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Items: 1 to 50 of 306

1.

Genome-Wide Off-Target Analysis in CRISPR-Cas9 Modified Mice and Their Offspring.

Dong Y, Li H, Zhao L, Koopman P, Zhang F, Huang JX.

G3 (Bethesda). 2019 Nov 5;9(11):3645-3651. doi: 10.1534/g3.119.400503.

2.

Endocardium differentiation through Sox17 expression in endocardium precursor cells regulates heart development in mice.

Saba R, Kitajima K, Rainbow L, Engert S, Uemura M, Ishida H, Kokkinopoulos I, Shintani Y, Miyagawa S, Kanai Y, Kanai-Azuma M, Koopman P, Meno C, Kenny J, Lickert H, Saga Y, Suzuki K, Sawa Y, Yashiro K.

Sci Rep. 2019 Aug 16;9(1):11953. doi: 10.1038/s41598-019-48321-y.

3.

Author Correction: Human sex reversal is caused by duplication or deletion of core enhancers upstream of SOX9.

Croft B, Ohnesorg T, Hewitt J, Bowles J, Quinn A, Tan J, Corbin V, Pelosi E, van den Bergen J, Sreenivasan R, Knarston I, Robevska G, Vu DC, Hutson J, Harley V, Ayers K, Koopman P, Sinclair A.

Nat Commun. 2019 Jul 23;10(1):3351. doi: 10.1038/s41467-019-11310-w.

4.

Nr5a1 suppression during the murine fetal period optimizes ovarian development by fine-tuning Notch signaling.

Nomura R, Kashimada K, Suzuki H, Zhao L, Tsuji-Hosokawa A, Yagita H, Takagi M, Kanai Y, Bowles J, Koopman P, Kanai-Azuma M, Morio T.

J Cell Sci. 2019 Apr 15;132(8). pii: jcs223768. doi: 10.1242/jcs.223768.

5.

Gene editing of the multi-copy H2A.B gene and its importance for fertility.

Anuar ND, Kurscheid S, Field M, Zhang L, Rebar E, Gregory P, Buchou T, Bowles J, Koopman P, Tremethick DJ, Soboleva TA.

Genome Biol. 2019 Jan 31;20(1):23. doi: 10.1186/s13059-019-1633-3.

6.

Corrigendum and Editorial Warning Regarding Use of the MMAS-8 Scale (The Health Buddies App as a Novel Tool to Improve Adherence and Knowledge in Atrial Fibrillation Patients: A Pilot Study).

Desteghe L, Kluts K, Vijgen J, Koopman P, Dilling-Boer D, Schurmans J, Dendale P, Heidbuchel H.

JMIR Mhealth Uhealth. 2018 Nov 30;6(11):e12202. doi: 10.2196/12202.

7.

Human sex reversal is caused by duplication or deletion of core enhancers upstream of SOX9.

Croft B, Ohnesorg T, Hewitt J, Bowles J, Quinn A, Tan J, Corbin V, Pelosi E, van den Bergen J, Sreenivasan R, Knarston I, Robevska G, Vu DC, Hutson J, Harley V, Ayers K, Koopman P, Sinclair A.

Nat Commun. 2018 Dec 14;9(1):5319. doi: 10.1038/s41467-018-07784-9. Erratum in: Nat Commun. 2019 Jul 23;10(1):3351.

8.

Identification of Candidate Genes for Mayer-Rokitansky-Küster-Hauser Syndrome Using Genomic Approaches.

Backhouse B, Hanna C, Robevska G, van den Bergen J, Pelosi E, Simons C, Koopman P, Juniarto AZ, Grover S, Faradz S, Sinclair A, Ayers K, Tan TY.

Sex Dev. 2019;13(1):26-34. doi: 10.1159/000494896. Epub 2018 Dec 1.

9.

Effect of reinforced, targeted in-person education using the Jessa Atrial fibrillation Knowledge Questionnaire in patients with atrial fibrillation: A randomized controlled trial.

Desteghe L, Engelhard L, Vijgen J, Koopman P, Dilling-Boer D, Schurmans J, Delesie M, Dendale P, Heidbuchel H.

Eur J Cardiovasc Nurs. 2019 Mar;18(3):194-203. doi: 10.1177/1474515118804353. Epub 2018 Oct 17.

PMID:
30328701
10.

Retinoic Acid Antagonizes Testis Development in Mice.

Bowles J, Feng CW, Ineson J, Miles K, Spiller CM, Harley VR, Sinclair AH, Koopman P.

Cell Rep. 2018 Jul 31;24(5):1330-1341. doi: 10.1016/j.celrep.2018.06.111.

11.

Mutant NR5A1/SF-1 in patients with disorders of sex development shows defective activation of the SOX9 TESCO enhancer.

Sreenivasan R, Ludbrook L, Fisher B, Declosmenil F, Knower KC, Croft B, Bird AD, Ryan J, Bashamboo A, Sinclair AH, Koopman P, McElreavey K, Poulat F, Harley VR.

Hum Mutat. 2018 Dec;39(12):1861-1874. doi: 10.1002/humu.23603. Epub 2018 Aug 22.

PMID:
30067310
12.

Transcriptomic analysis of mRNA expression and alternative splicing during mouse sex determination.

Zhao L, Wang C, Lehman ML, He M, An J, Svingen T, Spiller CM, Ng ET, Nelson CC, Koopman P.

Mol Cell Endocrinol. 2018 Dec 15;478:84-96. doi: 10.1016/j.mce.2018.07.010. Epub 2018 Jul 24.

PMID:
30053582
13.

Effectiveness and usability of an online tailored education platform for atrial fibrillation patients undergoing a direct current cardioversion or pulmonary vein isolation.

Desteghe L, Germeys J, Vijgen J, Koopman P, Dilling-Boer D, Schurmans J, Delesie M, Dendale P, Heidbuchel H.

Int J Cardiol. 2018 Dec 1;272:123-129. doi: 10.1016/j.ijcard.2018.07.065. Epub 2018 Jul 17.

PMID:
30049498
14.

Innovation in dental education: The "On-the-Fly" approach to simultaneous development, implementation and evidence collection.

de Boer IR, Bakker DR, Serrano CM, Koopman P, Wesselink PR, Vervoorn JM.

Eur J Dent Educ. 2018 Nov;22(4):215-222. doi: 10.1111/eje.12331. Epub 2018 Mar 1.

PMID:
29498178
15.

A predominant cardiac phenotype of Anderson-Fabry disease in presence of a MYBPC3 gene mutation and a LAMA4 gene mutation.

Laenens D, Koopman P, Cools T.

Acta Cardiol. 2019 Feb;74(1):84-85. doi: 10.1080/00015385.2018.1433458. Epub 2018 Feb 7. No abstract available.

PMID:
29415625
16.

Telemonitoring-based feedback improves adherence to non-vitamin K antagonist oral anticoagulants intake in patients with atrial fibrillation.

Desteghe L, Vijgen J, Koopman P, Dilling-Boer D, Schurmans J, Dendale P, Heidbuchel H.

Eur Heart J. 2018 Apr 21;39(16):1394-1403. doi: 10.1093/eurheartj/ehx762.

PMID:
29300888
17.

SOX30 is required for male fertility in mice.

Feng CA, Spiller C, Merriner DJ, O'Bryan MK, Bowles J, Koopman P.

Sci Rep. 2017 Dec 15;7(1):17619. doi: 10.1038/s41598-017-17854-5.

18.

Testis Determination Requires a Specific FGFR2 Isoform to Repress FOXL2.

Bagheri-Fam S, Bird AD, Zhao L, Ryan JM, Yong M, Wilhelm D, Koopman P, Eswarakumar VP, Harley VR.

Endocrinology. 2017 Nov 1;158(11):3832-3843. doi: 10.1210/en.2017-00674.

19.

RNA binding protein Musashi-2 regulates PIWIL1 and TBX1 in mouse spermatogenesis.

Sutherland JM, Sobinoff AP, Fraser BA, Redgrove KA, Siddall NA, Koopman P, Hime GR, McLaughlin EA.

J Cell Physiol. 2018 Apr;233(4):3262-3273. doi: 10.1002/jcp.26168. Epub 2017 Oct 4.

PMID:
28884822
20.

Sex Determination in the Mammalian Germline.

Spiller C, Koopman P, Bowles J.

Annu Rev Genet. 2017 Nov 27;51:265-285. doi: 10.1146/annurev-genet-120215-035449. Epub 2017 Aug 30. Review.

PMID:
28853925
21.

The Health Buddies App as a Novel Tool to Improve Adherence and Knowledge in Atrial Fibrillation Patients: A Pilot Study.

Desteghe L, Kluts K, Vijgen J, Koopman P, Dilling-Boer D, Schurmans J, Dendale P, Heidbuchel H.

JMIR Mhealth Uhealth. 2017 Jul 19;5(7):e98. doi: 10.2196/mhealth.7420. Erratum in: JMIR Mhealth Uhealth. 2018 Nov 30;6(11):e12202.

22.

Small-Molecule Inhibitors of the SOX18 Transcription Factor.

Fontaine F, Overman J, Moustaqil M, Mamidyala S, Salim A, Narasimhan K, Prokoph N, Robertson AAB, Lua L, Alexandrov K, Koopman P, Capon RJ, Sierecki E, Gambin Y, Jauch R, Cooper MA, Zuegg J, Francois M.

Cell Chem Biol. 2017 Mar 16;24(3):346-359. doi: 10.1016/j.chembiol.2017.01.003. Epub 2017 Feb 2.

23.

Reduced Activity of SRY and its Target Enhancer Sox9-TESCO in a Mouse Species with X*Y Sex Reversal.

Zhao L, Quinn A, Ng ET, Veyrunes F, Koopman P.

Sci Rep. 2017 Feb 3;7:41378. doi: 10.1038/srep41378.

24.

Correction: Normal Levels of Sox9 Expression in the Developing Mouse Testis Depend on the TES/TESCO Enhancer, but This Does Not Act Alone.

Gonen N, Quinn A, O'Neill HC, Koopman P, Lovell-Badge R.

PLoS Genet. 2017 Feb 1;13(2):e1006584. doi: 10.1371/journal.pgen.1006584. eCollection 2017 Feb.

25.

Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice.

Overman J, Fontaine F, Moustaqil M, Mittal D, Sierecki E, Sacilotto N, Zuegg J, Robertson AA, Holmes K, Salim AA, Mamidyala S, Butler MS, Robinson AS, Lesieur E, Johnston W, Alexandrov K, Black BL, Hogan BM, De Val S, Capon RJ, Carroll JS, Bailey TL, Koopman P, Jauch R, Smyth MJ, Cooper MA, Gambin Y, Francois M.

Elife. 2017 Jan 31;6. pii: e21221. doi: 10.7554/eLife.21221.

26.

SOX4 regulates gonad morphogenesis and promotes male germ cell differentiation in mice.

Zhao L, Arsenault M, Ng ET, Longmuss E, Chau TC, Hartwig S, Koopman P.

Dev Biol. 2017 Mar 1;423(1):46-56. doi: 10.1016/j.ydbio.2017.01.013. Epub 2017 Jan 21.

27.

Mice Lacking Hbp1 Function Are Viable and Fertile.

Spiller CM, Wilhelm D, Jans DA, Bowles J, Koopman P.

PLoS One. 2017 Jan 20;12(1):e0170576. doi: 10.1371/journal.pone.0170576. eCollection 2017.

28.

Normal Levels of Sox9 Expression in the Developing Mouse Testis Depend on the TES/TESCO Enhancer, but This Does Not Act Alone.

Gonen N, Quinn A, O'Neill HC, Koopman P, Lovell-Badge R.

PLoS Genet. 2017 Jan 3;13(1):e1006520. doi: 10.1371/journal.pgen.1006520. eCollection 2017 Jan. Erratum in: PLoS Genet. 2017 Feb 1;13(2):e1006584.

29.

Disorders of sex development: insights from targeted gene sequencing of a large international patient cohort.

Eggers S, Sadedin S, van den Bergen JA, Robevska G, Ohnesorg T, Hewitt J, Lambeth L, Bouty A, Knarston IM, Tan TY, Cameron F, Werther G, Hutson J, O'Connell M, Grover SR, Heloury Y, Zacharin M, Bergman P, Kimber C, Brown J, Webb N, Hunter MF, Srinivasan S, Titmuss A, Verge CF, Mowat D, Smith G, Smith J, Ewans L, Shalhoub C, Crock P, Cowell C, Leong GM, Ono M, Lafferty AR, Huynh T, Visser U, Choong CS, McKenzie F, Pachter N, Thompson EM, Couper J, Baxendale A, Gecz J, Wheeler BJ, Jefferies C, MacKenzie K, Hofman P, Carter P, King RI, Krausz C, van Ravenswaaij-Arts CM, Looijenga L, Drop S, Riedl S, Cools M, Dawson A, Juniarto AZ, Khadilkar V, Khadilkar A, Bhatia V, Dũng VC, Atta I, Raza J, Thi Diem Chi N, Hao TK, Harley V, Koopman P, Warne G, Faradz S, Oshlack A, Ayers KL, Sinclair AH.

Genome Biol. 2016 Nov 29;17(1):243.

30.

Clinical benefit of atrio-ventricular delay optimization in patients with a dual-chamber pacemaker: a pilot study.

Cools T, Daerden T, Herbots L, Geukens R, Verwerft J, Koopman P, Dilling-Boer D, Hansen D, Vranckx P, Dendale P.

Acta Cardiol. 2016 Jun;71(3):257-65. doi: 10.2143/AC.71.3.3152085. No abstract available.

PMID:
27594120
31.

Knowledge gaps in patients with atrial fibrillation revealed by a new validated knowledge questionnaire.

Desteghe L, Engelhard L, Raymaekers Z, Kluts K, Vijgen J, Dilling-Boer D, Koopman P, Schurmans J, Dendale P, Heidbuchel H.

Int J Cardiol. 2016 Nov 15;223:906-914. doi: 10.1016/j.ijcard.2016.08.303. Epub 2016 Aug 21.

PMID:
27589038
32.

SOX9 regulates expression of the male fertility gene Ets variant factor 5 (ETV5) during mammalian sex development.

Alankarage D, Lavery R, Svingen T, Kelly S, Ludbrook L, Bagheri-Fam S, Koopman P, Harley V.

Int J Biochem Cell Biol. 2016 Oct;79:41-51. doi: 10.1016/j.biocel.2016.08.005. Epub 2016 Aug 4.

PMID:
27498191
33.

Of sex and determination: marking 25 years of Randy, the sex-reversed mouse.

Koopman P, Sinclair A, Lovell-Badge R.

Development. 2016 May 15;143(10):1633-7. doi: 10.1242/dev.137372.

34.

The Curious World of Gonadal Development in Mammals.

Koopman P.

Curr Top Dev Biol. 2016;116:537-45. doi: 10.1016/bs.ctdb.2015.12.009. Epub 2016 Feb 17. Review.

PMID:
26970639
35.

Performance of handheld electrocardiogram devices to detect atrial fibrillation in a cardiology and geriatric ward setting.

Desteghe L, Raymaekers Z, Lutin M, Vijgen J, Dilling-Boer D, Koopman P, Schurmans J, Vanduynhoven P, Dendale P, Heidbuchel H.

Europace. 2017 Jan;19(1):29-39. doi: 10.1093/europace/euw025. Epub 2016 Feb 17.

PMID:
26893496
36.

ALDH1A1 provides a source of meiosis-inducing retinoic acid in mouse fetal ovaries.

Bowles J, Feng CW, Miles K, Ineson J, Spiller C, Koopman P.

Nat Commun. 2016 Feb 19;7:10845. doi: 10.1038/ncomms10845.

37.

Intrauterine Exposure to Paracetamol and Aniline Impairs Female Reproductive Development by Reducing Follicle Reserves and Fertility.

Holm JB, Mazaud-Guittot S, Danneskiold-Samsøe NB, Chalmey C, Jensen B, Nørregård MM, Hansen CH, Styrishave B, Svingen T, Vinggaard AM, Koch HM, Bowles J, Koopman P, Jégou B, Kristiansen K, Kristensen DM.

Toxicol Sci. 2016 Mar;150(1):178-89. doi: 10.1093/toxsci/kfv332. Epub 2016 Jan 5.

PMID:
26732887
38.

Cripto: Expression, epigenetic regulation and potential diagnostic use in testicular germ cell tumors.

Spiller CM, Gillis AJ, Burnet G, Stoop H, Koopman P, Bowles J, Looijenga LH.

Mol Oncol. 2016 Apr;10(4):526-37. doi: 10.1016/j.molonc.2015.11.003. Epub 2015 Nov 18.

39.

Germ cells influence cord formation and Leydig cell gene expression during mouse testis development.

Rios-Rojas C, Spiller C, Bowles J, Koopman P.

Dev Dyn. 2016 Apr;245(4):433-44. doi: 10.1002/dvdy.24371. Epub 2016 Jan 8.

40.

Conservation analysis of sequences flanking the testis-determining gene Sry in 17 mammalian species.

Larney C, Bailey TL, Koopman P.

BMC Dev Biol. 2015 Oct 6;15:34. doi: 10.1186/s12861-015-0085-6.

41.

FGFR2 mutation in 46,XY sex reversal with craniosynostosis.

Bagheri-Fam S, Ono M, Li L, Zhao L, Ryan J, Lai R, Katsura Y, Rossello FJ, Koopman P, Scherer G, Bartsch O, Eswarakumar JV, Harley VR.

Hum Mol Genet. 2015 Dec 1;24(23):6699-710. doi: 10.1093/hmg/ddv374. Epub 2015 Sep 11.

42.

ROBO2 restricts the nephrogenic field and regulates Wolffian duct-nephrogenic cord separation.

Wainwright EN, Wilhelm D, Combes AN, Little MH, Koopman P.

Dev Biol. 2015 Aug 15;404(2):88-102. doi: 10.1016/j.ydbio.2015.05.023. Epub 2015 Jun 23.

43.

Purification and Transcriptomic Analysis of Mouse Fetal Leydig Cells Reveals Candidate Genes for Specification of Gonadal Steroidogenic Cells.

McClelland KS, Bell K, Larney C, Harley VR, Sinclair AH, Oshlack A, Koopman P, Bowles J.

Biol Reprod. 2015 Jun;92(6):145. doi: 10.1095/biolreprod.115.128918. Epub 2015 Apr 8.

PMID:
25855264
44.

RNA binding protein Musashi-1 directly targets Msi2 and Erh during early testis germ cell development and interacts with IPO5 upon translocation to the nucleus.

Sutherland JM, Sobinoff AP, Fraser BA, Redgrove KA, Davidson TL, Siddall NA, Koopman P, Hime GR, McLaughlin EA.

FASEB J. 2015 Jul;29(7):2759-68. doi: 10.1096/fj.14-265868. Epub 2015 Mar 17.

PMID:
25782991
45.

Female-to-male sex reversal in mice caused by transgenic overexpression of Dmrt1.

Zhao L, Svingen T, Ng ET, Koopman P.

Development. 2015 Mar 15;142(6):1083-8. doi: 10.1242/dev.122184. Epub 2015 Feb 27.

46.

Specific interaction with the nuclear transporter importin α2 can modulate paraspeckle protein 1 delivery to nuclear paraspeckles.

Major AT, Hogarth CA, Miyamoto Y, Sarraj MA, Smith CL, Koopman P, Kurihara Y, Jans DA, Loveland KL.

Mol Biol Cell. 2015 Apr 15;26(8):1543-58. doi: 10.1091/mbc.E14-01-0678. Epub 2015 Feb 18.

47.

Rapid screening of gene function by systemic delivery of morpholino oligonucleotides to live mouse embryos.

McClelland KS, Wainwright EN, Bowles J, Koopman P.

PLoS One. 2015 Jan 28;10(1):e0114932. doi: 10.1371/journal.pone.0114932. eCollection 2015.

48.

On the role of germ cells in mammalian gonad development: quiet passengers or back-seat drivers?

Rios-Rojas C, Bowles J, Koopman P.

Reproduction. 2015 Apr;149(4):R181-91. doi: 10.1530/REP-14-0663. Epub 2015 Jan 27. Review.

PMID:
25628441
49.

Primary cilia function regulates the length of the embryonic trunk axis and urogenital field in mice.

Wainwright EN, Svingen T, Ng ET, Wicking C, Koopman P.

Dev Biol. 2014 Nov 15;395(2):342-54. doi: 10.1016/j.ydbio.2014.08.037. Epub 2014 Sep 16.

50.

Whole exome sequencing combined with linkage analysis identifies a novel 3 bp deletion in NR5A1.

Eggers S, Smith KR, Bahlo M, Looijenga LH, Drop SL, Juniarto ZA, Harley VR, Koopman P, Faradz SM, Sinclair AH.

Eur J Hum Genet. 2015 Apr;23(4):486-93. doi: 10.1038/ejhg.2014.130. Epub 2014 Aug 6.

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