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Items: 1 to 50 of 137

1.

A20 is an immune tolerance factor that can determine islet transplant outcomes.

Zammit NW, Walters SN, Seeberger KL, O'Connell PJ, Korbutt GS, Grey ST.

JCI Insight. 2019 Oct 3. pii: 131028. doi: 10.1172/jci.insight.131028. [Epub ahead of print]

2.

Improved islet recovery and efficacy through co-culture and co-transplantation of islets with human adipose-derived mesenchymal stem cells.

Gamble A, Pawlick R, Pepper AR, Bruni A, Adesida A, Senior PA, Korbutt GS, Shapiro AMJ.

PLoS One. 2018 Nov 12;13(11):e0206449. doi: 10.1371/journal.pone.0206449. eCollection 2018.

3.

In vitro characterization of neonatal, juvenile, and adult porcine islet oxygen demand, β-cell function, and transcriptomes.

Smith KE, Purvis WG, Davis MA, Min CG, Cooksey AM, Weber CS, Jandova J, Price ND, Molano DS, Stanton JB, Kelly AC, Steyn LV, Lynch RM, Limesand SW, Alexander M, Lakey JRT, Seeberger K, Korbutt GS, Mueller KR, Hering BJ, McCarthy FM, Papas KK.

Xenotransplantation. 2018 Nov;25(6):e12432. doi: 10.1111/xen.12432. Epub 2018 Jul 27.

PMID:
30052287
4.

Functional Maturation and In Vitro Differentiation of Neonatal Porcine Islet Grafts.

Hassouna T, Seeberger KL, Salama B, Korbutt GS.

Transplantation. 2018 Oct;102(10):e413-e423. doi: 10.1097/TP.0000000000002354.

PMID:
29975241
5.

Ferroptosis-inducing agents compromise in vitro human islet viability and function.

Bruni A, Pepper AR, Pawlick RL, Gala-Lopez B, Gamble AF, Kin T, Seeberger K, Korbutt GS, Bornstein SR, Linkermann A, Shapiro AMJ.

Cell Death Dis. 2018 May 22;9(6):595. doi: 10.1038/s41419-018-0506-0.

6.

Porcine Islet Xenografts: a Clinical Source of ß-Cell Grafts.

Salama BF, Korbutt GS.

Curr Diab Rep. 2017 Mar;17(3):14. doi: 10.1007/s11892-017-0846-7. Review.

PMID:
28271465
7.

Cotransplantation of Mesenchymal Stem Cells With Neonatal Porcine Islets Improve Graft Function in Diabetic Mice.

Hayward JA, Ellis CE, Seeberger K, Lee T, Salama B, Mulet-Sierra A, Kuppan P, Adesida A, Korbutt GS.

Diabetes. 2017 May;66(5):1312-1321. doi: 10.2337/db16-1068. Epub 2017 Feb 28.

8.

The effect of additive compounds on glycerol-induced damage to human chondrocytes.

Hahn J, Laouar L, Elliott JAW, Korbutt GS, Jomha NM.

Cryobiology. 2017 Apr;75:68-74. doi: 10.1016/j.cryobiol.2017.02.002. Epub 2017 Feb 10.

PMID:
28192075
9.

Justifying clinical trials for porcine islet xenotransplantation.

Ellis CE, Korbutt GS.

Xenotransplantation. 2015 Sep-Oct;22(5):336-44. doi: 10.1111/xen.12196. Review.

PMID:
26381492
10.

Optimization and Scale-up Isolation and Culture of Neonatal Porcine Islets: Potential for Clinical Application.

Ellis C, Lyon JG, Korbutt GS.

Cell Transplant. 2016;25(3):539-47. doi: 10.3727/096368915X689451. Epub 2015 Sep 15.

PMID:
26377964
11.

Development and Characterization of a Collagen-Based Matrix for Vascularization and Cell Delivery.

Ellis CE, Ellis LK, Korbutt RS, Suuronen EJ, Korbutt GS.

Biores Open Access. 2015 Mar 1;4(1):188-97. doi: 10.1089/biores.2015.0007. eCollection 2015.

12.

Porcine Islet-Specific Tolerance Induced by the Combination of Anti-LFA-1 and Anti-CD154 mAbs Is Dependent on PD-1.

Arefanian H, Tredget EB, Mok DC, Ramji Q, Rafati S, Rodriguez-Barbosa J, Korbutt GS, Rajotte RV, Gill RG, Rayat GR.

Cell Transplant. 2016;25(2):327-42. doi: 10.3727/096368915X688506. Epub 2015 Jun 23.

PMID:
26109574
13.

Human islet function following 20 years of cryogenic biobanking.

Manning Fox JE, Lyon J, Dai XQ, Wright RC, Hayward J, van de Bunt M, Kin T, Shapiro AM, McCarthy MI, Gloyn AL, Ungrin MD, Lakey JR, Kneteman NM, Warnock GL, Korbutt GS, Rajotte RV, MacDonald PE.

Diabetologia. 2015 Jul;58(7):1503-12. doi: 10.1007/s00125-015-3598-4. Epub 2015 May 1.

14.

Identification and differentiation of PDX1 β-cell progenitors within the human pancreatic epithelium.

Seeberger KL, Anderson SJ, Ellis CE, Yeung TY, Korbutt GS.

World J Diabetes. 2014 Feb 15;5(1):59-68. doi: 10.4239/wjd.v5.i1.59.

15.

Nondividing, postpubertal rat sertoli cells resumed proliferation after transplantation.

Mital P, Kaur G, Bowlin B, Paniagua NJ, Korbutt GS, Dufour JM.

Biol Reprod. 2014 Jan 23;90(1):13. doi: 10.1095/biolreprod.113.110197. Print 2014 Jan.

16.

Bioengineering a highly vascularized matrix for the ectopic transplantation of islets.

Ellis CE, Vulesevic B, Suuronen E, Yeung T, Seeberger K, Korbutt GS.

Islets. 2013 Sep-Dec;5(5):216-25. doi: 10.4161/isl.27175. Epub 2013 Nov 21.

17.

Glyoxalase-1 overexpression in bone marrow cells reverses defective neovascularization in STZ-induced diabetic mice.

Vulesevic B, McNeill B, Geoffrion M, Kuraitis D, McBane JE, Lochhead M, Vanderhyden BC, Korbutt GS, Milne RW, Suuronen EJ.

Cardiovasc Res. 2014 Feb 1;101(2):306-16. doi: 10.1093/cvr/cvt259. Epub 2013 Nov 20.

PMID:
24259499
18.

Evaluation of a collagen-chitosan hydrogel for potential use as a pro-angiogenic site for islet transplantation.

McBane JE, Vulesevic B, Padavan DT, McEwan KA, Korbutt GS, Suuronen EJ.

PLoS One. 2013 Oct 18;8(10):e77538. doi: 10.1371/journal.pone.0077538. eCollection 2013.

19.

Collagen-chitosan-laminin hydrogels for the delivery of insulin-producing tissue.

McEwan K, Padavan DT, Ellis C, McBane JE, Vulesevic B, Korbutt GS, Suuronen EJ.

J Tissue Eng Regen Med. 2016 Oct;10(10):E397-E408. doi: 10.1002/term.1829. Epub 2013 Oct 30.

PMID:
24170711
20.

Possible link between ectopic pancreas and holoprosencephaly.

Kin T, Korbutt GS, Shapiro AM.

Islets. 2012 May-Jun;4(3):207-9. doi: 10.4161/isl.20478. Epub 2012 May 1.

21.

Human mesenchymal stem cells protect human islets from pro-inflammatory cytokines.

Yeung TY, Seeberger KL, Kin T, Adesida A, Jomha N, Shapiro AM, Korbutt GS.

PLoS One. 2012;7(5):e38189. doi: 10.1371/journal.pone.0038189. Epub 2012 May 30.

22.

Vascularization of collagen-chitosan scaffolds with circulating progenitor cells as potential site for islet transplantation.

Deng C, Vulesevic B, Ellis C, Korbutt GS, Suuronen EJ.

J Control Release. 2011 Nov 30;152 Suppl 1:e196-8. doi: 10.1016/j.jconrel.2011.09.005. No abstract available.

PMID:
22195848
23.

The importance of beta cell characterisation: generating human beta cells by differentiating human embryonic stem cells.

Korbutt GS, Yeung TY, Ellis CE.

Diabetologia. 2012 Feb;55(2):279-81. doi: 10.1007/s00125-011-2397-9. Epub 2011 Dec 7. No abstract available.

PMID:
22147019
24.

Tunable collagen hydrogels are modified by the therapeutic agents they are designed to deliver.

McEwan K, Padavan DT, Deng C, Vulesevic B, Kuraitis D, Korbutt GS, Suuronen EJ.

J Biomater Sci Polym Ed. 2012;23(11):1467-83. doi: 10.1163/092050611X584397. Epub 2012 May 8.

PMID:
21771391
25.

Isolation and culture of human multipotent stromal cells from the pancreas.

Seeberger KL, Eshpeter A, Korbutt GS.

Methods Mol Biol. 2011;698:123-40. doi: 10.1007/978-1-60761-999-4_10.

PMID:
21431515
26.

Loss of TGH/Ces3 in mice decreases blood lipids, improves glucose tolerance, and increases energy expenditure.

Wei E, Ben Ali Y, Lyon J, Wang H, Nelson R, Dolinsky VW, Dyck JR, Mitchell G, Korbutt GS, Lehner R.

Cell Metab. 2010 Mar 3;11(3):183-93. doi: 10.1016/j.cmet.2010.02.005.

27.

Islet amyloid deposition limits the viability of human islet grafts but not porcine islet grafts.

Potter KJ, Abedini A, Marek P, Klimek AM, Butterworth S, Driscoll M, Baker R, Nilsson MR, Warnock GL, Oberholzer J, Bertera S, Trucco M, Korbutt GS, Fraser PE, Raleigh DP, Verchere CB.

Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4305-10. doi: 10.1073/pnas.0909024107. Epub 2010 Feb 16.

28.

Short-term administrations of a combination of anti-LFA-1 and anti-CD154 monoclonal antibodies induce tolerance to neonatal porcine islet xenografts in mice.

Arefanian H, Tredget EB, Rajotte RV, Gill RG, Korbutt GS, Rayat GR.

Diabetes. 2010 Apr;59(4):958-66. doi: 10.2337/db09-0413. Epub 2010 Jan 19.

30.

The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes-- executive summary.

Hering BJ, Cooper DK, Cozzi E, Schuurman HJ, Korbutt GS, Denner J, O'Connell PJ, Vanderpool HY, Pierson RN 3rd.

Xenotransplantation. 2009 Jul-Aug;16(4):196-202. doi: 10.1111/j.1399-3089.2009.00547.x.

PMID:
19799759
31.

Prolonged survival of microencapsulated neonatal porcine islet xenografts in immune-competent mice without antirejection therapy.

Kobayashi T, Arefanian H, Harb G, Tredget EB, Rajotte RV, Korbutt GS, Rayat GR.

Cell Transplant. 2008;17(10-11):1243-56.

PMID:
19181218
32.

The use of an approved biodegradable polymer scaffold as a solid support system for improvement of islet engraftment.

Kin T, O'Neil JJ, Pawlick R, Korbutt GS, Shapiro AM, Lakey JR.

Artif Organs. 2008 Dec;32(12):990-3. doi: 10.1111/j.1525-1594.2008.00688.x.

PMID:
19133030
33.

Epithelial cells within the human pancreas do not coexpress mesenchymal antigens: epithelial-mesenchymal transition is an artifact of cell culture.

Seeberger KL, Eshpeter A, Rajotte RV, Korbutt GS.

Lab Invest. 2009 Feb;89(2):110-21. doi: 10.1038/labinvest.2008.122. Epub 2008 Dec 15.

34.

In vivo characterization of transplanted human embryonic stem cell-derived pancreatic endocrine islet cells.

Eshpeter A, Jiang J, Au M, Rajotte RV, Lu K, Lebkowski JS, Majumdar AS, Korbutt GS.

Cell Prolif. 2008 Dec;41(6):843-858. doi: 10.1111/j.1365-2184.2008.00564.x.

PMID:
19040565
35.

Alginate modification improves long-term survival and function of transplanted encapsulated islets.

Mallett AG, Korbutt GS.

Tissue Eng Part A. 2009 Jun;15(6):1301-9. doi: 10.1089/ten.tea.2008.0118.

PMID:
18950258
36.

Sertoli cell line lacks the immunoprotective properties associated with primary Sertoli cells.

Dufour JM, Dass B, Halley KR, Korbutt GS, Dixon DE, Rajotte RV.

Cell Transplant. 2008;17(5):525-34.

PMID:
18714671
37.

What type of islets should be used?

Korbutt GS.

Xenotransplantation. 2008 Mar-Apr;15(2):81-2. doi: 10.1111/j.1399-3089.2008.00455.x. No abstract available.

PMID:
18447872
38.

Treatment of obesity and diabetes in mice by transplant of gut cells engineered to produce leptin.

Oosman SN, Lam AW, Harb G, Unniappan S, Lam NT, Webber T, Bruch D, Zhang QX, Korbutt GS, Kieffer TJ.

Mol Ther. 2008 Jun;16(6):1138-45. doi: 10.1038/mt.2008.62. Epub 2008 Apr 15.

39.

Comparison of successful and unsuccessful islet/Sertoli cell cotransplant grafts in streptozotocin-induced diabetic mice.

Dufour JM, Lord SJ, Kin T, Rayat GR, Dixon DE, Bleackley RC, Korbutt GS, Rajotte RV.

Cell Transplant. 2008;16(10):1029-38.

PMID:
18351019
40.
41.

Comparison of Successful and Unsuccessful Islet/Sertoli Cell Cotransplant Grafts in Streptozotocin-Induced Diabetic Mice.

Dufour JM, Lord SJ, Kin T, Rayat GR, Dixon DE, Bleackley RC, Korbutt GS, Rajotte RV.

Cell Transplant. 2007 Nov;16(10):1029-1038. doi: 10.3727/000000007783472417.

PMID:
28866926
42.
43.

Long-term graft function after allogeneic islet transplantation.

Lakey JR, Kin T, Warnock GL, Shapiro AM, Tsapogas P, Imes S, Korbutt GS, Kneteman NM, Rajotte RV, Ryan EA.

Cell Transplant. 2007;16(4):441-6.

PMID:
17658134
44.

NMR assessment of Me(2)SO in decellularized cryopreserved aortic valve conduits.

Lehr EJ, Hermary S, McKay RT, Webb DN, Abazari A, McGann LE, Coe JY, Korbutt GS, Ross DB.

J Surg Res. 2007 Jul;141(1):60-7. Epub 2007 May 18.

PMID:
17512545
45.

Enriched human pancreatic ductal cultures obtained from selective death of acinar cells express pancreatic and duodenal homeobox gene-1 age-dependently.

Street CN, Lakey JR, Rajotte RV, Shapiro AM, Kieffer TJ, Lyon JG, Kin T, Korbutt GS.

Rev Diabet Stud. 2004 Summer;1(2):66-79. Epub 2004 Aug 10.

46.

Long-Term Graft Function after Allogeneic Islet Transplantation.

Lakey JRT, Kin T, Warnock GL, Shapiro AMJ, Tsapogas P, Imes S, Korbutt GS, Kneteman NM, Rajotte RV, Ryan EA.

Cell Transplant. 2007 Apr;16(4):441-446. doi: 10.3727/000000007783464849.

PMID:
28858603
47.
48.

Inbred or outbred? An evaluation of the functional allogenicity of farm sheep used in cardiac valve studies.

Lehr EJ, Rayat GR, Desai LS, Coe JY, Korbutt GS, Ross DB.

J Thorac Cardiovasc Surg. 2006 Nov;132(5):1156-61.

49.

Immune mechanisms associated with the rejection of encapsulated neonatal porcine islet xenografts.

Kobayashi T, Harb G, Rajotte RV, Korbutt GS, Mallett AG, Arefanian H, Mok D, Rayat GR.

Xenotransplantation. 2006 Nov;13(6):547-59.

PMID:
17059582
50.

Identification of a novel human granzyme B inhibitor secreted by cultured sertoli cells.

Sipione S, Simmen KC, Lord SJ, Motyka B, Ewen C, Shostak I, Rayat GR, Dufour JM, Korbutt GS, Rajotte RV, Bleackley RC.

J Immunol. 2006 Oct 15;177(8):5051-8.

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