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The Loss of TET2 Promotes CD8+ T Cell Memory Differentiation.

Carty SA, Gohil M, Banks LB, Cotton RM, Johnson ME, Stelekati E, Wells AD, Wherry EJ, Koretzky GA, Jordan MS.

J Immunol. 2018 Jan 1;200(1):82-91. doi: 10.4049/jimmunol.1700559. Epub 2017 Nov 17.


Review: Cytokine Storm Syndrome: Looking Toward the Precision Medicine Era.

Behrens EM, Koretzky GA.

Arthritis Rheumatol. 2017 Jun;69(6):1135-1143. doi: 10.1002/art.40071. Review. No abstract available.


Interleukin-4 regulates eomesodermin in CD8+ T cell development and differentiation.

Carty SA, Koretzky GA, Jordan MS.

PLoS One. 2014 Sep 10;9(9):e106659. doi: 10.1371/journal.pone.0106659. eCollection 2014.


Loss of PIKfyve in platelets causes a lysosomal disease leading to inflammation and thrombosis in mice.

Min SH, Suzuki A, Stalker TJ, Zhao L, Wang Y, McKennan C, Riese MJ, Guzman JF, Zhang S, Lian L, Joshi R, Meng R, Seeholzer SH, Choi JK, Koretzky G, Marks MS, Abrams CS.

Nat Commun. 2014 Sep 2;5:4691. doi: 10.1038/ncomms5691.


Diacylglycerol kinase α establishes T cell polarity by shaping diacylglycerol accumulation at the immunological synapse.

Chauveau A, Le Floc'h A, Bantilan NS, Koretzky GA, Huse M.

Sci Signal. 2014 Aug 26;7(340):ra82. doi: 10.1126/scisignal.2005287.


Retraction. The requirements for natural Th17 cell development are distinct from those of conventional Th17 cells.

Kim JS, Smith-Garvin JE, Koretzky GA, Jordan MS.

J Exp Med. 2014 Aug 25;211(9):1919. doi: 10.1084/jem.2011068007292014r. Epub 2014 Aug 11. No abstract available.


Preview of Immunological Reviews for 2014.

Koretzky G.

Immunol Rev. 2014 Jan;257(1):5. doi: 10.1111/imr.12144. No abstract available.


The ζ isoform of diacylglycerol kinase plays a predominant role in regulatory T cell development and TCR-mediated ras signaling.

Joshi RP, Schmidt AM, Das J, Pytel D, Riese MJ, Lester M, Diehl JA, Behrens EM, Kambayashi T, Koretzky GA.

Sci Signal. 2013 Nov 26;6(303):ra102. doi: 10.1126/scisignal.2004373.


Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways.

Kim JS, Sklarz T, Banks LB, Gohil M, Waickman AT, Skuli N, Krock BL, Luo CT, Hu W, Pollizzi KN, Li MO, Rathmell JC, Birnbaum MJ, Powell JD, Jordan MS, Koretzky GA.

Nat Immunol. 2013 Jun;14(6):611-8. doi: 10.1038/ni.2607. Epub 2013 May 5. Retraction in: Nat Immunol. 2014 Oct;15(10):996.


Enhanced effector responses in activated CD8+ T cells deficient in diacylglycerol kinases.

Riese MJ, Wang LC, Moon EK, Joshi RP, Ranganathan A, June CH, Koretzky GA, Albelda SM.

Cancer Res. 2013 Jun 15;73(12):3566-77. doi: 10.1158/0008-5472.CAN-12-3874. Epub 2013 Apr 10.


Diacylglycerol kinases: regulated controllers of T cell activation, function, and development.

Joshi RP, Koretzky GA.

Int J Mol Sci. 2013 Mar 26;14(4):6649-73. doi: 10.3390/ijms14046649. Review.


Transient PKCα shuttling to the immunological synapse is governed by DGKζ and regulates L-selectin shedding.

Gharbi SI, Avila-Flores A, Soutar D, Orive A, Koretzky GA, Albar JP, Mérida I.

J Cell Sci. 2013 May 15;126(Pt 10):2176-86. doi: 10.1242/jcs.118513. Epub 2013 Mar 22.


FoxO-dependent regulation of diacylglycerol kinase α gene expression.

Martínez-Moreno M, García-Liévana J, Soutar D, Torres-Ayuso P, Andrada E, Zhong XP, Koretzky GA, Mérida I, Ávila-Flores A.

Mol Cell Biol. 2012 Oct;32(20):4168-80. Epub 2012 Aug 13.


SLP-76 is required for optimal CXCR4-stimulated T lymphocyte firm arrest to ICAM-1 under shear flow.

Lee D, Kim J, Baker RG, Koretzky GA, Hammer DA.

Eur J Immunol. 2012 Oct;42(10):2736-43. doi: 10.1002/eji.201142303. Epub 2012 Sep 10.


Diacylglycerol kinase zeta negatively regulates CXCR4-stimulated T lymphocyte firm arrest to ICAM-1 under shear flow.

Lee D, Kim J, Beste MT, Koretzky GA, Hammer DA.

Integr Biol (Camb). 2012 Jun;4(6):606-14. doi: 10.1039/c2ib00002d. Epub 2012 May 1.


PERK utilizes intrinsic lipid kinase activity to generate phosphatidic acid, mediate Akt activation, and promote adipocyte differentiation.

Bobrovnikova-Marjon E, Pytel D, Riese MJ, Vaites LP, Singh N, Koretzky GA, Witze ES, Diehl JA.

Mol Cell Biol. 2012 Jun;32(12):2268-78. doi: 10.1128/MCB.00063-12. Epub 2012 Apr 9.


Lymphocyte signaling: a Tuscan affair.

Baldari CT, Acuto O, Batista F, Koretzky G, Weiss A.

Nat Immunol. 2011 Dec 16;13(1):3-6. doi: 10.1038/ni.2185. No abstract available.


Preview of immunological reviews for 2012.

Koretzky G.

Immunol Rev. 2012 Jan;245(1):5-6. doi: 10.1111/j.1600-065X.2011.01087.x. No abstract available.


An integrated stochastic model of "inside-out" integrin activation and selective T-lymphocyte recruitment.

Beste MT, Lee D, King MR, Koretzky GA, Hammer DA.

Langmuir. 2012 Jan 31;28(4):2225-37. doi: 10.1021/la203803e. Epub 2012 Jan 4.


The SLP-76 Src homology 2 domain is required for T cell development and activation.

Burns JC, Corbo E, Degen J, Gohil M, Anterasian C, Schraven B, Koretzky GA, Kliche S, Jordan MS.

J Immunol. 2011 Nov 1;187(9):4459-66. doi: 10.4049/jimmunol.0903379. Epub 2011 Sep 26.


The requirements for natural Th17 cell development are distinct from those of conventional Th17 cells.

Kim JS, Smith-Garvin JE, Koretzky GA, Jordan MS.

J Exp Med. 2011 Oct 24;208(11):2201-7. doi: 10.1084/jem.20110680. Epub 2011 Sep 26. Retraction in: Kim JS, Smith-Garvin JE, Koretzky GA, Jordan MS. J Exp Med. 2014 Aug 25;211(9):1919.


Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells.

Sela M, Bogin Y, Beach D, Oellerich T, Lehne J, Smith-Garvin JE, Okumura M, Starosvetsky E, Kosoff R, Libman E, Koretzky G, Kambayashi T, Urlaub H, Wienands J, Chernoff J, Yablonski D.

EMBO J. 2011 Jul 1;30(15):3160-72. doi: 10.1038/emboj.2011.213.


Repeated TLR9 stimulation results in macrophage activation syndrome-like disease in mice.

Behrens EM, Canna SW, Slade K, Rao S, Kreiger PA, Paessler M, Kambayashi T, Koretzky GA.

J Clin Invest. 2011 Jun;121(6):2264-77. doi: 10.1172/JCI43157. Epub 2011 May 16.


Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division.

Chang JT, Ciocca ML, Kinjyo I, Palanivel VR, McClurkin CE, Dejong CS, Mooney EC, Kim JS, Steinel NC, Oliaro J, Yin CC, Florea BI, Overkleeft HS, Berg LJ, Russell SM, Koretzky GA, Jordan MS, Reiner SL.

Immunity. 2011 Apr 22;34(4):492-504. doi: 10.1016/j.immuni.2011.03.017. Epub 2011 Apr 14.


Requirements for eomesodermin and promyelocytic leukemia zinc finger in the development of innate-like CD8+ T cells.

Gordon SM, Carty SA, Kim JS, Zou T, Smith-Garvin J, Alonzo ES, Haimm E, Sant'Angelo DB, Koretzky GA, Reiner SL, Jordan MS.

J Immunol. 2011 Apr 15;186(8):4573-8. doi: 10.4049/jimmunol.1100037. Epub 2011 Mar 7.


Decreased diacylglycerol metabolism enhances ERK activation and augments CD8+ T cell functional responses.

Riese MJ, Grewal J, Das J, Zou T, Patil V, Chakraborty AK, Koretzky GA.

J Biol Chem. 2011 Feb 18;286(7):5254-65. doi: 10.1074/jbc.M110.171884. Epub 2010 Dec 7.


Understanding signal integration through targeted mutations of an adapter protein.

Zou T, May RM, Koretzky GA.

FEBS Lett. 2010 Dec 15;584(24):4901-9. doi: 10.1016/j.febslet.2010.10.025. Epub 2010 Oct 21.


T-cell receptor signals direct the composition and function of the memory CD8+ T-cell pool.

Smith-Garvin JE, Burns JC, Gohil M, Zou T, Kim JS, Maltzman JS, Wherry EJ, Koretzky GA, Jordan MS.

Blood. 2010 Dec 16;116(25):5548-59. doi: 10.1182/blood-2010-06-292748. Epub 2010 Sep 16.


Multiple roles of CD4 and CD8 in T cell activation.

Koretzky GA.

J Immunol. 2010 Sep 1;185(5):2643-4. doi: 10.4049/jimmunol.1090076. No abstract available.


Dendritic cells induce regulatory T cell proliferation through antigen-dependent and -independent interactions.

Zou T, Caton AJ, Koretzky GA, Kambayashi T.

J Immunol. 2010 Sep 1;185(5):2790-9. doi: 10.4049/jimmunol.0903740. Epub 2010 Aug 4.


Independent and cooperative roles of adaptor molecules in proximal signaling during FcepsilonRI-mediated mast cell activation.

Kambayashi T, Okumura M, Baker RG, Hsu CJ, Baumgart T, Zhang W, Koretzky GA.

Mol Cell Biol. 2010 Sep;30(17):4188-96. doi: 10.1128/MCB.00305-10. Epub 2010 Jul 6.


Coordination of receptor signaling in multiple hematopoietic cell lineages by the adaptor protein SLP-76.

Jordan MS, Koretzky GA.

Cold Spring Harb Perspect Biol. 2010 Apr;2(4):a002501. doi: 10.1101/cshperspect.a002501. Epub 2010 Mar 17. Review.


Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling.

Bertozzi CC, Schmaier AA, Mericko P, Hess PR, Zou Z, Chen M, Chen CY, Xu B, Lu MM, Zhou D, Sebzda E, Santore MT, Merianos DJ, Stadtfeld M, Flake AW, Graf T, Skoda R, Maltzman JS, Koretzky GA, Kahn ML.

Blood. 2010 Jul 29;116(4):661-70. doi: 10.1182/blood-2010-02-270876. Epub 2010 Apr 2.


AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species.

Juntilla MM, Patil VD, Calamito M, Joshi RP, Birnbaum MJ, Koretzky GA.

Blood. 2010 May 20;115(20):4030-8. doi: 10.1182/blood-2009-09-241000. Epub 2010 Mar 30.


MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele.

Thiel AT, Blessington P, Zou T, Feather D, Wu X, Yan J, Zhang H, Liu Z, Ernst P, Koretzky GA, Hua X.

Cancer Cell. 2010 Feb 17;17(2):148-59. doi: 10.1016/j.ccr.2009.12.034.


The Role of SH2 Domain-containing Leukocyte Phosphoprotein of 76 kDa in the Regulation of Immune Cell Development and Function.

Koretzky GA.

Immune Netw. 2009 Jun;9(3):75-83. doi: 10.4110/in.2009.9.3.75. Epub 2009 Jun 30.


The physician's voice in the health care debate.

Epstein JA, Turka LA, Birnbaum M, Koretzky G.

J Clin Invest. 2009 Oct;119(10):2846. No abstract available.


Akt1 and Akt2 promote peripheral B-cell maturation and survival.

Calamito M, Juntilla MM, Thomas M, Northrup DL, Rathmell J, Birnbaum MJ, Koretzky G, Allman D.

Blood. 2010 May 20;115(20):4043-50. doi: 10.1182/blood-2009-09-241638. Epub 2009 Dec 30.


Development of promyelocytic zinc finger and ThPOK-expressing innate gamma delta T cells is controlled by strength of TCR signaling and Id3.

Alonzo ES, Gottschalk RA, Das J, Egawa T, Hobbs RM, Pandolfi PP, Pereira P, Nichols KE, Koretzky GA, Jordan MS, Sant'Angelo DB.

J Immunol. 2010 Feb 1;184(3):1268-79. doi: 10.4049/jimmunol.0903218. Epub 2009 Dec 28.


Mislocalization of SLP-76 leads to aberrant inflammatory cytokine and autoantibody production.

Sonnenberg GF, Mangan PR, Bezman NA, Sekiguchi DR, Luning Prak ET, Erikson J, Maltzman JS, Jordan MS, Koretzky GA.

Blood. 2010 Mar 18;115(11):2186-95. doi: 10.1182/blood-2009-08-237438. Epub 2009 Dec 22.


Lymphocyte signaling in the Tuscan hills.

Baldari CT, Koretzky GA.

Immunity. 2009 Nov 20;31(5):692-5. doi: 10.1016/j.immuni.2009.11.001.


Cooperation of adapter molecules in proximal signaling cascades during allergic inflammation.

Kambayashi T, Larosa DF, Silverman MA, Koretzky GA.

Immunol Rev. 2009 Nov;232(1):99-114. doi: 10.1111/j.1600-065X.2009.00825.x. Review.


Mutation of tyrosine 145 of lymphocyte cytosolic protein 2 protects mice from anaphylaxis and arthritis.

Lenox LE, Kambayashi T, Okumura M, Prieto C, Sauer K, Bunte RM, Jordan MS, Koretzky GA, Nichols KE.

J Allergy Clin Immunol. 2009 Nov;124(5):1088-98. doi: 10.1016/j.jaci.2009.08.038.


Histone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombination.

Yin B, Savic V, Juntilla MM, Bredemeyer AL, Yang-Iott KS, Helmink BA, Koretzky GA, Sleckman BP, Bassing CH.

J Exp Med. 2009 Nov 23;206(12):2625-39. doi: 10.1084/jem.20091320. Epub 2009 Nov 2.


Navigating the leukocyte signaling maze guided by Ariadne's thread.

Altman A, Koretzky GA, Tsoukas CD.

Nat Immunol. 2009 Nov;10(11):1134-6. doi: 10.1038/ni1109-1134.


The adapter protein SLP-76 mediates "outside-in" integrin signaling and function in T cells.

Baker RG, Hsu CJ, Lee D, Jordan MS, Maltzman JS, Hammer DA, Baumgart T, Koretzky GA.

Mol Cell Biol. 2009 Oct;29(20):5578-89. doi: 10.1128/MCB.00283-09. Epub 2009 Aug 10.


Cutting edge: rescue of pre-TCR but not mature TCR signaling in mice expressing membrane-targeted SLP-76.

Bezman NA, Baker RG, Lenox LE, Jordan MS, Koretzky GA.

J Immunol. 2009 May 1;182(9):5183-7. doi: 10.4049/jimmunol.0802176.


Inducible MHC class II expression by mast cells supports effector and regulatory T cell activation.

Kambayashi T, Allenspach EJ, Chang JT, Zou T, Shoag JE, Reiner SL, Caton AJ, Koretzky GA.

J Immunol. 2009 Apr 15;182(8):4686-95. doi: 10.4049/jimmunol.0803180.


Synaptic removal of diacylglycerol by DGKzeta and PSD-95 regulates dendritic spine maintenance.

Kim K, Yang J, Zhong XP, Kim MH, Kim YS, Lee HW, Han S, Choi J, Han K, Seo J, Prescott SM, Topham MK, Bae YC, Koretzky G, Choi SY, Kim E.

EMBO J. 2009 Apr 22;28(8):1170-9. doi: 10.1038/emboj.2009.44. Epub 2009 Feb 19.

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