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Items: 1 to 50 of 113

1.

ELQ-331 as a prototype for extremely durable chemoprotection against malaria.

Smilkstein MJ, Pou S, Krollenbrock A, Bleyle LA, Dodean RA, Frueh L, Hinrichs DJ, Li Y, Martinson T, Munar MY, Winter RW, Bruzual I, Whiteside S, Nilsen A, Koop DR, Kelly JX, Kappe SHI, Wilder BK, Riscoe MK.

Malar J. 2019 Aug 27;18(1):291. doi: 10.1186/s12936-019-2921-9.

2.

Alkoxycarbonate Ester Prodrugs of Preclinical Drug Candidate ELQ-300 for Prophylaxis and Treatment of Malaria.

Frueh L, Li Y, Mather MW, Li Q, Pou S, Nilsen A, Winter RW, Forquer IP, Pershing AM, Xie LH, Smilkstein MJ, Caridha D, Koop DR, Campbell RF, Sciotti RJ, Kreishman-Deitrick M, Kelly JX, Vesely B, Vaidya AB, Riscoe MK.

ACS Infect Dis. 2017 Oct 13;3(10):728-735. doi: 10.1021/acsinfecdis.7b00062. Epub 2017 Sep 27.

3.

Longitudinal study on the use of dried blood spots for home monitoring in children after kidney transplantation.

Al-Uzri A, Freeman KA, Wade J, Clark K, Bleyle LA, Munar M, Koop DR.

Pediatr Transplant. 2017 Sep;21(6). doi: 10.1111/petr.12983. Epub 2017 Jun 20.

PMID:
28635157
4.

Intestinal Metabolites Are Profoundly Altered in the Context of HLA-B27 Expression and Functionally Modulate Disease in a Rat Model of Spondyloarthritis.

Asquith M, Davin S, Stauffer P, Michell C, Janowitz C, Lin P, Ensign-Lewis J, Kinchen JM, Koop DR, Rosenbaum JT.

Arthritis Rheumatol. 2017 Oct;69(10):1984-1995. doi: 10.1002/art.40183. Epub 2017 Aug 31.

5.

Diphenylether-Modified 1,2-Diamines with Improved Drug Properties for Development against Mycobacterium tuberculosis.

Foss MH, Pou S, Davidson PM, Dunaj JL, Winter RW, Pou S, Licon MH, Doh JK, Li Y, Kelly JX, Dodean RA, Koop DR, Riscoe MK, Purdy GE.

ACS Infect Dis. 2016 Jul 8;2(7):500-8. doi: 10.1021/acsinfecdis.6b00052. Epub 2016 May 13.

6.

A comparison of salivary testosterone measurement using immunoassays and tandem mass spectrometry.

Welker KM, Lassetter B, Brandes CM, Prasad S, Koop DR, Mehta PH.

Psychoneuroendocrinology. 2016 Sep;71:180-8. doi: 10.1016/j.psyneuen.2016.05.022. Epub 2016 May 24.

PMID:
27295182
7.

A role for adenine nucleotides in the sensing mechanism to purine starvation in Leishmania donovani.

Martin JL, Yates PA, Boitz JM, Koop DR, Fulwiler AL, Cassera MB, Ullman B, Carter NS.

Mol Microbiol. 2016 Jul;101(2):299-313. doi: 10.1111/mmi.13390. Epub 2016 May 3.

8.

A phase II study of sulforaphane-rich broccoli sprout extracts in men with recurrent prostate cancer.

Alumkal JJ, Slottke R, Schwartzman J, Cherala G, Munar M, Graff JN, Beer TM, Ryan CW, Koop DR, Gibbs A, Gao L, Flamiatos JF, Tucker E, Kleinschmidt R, Mori M.

Invest New Drugs. 2015 Apr;33(2):480-9. doi: 10.1007/s10637-014-0189-z. Epub 2014 Nov 29.

9.

Threshold levels of ABL tyrosine kinase inhibitors retained in chronic myeloid leukemia cells determine their commitment to apoptosis.

O'Hare T, Eide CA, Agarwal A, Adrian LT, Zabriskie MS, Mackenzie RJ, Latocha DH, Johnson KJ, You H, Luo J, Riddle SM, Marks BD, Vogel KW, Koop DR, Apgar J, Tyner JW, Deininger MW, Druker BJ.

Cancer Res. 2013 Jun 1;73(11):3356-70. doi: 10.1158/0008-5472.CAN-12-3904. Epub 2013 Apr 10.

10.

Analysis of tacrolimus and creatinine from a single dried blood spot using liquid chromatography tandem mass spectrometry.

Koop DR, Bleyle LA, Munar M, Cherala G, Al-Uzri A.

J Chromatogr B Analyt Technol Biomed Life Sci. 2013 May 1;926:54-61. doi: 10.1016/j.jchromb.2013.02.035. Epub 2013 Mar 4.

11.

Naloxone pro-drug rescues morphine induced respiratory depression in Sprague-Dawley rats.

Wallisch M, El Rody NM, Huang B, Koop DR, Baker JR Jr, Olsen GD.

Respir Physiol Neurobiol. 2012 Jan 15;180(1):52-60. doi: 10.1016/j.resp.2011.10.009. Epub 2011 Oct 19.

PMID:
22027217
12.

The effects of nitrogen-heme-iron coordination on substrate affinities for cytochrome P450 2E1.

Jones JP, Joswig-Jones CA, Hebner M, Chu Y, Koop DR.

Chem Biol Interact. 2011 Aug 15;193(1):50-6. doi: 10.1016/j.cbi.2011.05.001. Epub 2011 May 10.

13.

Ubiquitin-dependent proteasomal degradation of human liver cytochrome P450 2E1: identification of sites targeted for phosphorylation and ubiquitination.

Wang Y, Guan S, Acharya P, Koop DR, Liu Y, Liao M, Burlingame AL, Correia MA.

J Biol Chem. 2011 Mar 18;286(11):9443-56. doi: 10.1074/jbc.M110.176685. Epub 2011 Jan 5.

14.

Interstrain differences in the liver effects of trichloroethylene in a multistrain panel of inbred mice.

Bradford BU, Lock EF, Kosyk O, Kim S, Uehara T, Harbourt D, DeSimone M, Threadgill DW, Tryndyak V, Pogribny IP, Bleyle L, Koop DR, Rusyn I.

Toxicol Sci. 2011 Mar;120(1):206-17. doi: 10.1093/toxsci/kfq362. Epub 2010 Dec 6.

15.

Optimization of endochin-like quinolones for antimalarial activity.

Winter R, Kelly JX, Smilkstein MJ, Hinrichs D, Koop DR, Riscoe MK.

Exp Parasitol. 2011 Feb;127(2):545-51. doi: 10.1016/j.exppara.2010.10.016. Epub 2010 Oct 30.

16.

Pharmacokinetic study of lipoic acid in multiple sclerosis: comparing mice and human pharmacokinetic parameters.

Yadav V, Marracci GH, Munar MY, Cherala G, Stuber LE, Alvarez L, Shinto L, Koop DR, Bourdette DN.

Mult Scler. 2010 Apr;16(4):387-97. doi: 10.1177/1352458509359722. Epub 2010 Feb 11.

17.

Mechanism for prevention of alcohol-induced liver injury by dietary methyl donors.

Powell CL, Bradford BU, Craig CP, Tsuchiya M, Uehara T, O'Connell TM, Pogribny IP, Melnyk S, Koop DR, Bleyle L, Threadgill DW, Rusyn I.

Toxicol Sci. 2010 May;115(1):131-9. doi: 10.1093/toxsci/kfq031. Epub 2010 Jan 29.

18.

Paired assessment of volatile anesthetic concentrations with synaptic actions recorded in vitro.

McDougall SJ, Peters JH, LaBrant L, Wang X, Koop DR, Andresen MC.

PLoS One. 2008 Oct 8;3(10):e3372. doi: 10.1371/journal.pone.0003372.

19.

Soluble epoxide hydrolase gene deletion is protective against experimental cerebral ischemia.

Zhang W, Otsuka T, Sugo N, Ardeshiri A, Alhadid YK, Iliff JJ, DeBarber AE, Koop DR, Alkayed NJ.

Stroke. 2008 Jul;39(7):2073-8. doi: 10.1161/STROKEAHA.107.508325. Epub 2008 Mar 27.

20.

Isoflurane differentially modulates inhibitory and excitatory synaptic transmission to the solitary tract nucleus.

Peters JH, McDougall SJ, Mendelowitz D, Koop DR, Andresen MC.

Anesthesiology. 2008 Apr;108(4):675-83. doi: 10.1097/ALN.0b013e318167af9a.

PMID:
18362600
22.

Effect of pregnancy on the pharmacokinetics of paclitaxel: a case report.

Lycette JL, Dul CL, Munar M, Belle D, Chui SY, Koop DR, Nichols CR.

Clin Breast Cancer. 2006 Oct;7(4):342-4.

PMID:
17092404
23.

Steatohepatitis induced by intragastric overfeeding in mice.

Deng QG, She H, Cheng JH, French SW, Koop DR, Xiong S, Tsukamoto H.

Hepatology. 2005 Oct;42(4):905-14.

PMID:
16175602
24.

Centella asiatica accelerates nerve regeneration upon oral administration and contains multiple active fractions increasing neurite elongation in-vitro.

Soumyanath A, Zhong YP, Gold SA, Yu X, Koop DR, Bourdette D, Gold BG.

J Pharm Pharmacol. 2005 Sep;57(9):1221-9.

PMID:
16105244
25.

A phase I study of 5-fluorouracil, leucovorin, and celecoxib in patients with incurable colorectal cancer.

Blanke CD, Mattek NC, Deloughery TG, Koop DR.

Prostaglandins Other Lipid Mediat. 2005 Jan;75(1-4):169-72.

PMID:
15789623
26.

Cytochrome P450 CYP2E1, but not nicotinamide adenine dinucleotide phosphate oxidase, is required for ethanol-induced oxidative DNA damage in rodent liver.

Bradford BU, Kono H, Isayama F, Kosyk O, Wheeler MD, Akiyama TE, Bleye L, Krausz KW, Gonzalez FJ, Koop DR, Rusyn I.

Hepatology. 2005 Feb;41(2):336-44.

PMID:
15660387
27.

Proteasome-dependent degradation of cytochromes P450 2E1 and 2B1 expressed in tetracycline-regulated HeLa cells.

Huan JY, Streicher JM, Bleyle LA, Koop DR.

Toxicol Appl Pharmacol. 2004 Sep 15;199(3):332-43.

PMID:
15364548
28.

Omega-hydroxylation of farnesol by mammalian cytochromes p450.

DeBarber AE, Bleyle LA, Roullet JB, Koop DR.

Biochim Biophys Acta. 2004 Jun 1;1682(1-3):18-27.

PMID:
15158752
29.

CYP2E1 overexpression alters hepatocyte death from menadione and fatty acids by activation of ERK1/2 signaling.

Schattenberg JM, Wang Y, Rigoli RM, Koop DR, Czaja MJ.

Hepatology. 2004 Feb;39(2):444-55.

PMID:
14767997
30.

The CYP inhibitor 1-aminobenzotriazole does not prevent oxidative stress associated with alcohol-induced liver injury in rats and mice.

Isayama F, Froh M, Bradford BU, McKim SE, Kadiiska MB, Connor HD, Mason RP, Koop DR, Wheeler MD, Arteel GE.

Free Radic Biol Med. 2003 Dec 15;35(12):1568-81.

PMID:
14680680
31.

Rat hepatic CYP2E1 is induced by very low nicotine doses: an investigation of induction, time course, dose response, and mechanism.

Micu AL, Miksys S, Sellers EM, Koop DR, Tyndale RF.

J Pharmacol Exp Ther. 2003 Sep;306(3):941-7. Epub 2003 May 15.

PMID:
12750430
32.

Analysis of differential substrate selectivities of CYP2B6 and CYP2E1 by site-directed mutagenesis and molecular modeling.

Spatzenegger M, Liu H, Wang Q, Debarber A, Koop DR, Halpert JR.

J Pharmacol Exp Ther. 2003 Jan;304(1):477-87.

PMID:
12490624
33.

Cytochrome P450 2E1 expression induces hepatocyte resistance to cell death from oxidative stress.

Jones BE, Liu H, Lo CR, Koop DR, Czaja MJ.

Antioxid Redox Signal. 2002 Oct;4(5):701-9.

PMID:
12470497
35.
36.

Attenuation of CCl(4)-induced hepatic fibrosis by GdCl(3) treatment or dietary glycine.

Rivera CA, Bradford BU, Hunt KJ, Adachi Y, Schrum LW, Koop DR, Burchardt ER, Rippe RA, Thurman RG.

Am J Physiol Gastrointest Liver Physiol. 2001 Jul;281(1):G200-7.

37.

Retention of nociceptor responses during deep barbiturate anesthesia in frogs.

Downes H, Koop DR, Klopfenstein B, Lessov N.

Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1999 Oct;124(2):203-10.

PMID:
10622437
38.

CYP2E1 is not involved in early alcohol-induced liver injury.

Kono H, Bradford BU, Yin M, Sulik KK, Koop DR, Peters JM, Gonzalez FJ, McDonald T, Dikalova A, Kadiiska MB, Mason RP, Thurman RG.

Am J Physiol. 1999 Dec;277(6):G1259-67. doi: 10.1152/ajpgi.1999.277.6.G1259.

PMID:
10600824
39.
40.
41.

Enzymatic determinants of the substrate specificity of CYP2C9: role of B'-C loop residues in providing the pi-stacking anchor site for warfarin binding.

Haining RL, Jones JP, Henne KR, Fisher MB, Koop DR, Trager WF, Rettie AE.

Biochemistry. 1999 Mar 16;38(11):3285-92.

PMID:
10079071
42.

Role of human CYP4F2 in hepatic catabolism of the proinflammatory agent leukotriene B4.

Jin R, Koop DR, Raucy JL, Lasker JM.

Arch Biochem Biophys. 1998 Nov 1;359(1):89-98.

PMID:
9799565
43.

Oxidation of 1,3-butadiene to (R)- and (S)-butadiene monoxide by purified recombinant cytochrome P450 2E1 from rabbit, rat and human.

Nieusma JL, Claffey DJ, Koop DR, Chen W, Peter RM, Nelson SD, Ruth JA, Ross D.

Toxicol Lett. 1998 Mar 31;95(2):123-9.

PMID:
9635416
44.

Cyclosporine suppresses rat hepatic cytochrome P450 in a time-dependent manner.

Brunner LJ, Bennett WM, Koop DR.

Kidney Int. 1998 Jul;54(1):216-23.

45.

Cytochrome P450-dependent desaturation of lauric acid: isoform selectivity and mechanism of formation of 11-dodecenoic acid.

Guan X, Fisher MB, Lang DH, Zheng YM, Koop DR, Rettie AE.

Chem Biol Interact. 1998 Mar 12;110(1-2):103-21.

PMID:
9566728
46.
47.
48.

Epoxidation of C18 unsaturated fatty acids by cytochromes P4502C2 and P4502CAA.

Laethem RM, Balazy M, Koop DR.

Drug Metab Dispos. 1996 Jun;24(6):664-8.

PMID:
8781783
49.

Selective suppression of rat hepatic microsomal activity during chronic cyclosporine nephrotoxicity.

Brunner LJ, Bennett WM, Koop DR.

J Pharmacol Exp Ther. 1996 Jun;277(3):1710-8.

PMID:
8667242
50.

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