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Items: 1 to 50 of 341

1.

Stimulus-dependent chromatin dynamics, citrullination, calcium signalling and ROS production during NET formation.

de Bont CM, Koopman WJH, Boelens WC, Pruijn GJM.

Biochim Biophys Acta Mol Cell Res. 2018 Nov;1865(11 Pt A):1621-1629. doi: 10.1016/j.bbamcr.2018.08.014. Epub 2018 Aug 25.

PMID:
30327203
2.

Mitochondrial morphofunction in mammalian cells.

Bulthuis EP, Adjobo-Hermans MW, Willems PHGM, Koopman WJH.

Antioxid Redox Signal. 2018 Sep 28. doi: 10.1089/ars.2018.7534. [Epub ahead of print]

PMID:
30266077
3.

Corrigendum to "Mitigation of NADH:ubiquinone oxidoreductase deficiency by chronic Trolox treatment" [Biochimica et Biophysica Acta 1777/7-8 (2008) 853-859].

Koopman WJH, Verkaart S, van Emst-de Vries SE, Grefte S, Smeitink JAM, Nijtmans LGJ, Willems PHGM.

Biochim Biophys Acta Bioenerg. 2018 Jun 5. pii: S0005-2728(18)30149-X. doi: 10.1016/j.bbabio.2018.06.003. [Epub ahead of print] No abstract available.

PMID:
29883590
4.

Extracellular acidification induces ROS- and mPTP-mediated death in HEK293 cells.

Teixeira J, Basit F, Swarts HG, Forkink M, Oliveira PJ, Willems PHGM, Koopman WJH.

Redox Biol. 2018 May;15:394-404. doi: 10.1016/j.redox.2017.12.018. Epub 2017 Dec 30.

5.

Frapbot: An open-source application for FRAP data.

Kohze R, Dieteren CEJ, Koopman WJH, Brock R, Schmidt S.

Cytometry A. 2017 Aug;91(8):810-814. doi: 10.1002/cyto.a.23172. Epub 2017 Jul 20.

6.

Modulation of oxidative phosphorylation and redox homeostasis in mitochondrial NDUFS4 deficiency via mesenchymal stem cells.

Melcher M, Danhauser K, Seibt A, Degistirici Ö, Baertling F, Kondadi AK, Reichert AS, Koopman WJH, Willems PHGM, Rodenburg RJ, Mayatepek E, Meisel R, Distelmaier F.

Stem Cell Res Ther. 2017 Jun 24;8(1):150. doi: 10.1186/s13287-017-0601-7.

7.

Cellular Redox Profiling Using High-content Microscopy.

Sieprath T, Corne T, Robijns J, Koopman WJH, De Vos WH.

J Vis Exp. 2017 May 14;(123). doi: 10.3791/55449.

PMID:
28570523
8.

Survey of Canadian Myotonic Dystrophy Patients' Access to Computer Technology.

Climans SA, Piechowicz C, Koopman WJ, Venance SL.

Can J Neurol Sci. 2017 Sep;44(5):567-571. doi: 10.1017/cjn.2017.47. Epub 2017 May 24.

PMID:
28535832
9.

Mitochondrial complex I inhibition triggers a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis in melanoma cells.

Basit F, van Oppen LM, Schöckel L, Bossenbroek HM, van Emst-de Vries SE, Hermeling JC, Grefte S, Kopitz C, Heroult M, Hgm Willems P, Koopman WJ.

Cell Death Dis. 2017 Mar 30;8(3):e2716. doi: 10.1038/cddis.2017.133.

10.

Acute stimulation of glucose influx upon mitoenergetic dysfunction requires LKB1, AMPK, Sirt2 and mTOR-RAPTOR.

Liemburg-Apers DC, Wagenaars JA, Smeitink JA, Willems PH, Koopman WJ.

J Cell Sci. 2016 Dec 1;129(23):4411-4423. Epub 2016 Oct 28.

11.

Quantifying ROS levels using CM-H2DCFDA and HyPer.

Oparka M, Walczak J, Malinska D, van Oppen LMPE, Szczepanowska J, Koopman WJH, Wieckowski MR.

Methods. 2016 Oct 15;109:3-11. doi: 10.1016/j.ymeth.2016.06.008. Epub 2016 Jun 11. Review.

PMID:
27302663
12.

Enteric neurons from Parkinson's disease patients display ex vivo aberrations in mitochondrial structure.

Baumuratov AS, Antony PM, Ostaszewski M, He F, Salamanca L, Antunes L, Weber J, Longhino L, Derkinderen P, Koopman WJ, Diederich NJ.

Sci Rep. 2016 Sep 14;6:33117. doi: 10.1038/srep33117.

13.

Multiplexed high-content analysis of mitochondrial morphofunction using live-cell microscopy.

Iannetti EF, Smeitink JA, Beyrath J, Willems PH, Koopman WJ.

Nat Protoc. 2016 Sep;11(9):1693-710. doi: 10.1038/nprot.2016.094. Epub 2016 Aug 18.

PMID:
27560174
14.

A Review of Azathioprine-Associated Hepatotoxicity and Myelosuppression in Myasthenia Gravis.

Jack KL, Koopman WJ, Hulley D, Nicolle MW.

J Clin Neuromuscul Dis. 2016 Sep;18(1):12-20. doi: 10.1097/CND.0000000000000133.

PMID:
27552384
15.

Hope, Coping, and Quality of Life in Adults with Myasthenia Gravis.

Koopman WJ, LeBlanc N, Fowler S, Nicolle MW, Hulley D.

Can J Neurosci Nurs. 2016;38(1):56-64.

PMID:
27468602
16.

Integrated High-Content Quantification of Intracellular ROS Levels and Mitochondrial Morphofunction.

Sieprath T, Corne TD, Willems PH, Koopman WJ, De Vos WH.

Adv Anat Embryol Cell Biol. 2016;219:149-77. doi: 10.1007/978-3-319-28549-8_6. Review.

PMID:
27207366
17.

Mitochondrial disorders in children: toward development of small-molecule treatment strategies.

Koopman WJ, Beyrath J, Fung CW, Koene S, Rodenburg RJ, Willems PH, Smeitink JA.

EMBO Mol Med. 2016 Apr 1;8(4):311-27. doi: 10.15252/emmm.201506131. Review.

18.

Hard to Swallow: A Phenomenological Exploration of the Experience of Caring for Individuals With Myotonic Dystrophy and Dysphagia.

LaDonna KA, Koopman WJ, Ray SL, Venance SL.

J Neurosci Nurs. 2016 Feb;48(1):42-51. doi: 10.1097/JNN.0000000000000178.

PMID:
26720320
19.

Impaired primary mouse myotube formation on crosslinked type I collagen films is enhanced by laminin and entactin.

Grefte S, Adjobo-Hermans MJW, Versteeg EMM, Koopman WJH, Daamen WF.

Acta Biomater. 2016 Jan;30:265-276. doi: 10.1016/j.actbio.2015.11.009. Epub 2015 Nov 7.

PMID:
26555376
20.

Complex I and complex III inhibition specifically increase cytosolic hydrogen peroxide levels without inducing oxidative stress in HEK293 cells.

Forkink M, Basit F, Teixeira J, Swarts HG, Koopman WJ, Willems PH.

Redox Biol. 2015 Dec;6:607-16. doi: 10.1016/j.redox.2015.09.003. Epub 2015 Oct 23.

21.

Targeting mitochondrial complex I using BAY 87-2243 reduces melanoma tumor growth.

Schöckel L, Glasauer A, Basit F, Bitschar K, Truong H, Erdmann G, Algire C, Hägebarth A, Willems PH, Kopitz C, Koopman WJ, Héroult M.

Cancer Metab. 2015 Oct 20;3:11. doi: 10.1186/s40170-015-0138-0. eCollection 2015.

22.

Mitoenergetic Dysfunction Triggers a Rapid Compensatory Increase in Steady-State Glucose Flux.

Liemburg-Apers DC, Schirris TJ, Russel FG, Willems PH, Koopman WJ.

Biophys J. 2015 Oct 6;109(7):1372-86. doi: 10.1016/j.bpj.2015.08.002.

23.

Statin-Induced Myopathy Is Associated with Mitochondrial Complex III Inhibition.

Schirris TJ, Renkema GH, Ritschel T, Voermans NC, Bilos A, van Engelen BG, Brandt U, Koopman WJ, Beyrath JD, Rodenburg RJ, Willems PH, Smeitink JA, Russel FG.

Cell Metab. 2015 Sep 1;22(3):399-407. doi: 10.1016/j.cmet.2015.08.002.

24.

Increased mitochondrial ATP production capacity in brain of healthy mice and a mouse model of isolated complex I deficiency after isoflurane anesthesia.

Manjeri GR, Rodenburg RJ, Blanchet L, Roelofs S, Nijtmans LG, Smeitink JA, Driessen JJ, Koopman WJ, Willems PH.

J Inherit Metab Dis. 2016 Jan;39(1):59-65. doi: 10.1007/s10545-015-9885-x. Epub 2015 Aug 27.

25.

Redox Homeostasis and Mitochondrial Dynamics.

Willems PH, Rossignol R, Dieteren CE, Murphy MP, Koopman WJ.

Cell Metab. 2015 Aug 4;22(2):207-18. doi: 10.1016/j.cmet.2015.06.006. Epub 2015 Jul 9. Review.

26.

Interactions between mitochondrial reactive oxygen species and cellular glucose metabolism.

Liemburg-Apers DC, Willems PH, Koopman WJ, Grefte S.

Arch Toxicol. 2015 Aug;89(8):1209-26. doi: 10.1007/s00204-015-1520-y. Epub 2015 Jun 6. Review.

27.

Sustained accumulation of prelamin A and depletion of lamin A/C both cause oxidative stress and mitochondrial dysfunction but induce different cell fates.

Sieprath T, Corne TD, Nooteboom M, Grootaert C, Rajkovic A, Buysschaert B, Robijns J, Broers JL, Ramaekers FC, Koopman WJ, Willems PH, De Vos WH.

Nucleus. 2015;6(3):236-46. doi: 10.1080/19491034.2015.1050568. Epub 2015 May 21.

28.

Rotenone inhibits primary murine myotube formation via Raf-1 and ROCK2.

Grefte S, Wagenaars JA, Jansen R, Willems PH, Koopman WJ.

Biochim Biophys Acta. 2015 Jul;1853(7):1606-14. doi: 10.1016/j.bbamcr.2015.03.010. Epub 2015 Mar 28.

29.

PKC-mediated inhibitory feedback of the cholecystokinin 1 receptor controls the shape of oscillatory Ca²⁺ signals.

Willems PH, Pahle J, Stalpers XL, Mugahid D, Nikolaew A, Koopman WJ, Kummer U.

FEBS J. 2015 Jun;282(11):2187-201. doi: 10.1111/febs.13267. Epub 2015 Apr 13.

30.

Skeletal muscle mitochondria of NDUFS4-/- mice display normal maximal pyruvate oxidation and ATP production.

Alam MT, Manjeri GR, Rodenburg RJ, Smeitink JA, Notebaart RA, Huynen M, Willems PH, Koopman WJ.

Biochim Biophys Acta. 2015 Jun-Jul;1847(6-7):526-33. doi: 10.1016/j.bbabio.2015.02.006. Epub 2015 Feb 14.

31.

Toward high-content screening of mitochondrial morphology and membrane potential in living cells.

Iannetti EF, Willems PH, Pellegrini M, Beyrath J, Smeitink JA, Blanchet L, Koopman WJ.

Int J Biochem Cell Biol. 2015 Jun;63:66-70. doi: 10.1016/j.biocel.2015.01.020. Epub 2015 Feb 8. Review.

PMID:
25668473
32.

A genome-wide association study of myasthenia gravis.

Renton AE, Pliner HA, Provenzano C, Evoli A, Ricciardi R, Nalls MA, Marangi G, Abramzon Y, Arepalli S, Chong S, Hernandez DG, Johnson JO, Bartoccioni E, Scuderi F, Maestri M, Gibbs JR, Errichiello E, Chiò A, Restagno G, Sabatelli M, Macek M, Scholz SW, Corse A, Chaudhry V, Benatar M, Barohn RJ, McVey A, Pasnoor M, Dimachkie MM, Rowin J, Kissel J, Freimer M, Kaminski HJ, Sanders DB, Lipscomb B, Massey JM, Chopra M, Howard JF Jr, Koopman WJ, Nicolle MW, Pascuzzi RM, Pestronk A, Wulf C, Florence J, Blackmore D, Soloway A, Siddiqi Z, Muppidi S, Wolfe G, Richman D, Mezei MM, Jiwa T, Oger J, Drachman DB, Traynor BJ.

JAMA Neurol. 2015 Apr;72(4):396-404. doi: 10.1001/jamaneurol.2014.4103.

33.

Live-cell assessment of mitochondrial reactive oxygen species using dihydroethidine.

Forkink M, Willems PH, Koopman WJ, Grefte S.

Methods Mol Biol. 2015;1264:161-9. doi: 10.1007/978-1-4939-2257-4_15.

PMID:
25631012
34.

Quantifying small molecule phenotypic effects using mitochondrial morpho-functional fingerprinting and machine learning.

Blanchet L, Smeitink JA, van Emst-de Vries SE, Vogels C, Pellegrini M, Jonckheere AI, Rodenburg RJ, Buydens LM, Beyrath J, Willems PH, Koopman WJ.

Sci Rep. 2015 Jan 26;5:8035. doi: 10.1038/srep08035.

35.

Mitochondrial dysfunction in primary human fibroblasts triggers an adaptive cell survival program that requires AMPK-α.

Distelmaier F, Valsecchi F, Liemburg-Apers DC, Lebiedzinska M, Rodenburg RJ, Heil S, Keijer J, Fransen J, Imamura H, Danhauser K, Seibt A, Viollet B, Gellerich FN, Smeitink JA, Wieckowski MR, Willems PH, Koopman WJ.

Biochim Biophys Acta. 2015 Mar;1852(3):529-40. doi: 10.1016/j.bbadis.2014.12.012. Epub 2014 Dec 20.

36.

Photo-induction and automated quantification of reversible mitochondrial permeability transition pore opening in primary mouse myotubes.

Blanchet L, Grefte S, Smeitink JA, Willems PH, Koopman WJ.

PLoS One. 2014 Nov 25;9(11):e114090. doi: 10.1371/journal.pone.0114090. eCollection 2014.

37.

Automated quantification and integrative analysis of 2D and 3D mitochondrial shape and network properties.

Nikolaisen J, Nilsson LI, Pettersen IK, Willems PH, Lorens JB, Koopman WJ, Tronstad KJ.

PLoS One. 2014 Jul 2;9(7):e101365. doi: 10.1371/journal.pone.0101365. eCollection 2014.

38.

Mitochondrial hyperpolarization during chronic complex I inhibition is sustained by low activity of complex II, III, IV and V.

Forkink M, Manjeri GR, Liemburg-Apers DC, Nibbeling E, Blanchard M, Wojtala A, Smeitink JA, Wieckowski MR, Willems PH, Koopman WJ.

Biochim Biophys Acta. 2014 Aug;1837(8):1247-56. doi: 10.1016/j.bbabio.2014.04.008. Epub 2014 Apr 24.

39.

Function and regulation of the Na+-Ca2+ exchanger NCX3 splice variants in brain and skeletal muscle.

Michel LY, Verkaart S, Koopman WJ, Willems PH, Hoenderop JG, Bindels RJ.

J Biol Chem. 2014 Apr 18;289(16):11293-303. doi: 10.1074/jbc.M113.529388. Epub 2014 Mar 10.

40.

Regulation and quantification of cellular mitochondrial morphology and content.

Tronstad KJ, Nooteboom M, Nilsson LI, Nikolaisen J, Sokolewicz M, Grefte S, Pettersen IK, Dyrstad S, Hoel F, Willems PH, Koopman WJ.

Curr Pharm Des. 2014;20(35):5634-52. Review.

PMID:
24606803
41.

A guide to diagnosis and treatment of Leigh syndrome.

Baertling F, Rodenburg RJ, Schaper J, Smeitink JA, Koopman WJ, Mayatepek E, Morava E, Distelmaier F.

J Neurol Neurosurg Psychiatry. 2014 Mar;85(3):257-65. doi: 10.1136/jnnp-2012-304426. Epub 2013 Jun 14. Review.

PMID:
23772060
42.

Cellular and animal models for mitochondrial complex I deficiency: a focus on the NDUFS4 subunit.

Breuer ME, Willems PH, Smeitink JA, Koopman WJ, Nooteboom M.

IUBMB Life. 2013 Mar;65(3):202-8. doi: 10.1002/iub.1127. Epub 2013 Feb 3. Review.

43.

Primary fibroblasts of NDUFS4(-/-) mice display increased ROS levels and aberrant mitochondrial morphology.

Valsecchi F, Grefte S, Roestenberg P, Joosten-Wagenaars J, Smeitink JA, Willems PH, Koopman WJ.

Mitochondrion. 2013 Sep;13(5):436-43. doi: 10.1016/j.mito.2012.12.001. Epub 2012 Dec 9.

PMID:
23234723
44.

OXPHOS mutations and neurodegeneration.

Koopman WJ, Distelmaier F, Smeitink JA, Willems PH.

EMBO J. 2013 Jan 9;32(1):9-29. doi: 10.1038/emboj.2012.300. Epub 2012 Nov 13. Review.

45.

A mutation in the FAM36A gene, the human ortholog of COX20, impairs cytochrome c oxidase assembly and is associated with ataxia and muscle hypotonia.

Szklarczyk R, Wanschers BF, Nijtmans LG, Rodenburg RJ, Zschocke J, Dikow N, van den Brand MA, Hendriks-Franssen MG, Gilissen C, Veltman JA, Nooteboom M, Koopman WJ, Willems PH, Smeitink JA, Huynen MA, van den Heuvel LP.

Hum Mol Genet. 2013 Feb 15;22(4):656-67. doi: 10.1093/hmg/dds473. Epub 2012 Nov 2.

PMID:
23125284
46.

Subunit-specific incorporation efficiency and kinetics in mitochondrial complex I homeostasis.

Dieteren CE, Koopman WJ, Swarts HG, Peters JG, Maczuga P, van Gemst JJ, Masereeuw R, Smeitink JA, Nijtmans LG, Willems PH.

J Biol Chem. 2012 Dec 7;287(50):41851-60. doi: 10.1074/jbc.M112.391151. Epub 2012 Oct 4.

47.

Patient-derived fibroblasts indicate oxidative stress status and may justify antioxidant therapy in OXPHOS disorders.

Voets AM, Lindsey PJ, Vanherle SJ, Timmer ED, Esseling JJ, Koopman WJ, Willems PH, Schoonderwoerd GC, De Groote D, Poll-The BT, de Coo IF, Smeets HJ.

Biochim Biophys Acta. 2012 Nov;1817(11):1971-8. doi: 10.1016/j.bbabio.2012.07.001. Epub 2012 Jul 13.

48.

A ratiometric fluorescent probe for assessing mitochondrial phospholipid peroxidation within living cells.

Prime TA, Forkink M, Logan A, Finichiu PG, McLachlan J, Li Pun PB, Koopman WJ, Larsen L, Latter MJ, Smith RA, Murphy MP.

Free Radic Biol Med. 2012 Aug 1;53(3):544-53. doi: 10.1016/j.freeradbiomed.2012.05.033. Epub 2012 May 29.

PMID:
22659314
49.

Trolox-sensitive reactive oxygen species regulate mitochondrial morphology, oxidative phosphorylation and cytosolic calcium handling in healthy cells.

Distelmaier F, Valsecchi F, Forkink M, van Emst-de Vries S, Swarts HG, Rodenburg RJ, Verwiel ET, Smeitink JA, Willems PH, Koopman WJ.

Antioxid Redox Signal. 2012 Dec 15;17(12):1657-69. doi: 10.1089/ars.2011.4294. Epub 2012 Jun 13.

50.

Monogenic mitochondrial disorders.

Koopman WJ, Willems PH, Smeitink JA.

N Engl J Med. 2012 Mar 22;366(12):1132-41. doi: 10.1056/NEJMra1012478. Review. No abstract available.

PMID:
22435372

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