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Items: 1 to 50 of 149

1.

Hamartin regulates cessation of mouse nephrogenesis independently of Mtor.

Volovelsky O, Nguyen T, Jarmas AE, Combes AN, Wilson SB, Little MH, Witte DP, Brunskill EW, Kopan R.

Proc Natl Acad Sci U S A. 2018 Jun 5;115(23):5998-6003. doi: 10.1073/pnas.1712955115. Epub 2018 May 21.

2.

Glomerular endothelial cell maturation depends on ADAM10, a key regulator of Notch signaling.

Farber G, Hurtado R, Loh S, Monette S, Mtui J, Kopan R, Quaggin S, Meyer-Schwesinger C, Herzlinger D, Scott RP, Blobel CP.

Angiogenesis. 2018 May;21(2):335-347. doi: 10.1007/s10456-018-9599-4. Epub 2018 Feb 3.

3.

Haploinsufficiency for the Six2 gene increases nephron progenitor proliferation promoting branching and nephron number.

Combes AN, Wilson S, Phipson B, Binnie BB, Ju A, Lawlor KT, Cebrian C, Walton SL, Smyth IM, Moritz KM, Kopan R, Oshlack A, Little MH.

Kidney Int. 2018 Mar;93(3):589-598. doi: 10.1016/j.kint.2017.09.015. Epub 2017 Dec 6.

4.

Analysis of chromatin accessibility in human epidermis identifies putative barrier dysfunction-sensing enhancers.

Lander JM, Supp DM, He H, Martin LJ, Chen X, Weirauch MT, Boyce ST, Kopan R.

PLoS One. 2017 Sep 27;12(9):e0184500. doi: 10.1371/journal.pone.0184500. eCollection 2017.

5.

The Canonical Notch Signaling Pathway: Structural and Biochemical Insights into Shape, Sugar, and Force.

Kovall RA, Gebelein B, Sprinzak D, Kopan R.

Dev Cell. 2017 May 8;41(3):228-241. doi: 10.1016/j.devcel.2017.04.001. Review.

6.

Randomized trial of calcipotriol combined with 5-fluorouracil for skin cancer precursor immunotherapy.

Cunningham TJ, Tabacchi M, Eliane JP, Tuchayi SM, Manivasagam S, Mirzaalian H, Turkoz A, Kopan R, Schaffer A, Saavedra AP, Wallendorf M, Cornelius LA, Demehri S.

J Clin Invest. 2017 Jan 3;127(1):106-116. doi: 10.1172/JCI89820. Epub 2016 Nov 21.

7.

Making new kidneys: On the road from science fiction to science fact.

Volovelsky O, Kopan R.

Curr Opin Organ Transplant. 2016 Dec;21(6):574-580. Review.

8.

SpDamID: Marking DNA Bound by Protein Complexes Identifies Notch-Dimer Responsive Enhancers.

Hass MR, Liow HH, Chen X, Sharma A, Inoue YU, Inoue T, Reeb A, Martens A, Fulbright M, Raju S, Stevens M, Boyle S, Park JS, Weirauch MT, Brent MR, Kopan R.

Mol Cell. 2016 Oct 6;64(1):213. doi: 10.1016/j.molcel.2016.09.035. No abstract available.

9.

RNF4-Dependent Oncogene Activation by Protein Stabilization.

Thomas JJ, Abed M, Heuberger J, Novak R, Zohar Y, Beltran Lopez AP, Trausch-Azar JS, Ilagan MXG, Benhamou D, Dittmar G, Kopan R, Birchmeier W, Schwartz AL, Orian A.

Cell Rep. 2016 Sep 20;16(12):3388-3400. doi: 10.1016/j.celrep.2016.08.024.

10.

A novel non-canonical Notch signaling regulates expression of synaptic vesicle proteins in excitatory neurons.

Hayashi Y, Nishimune H, Hozumi K, Saga Y, Harada A, Yuzaki M, Iwatsubo T, Kopan R, Tomita T.

Sci Rep. 2016 Apr 4;6:23969. doi: 10.1038/srep23969.

11.

The Unaimed Arrow Never Misses.

Kopan R.

Curr Top Dev Biol. 2016;116:547-50. doi: 10.1016/bs.ctdb.2015.10.007. Epub 2016 Jan 23. Review.

PMID:
26970640
12.

The Notch Intracellular Domain Has an RBPj-Independent Role during Mouse Hair Follicular Development.

Turkoz M, Townsend RR, Kopan R.

J Invest Dermatol. 2016 Jun;136(6):1106-1115. doi: 10.1016/j.jid.2016.02.018. Epub 2016 Mar 3.

13.

Corrigendum: Notch signal strength controls cell fate in the haemogenic endothelium.

Gama-Norton L, Ferrando E, Ruiz-Herguido C, Liu Z, Guiu J, Islam AB, Lee SU, Yan M, Guidos CJ, López-Bigas N, Maeda T, Espinosa L, Kopan R, Bigas A.

Nat Commun. 2016 Mar 4;7:10978. doi: 10.1038/ncomms10978. No abstract available.

14.

The anatomical distribution of genetic associations.

Wells A, Kopp N, Xu X, O'Brien DR, Yang W, Nehorai A, Adair-Kirk TL, Kopan R, Dougherty JD.

Nucleic Acids Res. 2015 Dec 15;43(22):10804-20. doi: 10.1093/nar/gkv1262. Epub 2015 Nov 19.

15.

Notch signal strength controls cell fate in the haemogenic endothelium.

Gama-Norton L, Ferrando E, Ruiz-Herguido C, Liu Z, Guiu J, Islam AB, Lee SU, Yan M, Guidos CJ, López-Bigas N, Maeda T, Espinosa L, Kopan R, Bigas A.

Nat Commun. 2015 Oct 14;6:8510. doi: 10.1038/ncomms9510. Erratum in: Nat Commun. 2016;7:10978. Liu, Zenhy [Corrected to Liu, Zhenyi].

16.

Intrinsic Age-Dependent Changes and Cell-Cell Contacts Regulate Nephron Progenitor Lifespan.

Chen S, Brunskill EW, Potter SS, Dexheimer PJ, Salomonis N, Aronow BJ, Hong CI, Zhang T, Kopan R.

Dev Cell. 2015 Oct 12;35(1):49-62. doi: 10.1016/j.devcel.2015.09.009.

17.

Corrigendum: Simple Copy Number Determination with Reference Query Pyrosequencing (RQPS).

Liu Z, Schneider DL, Kornfeld K, Kopan R.

Cold Spring Harb Protoc. 2015 Oct 1;2015(10):950. doi: 10.1101/pdb.corr090167. No abstract available.

PMID:
26430946
18.

Notch signaling regulates gastric antral LGR5 stem cell function.

Demitrack ES, Gifford GB, Keeley TM, Carulli AJ, VanDussen KL, Thomas D, Giordano TJ, Liu Z, Kopan R, Samuelson LC.

EMBO J. 2015 Oct 14;34(20):2522-36. doi: 10.15252/embj.201490583. Epub 2015 Aug 12.

19.

SpDamID: Marking DNA Bound by Protein Complexes Identifies Notch-Dimer Responsive Enhancers.

Hass MR, Liow HH, Chen X, Sharma A, Inoue YU, Inoue T, Reeb A, Martens A, Fulbright M, Raju S, Stevens M, Boyle S, Park JS, Weirauch MT, Brent MR, Kopan R.

Mol Cell. 2015 Aug 20;59(4):685-97. doi: 10.1016/j.molcel.2015.07.008. Epub 2015 Aug 6. Erratum in: Mol Cell. 2016 Oct 6;64(1):213.

20.

The intracellular domains of Notch1 and Notch2 are functionally equivalent during development and carcinogenesis.

Liu Z, Brunskill E, Varnum-Finney B, Zhang C, Zhang A, Jay PY, Bernstein I, Morimoto M, Kopan R.

Development. 2015 Jul 15;142(14):2452-63. doi: 10.1242/dev.125492. Epub 2015 Jun 10.

21.

Second-generation Notch1 activity-trap mouse line (N1IP::CreHI) provides a more comprehensive map of cells experiencing Notch1 activity.

Liu Z, Brunskill E, Boyle S, Chen S, Turkoz M, Guo Y, Grant R, Kopan R.

Development. 2015 Mar 15;142(6):1193-202. doi: 10.1242/dev.119529. Epub 2015 Feb 27.

22.

Monitoring Notch activation in cultured mammalian cells: luciferase complementation imaging assays.

Ilagan MX, Kopan R.

Methods Mol Biol. 2014;1187:155-68. doi: 10.1007/978-1-4939-1139-4_12.

PMID:
25053488
23.

Monitoring Notch activation in cultured mammalian cells: transcriptional reporter assays.

Ilagan MX, Kopan R.

Methods Mol Biol. 2014;1187:143-54. doi: 10.1007/978-1-4939-1139-4_11. Review.

PMID:
25053487
24.

Nephron progenitor cells: shifting the balance of self-renewal and differentiation.

Kopan R, Chen S, Little M.

Curr Top Dev Biol. 2014;107:293-331. doi: 10.1016/B978-0-12-416022-4.00011-1. Review.

PMID:
24439811
25.

Circulating TSLP associates with decreased wheezing in non-atopic preschool children: data from the URECA birth cohort.

Demehri S, Yockey LJ, Visness CM, Jaffee KF, Turkoz A, Wood RA, O'Connor GT, Kattan M, Gern JE, Gergen PJ, Holtzman M, Bloomberg G, Kopan R.

Clin Exp Allergy. 2014 Jun;44(6):851-7. doi: 10.1111/cea.12270.

26.

Notch signaling is required for the formation of mesangial cells from a stromal mesenchyme precursor during kidney development.

Boyle SC, Liu Z, Kopan R.

Development. 2014 Jan;141(2):346-54. doi: 10.1242/dev.100271. Epub 2013 Dec 18.

27.

Alagille, Notch, and robustness: why duplicating systems does not ensure redundancy.

Kopan R, Chen S, Liu Z.

Pediatr Nephrol. 2014 Apr;29(4):651-7. doi: 10.1007/s00467-013-2661-y. Epub 2013 Nov 24. Review.

28.

Structural analysis uncovers lipid-binding properties of Notch ligands.

Chillakuri CR, Sheppard D, Ilagan MX, Holt LR, Abbott F, Liang S, Kopan R, Handford PA, Lea SM.

Cell Rep. 2013 Nov 27;5(4):861-7. doi: 10.1016/j.celrep.2013.10.029. Epub 2013 Nov 14.

29.

Chronic itch development in sensory neurons requires BRAF signaling pathways.

Zhao ZQ, Huo FQ, Jeffry J, Hampton L, Demehri S, Kim S, Liu XY, Barry DM, Wan L, Liu ZC, Li H, Turkoz A, Ma K, Cornelius LA, Kopan R, Battey JF Jr, Zhong J, Chen ZF.

J Clin Invest. 2013 Nov;123(11):4769-80.

30.

Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens.

Satpathy AT, Briseño CG, Lee JS, Ng D, Manieri NA, Kc W, Wu X, Thomas SR, Lee WL, Turkoz M, McDonald KG, Meredith MM, Song C, Guidos CJ, Newberry RD, Ouyang W, Murphy TL, Stappenbeck TS, Gommerman JL, Nussenzweig MC, Colonna M, Kopan R, Murphy KM.

Nat Immunol. 2013 Sep;14(9):937-48. doi: 10.1038/ni.2679. Epub 2013 Aug 4.

31.

The extracellular domain of Notch2 increases its cell-surface abundance and ligand responsiveness during kidney development.

Liu Z, Chen S, Boyle S, Zhu Y, Zhang A, Piwnica-Worms DR, Ilagan MX, Kopan R.

Dev Cell. 2013 Jun 24;25(6):585-98. doi: 10.1016/j.devcel.2013.05.022.

32.

In vivo visualization of Notch1 proteolysis reveals the heterogeneity of Notch1 signaling activity in the mouse cochlea.

Liu Z, Liu Z, Walters BJ, Owen T, Kopan R, Zuo J.

PLoS One. 2013 May 31;8(5):e64903. doi: 10.1371/journal.pone.0064903. Print 2013.

33.

The absence of a microbiota enhances TSLP expression in mice with defective skin barrier but does not affect the severity of their allergic inflammation.

Yockey LJ, Demehri S, Turkoz M, Turkoz A, Ahern PP, Jassim O, Manivasagam S, Kearney JF, Gordon JI, Kopan R.

J Invest Dermatol. 2013 Dec;133(12):2714-2721. doi: 10.1038/jid.2013.228. Epub 2013 May 22.

34.

Epidermal ADAM17 is dispensable for notch activation.

Groot AJ, Cobzaru C, Weber S, Saftig P, Blobel CP, Kopan R, Vooijs M, Franzke CW.

J Invest Dermatol. 2013 Sep;133(9):2286-8. doi: 10.1038/jid.2013.162. Epub 2013 Apr 3. No abstract available.

35.

Selective blockade of transport via SERCA inhibition: the answer for oncogenic forms of Notch?

Ilagan MX, Kopan R.

Cancer Cell. 2013 Mar 18;23(3):267-9. doi: 10.1016/j.ccr.2013.02.020.

36.

Different assemblies of Notch receptors coordinate the distribution of the major bronchial Clara, ciliated and neuroendocrine cells.

Morimoto M, Nishinakamura R, Saga Y, Kopan R.

Development. 2012 Dec 1;139(23):4365-73. doi: 10.1242/dev.083840.

37.

Loss of RBPj in postnatal excitatory neurons does not cause neurodegeneration or memory impairments in aged mice.

Sato C, Turkoz M, Dearborn JT, Wozniak DF, Kopan R, Hass MR.

PLoS One. 2012;7(10):e48180. doi: 10.1371/journal.pone.0048180. Epub 2012 Oct 26.

38.

Elevated epidermal thymic stromal lymphopoietin levels establish an antitumor environment in the skin.

Demehri S, Turkoz A, Manivasagam S, Yockey LJ, Turkoz M, Kopan R.

Cancer Cell. 2012 Oct 16;22(4):494-505. doi: 10.1016/j.ccr.2012.08.017.

39.

Notch signaling.

Kopan R.

Cold Spring Harb Perspect Biol. 2012 Oct 1;4(10). pii: a011213. doi: 10.1101/cshperspect.a011213. Review. No abstract available.

40.

FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man.

Barak H, Huh SH, Chen S, Jeanpierre C, Martinovic J, Parisot M, Bole-Feysot C, Nitschké P, Salomon R, Antignac C, Ornitz DM, Kopan R.

Dev Cell. 2012 Jun 12;22(6):1191-207. doi: 10.1016/j.devcel.2012.04.018.

41.

Conditional deletion of Notch1 and Notch2 genes in excitatory neurons of postnatal forebrain does not cause neurodegeneration or reduction of Notch mRNAs and proteins.

Zheng J, Watanabe H, Wines-Samuelson M, Zhao H, Gridley T, Kopan R, Shen J.

J Biol Chem. 2012 Jun 8;287(24):20356-68. doi: 10.1074/jbc.M112.349738. Epub 2012 Apr 13.

42.

Physiological notch signaling maintains bone homeostasis via RBPjk and Hey upstream of NFATc1.

Tu X, Chen J, Lim J, Karner CM, Lee SY, Heisig J, Wiese C, Surendran K, Kopan R, Gessler M, Long F.

PLoS Genet. 2012;8(3):e1002577. doi: 10.1371/journal.pgen.1002577. Epub 2012 Mar 22.

43.

The black box illuminated: signals and signaling.

Mascia F, Denning M, Kopan R, Yuspa SH.

J Invest Dermatol. 2012 Mar;132(3 Pt 2):811-9. doi: 10.1038/jid.2011.406. Epub 2011 Dec 15. Review.

44.

AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch.

Lee JS, Cella M, McDonald KG, Garlanda C, Kennedy GD, Nukaya M, Mantovani A, Kopan R, Bradfield CA, Newberry RD, Colonna M.

Nat Immunol. 2011 Nov 20;13(2):144-51. doi: 10.1038/ni.2187.

45.

Notch pathway activation can replace the requirement for Wnt4 and Wnt9b in mesenchymal-to-epithelial transition of nephron stem cells.

Boyle SC, Kim M, Valerius MT, McMahon AP, Kopan R.

Development. 2011 Oct;138(19):4245-54. doi: 10.1242/dev.070433. Epub 2011 Aug 18.

46.

Real-time imaging of notch activation with a luciferase complementation-based reporter.

Ilagan MX, Lim S, Fulbright M, Piwnica-Worms D, Kopan R.

Sci Signal. 2011 Jul 12;4(181):rs7. doi: 10.1126/scisignal.2001656.

47.

Chromatin-based mechanisms of renal epithelial differentiation.

Surendran K, Kopan R.

J Am Soc Nephrol. 2011 Jul;22(7):1208-12. doi: 10.1681/ASN.2010101018. Epub 2011 Jun 23. Review.

48.

Notch: architect, landscaper, and guardian of the intestine.

Vooijs M, Liu Z, Kopan R.

Gastroenterology. 2011 Aug;141(2):448-59. doi: 10.1053/j.gastro.2011.06.003. Epub 2011 Jun 12.

49.

Notch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in mice.

Liu Z, Turkoz A, Jackson EN, Corbo JC, Engelbach JA, Garbow JR, Piwnica-Worms DR, Kopan R.

J Clin Invest. 2011 Feb;121(2):800-8. doi: 10.1172/JCI43114. Epub 2011 Jan 25.

50.

Dll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells.

Pellegrinet L, Rodilla V, Liu Z, Chen S, Koch U, Espinosa L, Kaestner KH, Kopan R, Lewis J, Radtke F.

Gastroenterology. 2011 Apr;140(4):1230-1240.e1-7. doi: 10.1053/j.gastro.2011.01.005. Epub 2011 Jan 14.

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