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Items: 1 to 50 of 114

1.

Urokinase-type plasminogen activator (uPA) is not essential for epithelial sodium channel (ENaC)-mediated sodium retention in experimental nephrotic syndrome.

Bohnert BN, Daiminger S, Wörn M, Sure F, Staudner T, Ilyaskin AV, Batbouta F, Janessa A, Schneider JC, Essigke D, Kanse S, Haerteis S, Korbmacher C, Artunc F.

Acta Physiol (Oxf). 2019 Dec;227(4):e13286. doi: 10.1111/apha.13286. Epub 2019 May 20.

PMID:
31006168
2.

Bile acids inhibit human purinergic receptor P2X4 in a heterologous expression system.

Ilyaskin AV, Sure F, Nesterov V, Haerteis S, Korbmacher C.

J Gen Physiol. 2019 Jun 3;151(6):820-833. doi: 10.1085/jgp.201812291. Epub 2019 Apr 15.

PMID:
30988062
3.

The degenerin region of the human bile acid-sensitive ion channel (BASIC) is involved in channel inhibition by calcium and activation by bile acids.

Ilyaskin AV, Kirsch SA, Böckmann RA, Sticht H, Korbmacher C, Haerteis S, Diakov A.

Pflugers Arch. 2018 Jul;470(7):1087-1102. doi: 10.1007/s00424-018-2142-z. Epub 2018 Mar 27.

PMID:
29589117
4.

Plasma kallikrein activates the epithelial sodium channel in vitro but is not essential for volume retention in nephrotic mice.

Haerteis S, Schork A, Dörffel T, Bohnert BN, Nacken R, Wörn M, Xiao M, Essigke D, Janessa A, Schmaier AH, Feener EP, Häring HU, Bertog M, Korbmacher C, Artunc F.

Acta Physiol (Oxf). 2018 Sep;224(1):e13060. doi: 10.1111/apha.13060. Epub 2018 Mar 25.

PMID:
29489063
5.

The phosphorylation site T613 in the β-subunit of rat epithelial Na+ channel (ENaC) modulates channel inhibition by Nedd4-2.

Krueger B, Yang L, Korbmacher C, Rauh R.

Pflugers Arch. 2018 Apr;470(4):649-660. doi: 10.1007/s00424-018-2115-2. Epub 2018 Feb 3.

PMID:
29397423
6.

Aprotinin prevents proteolytic epithelial sodium channel (ENaC) activation and volume retention in nephrotic syndrome.

Bohnert BN, Menacher M, Janessa A, Wörn M, Schork A, Daiminger S, Kalbacher H, Häring HU, Daniel C, Amann K, Sure F, Bertog M, Haerteis S, Korbmacher C, Artunc F.

Kidney Int. 2018 Jan;93(1):159-172. doi: 10.1016/j.kint.2017.07.023. Epub 2017 Oct 14.

PMID:
29042083
7.

Inhibitors of the proteasome stimulate the epithelial sodium channel (ENaC) through SGK1 and mimic the effect of aldosterone.

Mansley MK, Korbmacher C, Bertog M.

Pflugers Arch. 2018 Feb;470(2):295-304. doi: 10.1007/s00424-017-2060-5. Epub 2017 Aug 31.

PMID:
28861610
8.

Erratum to: Sensitisation of TRPV4 by PAR2 is independent of intracellular calcium signalling and can be mediated by the biased agonist neutrophil elastase.

Sostegni S, Diakov A, McIntyre P, Bunnett N, Korbmacher C, Haerteis S.

Pflugers Arch. 2017 Jun;469(5-6):845-846. doi: 10.1007/s00424-017-1973-3. No abstract available.

PMID:
28389775
9.

Bile acids potentiate proton-activated currents in Xenopus laevis oocytes expressing human acid-sensing ion channel (ASIC1a).

Ilyaskin AV, Diakov A, Korbmacher C, Haerteis S.

Physiol Rep. 2017 Feb;5(3). pii: e13132. doi: 10.14814/phy2.13132.

10.

δβγ-ENaC is inhibited by CFTR but stimulated by cAMP in Xenopus laevis oocytes.

Rauh R, Hoerner C, Korbmacher C.

Am J Physiol Lung Cell Mol Physiol. 2017 Feb 1;312(2):L277-L287. doi: 10.1152/ajplung.00375.2016. Epub 2016 Dec 9.

11.

Activation of the Human Epithelial Sodium Channel (ENaC) by Bile Acids Involves the Degenerin Site.

Ilyaskin AV, Diakov A, Korbmacher C, Haerteis S.

J Biol Chem. 2016 Sep 16;291(38):19835-47. doi: 10.1074/jbc.M116.726471. Epub 2016 Aug 3.

12.

In Liddle Syndrome, Epithelial Sodium Channel Is Hyperactive Mainly in the Early Part of the Aldosterone-Sensitive Distal Nephron.

Nesterov V, Krueger B, Bertog M, Dahlmann A, Palmisano R, Korbmacher C.

Hypertension. 2016 Jun;67(6):1256-62. doi: 10.1161/HYPERTENSIONAHA.115.07061.

PMID:
27170740
13.

mTORC2 critically regulates renal potassium handling.

Grahammer F, Nesterov V, Ahmed A, Steinhardt F, Sandner L, Arnold F, Cordts T, Negrea S, Bertog M, Ruegg MA, Hall MN, Walz G, Korbmacher C, Artunc F, Huber TB.

J Clin Invest. 2016 May 2;126(5):1773-82. doi: 10.1172/JCI80304. Epub 2016 Apr 4.

14.

Association of Plasminuria with Overhydration in Patients with CKD.

Schork A, Woern M, Kalbacher H, Voelter W, Nacken R, Bertog M, Haerteis S, Korbmacher C, Heyne N, Peter A, Häring HU, Artunc F.

Clin J Am Soc Nephrol. 2016 May 6;11(5):761-9. doi: 10.2215/CJN.12261115. Epub 2016 Mar 1.

15.

Atomic force microscopy imaging reveals the formation of ASIC/ENaC cross-clade ion channels.

Jeggle P, Smith ES, Stewart AP, Haerteis S, Korbmacher C, Edwardson JM.

Biochem Biophys Res Commun. 2015 Aug 14;464(1):38-44. doi: 10.1016/j.bbrc.2015.05.091. Epub 2015 May 29.

PMID:
26032502
16.

Neutrophil Elastase Activates Protease-activated Receptor-2 (PAR2) and Transient Receptor Potential Vanilloid 4 (TRPV4) to Cause Inflammation and Pain.

Zhao P, Lieu T, Barlow N, Sostegni S, Haerteis S, Korbmacher C, Liedtke W, Jimenez-Vargas NN, Vanner SJ, Bunnett NW.

J Biol Chem. 2015 May 29;290(22):13875-87. doi: 10.1074/jbc.M115.642736. Epub 2015 Apr 15.

17.

Norepinephrine stimulates the epithelial Na+ channel in cortical collecting duct cells via α2-adrenoceptors.

Mansley MK, Neuhuber W, Korbmacher C, Bertog M.

Am J Physiol Renal Physiol. 2015 Mar 1;308(5):F450-8. doi: 10.1152/ajprenal.00548.2014. Epub 2014 Dec 17.

18.

The bile acid receptor TGR5 activates the TRPA1 channel to induce itch in mice.

Lieu T, Jayaweera G, Zhao P, Poole DP, Jensen D, Grace M, McIntyre P, Bron R, Wilson YM, Krappitz M, Haerteis S, Korbmacher C, Steinhoff MS, Nassini R, Materazzi S, Geppetti P, Corvera CU, Bunnett NW.

Gastroenterology. 2014 Dec;147(6):1417-28. doi: 10.1053/j.gastro.2014.08.042. Epub 2014 Sep 3.

19.

Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4.

Zhao P, Lieu T, Barlow N, Metcalf M, Veldhuis NA, Jensen DD, Kocan M, Sostegni S, Haerteis S, Baraznenok V, Henderson I, Lindström E, Guerrero-Alba R, Valdez-Morales EE, Liedtke W, McIntyre P, Vanner SJ, Korbmacher C, Bunnett NW.

J Biol Chem. 2014 Sep 26;289(39):27215-34. doi: 10.1074/jbc.M114.599712. Epub 2014 Aug 12. Erratum in: J Biol Chem. 2014 Dec 26;289(52):35858.

20.

Mechanisms of renal control of potassium homeostasis in complete aldosterone deficiency.

Todkar A, Picard N, Loffing-Cueni D, Sorensen MV, Mihailova M, Nesterov V, Makhanova N, Korbmacher C, Wagner CA, Loffing J.

J Am Soc Nephrol. 2015 Feb;26(2):425-38. doi: 10.1681/ASN.2013111156. Epub 2014 Jul 28.

21.
22.

Sensitisation of TRPV4 by PAR2 is independent of intracellular calcium signalling and can be mediated by the biased agonist neutrophil elastase.

Sostegni S, Diakov A, McIntyre P, Bunnett N, Korbmacher C, Haerteis S.

Pflugers Arch. 2015 Apr;467(4):687-701. doi: 10.1007/s00424-014-1539-6. Epub 2014 Jun 8. Erratum in: Pflugers Arch. 2017 Jun;469(5-6):845-846.

PMID:
24906497
23.

Proteolytic activation of the human epithelial sodium channel by trypsin IV and trypsin I involves distinct cleavage sites.

Haerteis S, Krappitz A, Krappitz M, Murphy JE, Bertog M, Krueger B, Nacken R, Chung H, Hollenberg MD, Knecht W, Bunnett NW, Korbmacher C.

J Biol Chem. 2014 Jul 4;289(27):19067-78. doi: 10.1074/jbc.M113.538470. Epub 2014 May 19.

24.

Pharmacological and electrophysiological characterization of the human bile acid-sensitive ion channel (hBASIC).

Lefèvre CM, Diakov A, Haerteis S, Korbmacher C, Gründer S, Wiemuth D.

Pflugers Arch. 2014 Feb;466(2):253-63. doi: 10.1007/s00424-013-1310-4. Epub 2013 Jul 11.

PMID:
23842738
25.

The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts.

Jensen DD, Godfrey CB, Niklas C, Canals M, Kocan M, Poole DP, Murphy JE, Alemi F, Cottrell GS, Korbmacher C, Lambert NA, Bunnett NW, Corvera CU.

J Biol Chem. 2013 Aug 9;288(32):22942-60. doi: 10.1074/jbc.M113.455774. Epub 2013 Jul 1.

26.

Characterization of the mouse ClC-K1/Barttin chloride channel.

L'Hoste S, Diakov A, Andrini O, Genete M, Pinelli L, Grand T, Keck M, Paulais M, Beck L, Korbmacher C, Teulon J, Lourdel S.

Biochim Biophys Acta. 2013 Nov;1828(11):2399-409. doi: 10.1016/j.bbamem.2013.06.012. Epub 2013 Jun 18.

27.

A mutation in the β-subunit of ENaC identified in a patient with cystic fibrosis-like symptoms has a gain-of-function effect.

Rauh R, Soell D, Haerteis S, Diakov A, Nesterov V, Krueger B, Sticht H, Korbmacher C.

Am J Physiol Lung Cell Mol Physiol. 2013 Jan 1;304(1):L43-55. doi: 10.1152/ajplung.00093.2012. Epub 2012 Oct 19.

28.

Plasmin and chymotrypsin have distinct preferences for channel activating cleavage sites in the γ subunit of the human epithelial sodium channel.

Haerteis S, Krappitz M, Diakov A, Krappitz A, Rauh R, Korbmacher C.

J Gen Physiol. 2012 Oct;140(4):375-89. Epub 2012 Sep 10.

29.

Aldosterone-dependent and -independent regulation of the epithelial sodium channel (ENaC) in mouse distal nephron.

Nesterov V, Dahlmann A, Krueger B, Bertog M, Loffing J, Korbmacher C.

Am J Physiol Renal Physiol. 2012 Nov 1;303(9):F1289-99. doi: 10.1152/ajprenal.00247.2012. Epub 2012 Aug 29.

30.

Proteolytic activation of the epithelial sodium channel (ENaC) by the cysteine protease cathepsin-S.

Haerteis S, Krappitz M, Bertog M, Krappitz A, Baraznenok V, Henderson I, Lindström E, Murphy JE, Bunnett NW, Korbmacher C.

Pflugers Arch. 2012 Oct;464(4):353-65. Epub 2012 Aug 5.

31.

An inhibitory peptide derived from the α-subunit of the epithelial sodium channel (ENaC) shows a helical conformation.

Haerteis S, Schaal D, Brauer F, Brüschke S, Schweimer K, Rauh R, Sticht H, Rösch P, Schwarzinger S, Korbmacher C.

Cell Physiol Biochem. 2012;29(5-6):761-74. doi: 10.1159/000312590. Epub 2012 May 11.

32.

Four subunits (αβγδ) of the epithelial sodium channel (ENaC) are expressed in the human eye in various locations.

Krueger B, Schlötzer-Schrehardt U, Haerteis S, Zenkel M, Chankiewitz VE, Amann KU, Kruse FE, Korbmacher C.

Invest Ophthalmol Vis Sci. 2012 Feb 2;53(2):596-604. doi: 10.1167/iovs.11-8581.

PMID:
22167092
33.

Atomic force microscopy reveals the architecture of the epithelial sodium channel (ENaC).

Stewart AP, Haerteis S, Diakov A, Korbmacher C, Edwardson JM.

J Biol Chem. 2011 Sep 16;286(37):31944-52. doi: 10.1074/jbc.M111.275289. Epub 2011 Jul 20.

34.

Protein kinase B alpha (PKBα) stimulates the epithelial sodium channel (ENaC) heterologously expressed in Xenopus laevis oocytes by two distinct mechanisms.

Diakov A, Nesterov V, Mokrushina M, Rauh R, Korbmacher C.

Cell Physiol Biochem. 2010;26(6):913-24. doi: 10.1159/000324000. Epub 2011 Jan 4.

35.

A mutation of the epithelial sodium channel associated with atypical cystic fibrosis increases channel open probability and reduces Na+ self inhibition.

Rauh R, Diakov A, Tzschoppe A, Korbmacher J, Azad AK, Cuppens H, Cassiman JJ, Dötsch J, Sticht H, Korbmacher C.

J Physiol. 2010 Apr 15;588(Pt 8):1211-25. doi: 10.1113/jphysiol.2009.180224. Epub 2010 Mar 1.

36.

Functional characterization of a partial loss-of-function mutation of the epithelial sodium channel (ENaC) associated with atypical cystic fibrosis.

Huber R, Krueger B, Diakov A, Korbmacher J, Haerteis S, Einsiedel J, Gmeiner P, Azad AK, Cuppens H, Cassiman JJ, Korbmacher C, Rauh R.

Cell Physiol Biochem. 2010;25(1):145-58. doi: 10.1159/000272059. Epub 2009 Dec 22.

37.

Cholesterol depletion of the plasma membrane prevents activation of the epithelial sodium channel (ENaC) by SGK1.

Krueger B, Haerteis S, Yang L, Hartner A, Rauh R, Korbmacher C, Diakov A.

Cell Physiol Biochem. 2009;24(5-6):605-18. doi: 10.1159/000257516. Epub 2009 Nov 4.

38.

The delta-subunit of the epithelial sodium channel (ENaC) enhances channel activity and alters proteolytic ENaC activation.

Haerteis S, Krueger B, Korbmacher C, Rauh R.

J Biol Chem. 2009 Oct 16;284(42):29024-40. doi: 10.1074/jbc.M109.018945. Epub 2009 Aug 28.

39.

Mutations in the amiloride-sensitive epithelial sodium channel in patients with cystic fibrosis-like disease.

Azad AK, Rauh R, Vermeulen F, Jaspers M, Korbmacher J, Boissier B, Bassinet L, Fichou Y, des Georges M, Stanke F, De Boeck K, Dupont L, Balascáková M, Hjelte L, Lebecque P, Radojkovic D, Castellani C, Schwartz M, Stuhrmann M, Schwarz M, Skalicka V, de Monestrol I, Girodon E, Férec C, Claustres M, Tümmler B, Cassiman JJ, Korbmacher C, Cuppens H.

Hum Mutat. 2009 Jul;30(7):1093-103. doi: 10.1002/humu.21011.

PMID:
19462466
40.

HIF-prolyl hydroxylases in the rat kidney: physiologic expression patterns and regulation in acute kidney injury.

Schödel J, Klanke B, Weidemann A, Buchholz B, Bernhardt W, Bertog M, Amann K, Korbmacher C, Wiesener M, Warnecke C, Kurtz A, Eckardt KU, Willam C.

Am J Pathol. 2009 May;174(5):1663-74. doi: 10.2353/ajpath.2009.080687. Epub 2009 Apr 6.

41.

Regulated sodium transport in the renal connecting tubule (CNT) via the epithelial sodium channel (ENaC).

Loffing J, Korbmacher C.

Pflugers Arch. 2009 May;458(1):111-35. doi: 10.1007/s00424-009-0656-0. Epub 2009 Mar 11. Review.

PMID:
19277701
42.

Proteolytic activation of the epithelial sodium channel (ENaC) in health and disease.

Korbmacher C.

J Med Invest. 2009;56 Suppl:306-7. No abstract available.

43.

Plasmin in nephrotic urine activates the epithelial sodium channel.

Svenningsen P, Bistrup C, Friis UG, Bertog M, Haerteis S, Krueger B, Stubbe J, Jensen ON, Thiesson HC, Uhrenholt TR, Jespersen B, Jensen BL, Korbmacher C, Skøtt O.

J Am Soc Nephrol. 2009 Feb;20(2):299-310. doi: 10.1681/ASN.2008040364. Epub 2008 Dec 10.

44.

Cleavage in the {gamma}-subunit of the epithelial sodium channel (ENaC) plays an important role in the proteolytic activation of near-silent channels.

Diakov A, Bera K, Mokrushina M, Krueger B, Korbmacher C.

J Physiol. 2008 Oct 1;586(19):4587-608. doi: 10.1113/jphysiol.2008.154435. Epub 2008 Jul 31.

45.

Trypsin can activate the epithelial sodium channel (ENaC) in microdissected mouse distal nephron.

Nesterov V, Dahlmann A, Bertog M, Korbmacher C.

Am J Physiol Renal Physiol. 2008 Oct;295(4):F1052-62. doi: 10.1152/ajprenal.00031.2008. Epub 2008 Jul 23.

46.

Aldosterone responsiveness of the epithelial sodium channel (ENaC) in colon is increased in a mouse model for Liddle's syndrome.

Bertog M, Cuffe JE, Pradervand S, Hummler E, Hartner A, Porst M, Hilgers KF, Rossier BC, Korbmacher C.

J Physiol. 2008 Jan 15;586(2):459-75. Epub 2007 Nov 15.

47.

(NDRG2) stimulates amiloride-sensitive Na+ currents in Xenopus laevis oocytes and fisher rat thyroid cells.

Wielpütz MO, Lee IH, Dinudom A, Boulkroun S, Farman N, Cook DI, Korbmacher C, Rauh R.

J Biol Chem. 2007 Sep 21;282(38):28264-73. Epub 2007 Jul 25.

48.

Functional characterization of a novel CFTR mutation P67S identified in a patient with atypical cystic fibrosis.

Kraus C, Reis A, Naehrlich L, Dötsch J, Korbmacher C, Rauh R.

Cell Physiol Biochem. 2007;19(5-6):239-48.

49.
50.

Stimulation of the epithelial sodium channel (ENaC) by the serum- and glucocorticoid-inducible kinase (Sgk) involves the PY motifs of the channel but is independent of sodium feedback inhibition.

Rauh R, Dinudom A, Fotia AB, Paulides M, Kumar S, Korbmacher C, Cook DI.

Pflugers Arch. 2006 Jun;452(3):290-9. Epub 2006 Jan 17.

PMID:
16416336

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