant protein-C reduces respiratory syncytial virus induced lung injury.

Glasser SW, Senft AP, Maxfield MD, Ruetschilling TL, Baatz JE, Page K, Korfhagen TR.

Respir Res. 2013 Feb 12;14:19. doi: 10.1186/1465-9921-14-19.


SAM-pointed domain ETS factor mediates epithelial cell-intrinsic innate immune signaling during airway mucous metaplasia.

Korfhagen TR, Kitzmiller J, Chen G, Sridharan A, Haitchi HM, Hegde RS, Divanovic S, Karp CL, Whitsett JA.

Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16630-5. doi: 10.1073/pnas.1208092109. Epub 2012 Sep 24.


Resistin-like molecule α1 (Fizz1) recruits lung dendritic cells without causing pulmonary fibrosis.

Madala SK, Edukulla R, Davis KR, Schmidt S, Davidson C, Kitzmiller JA, Hardie WD, Korfhagen TR.

Respir Res. 2012 Jun 22;13:51. doi: 10.1186/1465-9921-13-51.


Rapamycin decreases airway remodeling and hyperreactivity in a transgenic model of noninflammatory lung disease.

Kramer EL, Hardie WD, Mushaben EM, Acciani TH, Pastura PA, Korfhagen TR, Hershey GK, Whitsett JA, Le Cras TD.

J Appl Physiol (1985). 2011 Dec;111(6):1760-7. doi: 10.1152/japplphysiol.00737.2011. Epub 2011 Sep 8.


Epithelial EGF receptor signaling mediates airway hyperreactivity and remodeling in a mouse model of chronic asthma.

Le Cras TD, Acciani TH, Mushaben EM, Kramer EL, Pastura PA, Hardie WD, Korfhagen TR, Sivaprasad U, Ericksen M, Gibson AM, Holtzman MJ, Whitsett JA, Hershey GK.

Am J Physiol Lung Cell Mol Physiol. 2011 Mar;300(3):L414-21. doi: 10.1152/ajplung.00346.2010. Epub 2010 Dec 17.


Signaling pathways in the epithelial origins of pulmonary fibrosis.

Hardie WD, Hagood JS, Dave V, Perl AK, Whitsett JA, Korfhagen TR, Glasser S.

Cell Cycle. 2010 Jul 15;9(14):2769-76. Epub 2010 Jul 3. Review.


Nitric oxide mediates relative airway hyporesponsiveness to lipopolysaccharide in surfactant protein A-deficient mice.

Pastva AM, Walker JK, Maddox LA, Mukherjee S, Giamberardino C, Hsia B, Potts E, Zhu H, Degan S, Sunday ME, Lawson BL, Korfhagen TR, Schwartz DA, Eu JP, Foster WM, McMahon TJ, Que L, Wright JR.

Am J Respir Cell Mol Biol. 2011 Feb;44(2):175-84. doi: 10.1165/rcmb.2009-0284OC. Epub 2010 Mar 26. Retraction in: Am J Respir Cell Mol Biol. 2016 Nov;55(5):758.


Pseudomonas aeruginosa biofilm infections in cystic fibrosis: insights into pathogenic processes and treatment strategies.

Hassett DJ, Korfhagen TR, Irvin RT, Schurr MJ, Sauer K, Lau GW, Sutton MD, Yu H, Hoiby N.

Expert Opin Ther Targets. 2010 Feb;14(2):117-30. doi: 10.1517/14728220903454988. Review.


Inhibition of PI3K by PX-866 prevents transforming growth factor-alpha-induced pulmonary fibrosis.

Le Cras TD, Korfhagen TR, Davidson C, Schmidt S, Fenchel M, Ikegami M, Whitsett JA, Hardie WD.

Am J Pathol. 2010 Feb;176(2):679-86. doi: 10.2353/ajpath.2010.090123. Epub 2009 Dec 30.


SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production.

Chen G, Korfhagen TR, Xu Y, Kitzmiller J, Wert SE, Maeda Y, Gregorieff A, Clevers H, Whitsett JA.

J Clin Invest. 2009 Oct;119(10):2914-24. doi: 10.1172/JCI39731. Epub 2009 Sep 14.


Matrix metalloproteinase-14 mediates a phenotypic shift in the airways to increase mucin production.

Deshmukh HS, McLachlan A, Atkinson JJ, Hardie WD, Korfhagen TR, Dietsch M, Liu Y, Di PY, Wesselkamper SC, Borchers MT, Leikauf GD.

Am J Respir Crit Care Med. 2009 Nov 1;180(9):834-45. doi: 10.1164/rccm.200903-0328OC. Epub 2009 Aug 6.


Surfactant protein C-deficient mice are susceptible to respiratory syncytial virus infection.

Glasser SW, Witt TL, Senft AP, Baatz JE, Folger D, Maxfield MD, Akinbi HT, Newton DA, Prows DR, Korfhagen TR.

Am J Physiol Lung Cell Mol Physiol. 2009 Jul;297(1):L64-72. doi: 10.1152/ajplung.90640.2008. Epub 2009 Mar 20.


Rapamycin prevents transforming growth factor-alpha-induced pulmonary fibrosis.

Korfhagen TR, Le Cras TD, Davidson CR, Schmidt SM, Ikegami M, Whitsett JA, Hardie WD.

Am J Respir Cell Mol Biol. 2009 Nov;41(5):562-72. doi: 10.1165/rcmb.2008-0377OC. Epub 2009 Feb 24.


Early growth response-1 suppresses epidermal growth factor receptor-mediated airway hyperresponsiveness and lung remodeling in mice.

Kramer EL, Mushaben EM, Pastura PA, Acciani TH, Deutsch GH, Khurana Hershey GK, Korfhagen TR, Hardie WD, Whitsett JA, Le Cras TD.

Am J Respir Cell Mol Biol. 2009 Oct;41(4):415-25. doi: 10.1165/rcmb.2008-0470OC. Epub 2009 Feb 2.


Surfactant-associated protein B is critical to survival in nickel-induced injury in mice.

Bein K, Wesselkamper SC, Liu X, Dietsch M, Majumder N, Concel VJ, Medvedovic M, Sartor MA, Henning LN, Venditto C, Borchers MT, Barchowsky A, Weaver TE, Tichelaar JW, Prows DR, Korfhagen TR, Hardie WD, Bachurski CJ, Leikauf GD.

Am J Respir Cell Mol Biol. 2009 Aug;41(2):226-36. doi: 10.1165/rcmb.2008-0317OC. Epub 2009 Jan 8.


Macrophage dysfunction and susceptibility to pulmonary Pseudomonas aeruginosa infection in surfactant protein C-deficient mice.

Glasser SW, Senft AP, Whitsett JA, Maxfield MD, Ross GF, Richardson TR, Prows DR, Xu Y, Korfhagen TR.

J Immunol. 2008 Jul 1;181(1):621-8.


EGF receptor tyrosine kinase inhibitors diminish transforming growth factor-alpha-induced pulmonary fibrosis.

Hardie WD, Davidson C, Ikegami M, Leikauf GD, Le Cras TD, Prestridge A, Whitsett JA, Korfhagen TR.

Am J Physiol Lung Cell Mol Physiol. 2008 Jun;294(6):L1217-25. doi: 10.1152/ajplung.00020.2008. Epub 2008 Apr 18.


Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production.

Deshmukh HS, Shaver C, Case LM, Dietsch M, Wesselkamper SC, Hardie WD, Korfhagen TR, Corradi M, Nadel JA, Borchers MT, Leikauf GD.

Am J Respir Cell Mol Biol. 2008 Apr;38(4):446-54. Epub 2007 Nov 15.


Genomic profile of matrix and vasculature remodeling in TGF-alpha induced pulmonary fibrosis.

Hardie WD, Korfhagen TR, Sartor MA, Prestridge A, Medvedovic M, Le Cras TD, Ikegami M, Wesselkamper SC, Davidson C, Dietsch M, Nichols W, Whitsett JA, Leikauf GD.

Am J Respir Cell Mol Biol. 2007 Sep;37(3):309-21. Epub 2007 May 11.


Perinatal increases in TGF-{alpha} disrupt the saccular phase of lung morphogenesis and cause remodeling: microarray analysis.

Kramer EL, Deutsch GH, Sartor MA, Hardie WD, Ikegami M, Korfhagen TR, Le Cras TD.

Am J Physiol Lung Cell Mol Physiol. 2007 Aug;293(2):L314-27. Epub 2007 Apr 27.


SPDEF regulates goblet cell hyperplasia in the airway epithelium.

Park KS, Korfhagen TR, Bruno MD, Kitzmiller JA, Wan H, Wert SE, Khurana Hershey GK, Chen G, Whitsett JA.

J Clin Invest. 2007 Apr;117(4):978-88. Epub 2007 Mar 8.


Altered postnatal lung development in C3H/HeJ mice.

Sampath V, Davis K, Senft AP, Richardson TR, Kitzmiller JA, Berclaz PY, Korfhagen TR.

Pediatr Res. 2006 Dec;60(6):663-8. Epub 2006 Oct 25.


Surfactant protein D regulates the cell surface expression of alveolar macrophage beta(2)-integrins.

Senft AP, Korfhagen TR, Whitsett JA, LeVine AM.

Am J Physiol Lung Cell Mol Physiol. 2007 Feb;292(2):L469-75. Epub 2006 Oct 20.


Neither SP-A nor NH2-terminal domains of SP-A can substitute for SP-D in regulation of alveolar homeostasis.

Zhang L, Ikegami M, Korfhagen TR, McCormack FX, Yoshida M, Senior RM, Shipley JM, Shapiro SD, Whitsett JA.

Am J Physiol Lung Cell Mol Physiol. 2006 Aug;291(2):L181-90. Epub 2006 Feb 24.


Surfactant protein-D regulates soluble CD14 through matrix metalloproteinase-12.

Senft AP, Korfhagen TR, Whitsett JA, Shapiro SD, LeVine AM.

J Immunol. 2005 Apr 15;174(8):4953-9.


TGF-alpha perturbs surfactant homeostasis in vivo.

Ikegami M, Le Cras TD, Hardie WD, Stahlman MT, Whitsett JA, Korfhagen TR.

Am J Physiol Lung Cell Mol Physiol. 2005 Jul;289(1):L34-43. Epub 2005 Mar 11.


Surfactant protein D influences surfactant ultrastructure and uptake by alveolar type II cells.

Ikegami M, Na CL, Korfhagen TR, Whitsett JA.

Am J Physiol Lung Cell Mol Physiol. 2005 Mar;288(3):L552-61. Epub 2004 Dec 3.


The murine SP-C promoter directs type II cell-specific expression in transgenic mice.

Glasser SW, Eszterhas SK, Detmer EA, Maxfield MD, Korfhagen TR.

Am J Physiol Lung Cell Mol Physiol. 2005 Apr;288(4):L625-32. Epub 2004 Dec 3.


Transient induction of TGF-alpha disrupts lung morphogenesis, causing pulmonary disease in adulthood.

Le Cras TD, Hardie WD, Deutsch GH, Albertine KH, Ikegami M, Whitsett JA, Korfhagen TR.

Am J Physiol Lung Cell Mol Physiol. 2004 Oct;287(4):L718-29. Epub 2004 Apr 16.


Conditional expression of transforming growth factor-alpha in adult mouse lung causes pulmonary fibrosis.

Hardie WD, Le Cras TD, Jiang K, Tichelaar JW, Azhar M, Korfhagen TR.

Am J Physiol Lung Cell Mol Physiol. 2004 Apr;286(4):L741-9. Epub 2003 Dec 5.


Mouse lysozyme M is important in pulmonary host defense against Klebsiella pneumoniae infection.

Markart P, Korfhagen TR, Weaver TE, Akinbi HT.

Am J Respir Crit Care Med. 2004 Feb 15;169(4):454-8. Epub 2003 Nov 14.


Disrupted pulmonary vascular development and pulmonary hypertension in transgenic mice overexpressing transforming growth factor-alpha.

Le Cras TD, Hardie WD, Fagan K, Whitsett JA, Korfhagen TR.

Am J Physiol Lung Cell Mol Physiol. 2003 Nov;285(5):L1046-54. Epub 2003 Aug 1.


In vivo measurements of changes in respiratory mechanics with age in mice deficient in surfactant protein D.

Collins RA, Ikegami M, Korfhagen TR, Whitsett JA, Sly PD.

Pediatr Res. 2003 Mar;53(3):463-7.


Reversibility of pulmonary abnormalities by conditional replacement of surfactant protein D (SP-D) in vivo.

Zhang L, Ikegami M, Dey CR, Korfhagen TR, Whitsett JA.

J Biol Chem. 2002 Oct 11;277(41):38709-13. Epub 2002 Aug 5.


Surfactant protein A regulates surfactant phospholipid clearance after LPS-induced injury in vivo.

Quintero OA, Korfhagen TR, Wright JR.

Am J Physiol Lung Cell Mol Physiol. 2002 Jul;283(1):L76-85.


The role of pulmonary collectin N-terminal domains in surfactant structure, function, and homeostasis in vivo.

Palaniyar N, Zhang L, Kuzmenko A, Ikegami M, Wan S, Wu H, Korfhagen TR, Whitsett JA, McCormack FX.

J Biol Chem. 2002 Jul 26;277(30):26971-9. Epub 2002 May 15.


Pathogenomic mechanisms for particulate matter induction of acute lung injury and inflammation in mice.

Leikauf GD, McDowell SA, Wesselkamper SC, Miller CR, Hardie WD, Gammon K, Biswas PP, Korfhagen TR, Bachurski CJ, Wiest JS, Willeke K, Bingham E, Leikauf JE, Aronow BJ, Prows DR.

Res Rep Health Eff Inst. 2001 Dec;(105):5-58; discussion 59-71.


Dose-related protection from nickel-induced lung injury in transgenic mice expressing human transforming growth factor-alpha.

Hardie WD, Prows DR, Piljan-Gentle A, Dunlavy MR, Wesselkamper SC, Leikauf GD, Korfhagen TR.

Am J Respir Cell Mol Biol. 2002 Apr;26(4):430-7.


Acute lung injury: functional genomics and genetic susceptibility.

Leikauf GD, McDowell SA, Wesselkamper SC, Hardie WD, Leikauf JE, Korfhagen TR, Prows DR.

Chest. 2002 Mar;121(3 Suppl):70S-75S.


Pulmonary surfactant and inflammation in septic adult mice: role of surfactant protein A.

Malloy JL, Veldhuizen RA, McCormack FX, Korfhagen TR, Whitsett JA, Lewis JF.

J Appl Physiol (1985). 2002 Feb;92(2):809-16.


Functional genomics of oxidant-induced lung injury.

Leikauf GD, McDowell SA, Bachurski CJ, Aronow BJ, Gammon K, Wesselkamper SC, Hardie W, Wiest JS, Leikauf JE, Korfhagen TR, Prows DR.

Adv Exp Med Biol. 2001;500:479-87. Review.


Surfactant protein A (SP-A)-mediated bacterial clearance: SP-A and cystic fibrosis.

Korfhagen TR.

Am J Respir Cell Mol Biol. 2001 Dec;25(6):668-72. No abstract available.


Overexpression of TGF-alpha increases lung tissue hysteresivity in transgenic mice.

Pillow JJ, Korfhagen TR, Ikegami M, Sly PD.

J Appl Physiol (1985). 2001 Dec;91(6):2730-4.

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