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Withdrawal: p53 protein regulates Hsp90 ATPase activity and thereby Wnt signaling by modulating Aha1 expression.

Okayama S, Kopelovich L, Balmus G, Weiss RS, Herbert BS, Dannenberg AJ, Subbaramaiah K.

J Biol Chem. 2020 Jan 3;295(1):289. doi: 10.1074/jbc.W119.012134. No abstract available.


Patched1 haploinsufficiency severely impacts intermediary metabolism in the skin of Ptch1+/-/ODC transgenic mice.

Li C, Mishra B, Kashyap M, Weng Z, Andrabi SA, Mukhtar SM, Kim AL, Bickers DR, Kopelovich L, Athar M.

Sci Rep. 2019 Sep 10;9(1):13072. doi: 10.1038/s41598-019-49470-w.


ETHE1 overexpression promotes SIRT1 and PGC1α mediated aerobic glycolysis, oxidative phosphorylation, mitochondrial biogenesis and colorectal cancer.

Witherspoon M, Sandu D, Lu C, Wang K, Edwards R, Yeung A, Gelincik O, Manfredi G, Gross S, Kopelovich L, Lipkin S.

Oncotarget. 2019 Jun 18;10(40):4004-4017. doi: 10.18632/oncotarget.26958. eCollection 2019 Jun 18.


Global gene expression of histologically normal primary skin cells from BCNS subjects reveals "single-hit" effects that are influenced by rapamycin.

Phatak A, Athar M, Crowell JA, Leffel D, Herbert BS, Bale AE, Kopelovich L.

Oncotarget. 2019 Feb 15;10(14):1360-1387. doi: 10.18632/oncotarget.26640. eCollection 2019 Feb 15.


Erratum: Drug-Targeted Inhibition of Peroxisome Proliferator-Activated Receptor-gamma Enhances the Chemopreventive Effect of Anti-Estrogen Therapy.

Yuan H, Kopelovich L, Yin Y, Lu J, Glazer RI.

Oncotarget. 2018 Sep 18;9(73):33866. doi: 10.18632/oncotarget.26161. eCollection 2018 Sep 18.


PPARs as determinants of the estrogen receptor lineage: use of synthetic lethality for the treatment of estrogen receptor-negative breast cancer.

Glazer RI, Kopelovich L.

Oncotarget. 2017 Apr 20;8(31):50337-50341. doi: 10.18632/oncotarget.17302. eCollection 2017 Aug 1.


Naproxen Inhibits UVB-induced Basal Cell and Squamous Cell Carcinoma Development in Ptch1+/- /SKH-1 Hairless Mice.

Chaudhary SC, Waseem M, Rana M, Xu H, Kopelovich L, Elmets CA, Athar M.

Photochem Photobiol. 2017 Jul;93(4):1016-1024. doi: 10.1111/php.12758. Epub 2017 May 9.


Haploinsufficiency in tumor predisposition syndromes: altered genomic transcription in morphologically normal cells heterozygous for VHL or TSC mutation.

Peri S, Caretti E, Tricarico R, Devarajan K, Cheung M, Sementino E, Menges CW, Nicolas E, Vanderveer LA, Howard S, Conrad P, Crowell JA, Campbell KS, Ross EA, Godwin AK, Yeung AT, Clapper ML, Uzzo RG, Henske EP, Ricketts CJ, Vocke CD, Linehan WM, Testa JR, Bellacosa A, Kopelovich L, Knudson AG.

Oncotarget. 2017 Mar 14;8(11):17628-17642. doi: 10.18632/oncotarget.12192.


Simultaneous targeting of 5-LOX-COX and ODC block NNK-induced lung adenoma progression to adenocarcinoma in A/J mice.

Kumar G, Patlolla JM, Madka V, Mohammed A, Li Q, Zhang Y, Biddick L, Singh A, Gillaspy A, Lightfoot S, Steele VE, Kopelovich L, Rao CV.

Am J Cancer Res. 2016 May 1;6(5):894-909. eCollection 2016.


Targeting cancer stem cells with p53 modulators.

Zhang Z, Liu L, Gomez-Casal R, Wang X, Hayashi R, Appella E, Kopelovich L, DeLeo AB.

Oncotarget. 2016 Jul 19;7(29):45079-45093. doi: 10.18632/oncotarget.8650.


Detection of Exosomal miRNAs in the Plasma of Melanoma Patients.

Pfeffer SR, Grossmann KF, Cassidy PB, Yang CH, Fan M, Kopelovich L, Leachman SA, Pfeffer LM.

J Clin Med. 2015 Dec 17;4(12):2012-27. doi: 10.3390/jcm4121957.


TP53 modulating agent, CP-31398 enhances antitumor effects of ODC inhibitor in mouse model of urinary bladder transitional cell carcinoma.

Madka V, Mohammed A, Li Q, Zhang Y, Kumar G, Lightfoot S, Wu X, Steele V, Kopelovich L, Rao CV.

Am J Cancer Res. 2015 Sep 15;5(10):3030-41. eCollection 2015.


Targeting mTOR and p53 Signaling Inhibits Muscle Invasive Bladder Cancer In Vivo.

Madka V, Mohammed A, Li Q, Zhang Y, Biddick L, Patlolla JM, Lightfoot S, Towner RA, Wu XR, Steele VE, Kopelovich L, Rao CV.

Cancer Prev Res (Phila). 2016 Jan;9(1):53-62. doi: 10.1158/1940-6207.CAPR-15-0199. Epub 2015 Nov 17.


Shh and p50/Bcl3 signaling crosstalk drives pathogenesis of BCCs in Gorlin syndrome.

Chaudhary SC, Tang X, Arumugam A, Li C, Srivastava RK, Weng Z, Xu J, Zhang X, Kim AL, McKay K, Elmets CA, Kopelovich L, Bickers DR, Athar M.

Oncotarget. 2015 Nov 3;6(34):36789-814. doi: 10.18632/oncotarget.5103.


Early and delayed intervention with rapamycin prevents NNK-induced lung adenocarcinoma in A/J mice.

Patlolla JM, Kopelovich L, Qian L, Zhang Y, Kumar G, Madka V, Mohammed A, Biddick L, Sadeghi M, Lightfoot S, Rao CV.

Oncol Rep. 2015 Dec;34(6):2925-34. doi: 10.3892/or.2015.4277. Epub 2015 Sep 16.


Small-Molecule NSC59984 Restores p53 Pathway Signaling and Antitumor Effects against Colorectal Cancer via p73 Activation and Degradation of Mutant p53.

Zhang S, Zhou L, Hong B, van den Heuvel AP, Prabhu VV, Warfel NA, Kline CL, Dicker DT, Kopelovich L, El-Deiry WS.

Cancer Res. 2015 Sep 15;75(18):3842-52. doi: 10.1158/0008-5472.CAN-13-1079. Epub 2015 Aug 20.


Screening-level human health risk assessment of toluene and dibutyl phthalate in nail lacquers.

Kopelovich L, Perez AL, Jacobs N, Mendelsohn E, Keenan JJ.

Food Chem Toxicol. 2015 Jul;81:46-53. doi: 10.1016/j.fct.2015.04.011. Epub 2015 Apr 9.


Sulindac reversal of 15-PGDH-mediated resistance to colon tumor chemoprevention with NSAIDs.

Fink SP, Dawson DM, Zhang Y, Kresak A, Lawrence EG, Yang P, Chen Y, Barnholtz-Sloan JS, Willis JE, Kopelovich L, Markowitz SD.

Carcinogenesis. 2015 Feb;36(2):291-8. doi: 10.1093/carcin/bgu241. Epub 2014 Dec 10.


Differential roles of ERα and ERβ in normal and neoplastic development in the mouse mammary gland.

Mehta RG, Hawthorne M, Mehta RR, Torres KE, Peng X, McCormick DL, Kopelovich L.

PLoS One. 2014 Nov 18;9(11):e113175. doi: 10.1371/journal.pone.0113175. eCollection 2014.


Chemoprevention of urothelial cell carcinoma growth and invasion by the dual COX-LOX inhibitor licofelone in UPII-SV40T transgenic mice.

Madka V, Mohammed A, Li Q, Zhang Y, Patlolla JM, Biddick L, Lightfoot S, Wu XR, Steele V, Kopelovich L, Rao CV.

Cancer Prev Res (Phila). 2014 Jul;7(7):708-16. doi: 10.1158/1940-6207.CAPR-14-0087. Epub 2014 May 2.


Epithelial cell tumors of the hen reproductive tract.

Harris EA, Fletcher OJ, Anderson KE, Petitte JN, Kopelovich L, Mozdziak PE.

Avian Dis. 2014 Mar;58(1):95-101.


p53 modulates Hsp90 ATPase activity and regulates aryl hydrocarbon receptor signaling.

Kochhar A, Kopelovich L, Sue E, Guttenplan JB, Herbert BS, Dannenberg AJ, Subbaramaiah K.

Cancer Prev Res (Phila). 2014 Jun;7(6):596-606. doi: 10.1158/1940-6207.CAPR-14-0051. Epub 2014 Apr 15.


History and evolution of warning labels for automotive friction products.

Kopelovich LM, Thuett KA, Chapman PS, Paustenbach DJ.

Regul Toxicol Pharmacol. 2014 Apr;68(3):402-11. doi: 10.1016/j.yrtph.2014.01.015. Epub 2014 Feb 8.


p53 protein regulates Hsp90 ATPase activity and thereby Wnt signaling by modulating Aha1 expression.

Okayama S, Kopelovich L, Balmus G, Weiss RS, Herbert BS, Dannenberg AJ, Subbaramaiah K.

J Biol Chem. 2014 Mar 7;289(10):6513-25. doi: 10.1074/jbc.M113.532523. Epub 2014 Jan 22. Retraction in: J Biol Chem. 2020 Jan 3;295(1):289.


Polymorphisms in alcohol metabolism genes ADH1B and ALDH2, alcohol consumption and colorectal cancer.

Crous-Bou M, Rennert G, Cuadras D, Salazar R, Cordero D, Saltz Rennert H, Lejbkowicz F, Kopelovich L, Monroe Lipkin S, Bernard Gruber S, Moreno V.

PLoS One. 2013 Nov 25;8(11):e80158. doi: 10.1371/journal.pone.0080158. eCollection 2013.


Inhibiting cycloxygenase and ornithine decarboxylase by diclofenac and alpha-difluoromethylornithine blocks cutaneous SCCs by targeting Akt-ERK axis.

Arumugam A, Weng Z, Talwelkar SS, Chaudhary SC, Kopelovich L, Elmets CA, Afaq F, Athar M.

PLoS One. 2013 Nov 8;8(11):e80076. doi: 10.1371/journal.pone.0080076. eCollection 2013.


Isolation of circulating microRNAs from microvesicles found in human plasma.

Quackenbush JF, Cassidy PB, Pfeffer LM, Boucher KM, Hawkes JE, Pfeffer SR, Kopelovich L, Leachman SA.

Methods Mol Biol. 2014;1102:641-53. doi: 10.1007/978-1-62703-727-3_34.


Prodigiosin rescues deficient p53 signaling and antitumor effects via upregulating p73 and disrupting its interaction with mutant p53.

Hong B, Prabhu VV, Zhang S, van den Heuvel AP, Dicker DT, Kopelovich L, El-Deiry WS.

Cancer Res. 2014 Feb 15;74(4):1153-65. doi: 10.1158/0008-5472.CAN-13-0955. Epub 2013 Nov 18.


Erb-041, an estrogen receptor-β agonist, inhibits skin photocarcinogenesis in SKH-1 hairless mice by downregulating the WNT signaling pathway.

Chaudhary SC, Singh T, Talwelkar SS, Srivastava RK, Arumugam A, Weng Z, Elmets CA, Afaq F, Kopelovich L, Athar M.

Cancer Prev Res (Phila). 2014 Feb;7(2):186-98. doi: 10.1158/1940-6207.CAPR-13-0276. Epub 2013 Nov 11.


Chemopreventive effects of the p53-modulating agents CP-31398 and Prima-1 in tobacco carcinogen-induced lung tumorigenesis in A/J mice.

Rao CV, Patlolla JM, Qian L, Zhang Y, Brewer M, Mohammed A, Desai D, Amin S, Lightfoot S, Kopelovich L.

Neoplasia. 2013 Sep;15(9):1018-27.


Immunodepletion plasma proteomics by tripleTOF 5600 and Orbitrap elite/LTQ-Orbitrap Velos/Q exactive mass spectrometers.

Jones KA, Kim PD, Patel BB, Kelsen SG, Braverman A, Swinton DJ, Gafken PR, Jones LA, Lane WS, Neveu JM, Leung HE, Shaffer SA, Leszyk JD, Stanley BA, Fox TE, Stanley A, Hall MJ, Hampel H, South CD, de la Chapelle A, Burt RW, Jones DA, Kopelovich L, Yeung AT.

J Proteome Res. 2013 Oct 4;12(10):4351-65. doi: 10.1021/pr400307u. Epub 2013 Sep 19.


Inhibition of proliferation and induction of autophagy by atorvastatin in PC3 prostate cancer cells correlate with downregulation of Bcl2 and upregulation of miR-182 and p21.

Peng X, Li W, Yuan L, Mehta RG, Kopelovich L, McCormick DL.

PLoS One. 2013 Aug 1;8(8):e70442. doi: 10.1371/journal.pone.0070442. Print 2013.


p53-stabilizing agent CP-31398 prevents growth and invasion of urothelial cancer of the bladder in transgenic UPII-SV40T mice.

Madka V, Zhang Y, Li Q, Mohammed A, Sindhwani P, Lightfoot S, Wu XR, Kopelovich L, Rao CV.

Neoplasia. 2013 Aug;15(8):966-74.


Heritable one-hit events defining cancer prevention?

Kopelovich L, Shea-Herbert B.

Cell Cycle. 2013 Aug 15;12(16):2553-7. doi: 10.4161/cc.25690. Epub 2013 Jul 29.


Dietary polyphenols suppress elevated levels of proinflammatory mediators and aromatase in the mammary gland of obese mice.

Subbaramaiah K, Sue E, Bhardwaj P, Du B, Hudis CA, Giri D, Kopelovich L, Zhou XK, Dannenberg AJ.

Cancer Prev Res (Phila). 2013 Sep;6(9):886-97. doi: 10.1158/1940-6207.CAPR-13-0140. Epub 2013 Jul 23.


Laccaic acid A is a direct, DNA-competitive inhibitor of DNA methyltransferase 1.

Fagan RL, Cryderman DE, Kopelovich L, Wallrath LL, Brenner C.

J Biol Chem. 2013 Aug 16;288(33):23858-67. doi: 10.1074/jbc.M113.480517. Epub 2013 Jul 9.


PPARδ induces estrogen receptor-positive mammary neoplasia through an inflammatory and metabolic phenotype linked to mTOR activation.

Yuan H, Lu J, Xiao J, Upadhyay G, Umans R, Kallakury B, Yin Y, Fant ME, Kopelovich L, Glazer RI.

Cancer Res. 2013 Jul 15;73(14):4349-61. doi: 10.1158/0008-5472.CAN-13-0322. Epub 2013 Jun 27.


Unbiased metabolite profiling indicates that a diminished thymidine pool is the underlying mechanism of colon cancer chemoprevention by alpha-difluoromethylornithine.

Witherspoon M, Chen Q, Kopelovich L, Gross SS, Lipkin SM.

Cancer Discov. 2013 Sep;3(9):1072-81. doi: 10.1158/2159-8290.CD-12-0305. Epub 2013 Jun 14.


Rapamycin targeting mTOR and hedgehog signaling pathways blocks human rhabdomyosarcoma growth in xenograft murine model.

Kaylani SZ, Xu J, Srivastava RK, Kopelovich L, Pressey JG, Athar M.

Biochem Biophys Res Commun. 2013 Jun 14;435(4):557-61. doi: 10.1016/j.bbrc.2013.05.001. Epub 2013 May 9.


Caloric restriction reverses obesity-induced mammary gland inflammation in mice.

Bhardwaj P, Du B, Zhou XK, Sue E, Harbus MD, Falcone DJ, Giri D, Hudis CA, Kopelovich L, Subbaramaiah K, Dannenberg AJ.

Cancer Prev Res (Phila). 2013 Apr;6(4):282-9. doi: 10.1158/1940-6207.CAPR-12-0467. Epub 2013 Feb 19.


Altered transcriptome signature of phenotypically normal skin fibroblasts heterozygous for CDKN2A in familial melanoma: relevance to early intervention.

Fan M, Pfeffer SR, Lynch HT, Cassidy P, Leachman S, Pfeffer LM, Kopelovich L.

Oncotarget. 2013 Jan;4(1):128-41.


Nitric oxide-releasing sulindac is a novel skin cancer chemopreventive agent for UVB-induced photocarcinogenesis.

Chaudhary SC, Singh T, Kapur P, Weng Z, Arumugam A, Elmets CA, Kopelovich L, Athar M.

Toxicol Appl Pharmacol. 2013 May 1;268(3):249-55. doi: 10.1016/j.taap.2012.12.009. Epub 2012 Dec 27.


Vorinostat, an HDAC inhibitor attenuates epidermoid squamous cell carcinoma growth by dampening mTOR signaling pathway in a human xenograft murine model.

Kurundkar D, Srivastava RK, Chaudhary SC, Ballestas ME, Kopelovich L, Elmets CA, Athar M.

Toxicol Appl Pharmacol. 2013 Jan 15;266(2):233-44. doi: 10.1016/j.taap.2012.11.002. Epub 2012 Nov 9.


PPARγ antagonist GW9662 induces functional estrogen receptor in mouse mammary organ culture: potential translational significance.

Mehta RG, Peng X, Roy S, Hawthorne M, Kalra A, Alimirah F, Mehta RR, Kopelovich L.

Mol Cell Biochem. 2013 Jan;372(1-2):249-56. doi: 10.1007/s11010-012-1466-9. Epub 2012 Sep 24.


Metabolic profiling, a noninvasive approach for the detection of experimental colorectal neoplasia.

Montrose DC, Zhou XK, Kopelovich L, Yantiss RK, Karoly ED, Subbaramaiah K, Dannenberg AJ.

Cancer Prev Res (Phila). 2012 Dec;5(12):1358-67. doi: 10.1158/1940-6207.CAPR-12-0160. Epub 2012 Sep 7.


Pioglitazone, a PPARγ agonist, suppresses CYP19 transcription: evidence for involvement of 15-hydroxyprostaglandin dehydrogenase and BRCA1.

Subbaramaiah K, Howe LR, Zhou XK, Yang P, Hudis CA, Kopelovich L, Dannenberg AJ.

Cancer Prev Res (Phila). 2012 Oct;5(10):1183-94. doi: 10.1158/1940-6207.CAPR-12-0201. Epub 2012 Jul 10.


ATM mutations in patients with hereditary pancreatic cancer.

Roberts NJ, Jiao Y, Yu J, Kopelovich L, Petersen GM, Bondy ML, Gallinger S, Schwartz AG, Syngal S, Cote ML, Axilbund J, Schulick R, Ali SZ, Eshleman JR, Velculescu VE, Goggins M, Vogelstein B, Papadopoulos N, Hruban RH, Kinzler KW, Klein AP.

Cancer Discov. 2012 Jan;2(1):41-6. doi: 10.1158/2159-8290.CD-11-0194. Epub 2011 Dec 29.


Increased levels of COX-2 and prostaglandin E2 contribute to elevated aromatase expression in inflamed breast tissue of obese women.

Subbaramaiah K, Morris PG, Zhou XK, Morrow M, Du B, Giri D, Kopelovich L, Hudis CA, Dannenberg AJ.

Cancer Discov. 2012 Apr;2(4):356-65. doi: 10.1158/2159-8290.CD-11-0241. Epub 2012 Jan 27.


Metformin, an antidiabetic agent reduces growth of cutaneous squamous cell carcinoma by targeting mTOR signaling pathway.

Chaudhary SC, Kurundkar D, Elmets CA, Kopelovich L, Athar M.

Photochem Photobiol. 2012 Sep-Oct;88(5):1149-56. doi: 10.1111/j.1751-1097.2012.01165.x. Epub 2012 Jun 1.

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