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Items: 1 to 50 of 401

1.

Lavender Products Associated With Premature Thelarche and Prepubertal Gynecomastia: Case Reports and Endocrine-Disrupting Chemical Activities.

Ramsey JT, Li Y, Arao Y, Naidu A, Coons LA, Diaz A, Korach KS.

J Clin Endocrinol Metab. 2019 Nov 1;104(11):5393-5405. doi: 10.1210/jc.2018-01880.

PMID:
31393563
2.

Characterization of Estrogenic and Androgenic Activities for Bisphenol A-like Chemicals (BPs): In Vitro Estrogen and Androgen Receptors Transcriptional Activation, Gene Regulation, and Binding Profiles.

Pelch KE, Li Y, Perera L, Thayer KA, Korach KS.

Toxicol Sci. 2019 Aug 6. pii: kfz173. doi: 10.1093/toxsci/kfz173. [Epub ahead of print]

PMID:
31388671
3.

27-Hydroxycholesterol Promotes Adiposity and Mimics Adipogenic Diet-Induced Inflammatory Signaling.

Asghari A, Ishikawa T, Hiramitsu S, Lee WR, Umetani J, Bui L, Korach KS, Umetani M.

Endocrinology. 2019 Oct 1;160(10):2485-2494. doi: 10.1210/en.2019-00349.

PMID:
31386147
5.

Proposed Key Characteristics of Female Reproductive Toxicants as an Approach for Organizing and Evaluating Mechanistic Data in Hazard Assessment.

Luderer U, Eskenazi B, Hauser R, Korach KS, McHale CM, Moran F, Rieswijk L, Solomon G, Udagawa O, Zhang L, Zlatnik M, Zeise L, Smith MT.

Environ Health Perspect. 2019 Jul;127(7):75001. doi: 10.1289/EHP4971. Epub 2019 Jul 19.

6.

microRNA let-7 Downregulates Ligand Independent Estrogen Receptor Mediated Male Predominant Pulmonary Fibrosis.

Elliot S, Periera-Simon S, Xia X, Catanuto P, Rubio G, Shahzeidi S, El Salem F, Shapiro J, Briegel K, Korach KS, Glassberg MK.

Am J Respir Crit Care Med. 2019 Jul 10. doi: 10.1164/rccm.201903-0508OC. [Epub ahead of print]

PMID:
31291549
7.

Decoding the Inversion Symmetry Underlying Transcription Factor DNA-Binding Specificity and Functionality in the Genome.

Coons LA, Burkholder AB, Hewitt SC, McDonnell DP, Korach KS.

iScience. 2019 May 31;15:552-591. doi: 10.1016/j.isci.2019.04.006. Epub 2019 Apr 6.

8.

A distal super enhancer mediates estrogen-dependent mouse uterine-specific gene transcription of Igf1 (insulin-like growth factor 1).

Hewitt SC, Lierz SL, Garcia M, Hamilton KJ, Gruzdev A, Grimm SA, Lydon JP, Demayo FJ, Korach KS.

J Biol Chem. 2019 Jun 21;294(25):9746-9759. doi: 10.1074/jbc.RA119.008759. Epub 2019 May 9.

PMID:
31073032
9.

The Role of Dietary Phytoestrogens and the Nuclear Receptor PPARγ in Adipogenesis: An in Vitro Study.

Hall JM, Powell HA, Rajic L, Korach KS.

Environ Health Perspect. 2019 Mar;127(3):37007. doi: 10.1289/EHP3444.

10.

Dysregulation of hypothalamic-pituitary estrogen receptor α-mediated signaling causes episodic LH secretion and cystic ovary.

Arao Y, Hamilton KJ, Wu SP, Tsai MJ, DeMayo FJ, Korach KS.

FASEB J. 2019 Jun;33(6):7375-7386. doi: 10.1096/fj.201802653RR. Epub 2019 Mar 13.

PMID:
30866655
11.

Activation of hepatic estrogen receptor-α increases energy expenditure by stimulating the production of fibroblast growth factor 21 in female mice.

Allard C, Bonnet F, Xu B, Coons L, Albarado D, Hill C, Fagherazzi G, Korach KS, Levin ER, Lefante J, Morrison C, Mauvais-Jarvis F.

Mol Metab. 2019 Apr;22:62-70. doi: 10.1016/j.molmet.2019.02.002. Epub 2019 Feb 14.

12.
13.

Negative elongation factor is essential for endometrial function.

Hewitt SC, Li R, Adams N, Winuthayanon W, Hamilton KJ, Donoghue LJ, Lierz SL, Garcia M, Lydon JP, DeMayo FJ, Adelman K, Korach KS.

FASEB J. 2019 Feb;33(2):3010-3023. doi: 10.1096/fj.201801752. Epub 2018 Oct 17.

PMID:
30332301
14.

N-terminal transactivation function, AF-1, of estrogen receptor alpha controls obesity through enhancement of energy expenditure.

Arao Y, Hamilton KJ, Lierz SL, Korach KS.

Mol Metab. 2018 Dec;18:68-78. doi: 10.1016/j.molmet.2018.09.006. Epub 2018 Sep 20.

15.

Estrogens Promote Misfolded Proinsulin Degradation to Protect Insulin Production and Delay Diabetes.

Xu B, Allard C, Alvarez-Mercado AI, Fuselier T, Kim JH, Coons LA, Hewitt SC, Urano F, Korach KS, Levin ER, Arvan P, Floyd ZE, Mauvais-Jarvis F.

Cell Rep. 2018 Jul 3;24(1):181-196. doi: 10.1016/j.celrep.2018.06.019.

16.

Estrogen Receptors: New Directions in the New Millennium.

Hewitt SC, Korach KS.

Endocr Rev. 2018 Oct 1;39(5):664-675. doi: 10.1210/er.2018-00087. Review.

17.

DNA methylation and transcriptome aberrations mediated by ERα in mouse seminal vesicles following developmental DES exposure.

Li Y, Hamilton KJ, Wang T, Coons LA, Jefferson WN, Li R, Wang Y, Grimm SA, Ramsey JT, Liu L, Gerrish KE, Williams CJ, Wade PA, Korach KS.

Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4189-E4198. doi: 10.1073/pnas.1719010115. Epub 2018 Apr 16.

18.

The F domain of estrogen receptor α is involved in species-specific, tamoxifen-mediated transactivation.

Arao Y, Korach KS.

J Biol Chem. 2018 Jun 1;293(22):8495-8507. doi: 10.1074/jbc.RA117.001212. Epub 2018 Apr 9.

19.

Differential in Vitro Biological Action, Coregulator Interactions, and Molecular Dynamic Analysis of Bisphenol A (BPA), BPAF, and BPS Ligand-ERα Complexes.

Li Y, Perera L, Coons LA, Burns KA, Tyler Ramsey J, Pelch KE, Houtman R, van Beuningen R, Teng CT, Korach KS.

Environ Health Perspect. 2018 Jan 31;126(1):017012. doi: 10.1289/EHP2505.

20.

Estrogen receptor α protects pancreatic β-cells from apoptosis by preserving mitochondrial function and suppressing endoplasmic reticulum stress.

Zhou Z, Ribas V, Rajbhandari P, Drew BG, Moore TM, Fluitt AH, Reddish BR, Whitney KA, Georgia S, Vergnes L, Reue K, Liesa M, Shirihai O, van der Bliek AM, Chi NW, Mahata SK, Tiano JP, Hewitt SC, Tontonoz P, Korach KS, Mauvais-Jarvis F, Hevener AL.

J Biol Chem. 2018 Mar 30;293(13):4735-4751. doi: 10.1074/jbc.M117.805069. Epub 2018 Jan 29.

21.

Estrogen receptor beta maintains expression of KLF15 to prevent cardiac myocyte hypertrophy in female rodents.

Hoa N, Ge L, Korach KS, Levin ER.

Mol Cell Endocrinol. 2018 Jul 15;470:240-250. doi: 10.1016/j.mce.2017.11.004. Epub 2017 Nov 7.

22.

Experimental models for evaluating non-genomic estrogen signaling.

Stefkovich ML, Arao Y, Hamilton KJ, Korach KS.

Steroids. 2018 May;133:34-37. doi: 10.1016/j.steroids.2017.11.001. Epub 2017 Nov 6. Review.

23.

DNA Sequence Constraints Define Functionally Active Steroid Nuclear Receptor Binding Sites in Chromatin.

Coons LA, Hewitt SC, Burkholder AB, McDonnell DP, Korach KS.

Endocrinology. 2017 Oct 1;158(10):3212-3234. doi: 10.1210/en.2017-00468.

24.

Combined low-dose zearalenone and aflatoxin B1 on cell growth and cell-cycle progression in breast cancer MCF-7 cells.

Yip KY, Wan MLY, Wong AST, Korach KS, El-Nezami H.

Toxicol Lett. 2017 Nov 5;281:139-151. doi: 10.1016/j.toxlet.2017.09.022. Epub 2017 Sep 28.

25.

Early Endometriosis in Females Is Directed by Immune-Mediated Estrogen Receptor α and IL-6 Cross-Talk.

Burns KA, Thomas SY, Hamilton KJ, Young SL, Cook DN, Korach KS.

Endocrinology. 2018 Jan 1;159(1):103-118. doi: 10.1210/en.2017-00562.

26.

Juxtacrine Activity of Estrogen Receptor α in Uterine Stromal Cells is Necessary for Estrogen-Induced Epithelial Cell Proliferation.

Winuthayanon W, Lierz SL, Delarosa KC, Sampels SR, Donoghue LJ, Hewitt SC, Korach KS.

Sci Rep. 2017 Aug 21;7(1):8377. doi: 10.1038/s41598-017-07728-1.

27.

Role of ERα in Mediating Female Uterine Transcriptional Responses to IGF1.

Hewitt SC, Winuthayanon W, Lierz SL, Hamilton KJ, Donoghue LJ, Ramsey JT, Grimm SA, Arao Y, Korach KS.

Endocrinology. 2017 Aug 1;158(8):2427-2435. doi: 10.1210/en.2017-00349.

28.

Estrogen Hormone Biology.

Hamilton KJ, Hewitt SC, Arao Y, Korach KS.

Curr Top Dev Biol. 2017;125:109-146. doi: 10.1016/bs.ctdb.2016.12.005. Epub 2017 Feb 3. Review.

29.

Sex-specific, reciprocal regulation of ERα and miR-22 controls muscle lipid metabolism in male mice.

Schweisgut J, Schutt C, Wüst S, Wietelmann A, Ghesquière B, Carmeliet P, Dröse S, Korach KS, Braun T, Boettger T.

EMBO J. 2017 May 2;36(9):1199-1214. doi: 10.15252/embj.201695988. Epub 2017 Mar 17.

30.

Hormone signaling and fatty liver in females: analysis of estrogen receptor α mutant mice.

Hart-Unger S, Arao Y, Hamilton KJ, Lierz SL, Malarkey DE, Hewitt SC, Freemark M, Korach KS.

Int J Obes (Lond). 2017 Jun;41(6):945-954. doi: 10.1038/ijo.2017.50. Epub 2017 Feb 21.

31.

SCA-1 Labels a Subset of Estrogen-Responsive Bipotential Repopulating Cells within the CD24+ CD49fhi Mammary Stem Cell-Enriched Compartment.

Dall GV, Vieusseux JL, Korach KS, Arao Y, Hewitt SC, Hamilton KJ, Dzierzak E, Boon WC, Simpson ER, Ramsay RG, Stein T, Morris JS, Anderson RL, Risbridger GP, Britt KL.

Stem Cell Reports. 2017 Feb 14;8(2):417-431. doi: 10.1016/j.stemcr.2016.12.022. Epub 2017 Jan 26.

32.

Estrogen receptor α is required for oviductal transport of embryos.

Li S, O'Neill SR, Zhang Y, Holtzman MJ, Takemaru KI, Korach KS, Winuthayanon W.

FASEB J. 2017 Apr;31(4):1595-1607. doi: 10.1096/fj.201601128R. Epub 2017 Jan 12.

33.

Familial Multiplicity of Estrogen Insensitivity Associated With a Loss-of-Function ESR1 Mutation.

Bernard V, Kherra S, Francou B, Fagart J, Viengchareun S, Guéchot J, Ladjouze A, Guiochon-Mantel A, Korach KS, Binart N, Lombès M, Christin-Maitre S.

J Clin Endocrinol Metab. 2017 Jan 1;102(1):93-99. doi: 10.1210/jc.2016-2749.

34.

Differential Activation of a Mouse Estrogen Receptor β Isoform (mERβ2) with Endocrine-Disrupting Chemicals (EDCs).

Donoghue LJ, Neufeld TI, Li Y, Arao Y, Coons LA, Korach KS.

Environ Health Perspect. 2017 Apr;125(4):634-642. doi: 10.1289/EHP396. Epub 2016 Sep 16.

35.

Design of pathway preferential estrogens that provide beneficial metabolic and vascular effects without stimulating reproductive tissues.

Madak-Erdogan Z, Kim SH, Gong P, Zhao YC, Zhang H, Chambliss KL, Carlson KE, Mayne CG, Shaul PW, Korach KS, Katzenellenbogen JA, Katzenellenbogen BS.

Sci Signal. 2016 May 24;9(429):ra53. doi: 10.1126/scisignal.aad8170.

36.

Skeletal muscle action of estrogen receptor α is critical for the maintenance of mitochondrial function and metabolic homeostasis in females.

Ribas V, Drew BG, Zhou Z, Phun J, Kalajian NY, Soleymani T, Daraei P, Widjaja K, Wanagat J, de Aguiar Vallim TQ, Fluitt AH, Bensinger S, Le T, Radu C, Whitelegge JP, Beaven SW, Tontonoz P, Lusis AJ, Parks BW, Vergnes L, Reue K, Singh H, Bopassa JC, Toro L, Stefani E, Watt MJ, Schenk S, Akerstrom T, Kelly M, Pedersen BK, Hewitt SC, Korach KS, Hevener AL.

Sci Transl Med. 2016 Apr 13;8(334):334ra54. doi: 10.1126/scitranslmed.aad3815.

37.

Distinct functions and regulation of epithelial progesterone receptor in the mouse cervix, vagina, and uterus.

Mehta FF, Son J, Hewitt SC, Jang E, Lydon JP, Korach KS, Chung SH.

Oncotarget. 2016 Apr 5;7(14):17455-67. doi: 10.18632/oncotarget.8159.

38.

Correction: Expression of Human NSAID Activated Gene 1 in Mice Leads to Altered Mammary Gland Differentiation and Impaired Lactation.

Binder AK, Kosak JP, Janardhan KS, Moser G, Eling TE, Korach KS.

PLoS One. 2016 Mar 10;11(3):e0151504. doi: 10.1371/journal.pone.0151504. eCollection 2016. No abstract available.

39.

What's new in estrogen receptor action in the female reproductive tract.

Hewitt SC, Winuthayanon W, Korach KS.

J Mol Endocrinol. 2016 Feb;56(2):R55-71. doi: 10.1530/JME-15-0254. Review.

40.

Expression of Human NSAID Activated Gene 1 in Mice Leads to Altered Mammary Gland Differentiation and Impaired Lactation.

Binder AK, Kosak JP, Janardhan KS, Moser G, Eling TE, Korach KS.

PLoS One. 2016 Jan 8;11(1):e0146518. doi: 10.1371/journal.pone.0146518. eCollection 2016. Erratum in: PLoS One. 2016;11(3):e0151504. Janhardhan, Kyathanahalli S [corrected to Janardhan, Kyathanahalli S].

41.

Oviductal estrogen receptor α signaling prevents protease-mediated embryo death.

Winuthayanon W, Bernhardt ML, Padilla-Banks E, Myers PH, Edin ML, Lih FB, Hewitt SC, Korach KS, Williams CJ.

Elife. 2015 Dec 1;4:e10453. doi: 10.7554/eLife.10453.

42.

Transactivation Function-2 of Estrogen Receptor α Contains Transactivation Function-1-regulating Element.

Arao Y, Coons LA, Zuercher WJ, Korach KS.

J Biol Chem. 2015 Jul 10;290(28):17611-27. doi: 10.1074/jbc.M115.638650. Epub 2015 May 31.

43.

Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis.

Zhao Y, Gong P, Chen Y, Nwachukwu JC, Srinivasan S, Ko C, Bagchi MK, Taylor RN, Korach KS, Nettles KW, Katzenellenbogen JA, Katzenellenbogen BS.

Sci Transl Med. 2015 Jan 21;7(271):271ra9. doi: 10.1126/scitranslmed.3010626. Erratum in: Sci Transl Med. 2015 Feb 11;7(274):274er1.

44.

Development of phenotypic and transcriptional biomarkers to evaluate relative activity of potentially estrogenic chemicals in ovariectomized mice.

Hewitt SC, Winuthayanon W, Pockette B, Kerns RT, Foley JF, Flagler N, Ney E, Suksamrarn A, Piyachaturawat P, Bushel PR, Korach KS.

Environ Health Perspect. 2015 Apr;123(4):344-52. doi: 10.1289/ehp.1307935. Epub 2015 Jan 9.

45.

Estrogen receptor (ER)α-regulated lipocalin 2 expression in adipose tissue links obesity with breast cancer progression.

Drew BG, Hamidi H, Zhou Z, Villanueva CJ, Krum SA, Calkin AC, Parks BW, Ribas V, Kalajian NY, Phun J, Daraei P, Christofk HR, Hewitt SC, Korach KS, Tontonoz P, Lusis AJ, Slamon DJ, Hurvitz SA, Hevener AL.

J Biol Chem. 2015 Feb 27;290(9):5566-81. doi: 10.1074/jbc.M114.606459. Epub 2014 Dec 2.

46.

Research Resource: STR DNA profile and gene expression comparisons of human BG-1 cells and a BG-1/MCF-7 clonal variant.

Li Y, Arao Y, Hall JM, Burkett S, Liu L, Gerrish K, Cavailles V, Korach KS.

Mol Endocrinol. 2014 Dec;28(12):2072-81. doi: 10.1210/me.2014-1229.

47.

The role of genetics in estrogen responses: a critical piece of an intricate puzzle.

Wall EH, Hewitt SC, Case LK, Lin CY, Korach KS, Teuscher C.

FASEB J. 2014 Dec;28(12):5042-54. doi: 10.1096/fj.14-260307. Epub 2014 Sep 11. Review.

48.

Uterine epithelial cell estrogen receptor alpha-dependent and -independent genomic profiles that underlie estrogen responses in mice.

Winuthayanon W, Hewitt SC, Korach KS.

Biol Reprod. 2014 Nov;91(5):110. doi: 10.1095/biolreprod.114.120170. Epub 2014 Sep 10.

49.

Endometrial CXCL13 expression is cycle regulated in humans and aberrantly expressed in humans and Rhesus macaques with endometriosis.

Franasiak JM, Burns KA, Slayden O, Yuan L, Fritz MA, Korach KS, Lessey BA, Young SL.

Reprod Sci. 2015 Apr;22(4):442-51. doi: 10.1177/1933719114542011. Epub 2014 Jul 16.

50.

An animal model with a cardiomyocyte-specific deletion of estrogen receptor alpha: functional, metabolic, and differential network analysis.

Devanathan S, Whitehead T, Schweitzer GG, Fettig N, Kovacs A, Korach KS, Finck BN, Shoghi KI.

PLoS One. 2014 Jul 7;9(7):e101900. doi: 10.1371/journal.pone.0101900. eCollection 2014.

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