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Mutation-Induced Functional Alterations of CCR6.

Julian B, Gao K, Harwood BN, Beinborn M, Kopin AS.

J Pharmacol Exp Ther. 2017 Jan;360(1):106-116. Epub 2016 Oct 27.


A critical role for the Drosophila dopamine D1-like receptor Dop1R2 at the onset of metamorphosis.

Regna K, Kurshan PT, Harwood BN, Jenkins AM, Lai CQ, Muskavitch MA, Kopin AS, Draper I.

BMC Dev Biol. 2016 May 16;16(1):15. doi: 10.1186/s12861-016-0115-z.


Novel Probes Establish Mas-Related G Protein-Coupled Receptor X1 Variants as Receptors with Loss or Gain of Function.

Heller D, Doyle JR, Raman VS, Beinborn M, Kumar K, Kopin AS.

J Pharmacol Exp Ther. 2016 Feb;356(2):276-83. doi: 10.1124/jpet.115.227058. Epub 2015 Nov 18.


Cell-tethered ligands modulate bone remodeling by osteoblasts and osteoclasts.

Hayden RS, Fortin JP, Harwood B, Subramanian B, Quinn KP, Georgakoudi I, Kopin AS, Kaplan DL.

Adv Funct Mater. 2014 Jan 29;24(4):472-479.


Development of an OP9 derived cell line as a robust model to rapidly study adipocyte differentiation.

Lane JM, Doyle JR, Fortin JP, Kopin AS, Ordovás JM.

PLoS One. 2014 Nov 19;9(11):e112123. doi: 10.1371/journal.pone.0112123. eCollection 2014.


A two-step strategy to enhance activity of low potency peptides.

Doyle JR, Harwood BN, Krishnaji ST, Krishnamurthy VM, Lin WE, Fortin JP, Kumar K, Kopin AS.

PLoS One. 2014 Nov 12;9(11):e110502. doi: 10.1371/journal.pone.0110502. eCollection 2014.


Targeted inactivation of the rickets receptor in muscle compromises Drosophila viability.

Harwood BN, Draper I, Kopin AS.

J Exp Biol. 2014 Nov 15;217(Pt 22):4091-8. doi: 10.1242/jeb.110098. Epub 2014 Oct 2.


Development of a membrane-anchored chemerin receptor agonist as a novel modulator of allergic airway inflammation and neuropathic pain.

Doyle JR, Krishnaji ST, Zhu G, Xu ZZ, Heller D, Ji RR, Levy BD, Kumar K, Kopin AS.

J Biol Chem. 2014 May 9;289(19):13385-96. doi: 10.1074/jbc.M113.522680. Epub 2014 Mar 21.


G-protein coupled receptor 56 promotes myoblast fusion through serum response factor- and nuclear factor of activated T-cell-mediated signalling but is not essential for muscle development in vivo.

Wu MP, Doyle JR, Barry B, Beauvais A, Rozkalne A, Piao X, Lawlor MW, Kopin AS, Walsh CA, Gussoni E.

FEBS J. 2013 Dec;280(23):6097-113. doi: 10.1111/febs.12529. Epub 2013 Oct 8.


Membrane tethered bursicon constructs as heterodimeric modulators of the Drosophila G protein-coupled receptor rickets.

Harwood BN, Fortin JP, Gao K, Chen C, Beinborn M, Kopin AS.

Mol Pharmacol. 2013 Apr;83(4):814-21. doi: 10.1124/mol.112.081570. Epub 2013 Jan 22.


Naturally occurring HCA1 missense mutations result in loss of function: potential impact on lipid deposition.

Doyle JR, Lane JM, Beinborn M, Kopin AS.

J Lipid Res. 2013 Mar;54(3):823-30. doi: 10.1194/jlr.M034660. Epub 2012 Dec 24.


Selected melanocortin 1 receptor single-nucleotide polymorphisms differentially alter multiple signaling pathways.

Doyle JR, Fortin JP, Beinborn M, Kopin AS.

J Pharmacol Exp Ther. 2012 Aug;342(2):318-26. doi: 10.1124/jpet.112.194548. Epub 2012 Apr 30.


Association of type 2 diabetes susceptibility loci with one-year weight loss in the look AHEAD clinical trial.

Peter I, McCaffery JM, Kelley-Hedgepeth A, Hakonarson H, Reis S, Wagenknecht LE, Kopin AS, Huggins GS; Genetics Subgroup of the Look AHEAD Study.

Obesity (Silver Spring). 2012 Aug;20(8):1675-82. doi: 10.1038/oby.2012.11. Epub 2012 Feb 6.


Discovery of dual-action membrane-anchored modulators of incretin receptors.

Fortin JP, Chinnapen D, Beinborn M, Lencer W, Kopin AS.

PLoS One. 2011;6(9):e24693. doi: 10.1371/journal.pone.0024693. Epub 2011 Sep 14.


Novel inactivating mutations in the GH secretagogue receptor gene in patients with constitutional delay of growth and puberty.

Pugliese-Pires PN, Fortin JP, Arthur T, Latronico AC, Mendonca BB, Villares SM, Arnhold IJ, Kopin AS, Jorge AA.

Eur J Endocrinol. 2011 Aug;165(2):233-41. doi: 10.1530/EJE-11-0168. Epub 2011 Jun 6.


Two naturally occurring mutations in the type 1 melanin-concentrating hormone receptor abolish agonist-induced signaling.

Goldstein C, Schroeder JC, Fortin JP, Goss JM, Schaus SE, Beinborn M, Kopin AS.

J Pharmacol Exp Ther. 2010 Dec;335(3):799-806. doi: 10.1124/jpet.110.174029. Epub 2010 Sep 10.


The μ-opioid receptor variant N190K is unresponsive to peptide agonists yet can be rescued by small-molecule drugs.

Fortin JP, Ci L, Schroeder J, Goldstein C, Montefusco MC, Peter I, Reis SE, Huggins GS, Beinborn M, Kopin AS.

Mol Pharmacol. 2010 Nov;78(5):837-45. doi: 10.1124/mol.110.064188. Epub 2010 Aug 11.


Contamination with E1A-positive wild-type adenovirus accounts for species-specific stimulation of islet cell proliferation by CCK: a cautionary note.

Lavine JA, Raess PW, Davis DB, Rabaglia ME, Presley BK, Keller MP, Beinfeld MC, Kopin AS, Newgard CB, Attie AD.

Mol Endocrinol. 2010 Feb;24(2):464-7. doi: 10.1210/me.2009-0384. Epub 2010 Jan 15.


Pharmacological characterization of human incretin receptor missense variants.

Fortin JP, Schroeder JC, Zhu Y, Beinborn M, Kopin AS.

J Pharmacol Exp Ther. 2010 Jan;332(1):274-80. doi: 10.1124/jpet.109.160531. Epub 2009 Oct 19.


The evolutionarily conserved RNA binding protein SMOOTH is essential for maintaining normal muscle function.

Draper I, Tabaka ME, Jackson FR, Salomon RN, Kopin AS.

Fly (Austin). 2009 Oct-Dec;3(4):235-46. Epub 2009 Oct 14.


Cellular dissection of circadian peptide signals with genetically encoded membrane-tethered ligands.

Choi C, Fortin JP, McCarthy Ev, Oksman L, Kopin AS, Nitabach MN.

Curr Biol. 2009 Jul 28;19(14):1167-75. doi: 10.1016/j.cub.2009.06.029. Epub 2009 Jul 9.


Membrane-tethered ligands are effective probes for exploring class B1 G protein-coupled receptor function.

Fortin JP, Zhu Y, Choi C, Beinborn M, Nitabach MN, Kopin AS.

Proc Natl Acad Sci U S A. 2009 May 12;106(19):8049-54. doi: 10.1073/pnas.0900149106. Epub 2009 Apr 23.


Overexpression of pre-pro-cholecystokinin stimulates beta-cell proliferation in mouse and human islets with retention of islet function.

Lavine JA, Raess PW, Davis DB, Rabaglia ME, Presley BK, Keller MP, Beinfeld MC, Kopin AS, Newgard CB, Attie AD.

Mol Endocrinol. 2008 Dec;22(12):2716-28. doi: 10.1210/me.2008-0255. Epub 2008 Oct 9. Retraction in: Mol Endocrinol. 2010 Feb;24(2):472.


Peptidergic influences on proliferation, migration, and placement of neural progenitors in the adult mouse forebrain.

Stanic D, Paratcha G, Ledda F, Herzog H, Kopin AS, Hökfelt T.

Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3610-5. doi: 10.1073/pnas.0712303105. Epub 2008 Feb 27.


Pharmacological analysis of human D1 AND D2 dopamine receptor missense variants.

Al-Fulaij MA, Ren Y, Beinborn M, Kopin AS.

J Mol Neurosci. 2008 Mar;34(3):211-23. doi: 10.1007/s12031-007-9030-x. Epub 2008 Jan 18.


Four missense mutations in the ghrelin receptor result in distinct pharmacological abnormalities.

Liu G, Fortin JP, Beinborn M, Kopin AS.

J Pharmacol Exp Ther. 2007 Sep;322(3):1036-43. Epub 2007 Jun 27.


Locomotor activity is regulated by D2-like receptors in Drosophila: an anatomic and functional analysis.

Draper I, Kurshan PT, McBride E, Jackson FR, Kopin AS.

Dev Neurobiol. 2007 Feb 15;67(3):378-93.


Differential body weight and feeding responses to high-fat diets in rats and mice lacking cholecystokinin 1 receptors.

Bi S, Chen J, Behles RR, Hyun J, Kopin AS, Moran TH.

Am J Physiol Regul Integr Comp Physiol. 2007 Jul;293(1):R55-63. Epub 2007 Apr 4.


Identification of amino acid determinants of dopamine 2 receptor synthetic agonist function.

Al-Fulaij MA, Ren Y, Beinborn M, Kopin AS.

J Pharmacol Exp Ther. 2007 Apr;321(1):298-307. Epub 2007 Jan 4.


Point mutations in either subunit of the GABAB receptor confer constitutive activity to the heterodimer.

Mukherjee RS, McBride EW, Beinborn M, Dunlap K, Kopin AS.

Mol Pharmacol. 2006 Oct;70(4):1406-13. Epub 2006 Jul 17.


Targeted disruption of the murine CCK1 receptor gene reduces intestinal lipid-induced feedback inhibition of gastric function.

Whited KL, Thao D, Lloyd KC, Kopin AS, Raybould HE.

Am J Physiol Gastrointest Liver Physiol. 2006 Jul;291(1):G156-62. Epub 2006 Mar 30.


A human glucagon-like peptide-1 receptor polymorphism results in reduced agonist responsiveness.

Beinborn M, Worrall CI, McBride EW, Kopin AS.

Regul Pept. 2005 Aug 15;130(1-2):1-6.


The "normal" endocrine cell of the gut: changing concepts and new evidences.

Rindi G, Leiter AB, Kopin AS, Bordi C, Solcia E.

Ann N Y Acad Sci. 2004 Apr;1014:1-12. Review.


Cholecystokinin modulates migration of gonadotropin-releasing hormone-1 neurons.

Giacobini P, Kopin AS, Beart PM, Mercer LD, Fasolo A, Wray S.

J Neurosci. 2004 May 19;24(20):4737-48.


Differential roles for cholecystokinin a receptors in energy balance in rats and mice.

Bi S, Scott KA, Kopin AS, Moran TH.

Endocrinology. 2004 Aug;145(8):3873-80. Epub 2004 May 3.


Ligand function at constitutively active receptor mutants is affected by two distinct yet interacting mechanisms.

Beinborn M, Ren Y, Bläker M, Chen C, Kopin AS.

Mol Pharmacol. 2004 Mar;65(3):753-60.


Conserved cholecystokinin receptor transmembrane domain IV amino acids confer peptide affinity.

Ren Y, Bläker M, Seshadri L, McBride EW, Beinborn M, Kopin AS.

J Mol Neurosci. 2003 Apr;20(2):115-24.


Established theory of radiation-induced decay is not generalizable to Bolton-Hunter labeled peptides.

Doran AC, Wan YP, Kopin AS, Beinborn M.

Biochem Pharmacol. 2003 May 1;65(9):1515-20.


Identification of a series of CCK-2 receptor nonpeptide agonists: sensitivity to stereochemistry and a receptor point mutation.

Kopin AS, McBride EW, Chen C, Freidinger RM, Chen D, Zhao CM, Beinborn M.

Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5525-30. Epub 2003 Apr 15.


A Drosophila dopamine 2-like receptor: Molecular characterization and identification of multiple alternatively spliced variants.

Hearn MG, Ren Y, McBride EW, Reveillaud I, Beinborn M, Kopin AS.

Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14554-9. Epub 2002 Oct 21.


Differentiation of gastric ECL cells is altered in CCK(2) receptor-deficient mice.

Chen D, Zhao CM, Al-Haider W, Håkanson R, Rehfeld JF, Kopin AS.

Gastroenterology. 2002 Aug;123(2):577-85.


Inhibition of morphine tolerance development by a substance P-opioid peptide chimera.

Foran SE, Carr DB, Lipkowski AW, Maszczynska I, Marchand JE, Misicka A, Beinborn M, Kopin AS, Kream RM.

J Pharmacol Exp Ther. 2000 Dec;295(3):1142-8.


CCK receptor polymorphisms: an illustration of emerging themes in pharmacogenomics.

Kopin AS, McBride EW, Schaffer K, Beinborn M.

Trends Pharmacol Sci. 2000 Sep;21(9):346-53. Review.


CCK-B/Gastrin receptor transmembrane domain mutations selectively alter synthetic agonist efficacy without affecting the activity of endogenous peptides.

Bläker M, Ren Y, Seshadri L, McBride EW, Beinborn M, Kopin AS.

Mol Pharmacol. 2000 Aug;58(2):399-406.


A substance P-opioid chimeric peptide as a unique nontolerance-forming analgesic.

Foran SE, Carr DB, Lipkowski AW, Maszczynska I, Marchand JE, Misicka A, Beinborn M, Kopin AS, Kream RM.

Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7621-6.


Abnormal gastric morphology and function in CCK-B/gastrin receptor-deficient mice.

Rindi G, Langhans N, Rehfeld JF, Beinborn M, Kopin AS.

Yale J Biol Med. 1998 May-Aug;71(3-4):347-54.


Small synthetic ligands of the cholecystokinin-B/gastrin receptor can mimic the function of endogenous peptide hormones.

Beinborn M, Chen C, DeMeo L, McBride EW, Kopin AS.

Yale J Biol Med. 1998 May-Aug;71(3-4):337-46.


The cholecystokinin-A receptor mediates inhibition of food intake yet is not essential for the maintenance of body weight.

Kopin AS, Mathes WF, McBride EW, Nguyen M, Al-Haider W, Schmitz F, Bonner-Weir S, Kanarek R, Beinborn M.

J Clin Invest. 1999 Feb;103(3):383-91. Erratum in: J Clin Invest 1999 Mar;103(5):759.

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