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Items: 1 to 50 of 86

1.

Correction: Spindle checkpoint silencing at kinetochores with submaximal microtubule occupancy (doi:10.1242/jcs.231589).

Etemad B, Vertesy A, Kuijt TEF, Sacristan C, van Oudenaarden A, Kops GJPL.

J Cell Sci. 2019 Sep 12;132(17). pii: jcs237750. doi: 10.1242/jcs.237750. No abstract available.

PMID:
31515464
2.

Organoids from colorectal peritoneal metastases as a platform for improving hyperthermic intraperitoneal chemotherapy.

Ubink I, Bolhaqueiro ACF, Elias SG, Raats DAE, Constantinides A, Peters NA, Wassenaar ECE, de Hingh IHJT, Rovers KP, van Grevenstein WMU, Laclé MM, Kops GJPL, Borel Rinkes IHM, Kranenburg O.

Br J Surg. 2019 Sep;106(10):1404-1414. doi: 10.1002/bjs.11206. Epub 2019 Jun 14.

3.

Spindle checkpoint silencing at kinetochores with submaximal microtubule occupancy.

Etemad B, Vertesy A, Kuijt TEF, Sacristan C, van Oudenaarden A, Kops GJPL.

J Cell Sci. 2019 Jun 17;132(12). pii: jcs231589. doi: 10.1242/jcs.231589. Erratum in: J Cell Sci. 2019 Sep 12;132(17):.

PMID:
31138679
4.

Mosaic origin of the eukaryotic kinetochore.

Tromer EC, van Hooff JJE, Kops GJPL, Snel B.

Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):12873-12882. doi: 10.1073/pnas.1821945116. Epub 2019 May 24.

5.

Oral Mucosal Organoids as a Potential Platform for Personalized Cancer Therapy.

Driehuis E, Kolders S, Spelier S, Lõhmussaar K, Willems SM, Devriese LA, de Bree R, de Ruiter EJ, Korving J, Begthel H, van Es JH, Geurts V, He GW, van Jaarsveld RH, Oka R, Muraro MJ, Vivié J, Zandvliet MMJM, Hendrickx APA, Iakobachvili N, Sridevi P, Kranenburg O, van Boxtel R, Kops GJPL, Tuveson DA, Peters PJ, van Oudenaarden A, Clevers H.

Cancer Discov. 2019 Jul;9(7):852-871. doi: 10.1158/2159-8290.CD-18-1522. Epub 2019 May 3.

PMID:
31053628
6.

The molecular basis of monopolin recruitment to the kinetochore.

Plowman R, Singh N, Tromer EC, Payan A, Duro E, Spanos C, Rappsilber J, Snel B, Kops GJPL, Corbett KD, Marston AL.

Chromosoma. 2019 Sep;128(3):331-354. doi: 10.1007/s00412-019-00700-0. Epub 2019 Apr 30.

7.

Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids.

Bolhaqueiro ACF, Ponsioen B, Bakker B, Klaasen SJ, Kucukkose E, van Jaarsveld RH, Vivié J, Verlaan-Klink I, Hami N, Spierings DCJ, Sasaki N, Dutta D, Boj SF, Vries RGJ, Lansdorp PM, van de Wetering M, van Oudenaarden A, Clevers H, Kranenburg O, Foijer F, Snippert HJG, Kops GJPL.

Nat Genet. 2019 May;51(5):824-834. doi: 10.1038/s41588-019-0399-6. Epub 2019 Apr 29.

PMID:
31036964
8.

Inferring the Evolutionary History of Your Favorite Protein: A Guide for Molecular Biologists.

van Hooff JJE, Tromer E, van Dam TJP, Kops GJPL, Snel B.

Bioessays. 2019 May;41(5):e1900006. doi: 10.1002/bies.201900006.

PMID:
31026339
9.

Interactions between N-terminal Modules in MPS1 Enable Spindle Checkpoint Silencing.

Pachis ST, Hiruma Y, Tromer EC, Perrakis A, Kops GJPL.

Cell Rep. 2019 Feb 19;26(8):2101-2112.e6. doi: 10.1016/j.celrep.2019.01.017.

10.

Ectopic Activation of the Spindle Assembly Checkpoint Signaling Cascade Reveals Its Biochemical Design.

Chen C, Whitney IP, Banerjee A, Sacristan C, Sekhri P, Kern DM, Fontan A, Kops GJPL, Tyson JJ, Cheeseman IM, Joglekar AP.

Curr Biol. 2019 Jan 7;29(1):104-119.e10. doi: 10.1016/j.cub.2018.11.054. Epub 2018 Dec 27.

PMID:
30595520
11.

Leader of the SAC: molecular mechanisms of Mps1/TTK regulation in mitosis.

Pachis ST, Kops GJPL.

Open Biol. 2018 Aug;8(8). pii: 180109. doi: 10.1098/rsob.180109. Review.

12.

Live imaging of cell division in 3D stem-cell organoid cultures.

Bolhaqueiro ACF, van Jaarsveld RH, Ponsioen B, Overmeer RM, Snippert HJ, Kops GJPL.

Methods Cell Biol. 2018;145:91-106. doi: 10.1016/bs.mcb.2018.03.016. Epub 2018 Apr 22.

PMID:
29957217
13.

Dynamic kinetochore size regulation promotes microtubule capture and chromosome biorientation in mitosis.

Sacristan C, Ahmad MUD, Keller J, Fermie J, Groenewold V, Tromer E, Fish A, Melero R, Carazo JM, Klumperman J, Musacchio A, Perrakis A, Kops GJ.

Nat Cell Biol. 2018 Jul;20(7):800-810. doi: 10.1038/s41556-018-0130-3. Epub 2018 Jun 18.

14.

Germline mutations in the spindle assembly checkpoint genes BUB1 and BUB3 are infrequent in familial colorectal cancer and polyposis.

Mur P, De Voer RM, Olivera-Salguero R, Rodríguez-Perales S, Pons T, Setién F, Aiza G, Valdés-Mas R, Bertini A, Pineda M, Vreede L, Navarro M, Iglesias S, González S, Brunet J, Valencia A, Esteller M, Lázaro C, Kops GJPL, Urioste M, Puente XS, Capellá G, Valle L.

Mol Cancer. 2018 Feb 15;17(1):23. doi: 10.1186/s12943-018-0762-8.

15.

Difference Makers: Chromosomal Instability versus Aneuploidy in Cancer.

van Jaarsveld RH, Kops GJPL.

Trends Cancer. 2016 Oct;2(10):561-571. doi: 10.1016/j.trecan.2016.09.003. Epub 2016 Sep 24. Review.

PMID:
28741487
16.

Evolutionary dynamics of the kinetochore network in eukaryotes as revealed by comparative genomics.

van Hooff JJ, Tromer E, van Wijk LM, Snel B, Kops GJ.

EMBO Rep. 2017 Sep;18(9):1559-1571. doi: 10.15252/embr.201744102. Epub 2017 Jun 22.

17.

Kinetochore Malfunction in Human Pathologies.

de Wolf B, Kops GJPL.

Adv Exp Med Biol. 2017;1002:69-91. doi: 10.1007/978-3-319-57127-0_4. Review.

PMID:
28600783
18.

Biallelic TRIP13 mutations predispose to Wilms tumor and chromosome missegregation.

Yost S, de Wolf B, Hanks S, Zachariou A, Marcozzi C, Clarke M, de Voer R, Etemad B, Uijttewaal E, Ramsay E, Wylie H, Elliott A, Picton S, Smith A, Smithson S, Seal S, Ruark E, Houge G, Pines J, Kops GJPL, Rahman N.

Nat Genet. 2017 Jul;49(7):1148-1151. doi: 10.1038/ng.3883. Epub 2017 May 29.

19.
20.

Phylogenomics-guided discovery of a novel conserved cassette of short linear motifs in BubR1 essential for the spindle checkpoint.

Tromer E, Bade D, Snel B, Kops GJ.

Open Biol. 2016 Dec;6(12). pii: 160315. doi: 10.1098/rsob.160315.

21.

Crystal structure of a PP2A B56-BubR1 complex and its implications for PP2A substrate recruitment and localization.

Wang J, Wang Z, Yu T, Yang H, Virshup DM, Kops GJ, Lee SH, Zhou W, Li X, Xu W, Rao Z.

Protein Cell. 2016 Jul;7(7):516-26. doi: 10.1007/s13238-016-0283-4. Epub 2016 Jun 28.

22.

Studying Kinetochore Kinases.

Saurin AT, Kops GJ.

Methods Mol Biol. 2016;1413:333-47. doi: 10.1007/978-1-4939-3542-0_21.

PMID:
27193859
23.

Attachment issues: kinetochore transformations and spindle checkpoint silencing.

Etemad B, Kops GJ.

Curr Opin Cell Biol. 2016 Apr;39:101-8. doi: 10.1016/j.ceb.2016.02.016. Epub 2016 Mar 3. Review.

PMID:
26947988
24.

Kinetochore-microtubule attachment is sufficient to satisfy the human spindle assembly checkpoint.

Etemad B, Kuijt TE, Kops GJ.

Nat Commun. 2015 Dec 1;6:8987. doi: 10.1038/ncomms9987.

25.

APC16 is a conserved subunit of the anaphase-promoting complex/cyclosome.

Kops GJ, van der Voet M, Manak MS, van Osch MH, Naini SM, Brear A, McLeod IX, Hentschel DM, Yates JR 3rd, van den Heuvel S, Shah JV.

J Cell Sci. 2015 Nov 1;128(21):4025. doi: 10.1242/jcs.180935. No abstract available.

26.

Widespread Recurrent Patterns of Rapid Repeat Evolution in the Kinetochore Scaffold KNL1.

Tromer E, Snel B, Kops GJ.

Genome Biol Evol. 2015 Aug 8;7(8):2383-93. doi: 10.1093/gbe/evv140.

27.

Inhibition of the spindle assembly checkpoint kinase TTK enhances the efficacy of docetaxel in a triple-negative breast cancer model.

Maia AR, de Man J, Boon U, Janssen A, Song JY, Omerzu M, Sterrenburg JG, Prinsen MB, Willemsen-Seegers N, de Roos JA, van Doornmalen AM, Uitdehaag JC, Kops GJ, Jonkers J, Buijsman RC, Zaman GJ, Medema RH.

Ann Oncol. 2015 Oct;26(10):2180-92. doi: 10.1093/annonc/mdv293. Epub 2015 Jul 7.

PMID:
26153498
28.

Dissecting the roles of human BUB1 in the spindle assembly checkpoint.

Vleugel M, Hoek TA, Tromer E, Sliedrecht T, Groenewold V, Omerzu M, Kops GJ.

J Cell Sci. 2015 Aug 15;128(16):2975-82. doi: 10.1242/jcs.169821. Epub 2015 Jul 6.

29.

Plk1 and Mps1 Cooperatively Regulate the Spindle Assembly Checkpoint in Human Cells.

von Schubert C, Cubizolles F, Bracher JM, Sliedrecht T, Kops GJPL, Nigg EA.

Cell Rep. 2015 Jul 7;12(1):66-78. doi: 10.1016/j.celrep.2015.06.007. Epub 2015 Jun 25.

30.

CELL DIVISION CYCLE. Competition between MPS1 and microtubules at kinetochores regulates spindle checkpoint signaling.

Hiruma Y, Sacristan C, Pachis ST, Adamopoulos A, Kuijt T, Ubbink M, von Castelmur E, Perrakis A, Kops GJ.

Science. 2015 Jun 12;348(6240):1264-7. doi: 10.1126/science.aaa4055. Epub 2015 Jun 11.

31.

Sequential cancer mutations in cultured human intestinal stem cells.

Drost J, van Jaarsveld RH, Ponsioen B, Zimberlin C, van Boxtel R, Buijs A, Sachs N, Overmeer RM, Offerhaus GJ, Begthel H, Korving J, van de Wetering M, Schwank G, Logtenberg M, Cuppen E, Snippert HJ, Medema JP, Kops GJ, Clevers H.

Nature. 2015 May 7;521(7550):43-7. doi: 10.1038/nature14415. Epub 2015 Apr 29.

PMID:
25924068
32.

Sequential multisite phospho-regulation of KNL1-BUB3 interfaces at mitotic kinetochores.

Vleugel M, Omerzu M, Groenewold V, Hadders MA, Lens SMA, Kops GJPL.

Mol Cell. 2015 Mar 5;57(5):824-835. doi: 10.1016/j.molcel.2014.12.036. Epub 2015 Feb 5.

33.

A molecular basis for the differential roles of Bub1 and BubR1 in the spindle assembly checkpoint.

Overlack K, Primorac I, Vleugel M, Krenn V, Maffini S, Hoffmann I, Kops GJ, Musacchio A.

Elife. 2015 Jan 22;4:e05269. doi: 10.7554/eLife.05269.

34.

Negative feedback at kinetochores underlies a responsive spindle checkpoint signal.

Nijenhuis W, Vallardi G, Teixeira A, Kops GJ, Saurin AT.

Nat Cell Biol. 2014 Dec;16(12):1257-64. doi: 10.1038/ncb3065. Epub 2014 Nov 17.

35.

Collateral genome instability by DNA damage in mitosis.

Jelluma N, Kops GJ.

Cancer Discov. 2014 Nov;4(11):1256-8. doi: 10.1158/2159-8290.CD-14-1097.

36.

Joined at the hip: kinetochores, microtubules, and spindle assembly checkpoint signaling.

Sacristan C, Kops GJ.

Trends Cell Biol. 2015 Jan;25(1):21-8. doi: 10.1016/j.tcb.2014.08.006. Epub 2014 Sep 11. Review.

PMID:
25220181
37.

Towards elucidating the stability, dynamics and architecture of the nucleosome remodeling and deacetylase complex by using quantitative interaction proteomics.

Kloet SL, Baymaz HI, Makowski M, Groenewold V, Jansen PW, Berendsen M, Niazi H, Kops GJ, Vermeulen M.

FEBS J. 2015 May;282(9):1774-85. doi: 10.1111/febs.12972. Epub 2014 Sep 11. Review.

38.

Distinct phosphatases antagonize the p53 response in different phases of the cell cycle.

Shaltiel IA, Aprelia M, Saurin AT, Chowdhury D, Kops GJ, Voest EE, Medema RH.

Proc Natl Acad Sci U S A. 2014 May 20;111(20):7313-8. doi: 10.1073/pnas.1322021111. Epub 2014 Apr 7.

39.

Conditional targeting of MAD1 to kinetochores is sufficient to reactivate the spindle assembly checkpoint in metaphase.

Kuijt TE, Omerzu M, Saurin AT, Kops GJ.

Chromosoma. 2014 Oct;123(5):471-80. doi: 10.1007/s00412-014-0458-9. Epub 2014 Apr 4.

40.

Cell division: SACing the anaphase problem.

Kops GJ.

Curr Biol. 2014 Mar 17;24(6):R224-6. doi: 10.1016/j.cub.2014.02.020.

41.

Assessing kinetics from fixed cells reveals activation of the mitotic entry network at the S/G2 transition.

Akopyan K, Silva Cascales H, Hukasova E, Saurin AT, Müllers E, Jaiswal H, Hollman DA, Kops GJ, Medema RH, Lindqvist A.

Mol Cell. 2014 Mar 6;53(5):843-53. doi: 10.1016/j.molcel.2014.01.031. Epub 2014 Feb 27.

42.

Arrayed BUB recruitment modules in the kinetochore scaffold KNL1 promote accurate chromosome segregation.

Vleugel M, Tromer E, Omerzu M, Groenewold V, Nijenhuis W, Snel B, Kops GJ.

J Cell Biol. 2013 Dec 23;203(6):943-55.

43.

Centromere binding and a conserved role in chromosome stability for SUMO-dependent ubiquitin ligases.

van de Pasch LA, Miles AJ, Nijenhuis W, Brabers NA, van Leenen D, Lijnzaad P, Brown MK, Ouellet J, Barral Y, Kops GJ, Holstege FC.

PLoS One. 2013 Jun 13;8(6):e65628. doi: 10.1371/journal.pone.0065628. Print 2013.

44.

Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant.

Earnshaw WC, Allshire RC, Black BE, Bloom K, Brinkley BR, Brown W, Cheeseman IM, Choo KH, Copenhaver GP, Deluca JG, Desai A, Diekmann S, Erhardt S, Fitzgerald-Hayes M, Foltz D, Fukagawa T, Gassmann R, Gerlich DW, Glover DM, Gorbsky GJ, Harrison SC, Heun P, Hirota T, Jansen LE, Karpen G, Kops GJ, Lampson MA, Lens SM, Losada A, Luger K, Maiato H, Maddox PS, Margolis RL, Masumoto H, McAinsh AD, Mellone BG, Meraldi P, Musacchio A, Oegema K, O'Neill RJ, Salmon ED, Scott KC, Straight AF, Stukenberg PT, Sullivan BA, Sullivan KF, Sunkel CE, Swedlow JR, Walczak CE, Warburton PE, Westermann S, Willard HF, Wordeman L, Yanagida M, Yen TJ, Yoda K, Cleveland DW.

Chromosome Res. 2013 Apr;21(2):101-6. doi: 10.1007/s10577-013-9347-y. Epub 2013 Apr 12.

45.

A TPR domain-containing N-terminal module of MPS1 is required for its kinetochore localization by Aurora B.

Nijenhuis W, von Castelmur E, Littler D, De Marco V, Tromer E, Vleugel M, van Osch MH, Snel B, Perrakis A, Kops GJ.

J Cell Biol. 2013 Apr 15;201(2):217-31. doi: 10.1083/jcb.201210033. Epub 2013 Apr 8.

46.

Universal quantitative kinase assay based on diagonal SCX chromatography and stable isotope dimethyl labeling provides high-definition kinase consensus motifs for PKA and human Mps1.

Hennrich ML, Marino F, Groenewold V, Kops GJ, Mohammed S, Heck AJ.

J Proteome Res. 2013 May 3;12(5):2214-24. doi: 10.1021/pr400074f. Epub 2013 Apr 3.

PMID:
23510141
47.

Integration of kinase and phosphatase activities by BUBR1 ensures formation of stable kinetochore-microtubule attachments.

Suijkerbuijk SJ, Vleugel M, Teixeira A, Kops GJ.

Dev Cell. 2012 Oct 16;23(4):745-55. doi: 10.1016/j.devcel.2012.09.005.

48.

Evolution and function of the mitotic checkpoint.

Vleugel M, Hoogendoorn E, Snel B, Kops GJ.

Dev Cell. 2012 Aug 14;23(2):239-50. doi: 10.1016/j.devcel.2012.06.013. Review.

49.

Connecting up and clearing out: how kinetochore attachment silences the spindle assembly checkpoint.

Kops GJ, Shah JV.

Chromosoma. 2012 Oct;121(5):509-25. doi: 10.1007/s00412-012-0378-5. Epub 2012 Jul 11. Review.

PMID:
22782189
50.

Mps1 promotes rapid centromere accumulation of Aurora B.

van der Waal MS, Saurin AT, Vromans MJ, Vleugel M, Wurzenberger C, Gerlich DW, Medema RH, Kops GJ, Lens SM.

EMBO Rep. 2012 Sep;13(9):847-54. doi: 10.1038/embor.2012.93. Epub 2012 Jun 26.

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