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Items: 1 to 50 of 58

1.

Pyrrolidine-constrained phenethylamines: The design of potent, selective, and pharmacologically efficacious dipeptidyl peptidase IV (DPP4) inhibitors from a lead-like screening hit.

Backes BJ, Longenecker K, Hamilton GL, Stewart K, Lai C, Kopecka H, von Geldern TW, Madar DJ, Pei Z, Lubben TH, Zinker BA, Tian Z, Ballaron SJ, Stashko MA, Mika AK, Beno DW, Kempf-Grote AJ, Black-Schaefer C, Sham HL, Trevillyan JM.

Bioorg Med Chem Lett. 2007 Apr 1;17(7):2005-12. Epub 2007 Jan 19.

PMID:
17276063
2.

Discovery of 2-[4-{{2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]- 4-methyl-1-piperidinyl]-4-pyridinecarboxylic acid (ABT-279): a very potent, selective, effective, and well-tolerated inhibitor of dipeptidyl peptidase-IV, useful for the treatment of diabetes.

Madar DJ, Kopecka H, Pireh D, Yong H, Pei Z, Li X, Wiedeman PE, Djuric SW, Von Geldern TW, Fickes MG, Bhagavatula L, McDermott T, Wittenberger S, Richards SJ, Longenecker KL, Stewart KD, Lubben TH, Ballaron SJ, Stashko MA, Long MA, Wells H, Zinker BA, Mika AK, Beno DW, Kempf-Grote AJ, Polakowski J, Segreti J, Reinhart GA, Fryer RM, Sham HL, Trevillyan JM.

J Med Chem. 2006 Oct 19;49(21):6416-20.

PMID:
17034148
3.

Detection of enteroviruses in cases of neurological disorders in the State of Pará, Brazil.

Gomes ML, Kopecka H, Linhares AC.

Rev Inst Med Trop Sao Paulo. 2001 Nov-Dec;43(6):321-4.

4.

Postpolio syndrome: poliovirus persistence is involved in the pathogenesis.

Julien J, Leparc-Goffart I, Lina B, Fuchs F, Foray S, Janatova I, Aymard M, Kopecka H.

J Neurol. 1999 Jun;246(6):472-6.

PMID:
10431774
5.

Enterovirus genome detection in wastewater: multi centric evaluation of a commercial kit.

Gantzer C, Menard D, Lina B, Maul A, Le Guyader S, Thouvenot D, Aymard M, Schwartzbrod L, Kopecka H.

Zentralbl Hyg Umweltmed. 1999 Jun;202(1):29-39.

PMID:
10418098
6.

Discovery of ascomycin analogs with potent topical but weak systemic activity for treatment of inflammatory skin diseases.

Mollison KW, Fey TA, Gauvin DM, Sheets MP, Smith ML, Pong M, Krause R, Miller L, Or YS, Kawai M, Wagner R, Wiedeman PE, Clark RF, Gunawardana IW, Rhoades TA, Henry CL, Tu NP, BaMaung NY, Kopecka H, Liu L, Xie Q, Lane BC, Trevillyan JM, Marsh K, Luly JR, et al.

Curr Pharm Des. 1998 Oct;4(5):367-79. Review.

PMID:
10197049
7.

Detection of enteroviral sequence in endomyocardial tissues from patients with cardiac diseases in northern Brazil.

Gomes Mde L, Kopecka H, Ferreira Júnior AG, Ferreira SM, Maneschy LA, Linhares AC.

Rev Soc Bras Med Trop. 1998 Sep-Oct;31(5):487-90.

PMID:
9789448
8.

Molecular epidemiological survey of rotaviruses in sewage by reverse transcriptase seminested PCR and restriction fragment length polymorphism assay.

Dubois E, Le Guyader F, Haugarreau L, Kopecka H, Cormier M, Pommepuy M.

Appl Environ Microbiol. 1997 May;63(5):1794-800.

9.

Minor structural differences in Boc-CCK-4 derivatives dictate affinity and selectivity for CCK-A and CCK-B receptors.

Shiosaki K, Lin CW, Kopecka H, Bianchi B, Miller T, Stashko M, Witte D.

J Med Chem. 1997 Mar 28;40(7):1169-72.

PMID:
9089338
10.

[Molecular biology of enteroviruses].

Kopecká H.

Epidemiol Mikrobiol Imunol. 1996 Dec;45(4):135-42. Czech.

PMID:
9072140
11.

Multicenter evaluating of a commercially available PCR assay for diagnosing enterovirus infection in a panel of cerebrospinal fluid specimens.

Lina B, Pozzetto B, Andreoletti L, Beguier E, Bourlet T, Dussaix E, Grangeot-Keros L, Gratacap-Cavallier B, Henquell C, Legrand-Quillien MC, Novillo A, Palmer P, Petitjean J, Sandres K, Dubreuil P, Fleury H, Freymuth F, Leparc-Goffart I, Hober D, Izopet J, Kopecka H, Lazizi Y, Lafeuille H, Lebon P, Roseto A, Marchadier E, Masquelier B, Picard B, Puel J, Seigneurin JM, Wattre P, Aymard M.

J Clin Microbiol. 1996 Dec;34(12):3002-6.

12.

Evidence of presence of poliovirus genomic sequences in cerebrospinal fluid from patients with postpolio syndrome.

Leparc-Goffart I, Julien J, Fuchs F, Janatova I, Aymard M, Kopecka H.

J Clin Microbiol. 1996 Aug;34(8):2023-6.

13.

Genotypic variation in coxsackievirus B5 isolates from three different outbreaks in the United States.

Kopecka H, Brown B, Pallansch M.

Virus Res. 1995 Oct;38(2-3):125-36.

PMID:
8578854
14.

Search for poliovirus in specimens from patients with the post-polio syndrome.

Leparc I, Kopecka H, Fuchs F, Janatova I, Aymard M, Julien J.

Ann N Y Acad Sci. 1995 May 25;753:233-6. No abstract available.

PMID:
7611632
15.

Novel Asp32-replacement tetrapeptide analogues as potent and selective CCK-A agonists.

Elliott RL, Kopecka H, Tufano MD, Shue YK, Gauri AJ, Lin CW, Bianchi BR, Miller TR, Witte DG, Stashko MA, et al.

J Med Chem. 1994 May 27;37(11):1562-8.

PMID:
8201590
16.

Tetrapeptide CCK-A agonists: effect of backbone N-methylations on in vitro and in vivo CCK activity.

Holladay MW, Kopecka H, Miller TR, Bednarz L, Nikkel AL, Bianchi BR, Witte DG, Shiosaki K, Lin CW, Asin KE, et al.

J Med Chem. 1994 Mar 4;37(5):630-5.

PMID:
8126703
17.

Detection of enteroviruses in cerebrospinal fluids: enzymatic amplification and hybridization with a biotinylated riboprobe.

Petitjean J, Freymuth F, Kopecka H, Brouard J, Boutard P, Lebon P.

Mol Cell Probes. 1994 Feb;8(1):15-22.

PMID:
8028604
18.

Tetrapeptide CCK agonists: structure-activity studies on modifications at the N-terminus.

Elliott RL, Kopecka H, Bennett MJ, Shue YK, Craig R, Lin CW, Bianchi BR, Miller TR, Witte DG, Stashko MA, et al.

J Med Chem. 1994 Jan 21;37(2):309-13.

PMID:
8295219
19.

Detection of enteroviruses in endomyocardial biopsy by molecular approach.

Petitjean J, Kopecka H, Freymuth F, Langlard JM, Scanu P, Galateau F, Bouhour JB, Ferrière M, Charbonneau P, Komajda M.

J Med Virol. 1993 Nov;41(3):260. No abstract available.

PMID:
8263507
20.

Use of the polymerase chain reaction with a murine model of picornavirus-induced myocarditis.

Leparc I, Fuchs F, Kopecka H, Aymard M.

J Clin Microbiol. 1993 Nov;31(11):2890-4.

21.

Double bond isosteres of the peptide bond: synthesis and biological activity of cholecystokinin (CCK) C-terminal hexapeptide analogs.

Shue YK, Tufano MD, Carrera GM Jr, Kopecka H, Kuyper SL, Holladay MW, Lin CW, Witte DG, Miller TR, Stashko M, et al.

Bioorg Med Chem. 1993 Sep;1(3):161-71.

PMID:
8081848
22.

[Enteroviruses and dilated cardiomyopathies].

Kopecka H, Bouhour JB, Langlard JM, Petitjean J, Freymuth F.

Pathol Biol (Paris). 1993 Jun;41(6):521-3. French. No abstract available.

PMID:
8247630
23.

Use of cRNA digoxigenin-labelled probes for detection of enteroviruses in humans and in the environment.

Fuchs F, Leparc I, Kopecka H, Garin D, Aymard M.

J Virol Methods. 1993 May;42(2-3):217-26.

PMID:
8390472
24.

Detection of naturally occurring enteroviruses in waters by reverse transcription, polymerase chain reaction, and hybridization.

Kopecka H, Dubrou S, Prevot J, Marechal J, López-Pila JM.

Appl Environ Microbiol. 1993 Apr;59(4):1213-9.

25.

[Virus and dilated cardiomyopathies].

Bouhour JB, Langlard JM, Kopecka H, Petitjean J, Freymuth F.

Arch Mal Coeur Vaiss. 1993 Feb;86 Spec No 2:15-20. Review. French.

PMID:
8215785
26.

Development of potent and selective CCK-A receptor agonists from Boc-CCK-4: tetrapeptides containing Lys(N epsilon)-amide residues.

Shiosaki K, Lin CW, Kopecka H, Craig RA, Bianchi BR, Miller TR, Witte DG, Stashko M, Nadzan AM.

J Med Chem. 1992 May 29;35(11):2007-14.

PMID:
1375964
27.

Detection of enteroviruses in endomyocardial biopsy by molecular approach.

Petitjean J, Kopecka H, Freymuth F, Langlard JM, Scanu P, Galateau F, Bouhour JB, Ferrière M, Charbonneau P, Komajda M.

J Med Virol. 1992 May;37(1):76-82. Erratum in: J Med Virol. 1993 Nov;41(3):260.

PMID:
1320101
28.

General primer-mediated polymerase chain reaction for detection of enteroviruses: application for diagnostic routine and persistent infections.

Zoll GJ, Melchers WJ, Kopecka H, Jambroes G, van der Poel HJ, Galama JM.

J Clin Microbiol. 1992 Jan;30(1):160-5.

29.

Cholecystokinin antagonists: (R)-tryptophan-based hybrid antagonists of high affinity and selectivity for CCK-A receptors.

Kerwin JF Jr, Wagenaar F, Kopecka H, Lin CW, Miller T, Witte D, Stashko M, Nadzan AM.

J Med Chem. 1991 Dec;34(12):3350-9.

PMID:
1766000
30.

Boc-CCK-4 derivatives containing side-chain ureas as potent and selective CCK-a receptor agonists.

Shiosaki K, Lin CW, Kopecka H, Tufano MD, Bianchi BR, Miller TR, Witte DG, Nadzan AM.

J Med Chem. 1991 Sep;34(9):2837-42.

PMID:
1716682
31.

Characterization of two novel cholecystokinin tetrapeptide (30-33) analogues, A-71623 and A-70874, that exhibit high potency and selectivity for cholecystokinin-A receptors.

Lin CW, Shiosaki K, Miller TR, Witte DG, Bianchi BR, Wolfram CA, Kopecka H, Craig R, Wagenaar F, Nadzan AM.

Mol Pharmacol. 1991 Mar;39(3):346-51.

PMID:
1706470
32.

Development of CCK-tetrapeptide analogues as potent and selective CCK-A receptor agonists.

Shiosaki K, Lin CW, Kopecka H, Craig R, Wagenaar FL, Bianchi B, Miller T, Witte D, Nadzan AM.

J Med Chem. 1990 Nov;33(11):2950-2. No abstract available.

PMID:
1700123
33.

Specific detection of enteroviruses in clinical samples by molecular hybridization using poliovirus subgenomic riboprobes.

Petitjean J, Quibriac M, Freymuth F, Fuchs F, Laconche N, Aymard M, Kopecka H.

J Clin Microbiol. 1990 Feb;28(2):307-11.

34.

Centrally administered CCK-8 suppresses activity in mice by a "peripheral-type" CCK receptor.

Britton DR, Yahiro L, Cullen MJ, Kerwin JF Jr, Kopecka H, Nadzan AM.

Pharmacol Biochem Behav. 1989 Dec;34(4):779-83.

PMID:
2623030
35.

Molecular pathogenesis of neural lesions induced by poliovirus type 1.

Couderc T, Christodoulou C, Kopecka H, Marsden S, Taffs LF, Crainic R, Horaud F.

J Gen Virol. 1989 Nov;70 ( Pt 11):2907-18.

PMID:
2555432
36.

Hybrid cholecystokinin (CCK) antagonists: new implications in the design and modification of CCK antagonists.

Kerwin JF Jr, Nadzan AM, Kopecka H, Lin CW, Miller T, Witte D, Burt S.

J Med Chem. 1989 Apr;32(4):739-42. No abstract available. Erratum in: J Med Chem 1989 Dec;32(12):2583.

PMID:
2704023
37.

Lack of evidence for strand-specific inhibition of poliovirus RNA synthesis by 3-methylquercetin.

Lopez Pila JM, Kopecka H, Vanden Berghe D.

Antiviral Res. 1989 Feb;11(1):47-53.

PMID:
2540709
38.

Evidence that type A CCK receptors facilitate dopamine efflux in rat brain.

Vickroy TW, Bianchi BR, Kerwin JF Jr, Kopecka H, Nadzan AM.

Eur J Pharmacol. 1988 Aug 2;152(3):371-2. No abstract available.

PMID:
3220112
39.

[cRNA probes (riboprobes) synthesized in vitro for detecting enterovirus by molecular hybridization].

Kopecka H, Prévot J, Girard M, Fuchs F, Aymard M.

Ann Inst Pasteur Virol. 1988 Apr-Jun;139(2):217-25. French.

PMID:
2849964
40.

Use of cRNA probes for the detection of enteroviruses by molecular hybridization.

Cova L, Kopecka H, Aymard M, Girard M.

J Med Virol. 1988 Jan;24(1):11-8.

PMID:
2448419
41.
42.

Cholecystokinin receptors: relationships among phosphoinositide breakdown, amylase release and receptor affinity in pancreas.

Lin CW, Bianchi BR, Grant D, Miller T, Danaher EA, Tufano MD, Kopecka H, Nadzan AM.

J Pharmacol Exp Ther. 1986 Mar;236(3):729-34.

PMID:
2419543
43.

The stabilization of vancomycin by peptidoglycan analogs.

Harris CM, Kopecka H, Harris TM.

J Antibiot (Tokyo). 1985 Jan;38(1):51-7.

44.

Expression of poliovirus capsid polypeptide VP1 in Escherichia coli.

van der Werf S, Dréano M, Bruneau P, Kopecka H, Girard M.

Gene. 1983 Jul;23(1):85-93.

PMID:
6311678
45.

Molecular cloning of the genome of poliovirus type 1.

van der Werf S, Bregegere F, Kopecka H, Kitamura N, Rothberg PG, Kourilsky P, Wimmer E, Girard M.

Proc Natl Acad Sci U S A. 1981 Oct;78(10):5983-7.

46.

Restriction map of poliovirus type 2 cDNA.

Kopecka H, van der Werf S, Bregegere F, Kitamura N, Dreano M, Rothberg PG, Wimmer E, Kourilsky P, Girard M.

Dev Biol Stand. 1981;50:301-9.

PMID:
6176488
47.

Cytotypically specific transfecting activity of DNA from C57BL/Ka mouse cells producing thymotropic in contrast to nonthymotropic retroviruses.

Kopecka H, Declève A, Lieberman M, Fry K, Kaplan HS.

Proc Natl Acad Sci U S A. 1980 Oct;77(10):6189-93.

48.

Restriction enzyme analysis of satellite DNA components from the bovine genome.

Kopecka H, Macaya G, Cortadas J, Thiéry JP, Bernardi G.

Eur J Biochem. 1978 Mar;84(1):189-95.

49.

The mitochondrial genome of wild-type yeast cells. V. Genome evolution.

Prunell A, Kopecka H, Strauss F, Bernardi G.

J Mol Biol. 1977 Feb 15;110(1):17-47. No abstract available.

PMID:
321789
50.

The Euglena gracilis chloroplast genome: analysis by restriction enzymes.

Kopecka H, Crouse EJ, Stutz E.

Eur J Biochem. 1977 Feb;72(3):525-35.

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