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Items: 45

1.

Calcium Signaling Controls Pathogenic Th17 Cell-Mediated Inflammation by Regulating Mitochondrial Function.

Kaufmann U, Kahlfuss S, Yang J, Ivanova E, Koralov SB, Feske S.

Cell Metab. 2019 Feb 12. pii: S1550-4131(19)30019-1. doi: 10.1016/j.cmet.2019.01.019. [Epub ahead of print]

PMID:
30773462
2.

Impaired Expression of Rearranged Immunoglobulin Genes and Premature p53 Activation Block B Cell Development in BMI1 Null Mice.

Cantor DJ, King B, Blumenberg L, DiMauro T, Aifantis I, Koralov SB, Skok JA, David G.

Cell Rep. 2019 Jan 2;26(1):108-118.e4. doi: 10.1016/j.celrep.2018.12.030.

3.

B Cell Defects Observed in Nod2 Knockout Mice Are a Consequence of a Dock2 Mutation Frequently Found in Inbred Strains.

Wong SY, Coffre M, Ramanan D, Hines MJ, Gomez LE, Peters LA, Schadt EE, Koralov SB, Cadwell K.

J Immunol. 2018 Sep 1;201(5):1442-1451. doi: 10.4049/jimmunol.1800014. Epub 2018 Jul 16.

PMID:
30012848
4.

Microbiota-Dependent Involvement of Th17 Cells in Murine Models of Inflammatory Arthritis.

Evans-Marin H, Rogier R, Koralov SB, Manasson J, Roeleveld D, van der Kraan PM, Scher JU, Koenders MI, Abdollahi-Roodsaz S.

Arthritis Rheumatol. 2018 Dec;70(12):1971-1983. doi: 10.1002/art.40657.

PMID:
29975009
5.

SATB1 in Malignant T Cells.

Fredholm S, Willerslev-Olsen A, Met Ö, Kubat L, Gluud M, Mathiasen SL, Friese C, Blümel E, Petersen DL, Hu T, Nastasi C, Lindahl LM, Buus TB, Krejsgaard T, Wasik MA, Kopp KL, Koralov SB, Persson JL, Bonefeld CM, Geisler C, Woetmann A, Iversen L, Becker JC, Ødum N.

J Invest Dermatol. 2018 Aug;138(8):1805-1815. doi: 10.1016/j.jid.2018.03.1526. Epub 2018 May 8.

PMID:
29751003
6.

Augmented Th17 Differentiation Leads to Cutaneous and Synovio-Entheseal Inflammation in a Novel Model of Psoriatic Arthritis.

Yang L, Fanok MH, Mediero-Munoz A, Fogli LK, Corciulo C, Abdollahi S, Cronstein BN, Scher JU, Koralov SB.

Arthritis Rheumatol. 2018 Jun;70(6):855-867. doi: 10.1002/art.40447. Epub 2018 Apr 18.

PMID:
29439292
7.

The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids.

Cao W, Kayama H, Chen ML, Delmas A, Sun A, Kim SY, Rangarajan ES, McKevitt K, Beck AP, Jackson CB, Crynen G, Oikonomopoulos A, Lacey PN, Martinez GJ, Izard T, Lorenz RG, Rodriguez-Palacios A, Cominelli F, Abreu MT, Hommes DW, Koralov SB, Takeda K, Sundrud MS.

Immunity. 2017 Dec 19;47(6):1182-1196.e10. doi: 10.1016/j.immuni.2017.11.012.

8.

Role of Dysregulated Cytokine Signaling and Bacterial Triggers in the Pathogenesis of Cutaneous T-Cell Lymphoma.

Fanok MH, Sun A, Fogli LK, Narendran V, Eckstein M, Kannan K, Dolgalev I, Lazaris C, Heguy A, Laird ME, Sundrud MS, Liu C, Kutok J, Lacruz RS, Latkowski JA, Aifantis I, Ødum N, Hymes KB, Goel S, Koralov SB.

J Invest Dermatol. 2018 May;138(5):1116-1125. doi: 10.1016/j.jid.2017.10.028. Epub 2017 Nov 8.

PMID:
29128259
9.

miRNAs in B Cell Development and Lymphomagenesis.

Coffre M, Koralov SB.

Trends Mol Med. 2017 Aug;23(8):721-736. doi: 10.1016/j.molmed.2017.06.001. Epub 2017 Jul 7. Review.

10.

miRNAs Are Essential for the Regulation of the PI3K/AKT/FOXO Pathway and Receptor Editing during B Cell Maturation.

Coffre M, Benhamou D, Rieß D, Blumenberg L, Snetkova V, Hines MJ, Chakraborty T, Bajwa S, Jensen K, Chong MMW, Getu L, Silverman GJ, Blelloch R, Littman DR, Calado D, Melamed D, Skok JA, Rajewsky K, Koralov SB.

Cell Rep. 2016 Nov 22;17(9):2271-2285. doi: 10.1016/j.celrep.2016.11.006.

11.

Enrichment of the lung microbiome with oral taxa is associated with lung inflammation of a Th17 phenotype.

Segal LN, Clemente JC, Tsay JC, Koralov SB, Keller BC, Wu BG, Li Y, Shen N, Ghedin E, Morris A, Diaz P, Huang L, Wikoff WR, Ubeda C, Artacho A, Rom WN, Sterman DH, Collman RG, Blaser MJ, Weiden MD.

Nat Microbiol. 2016 Apr 4;1:16031. doi: 10.1038/nmicrobiol.2016.31.

12.

STAT5 induces miR-21 expression in cutaneous T cell lymphoma.

Lindahl LM, Fredholm S, Joseph C, Nielsen BS, Jønson L, Willerslev-Olsen A, Gluud M, Blümel E, Petersen DL, Sibbesen N, Hu T, Nastasi C, Krejsgaard T, Jæhger D, Persson JL, Mongan N, Wasik MA, Litvinov IV, Sasseville D, Koralov SB, Bonefeld CM, Geisler C, Woetmann A, Ralfkiaer E, Iversen L, Odum N.

Oncotarget. 2016 Jul 19;7(29):45730-45744. doi: 10.18632/oncotarget.10160.

13.

Tissue-specific DNA demethylation is required for proper B-cell differentiation and function.

Orlanski S, Labi V, Reizel Y, Spiro A, Lichtenstein M, Levin-Klein R, Koralov SB, Skversky Y, Rajewsky K, Cedar H, Bergman Y.

Proc Natl Acad Sci U S A. 2016 May 3;113(18):5018-23. doi: 10.1073/pnas.1604365113. Epub 2016 Apr 18.

14.

The Expression of IL-21 Is Promoted by MEKK4 in Malignant T Cells and Associated with Increased Progression Risk in Cutaneous T-Cell Lymphoma.

Fredholm S, Litvinov IV, Mongan NP, Schiele S, Willerslev-Olsen A, Petersen DL, Krejsgaard T, Sibbesen N, Nastasi C, Bonefeld CM, Persson JL, Straten PT, Andersen MH, Koralov SB, Wasik MM, Geisler C, Sasseville D, Woetmann A, Ødum N.

J Invest Dermatol. 2016 Apr;136(4):866-869. doi: 10.1016/j.jid.2015.12.033. Epub 2016 Jan 21. No abstract available.

15.

Staphylococcal enterotoxin A (SEA) stimulates STAT3 activation and IL-17 expression in cutaneous T-cell lymphoma.

Willerslev-Olsen A, Krejsgaard T, Lindahl LM, Litvinov IV, Fredholm S, Petersen DL, Nastasi C, Gniadecki R, Mongan NP, Sasseville D, Wasik MA, Bonefeld CM, Geisler C, Woetmann A, Iversen L, Kilian M, Koralov SB, Odum N.

Blood. 2016 Mar 10;127(10):1287-96. doi: 10.1182/blood-2015-08-662353. Epub 2016 Jan 5.

16.

IL35-Producing B Cells Promote the Development of Pancreatic Neoplasia.

Pylayeva-Gupta Y, Das S, Handler JS, Hajdu CH, Coffre M, Koralov SB, Bar-Sagi D.

Cancer Discov. 2016 Mar;6(3):247-55. doi: 10.1158/2159-8290.CD-15-0843. Epub 2015 Dec 29.

17.

Ras Signaling Is a Key Determinant for Metastatic Dissemination and Poor Survival of Luminal Breast Cancer Patients.

Wright KL, Adams JR, Liu JC, Loch AJ, Wong RG, Jo CE, Beck LA, Santhanam DR, Weiss L, Mei X, Lane TF, Koralov SB, Done SJ, Woodgett JR, Zacksenhaus E, Hu P, Egan SE.

Cancer Res. 2015 Nov 15;75(22):4960-72. doi: 10.1158/0008-5472.CAN-14-2992. Epub 2015 Sep 23.

18.

Simultaneous deletion of the methylcytosine oxidases Tet1 and Tet3 increases transcriptome variability in early embryogenesis.

Kang J, Lienhard M, Pastor WA, Chawla A, Novotny M, Tsagaratou A, Lasken RS, Thompson EC, Surani MA, Koralov SB, Kalantry S, Chavez L, Rao A.

Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):E4236-45. doi: 10.1073/pnas.1510510112. Epub 2015 Jul 21.

19.

An oncogenic role for alternative NF-κB signaling in DLBCL revealed upon deregulated BCL6 expression.

Zhang B, Calado DP, Wang Z, Fröhler S, Köchert K, Qian Y, Koralov SB, Schmidt-Supprian M, Sasaki Y, Unitt C, Rodig S, Chen W, Dalla-Favera R, Alt FW, Pasqualucci L, Rajewsky K.

Cell Rep. 2015 May 5;11(5):715-26. doi: 10.1016/j.celrep.2015.03.059. Epub 2015 Apr 23.

20.

VH replacement in primary immunoglobulin repertoire diversification.

Sun A, Novobrantseva TI, Coffre M, Hewitt SL, Jensen K, Skok JA, Rajewsky K, Koralov SB.

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):E458-66. doi: 10.1073/pnas.1418001112. Epub 2015 Jan 21.

21.

Limited miR-17-92 overexpression drives hematologic malignancies.

Danielson LS, Reavie L, Coussens M, Davalos V, Castillo-Martin M, Guijarro MV, Coffre M, Cordon-Cardo C, Aifantis I, Ibrahim S, Liu C, Koralov SB, Hernando E.

Leuk Res. 2015 Mar;39(3):335-41. doi: 10.1016/j.leukres.2014.12.002. Epub 2014 Dec 10.

22.

TET proteins and 5-methylcytosine oxidation in hematological cancers.

Ko M, An J, Pastor WA, Koralov SB, Rajewsky K, Rao A.

Immunol Rev. 2015 Jan;263(1):6-21. doi: 10.1111/imr.12239. Review.

23.

STAT3 activation in Th17 and Th22 cells controls IL-22-mediated epithelial host defense during infectious colitis.

Backert I, Koralov SB, Wirtz S, Kitowski V, Billmeier U, Martini E, Hofmann K, Hildner K, Wittkopf N, Brecht K, Waldner M, Rajewsky K, Neurath MF, Becker C, Neufert C.

J Immunol. 2014 Oct 1;193(7):3779-91. doi: 10.4049/jimmunol.1303076. Epub 2014 Sep 3.

24.

Staphylococcal enterotoxins stimulate lymphoma-associated immune dysregulation.

Krejsgaard T, Willerslev-Olsen A, Lindahl LM, Bonefeld CM, Koralov SB, Geisler C, Wasik MA, Gniadecki R, Kilian M, Iversen L, Woetmann A, Odum N.

Blood. 2014 Jul 31;124(5):761-70. doi: 10.1182/blood-2014-01-551184. Epub 2014 Jun 23.

25.

Antibody repertoire deep sequencing reveals antigen-independent selection in maturing B cells.

Kaplinsky J, Li A, Sun A, Coffre M, Koralov SB, Arnaout R.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):E2622-9. doi: 10.1073/pnas.1403278111. Epub 2014 Jun 9.

26.

Halofuginone-induced amino acid starvation regulates Stat3-dependent Th17 effector function and reduces established autoimmune inflammation.

Carlson TJ, Pellerin A, Djuretic IM, Trivigno C, Koralov SB, Rao A, Sundrud MS.

J Immunol. 2014 Mar 1;192(5):2167-76. doi: 10.4049/jimmunol.1302316. Epub 2014 Jan 31.

27.

Negative selection, not receptor editing, is a physiological response of autoreactive thymocytes.

Kreslavsky T, Kim HJ, Koralov SB, Ghitza D, Buch T, Cantor H, Rajewsky K, von Boehmer H.

J Exp Med. 2013 Sep 23;210(10):1911-8. doi: 10.1084/jem.20130876. Epub 2013 Aug 26.

28.

T cell-derived IL-17 mediates epithelial changes in the airway and drives pulmonary neutrophilia.

Fogli LK, Sundrud MS, Goel S, Bajwa S, Jensen K, Derudder E, Sun A, Coffre M, Uyttenhove C, Van Snick J, Schmidt-Supprian M, Rao A, Grunig G, Durbin J, Casola S, Rajewsky K, Koralov SB.

J Immunol. 2013 Sep 15;191(6):3100-11. doi: 10.4049/jimmunol.1301360. Epub 2013 Aug 21. Erratum in: J Immunol. 2013 Nov 15;191(10):5318. Casola, Stefano S [corrected to Casola, Stefano].

29.

Bacterial toxins fuel disease progression in cutaneous T-cell lymphoma.

Willerslev-Olsen A, Krejsgaard T, Lindahl LM, Bonefeld CM, Wasik MA, Koralov SB, Geisler C, Kilian M, Iversen L, Woetmann A, Odum N.

Toxins (Basel). 2013 Aug 14;5(8):1402-21. doi: 10.3390/toxins5081402. Review.

30.

Elucidating the role of interleukin-17F in cutaneous T-cell lymphoma.

Krejsgaard T, Litvinov IV, Wang Y, Xia L, Willerslev-Olsen A, Koralov SB, Kopp KL, Bonefeld CM, Wasik MA, Geisler C, Woetmann A, Zhou Y, Sasseville D, Odum N.

Blood. 2013 Aug 8;122(6):943-50. doi: 10.1182/blood-2013-01-480889. Epub 2013 Jun 25.

31.

Tyk2 and Stat3 regulate brown adipose tissue differentiation and obesity.

Derecka M, Gornicka A, Koralov SB, Szczepanek K, Morgan M, Raje V, Sisler J, Zhang Q, Otero D, Cichy J, Rajewsky K, Shimoda K, Poli V, Strobl B, Pellegrini S, Harris TE, Seale P, Russell AP, McAinch AJ, O'Brien PE, Keller SR, Croniger CM, Kordula T, Larner AC.

Cell Metab. 2012 Dec 5;16(6):814-24. doi: 10.1016/j.cmet.2012.11.005.

32.

Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice.

Ko M, Bandukwala HS, An J, Lamperti ED, Thompson EC, Hastie R, Tsangaratou A, Rajewsky K, Koralov SB, Rao A.

Proc Natl Acad Sci U S A. 2011 Aug 30;108(35):14566-71. doi: 10.1073/pnas.1112317108. Epub 2011 Aug 22.

33.

High-resolution description of antibody heavy-chain repertoires in humans.

Arnaout R, Lee W, Cahill P, Honan T, Sparrow T, Weiand M, Nusbaum C, Rajewsky K, Koralov SB.

PLoS One. 2011;6(8):e22365. doi: 10.1371/journal.pone.0022365. Epub 2011 Aug 4.

34.

Hyperactivation of nuclear factor of activated T cells 1 (NFAT1) in T cells attenuates severity of murine autoimmune encephalomyelitis.

Ghosh S, Koralov SB, Stevanovic I, Sundrud MS, Sasaki Y, Rajewsky K, Rao A, Müller MR.

Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15169-74. doi: 10.1073/pnas.1009193107. Epub 2010 Aug 9.

35.

Enhanced Stat3 activation in POMC neurons provokes negative feedback inhibition of leptin and insulin signaling in obesity.

Ernst MB, Wunderlich CM, Hess S, Paehler M, Mesaros A, Koralov SB, Kleinridders A, Husch A, Münzberg H, Hampel B, Alber J, Kloppenburg P, Brüning JC, Wunderlich FT.

J Neurosci. 2009 Sep 16;29(37):11582-93. doi: 10.1523/JNEUROSCI.5712-08.2009.

36.

Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response.

Sundrud MS, Koralov SB, Feuerer M, Calado DP, Kozhaya AE, Rhule-Smith A, Lefebvre RE, Unutmaz D, Mazitschek R, Waldner H, Whitman M, Keller T, Rao A.

Science. 2009 Jun 5;324(5932):1334-8. doi: 10.1126/science.1172638.

37.

Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage.

Koralov SB, Muljo SA, Galler GR, Krek A, Chakraborty T, Kanellopoulou C, Jensen K, Cobb BS, Merkenschlager M, Rajewsky N, Rajewsky K.

Cell. 2008 Mar 7;132(5):860-74. doi: 10.1016/j.cell.2008.02.020.

38.

Activation of Stat3 signaling in AgRP neurons promotes locomotor activity.

Mesaros A, Koralov SB, Rother E, Wunderlich FT, Ernst MB, Barsh GS, Rajewsky K, Brüning JC.

Cell Metab. 2008 Mar;7(3):236-48. doi: 10.1016/j.cmet.2008.01.007.

39.
40.

Antibody repertoires generated by VH replacement and direct VH to JH joining.

Koralov SB, Novobrantseva TI, Königsmann J, Ehlich A, Rajewsky K.

Immunity. 2006 Jul;25(1):43-53.

41.

Tracking germinal center B cells expressing germ-line immunoglobulin gamma1 transcripts by conditional gene targeting.

Casola S, Cattoretti G, Uyttersprot N, Koralov SB, Seagal J, Hao Z, Waisman A, Egert A, Ghitza D, Rajewsky K.

Proc Natl Acad Sci U S A. 2006 May 9;103(19):7396-401. Epub 2006 May 1. Erratum in: Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):2025. Segal, Jane [corrected to Seagal, Jane].

42.

Direct in vivo VH to JH rearrangement violating the 12/23 rule.

Koralov SB, Novobrantseva TI, Hochedlinger K, Jaenisch R, Rajewsky K.

J Exp Med. 2005 Feb 7;201(3):341-8.

43.
44.

Regulation of humoral immune responses by CD21/CD35.

Chen Z, Koralov SB, Kelsoe G.

Immunol Rev. 2000 Aug;176:194-204. Review.

PMID:
11043778
45.

Humoral immune responses in Cr2-/- mice: enhanced affinity maturation but impaired antibody persistence.

Chen Z, Koralov SB, Gendelman M, Carroll MC, Kelsoe G.

J Immunol. 2000 May 1;164(9):4522-32.

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